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Xanthogranuloma

Deba P Sarma, MD Omaha

F 18, left scapula nodule.

CD 68

XIIIa

Diagnosis: Xanthogranuloma
Comment: Intact epidermis with a diffuse dermal proliferation of large cells with angulated nuclei, abundant foamy cytoplasm, and well defined cell borders. The nuclei show inconspicuous nucleoli. Several multinucleated Touton-type giant cells ase seen.

The cytoplasm of the cells stain for CD 68 and Factor XIIIa, but not with S-100 and CD 1a. The lesion is most commonly seen in children, but it can occur at any age.

Male,30, right elbow lesion.

Diagnosis: Xanthogranuloma

M 17 yrs, mid back

Diagnosis: Xanthogranuloma

M 39, right nasal ala.

Diagnosis: Xanthogranuloma

M 23, right nare.

Diagnosis: Xanthogranuloma

M,69, multiple indurated plaques,both upper arms, upper chest, face.

Diagnosis: Necrobiotic xanthogranuloma

References
Necrobiotic Xanthogranuloma A Review of 17 Cases With Emphasis on Clinical and Pathologic Correlation Angela J. Wood, MD; M. Veronica Uraga Wagner, MD; Jared J. Abbott, MD, PhD; Lawrence E. Gibson, MD

Arch Dermatol. 2009;145(3):279-284.