in silico

Virtual tissue culture

Grow, manipulate, and analyze cells
in vivo in vitro

E ndogenics offers services

modeling and simulation of the
development, dynamic organization,
for Advancing research by integrating computer
modeling and wet-bench approaches
simple or complex dynamic, multi-cellular
and function of living tissue. Cells systems

interact with and adapt to their analysis of data from individual cells or
microenvironment through regulatory populations

processes, metabolism, and controlled hypothesis testing and in vivo prediction

gene expression. Virtual tissues are Rapid and convenient pilot experiments
suitable for studying growth, signaling, build, test, & refine cell regulatory networks
differentiation, tumorigenesis, and other gene alterations (knockouts, knockdowns, ...)
processes.
network perturbations (RNAi, dose-response, ...)
micromanipulations (injections, cell ablations, ...)
Complementing wet-bench biology alter culture conditions (media, substrates, ...)

30
cell count

lineage marker
.30 .80
compactness
A dynamic cell mass experimentally manipulated to study homeostasis and shape stability (L-R, metabolic and gene regulatory network; graph
of cell mass developing from a single cell; growth advantage of a mutated cell (orange) causes the cell mass to reorganize).

60
average
[Matrix contact resource]

apical
c basal

b
a

Courtesy of C. Leung (HMS)

Cell a Cell b Cell c
Analysis of mammary acini (L-R, thin optical section of human mammary acinus in Matrigel™; cross-section of virtual mammary acinus; inset:
three polarized cells; resource distribution in individual polarized cells).

Endogenics
TM

280 S. Academy Ave. Ste. 140 Eagle, Idaho 83616

www.endogenics.com (208) 939-2976
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