Basic Replication STrategry Know th e antiviral drugs!!

RNA viruses replicate in cytoplasm-1 exception-Orthomyxo DNA replicate in NUCLEUS-ExceptionPOX

HEPADNA Virion maturation.Golgi?

Togaviruses mature at the membrane-P = PLASMA MEMBRANE Flavi viruses RER or golgi

All Negative Strand RNA viruses are Enveloped!!

Acute either kill you or immune for life. Measles SSPE Latent infections HERPES! Chronic: HCV, HBV Chronic infection w/ late disease: HIV, HCV, HBV, HTLV-1 Slow infectinprions, you are infected with a prion & it is not until 12 years later that you develop BSE or CJD?

Most common way RHINOVIRUSES are transmitted is through fomites.

Arena viruses maintained in rodents. Sexual contact: Herpes, Papilloma---also HIV or maybe hepatitis Genetic: Prionspossibly retroviruses

Common Cold: Rhinoviruses & Corona viruses

Pharyngitis: Adenovirus EBV on initial infection

Know the major bacteria that cause pneumonia: S. aureus Strep pneumonia H. influenza Herpes & CMV can also cause pneumonia in an immunocompromised host.

GASTROINTESTINAL: Infants Rotavirus

RASH: Know the difference between the MEASLES & RUBELLA RASH RUBELLA: Less severe, lasts a shorter period of time

Liver -Hepatitis ABCDE Yellow fever EBV- heptosplenomegaly in patients who have mono. Hepatitis CMV HSV-1 & 2 VZV Rubella virus Heart (Myocarditis & Pericarditis) Coxsackie B Kidney BK & CMV

Enteroviruses most common cause of viral meningitis!! Mumps & measles are neurotropic in nature Herpes virus causes encephalitis in the inferior temporal lobe ARboviruses HIV-invades the brain EARLY. Can cause Aids demential complex later on

Herpes is the most common cause of SPORADIC encephalitis in an epidemic

Question 1:

Answer: B o This is the only virus that causes Tropical Spastic Paraperesis o Key Word: TSP HTLVI!

Question 2

Answer: B

Question 3

Answer: B Current vaccine is an INACTIVE VIRUS Question 4

Answer: E S. aureus Question 5

Answer: D Window between disappearance of HBsAg & Antibodies to the surface antigen