Diabetes And Epigenetics
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Many of the risk factors that increase the likelihood of Type II Diabetes Mellitus can change the epigenetic pattern in liver, adipose tissue and skeletal muscle by varying gene expression and metabolism in such tissues.
Obesity contributes to the establishment of low-grade inflammation and insulin resistance states.
Carlos Herrero Carcedo
Autor de dos Libros con tapa: Manual Básico de Farmacología y 200 Ideas para Mejorar la Rentabilidad de tu Farmacia, una publicación en la revista Alimentación, Equipos y Tecnología: La histamina en las distintas etapas de fabricación de conservas de atún y seis Ebooks: Disruptores Endocrinos, La Salud no es un Negocio, Obesidad Infantil. Rista. Respuesta Insuficientemente Adecuada, Vivir sin Cáncer, Ser Mayor sin Edad y Predisposición a Ser Homosexual.Posee tres licenciaturas (Farmacia, Ciencias Químicas, Ciencia y Tecnología de los Alimentos) y experiencia en los departamentos de Calidad, Producción y Ventas.
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Diabetes And Epigenetics - Carlos Herrero Carcedo
DIABETES
AND
EPIGENETICS
Carlos Herrero Carcedo
www.carlosherrerocarcedo.com
DIABETES AND
EPIGENETICS
Carlos Herrero Carcedo
www.carlosherrerocarcedo.com
Copyright© 2020 by Carlos Herrero Carcedo
All rights reserved
LEGAL WARNING
It is strictly prohibited without the written permission of the copyright holder, the reproduction of this work by any means or process including reprography and computer processing.
TABLE OF CONTENTS
1. The Epidemic of Type II Diabetes Mellitus
2. Diabetes and Epigenetics
3. Diabetes and Inflammation
4. Diabetes and Atherosclerosis
5. Diabetes and Endocrine Disruptors
6. Abbreviations
1.The Epidemic of Type II Diabetes Mellitus
Type II Diabetes Mellitus is a chronic, complex and multifactorial disease that arises as a result of the interaction of the environment with the gene pool. Environmental factors that contribute to the prevalence of Type II Diabetes Mellitus worldwide are all risk factors that increase the susceptibility to develop this common disease, except for the specific genome of each person.
Thus, for Type II Diabetes Mellitus we have:
Modifiable factors: overweight, obesity, physical inactivity, unhealthy diet, smoking, unfavorable intrauterine environment, stress, drugs, poor or harmful intestinal microbiota, diseases that increase the risk of developing it and chemical compounds present in the environment (some of these synthetic substances are endocrine disruptors).
Unmodifiable factors: age, sex, ethnicity, family history, previous gestational diabetes and abnormal glucose tolerance.
The World Health Organization tells us that the number of people with diabetes has increased from 108 million in 1980 to 422 million in 2014 and the global prevalence of this epidemic has increased from 4.7 per cent in 1980 to 8.5 per cent in 2014.
13.8% of the Spanish population has Type II Diabetes Mellitus and 30% of all Spanish citizens present problems with glucose metabolism.
Although we have, overall, better analytical methods, 50% of cases of diabetes remain undiagnosed. That is, there is an undiagnosed diabetic patient for each one already diagnosed.
People with Type II Diabetes Mellitus can not regulate the amount of glucose in the blood, the insulin being secreted by the pancreas the hormone responsible for reducing the concentration of blood glucose (glycemia) by transporting glucose from the bloodstream to myocytes of the muscle, mainly, adipocytes of