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BY Dr.A.Sridhar
Any substance that is capable of producing a therapeutic effect can also produce unwanted or adverse effects
an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product
WHOs definition
a response to a drug that is noxious and unintended and occurs at doses normally used in man for the prophylaxis, diagnosis or therapy of
Toxicity Overdose of a drug that injures a physiologic system Side effect Expected or predictable undesirable effect of a drug that occurs at therapeutic doses Drugdrug interaction The presence of one drug effects the pharmacodynamics (absorption, distribution, metabolism, excretion) of another drug
Drugphysiology interaction The presence of a drug alters the bodies physiology, leading to a harmful condition (may overlap with the concept of side effect)
Druglaboratory test Drug interaction will alter laboratory test results without impacting the physiologic system being measured essentially a false-positive or false-negative laboratory test result Allergic reaction Drug triggers an immunologic response Idiosyncratic reaction Drug creates a physiologic or psychological response that is unpredictable and is unique to the individual