Amoxicillin 250 mg 2x2 Amoxicillin 500 mg 1x2

Amoxicillin -lactam antibiotic spectrum

: Streptococcus spp., penicillin-susceptible Streptococcus
pneumoniae, non -lactamase-producing Staphylococcus spp., and Enterococcus
faecalis.
: Non- -lactamase producing strains of the following bacteria:
Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia
coli, Proteus mirabilis and Salmonella spp.
: Penicillinase-producing organisms, particularly penicillinase-producing
Staphylococcus spp. Penicillinase-producing N. gonorrhoeae and H. influenzae are
also resistant. Pseudomonas spp., Klebsiella spp., Enterobacter spp.,
indole-positive Proteus spp., Serratia marcescens, and Citrobacter spp. are resistant.
Amoxiciiln -lactamase-producing resistant organisms,
including E. coli, (1)
Amoxicillin

1. Time dependent (

) Time dependent
MIC (minimal inhibitory concentration = )
(Interval) Amoxicillin 8
( MIC ( 4 x MIC) T>MIC
(peak level)
2. Post antibiotic effect (PAE) ( Amoxicillin
post antibiotic effect (PAE) ) Post antibiotic effect (PAE)
Concentration-dependent Aminoglycosides ;AMGs (
Gentamycin ) Quinolone ( Norfloxacin, Ofloxacin )
Amoxicillin PAE 1 2
( !!!)
Amoxicillin 8 ( Around-the-Clock
1x3 q8hr 08.00-16.00-24.00 . 06.00-14.0022.00 . 08.00-12.00-16.00.) (2)

 Amoxicillin
: 20-50 mg/kg/day 8 ( high dose Amoxicillin (AOM)
S. pneumoniae Amoxicillin dose 80-90 mg/kg/day 12
(2))
: 250-500 mg 8 500-875 mg 2 ( 2-3 /)
.. (4, 5) . Amoxicillin
bid Drug Facts and comparisons,
AHFS, PDR USP DI 2x2
1. / / (Mild/Moderate)
500 12 (SEVERE) 875 12
2. (Mild/Moderate SEVERE) 875 12
3. (DUODENAL ULCER RECURRENCE) Helicobacter pylori
1 12 14 ( clarithromycin lansoprazole)
microbiologist () MIC MIC MIC
MIC H.influenzae gram -ve enteric MIC
Streptococcus spp. (tid) (bid) 5

/ :
1. http://en.wikipedia.org/wiki/Amoxicillin
2. Lacy, FC et al. Drug Information Handbook, 9th edition, 2001-2002
3. http://www.rxlist.com/cgi/generic/amox_ids.htm
4. Hoffmann R, Kaemmerer W & Editorial Staff: Amoxicillin (Drug Evaluations). In:
Hutchison TA, Shahan DR & Anderson ML (Eds): DRUGDEX(R) System.
MICROMEDEX, Inc., Englewood, Colorado (Edition expires 12/2000). ( ..
)
5. http://drug.pharmacy.psu.ac.th/Question.asp?ID=500&gid=1
01/07/55 22.26 .