Purpose Acetoacetic Acid Synthesis Aldol condensation

Reagents

Things to Know

Birch Reduction

To convert arene into nonconjugated diene

Na, NH3,CH3OH

Alkylated dienes have alkyl group on double bond

Claisen Condensation Clemensen Reduction Corey-House Coupling Dieckmann Reaction Diels-Alder Reaction To create a cyclohexene ring benzene s-cis, C=O/C=N most reactive, one more ring than reactant To reduce aryl ketone to alkyl benzene Zn (Hg) in HCl Used w/ primary alkyl halides

Fisher Esterification Friedel Crafts Acylation Friedel Crafts Alkylation Gatterman Reaction Grignard Reaction To create aryl ketones To create an alkyl benzene AlCl3/CS2 *do not rearrange

AlCl3

*rearrangement w/ primary alkyl halides

Hell-Volhard Zelinsky Reaction Hoffmann Degradation Hoffmann Elimination Keto-enol Tauteromerism Malonic Ester Synthesis Robinson Annulation

Sandmeyer Reaction Simmons Smith Reaction