Benign epithelial tumours

LP 8
 Morfology of neoplasms
• Abnormal tissue proliferation
– The neoplasms are no concordant with nearby tissue
– persistent. and continue to proliferate after the
ceasing of the stimulus
• Tumour classification
– hystogenetic criteria
• epiteliale
• conjunctive
– Evolutive criteria
• benign
• malignant
 The benign epithelial tumours
• origin in the epithelial tissues
• Papilloma: benign epithelial tumour that is formed by papillar
structures composed of proliferated epithelium disposed on a
connective-vascular core.
• Adenoma: is a benign epithelial tumour that originate
in the glandular epithelium of cavitary organs and
exocrine or endocrine parenchyma.
• Microscopically
 Squamocellular papilloma
 Adenomatous polyp
 Fibroadenoma of breast
 Papiloma
Scuamocelular papiloma
- skin
• origin – epidermis
• prominent vegetant
tumours of the skin
• The tumoral proliferation
of epidermis is disposed
on a connective-vascular
core with the role of
nutrition and supporting
 Scuamocelular
papiloma - skin
•The epidermis keeps the normal
stratification:
•a basal layer
stratum spinosum (hyperacanthosis)
granular layer - hypergranulosis
•stratum corneum (hyperkaratosis)

•The basal membrane between the

proliferated epidermis and the
connective-vascular core is intact.
 Fibroadenoma of
breast
• Is a benign mixed tumour
hormonodependent
(hiperestrogenism)
formed by two
components
 Epithelial
component –
proliferation of the
ductular epithelium

 Connective
component –
fibroblasts
proliferation
• The tumour is
nodular,
enncapsulated
included in the
Fibroadenoma
• There are two
histologic variants:
 pericanalicular – the
connective tissue
proliferates arround
the ductular lumen
keeping the lumen
open
 intracanalicular –
connective tissue
proliferates and
compress the ductular
lumen which become as
a slit
• The two histologic
types can coexist in
the same tumour
 Adenomatous polyp
• Vegetant tumour,
that results from
the proliferation of
the surface and
glandular
epithelium
• The tumouris
composed from
vili sustained by a
branching
connective-
vascular core
 With the role of
support and
nutrition
 Contains numerous
glands limited by a
displastic
epithelium