Coagulation/clotting of blood

When the blood vessel is intact, blood does not clot due to the presence of active anticoagulants like heparin and antithrombin. But when there is an injury causing rupture of a blood vessel, bleeding starts. This bleeding is stopped by the process of blood clotting during which liquid blood is converted into semisolid jelly. The events occurring during blood clotting are as follows: 1. Release of thromboplastin from thrombocytes and injured tissue. 2. Formation of enzyme prothrombinase in the blood due to initiation of thromboplastin. 3. Conversion of inactive prothrombin into active thrombin by prothrombinase in presence of Ca ions. 4. Conversion of soluble fibrinogen into insoluble fibrin by thrombin 5. Formation of a clot by enmeshing platelets, other blood cells and plasma in the fibrin fibers enmesh. These reactions occur in 2 to 8 minutes. Therefore, clotting time is said to be 2 to 8 minutes. To get more information keep on visiting www.ednexa.com -Team Ednexa