Hydroxypropyl Mehtylcellulose Cellulose, 2-hydroxypropyl methyl ether Cellulose hydroxypropyl methyl ether [9004-65-3], available in grades containing 16.

5cto 30.0% of methoxy and 4.0 to 32.0% of hydroxypropyl groups, and thus in viscosity and thermal gelation temperatures of solutions of specified concentration. Preparation The appropriate grade of methylcellulose (see below) is treated with NaOH and reacted with propylene oxide at elevated temperatures and pressure and for a reaction time sufficient to produce the desired degree of attachment of methyl and hydroxypropyl groups by ether linkage to the anhydroglucose rings of cellulose. Description White to slightly of-white, fibrous or granular, free-flowing powder. Uses A protective collid that is useful as a dispersing and thickening agent, and in opthalmic solutions to provide the demulcent action and viscous properties essential for contact-lens use and in artificial-tear formulations. [page 1306] Hydroxypropyl Methylcellulose Opthalmic Solution A sterile solution of hydroxypropyl methylcelluose, of a grade containing 19.030.0% methoxy and 4.0-12.0% hydroxypropoxy groups; may ontain antimicrobial, buffering and stabilizing agents. Uses A wetting solution for contact lenses. Its demulcent action decrease the irritant effect of the lens on the cornea. It also imparts viscous properties to the wetting solution, which assists the lens in staying in place. The demulcent effect also finds application in ophthalmic decongestants. Artificial tear formulation containing this drug may be used when lacrimation is inadequate. A 2.5% solution is used in gonioscopes. Dose Topical,to the conjunctiva, 1 drop of 0.3 to 1% solution 3 or 4 times a day. Dosage form 0.3, 0.5 and 1% solution. [page 760] from Remingtons Pharmaceutical Scinces : Eighteenth edition