External electrical defibrillation remains the most successful treatment of VF.

Defibrillation success rates decrease 5-10% for each minute after onset of VF. defibrillation remains the most successful treatment of VF. A shock is delivered to the heart in order to uniformly and simultaneously depolarize a critical mass of the excitable myocardium. The objectives are to interfere with all reentrant arrhythmia and to allow any intrinsic cardiac pacemakers to assume the role of primary pacemaker.

Amiodarone is the first line antidysrhythmic for VF/VT refractory to defibrillation.