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  • Anti Metabolic Activity of L-Ascorbic Acid in Human and Animal Tumors.

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    Utopiaawaits
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    Vitamin C inhibited DNA synthesis by transformed cells 3-4 times more efficiently than by normal cells. Removal of Vitamin C caused an immediate onset of spontaneous repair of single or double stranded DNA breaks. If, however, vitamin was reintroduced into cell culture, this spontaneous repair was reversed.

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    Vitamin C inhibited DNA synthesis by transformed cells 3-4 times more efficiently than by normal cells. Removal of Vitamin C caused an immediate onset of spontaneous repair of single or double stranded DNA breaks. If, however, vitamin was reintroduced into cell culture, this spontaneous repair was reversed.

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    Anti Metabolic Activity of L-Ascorbic Acid in Human and Animal Tumors.

    Transféré par

    Utopiaawaits
    Vitamin C inhibited DNA synthesis by transformed cells 3-4 times more efficiently than by normal cells. Removal of Vitamin C caused an immediate onset of spontaneous repair of single or double stranded DNA breaks. If, however, vitamin was reintroduced into cell culture, this spontaneous repair was reversed.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
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    Title: Antimetabolic activity of L-ascorbic acid in human and animal tumors.
    Author: Pavelic, K : Kos, Z : Spaventi, S
    Citation: Int-J-Biochem. 1989; 21(8): 931-5
    1. The effect of high concentrations of L-ascorbic acid on the growth of some human and animal
    transformed and non-transformed cell lines has been investigated. Directly implemented into
    culture of transformed cell lines it decreased [3H]thymidine, [3H]uridine and [3H]leucine
    incorporation into cells. Vitamin C inhibited DNA synthesis by transformed cells 3-4 times more
    efficiently than by normal cells. 2. In vivo treatment of athymic nude mice bearing human
    mammary carcinoma with 500 mg/kg L-ascorbic acid for the first 15 days markedly inhibited the
    Abstract: growth of tumor cells. 3. As determined by alkaline elution, both DNA strand breaks and DNA
    cross links were observed in mammary carcinoma cells treated with vitamin C. DNA-DNA and
    DNA-protein cross links in cells treated with L-ascorbic acid were revealed by the proteinase K
    assay. Removal of vitamin C caused an immediate onset of spontaneous repair of single or
    double stranded DNA breaks. If, however, vitamin was reintroduced into cell culture, this
    spontaneous repair was reversed. 4. Our results indicate an antimetabolic activity of L-ascorbic
    acid in human and animal transformed cells, probably due to lethal damages in DNA.
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    Notes: None
    Language: English
    Publication
    Journal-Article
    Type:
    Keywords: Antimetabolites, Antineoplastic : Ascorbic Acid pharmacology
    URL: http://www.elsevier.com/locate/ijbiochemcb

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