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  • Reversal of age-related learning deficits in mice with antioxidant mimetics

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    sakuraleeshaoran
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    1. The document reports that mice experience a dramatic loss of learning and memory abilities between 8-11 months of age, associated with increased markers of oxidative stress in the brain. 2. Chronic administration of two synthetic compounds that act as catalytic scavengers of reactive oxygen species from 8-11 months almost completely reversed cognitive deficits and levels of oxidative stress that occurred during this period. 3. In particular, increased levels of protein oxidation were completely prevented by the compounds, while increased lipid peroxidation was reduced by around 50%.

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    Reversal of Age

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    1. The document reports that mice experience a dramatic loss of learning and memory abilities between 8-11 months of age, associated with increased markers of oxidative stress in the brain. 2. Chronic administration of two synthetic compounds that act as catalytic scavengers of reactive oxygen species from 8-11 months almost completely reversed cognitive deficits and levels of oxidative stress that occurred during this period. 3. In particular, increased levels of protein oxidation were completely prevented by the compounds, while increased lipid peroxidation was reduced by around 50%.

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    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    10 vues1 page

    Reversal of age-related learning deficits in mice with antioxidant mimetics

    Transféré par

    sakuraleeshaoran
    1. The document reports that mice experience a dramatic loss of learning and memory abilities between 8-11 months of age, associated with increased markers of oxidative stress in the brain. 2. Chronic administration of two synthetic compounds that act as catalytic scavengers of reactive oxygen species from 8-11 months almost completely reversed cognitive deficits and levels of oxidative stress that occurred during this period. 3. In particular, increased levels of protein oxidation were completely prevented by the compounds, while increased lipid peroxidation was reduced by around 50%.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 1

    Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

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    Ruolan Liu*, Ingrid Y. Liu*, Xiaoning Bi, Richard F. Thompson*, Susan R. Doctrow, Bernard Malfroy, and Michel Baudry* Author Affiliations
    Contributed by Richard F. Thompson, May 9, 2003

    Abstract
    Oxidative stress has been implicated in cognitive impairment in both old experimental animals and aged humans. This implication has led to the notion that antioxidant defense mechanisms in the brain are not sufficient to prevent age-related increase in oxidative damage and that dietary intake of a variety of antioxidants might be beneficial for preserving brain function. Here we report a dramatic loss of learning and memory function from 8 to 11 months of age in mice, associated with marked increases in several markers of brain oxidative stress. Chronic systemic administration of two synthetic catalytic scavengers of reactive oxygen species, Eukarion experimental compounds EUK-189 and EUK-207, from 8 to 11 months almost completely reversed cognitive deficits and increase in oxidative stress taking place during this time period in brain. In particular, increase in protein oxidation was completely prevented, whereas increase in lipid peroxidation was decreased by 50%. In addition, we observed a significant negative correlation between contextual fear learning and levels of protein oxidation in brain. These results further support the role of reactive oxygen species in age-related learning impairment and suggest potential clinical applications for synthetic catalytic scavengers of reactive oxygen species.

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