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  • Michelle Meyer, BS, Karie Vander Werf, DVM, Beth Davis, DVM, PHD, Dacvim, Butch Kukanich, DVM, PHD, Dacvcp

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    Ernesta Aulia R
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    This document summarizes a study that analyzed the pharmacokinetics of oral meloxicam tablets in healthy adult horses. The study administered 0.6mg/kg of meloxicam once daily for 14 days to 6 horses. Blood samples were collected on days 1, 7, and 14 to determine plasma meloxicam concentrations using mass spectrometry. The objectives were to determine the pharmacokinetic properties of oral meloxicam tablets compared to previous studies using oral suspensions and IV formulations, and to determine if oral meloxicam administration posed a risk of gastric ulceration in horses.

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    This document summarizes a study that analyzed the pharmacokinetics of oral meloxicam tablets in healthy adult horses. The study administered 0.6mg/kg of meloxicam once daily for 14 days to 6 horses. Blood samples were collected on days 1, 7, and 14 to determine plasma meloxicam concentrations using mass spectrometry. The objectives were to determine the pharmacokinetic properties of oral meloxicam tablets compared to previous studies using oral suspensions and IV formulations, and to determine if oral meloxicam administration posed a risk of gastric ulceration in horses.

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    11 vues1 page

    Michelle Meyer, BS, Karie Vander Werf, DVM, Beth Davis, DVM, PHD, Dacvim, Butch Kukanich, DVM, PHD, Dacvcp

    Transféré par

    Ernesta Aulia R
    This document summarizes a study that analyzed the pharmacokinetics of oral meloxicam tablets in healthy adult horses. The study administered 0.6mg/kg of meloxicam once daily for 14 days to 6 horses. Blood samples were collected on days 1, 7, and 14 to determine plasma meloxicam concentrations using mass spectrometry. The objectives were to determine the pharmacokinetic properties of oral meloxicam tablets compared to previous studies using oral suspensions and IV formulations, and to determine if oral meloxicam administration posed a risk of gastric ulceration in horses.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 1

    PharmacokineticandPharmacodynamicModelingofOralMeloxicaminHealthyAdult Horses

    MichelleMeyer,BS*,KarieVanderWerf,DVM,BethDavis,DVM,PhD,DACVIM,ButchKuKanich,DVM,PhD,DACVCP

    Meloxicamisrecognizedforprovidingselectiveinhibitionofcyclooxygenase(COX)2overthe COX1enzyme.Atherapeuticadvantageofsuchtherapyisthattheselectiveinhibitionof COX2providesantiinflammatoryandanalgesicpropertieswithalowerriskof gastrointestinalorrenaladverseeffects,whichmayoccurwhenusinganonselectiveCOX antagonist.Meloxicamisanonsteroidalantiinflammatorydrugusedtocontrolpainand inflammationinveterinarypatients.Thepurposeofthisinvestigationwastoanalyzeplasma pharmacokineticsoforalmeloxicamtabletsinsixhealthyhorsesatadoseof0.6mg/kgonce dailyfor14days.Completebloodcount,serumchemistryandurinalysiswereusedto determinehealthstatuspriortoinitiationoftreatment.Gastroscopywasperformedbefore andafterthe14daycourseoftreatmenttoevaluateforthepresenceofgastriculcers. Heparinizedwholebloodwascollectedat0,20,and40minutes,andat1,2,4,8,12,and24 hoursondays1,7,and14throughanindwellingjugularcatheter.Troughsampleswere collectedondays4and10toassessdrugaccumulation.Analysisofplasmameloxicam concentrationswithineachsamplewasperformedusingmassspectrometry.Theobjectives forthisstudyweretodeterminepharmacokineticpropertiesoforaltabletscomparedto previouslyreportedresultsusingoralmeloxicamsuspensionandIVformulations.In addition,itwasouraimtodetermineifariskofgastriculcerationwasassociatedwithoral meloxicamadministrationinhorses.

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