Partnership Towards Success & Growth

For over twenty years, we have built partnerships with our customers and with foreign manufacturers whose products we promote and distribute. From inception, Signet aligned its key focus to reflect a global perspective. Our goal was for Indian scientists and formulators to have access to raw materials and excipients available elsewhere in the world. With this in mind, we tied up with several major producers in USA, France, Germany, Japan and other countries. All are global leaders in their respective fields and today Signet proudly occupies a stellar position as Indias largest excipients distributing company. The following fundamentals have contributed to our success and steady growth. Customer Service: Close customer contact backed by well-trained and experienced team dedicated to every aspect pertinent to sales and personal service. Needs of timing, pricing, specifications and delivery are met in the best possible manner. Logistics Support: A management system that assures the right products in the right place at the right time. Careful strategic analysis of lead times, stock levels and pertinent costs that builds maximum efficiency into the supply chain. Technical Support: A team of qualified pharmaceutical personnel collaborating at all levels, whether it is introducing a new product, sampling, assistance in formulating or more complex issues involving our principals; Signet goes with you. Regulatory Support: Pharma industry operates in a regulatory environment. Whether it is for domestic markets or export areas, documents governing use, safety, etc. are a part of the process. GMP, DMF, TSE/BSE, GMO, OVI are just a few of them. Signet is committed to provide all that is available and required. We enjoy our legacy and reputation and continually look forward to deliver better and higher standards of service.

Contents
Index Application Guide
FMC BioPolymer Roquette Freres

Shin-Etsu Chemical Co.

Aqualon
(A division of Hercules Inc.)

BASF Aktiengesellschaft

Asahi Kasei Chemicals Coporation

1
Innophos Domo

4
CP Kelco

9
Rio Tinto Minerals (Luzenac)

17
Ferro Industrias Quimicas

25

29
Kronos International

33
Health & Beauty Solutions (Amcol) Specialty Minerals

39

41
Tereos Hanns G. Werner

43
Dead Sea Periclase

45
Scora

47
Cytec Industries

49
Stepan Co.

51

53
GumBase Co. Stearinerie Dubois

55

57
Lonza Musashino Chemical Laboratory

61
Glossary

63

65

67

69

71

73

77

79

81

Index
Company FMC BioPolymer Products
Avicel PH - Microcrystalline Cellulose (MCC) Avicel RC / CL - Microcrystalline Cellulose & Sodium CMC (Hydrocolloid) Avicel CE - Microcrystalline Cellulose & Guar Gum Ac-Di-Sol - Croscarmellose Sodium LustreClear LC 103 - Aqueous Film Coating System Aquacoat - Aqueous Dispersion for modified release Protanal - Alginate Protacid - Alginic Acid Marine Colloids - Carrageenan Protosan UP - Ultrapure Chitosan Salt Pronova UP / SL - Ultrapure / Sterile Sodium Alginate Sodium Hyaluronate Pearlitol C - Mannitol Crystalline Pearlitol SD / DC - Mannitol, Directly Compressible Kleptose - Betacyclodextrin Kleptose HPB - Hydroxy Propyl Betacyclodextrin Glycolys - Sodium Starch Glycolate Neosorb - Sorbitol Xylisorb - Xylitol Maltisorb - Maltitol Glucidex - Maltodextrin Lycoat - Peas Starch based aqueous film coating system ReadiLYCOAT - Ready-to-use, Aqueous film coating system Lycatab - Modified Starch Lycatab Mineral CC - Compound of Calcium Carbonate & Maize Starch G-D-L - Glucono Delta Lactone Lycadex PF - Injectable Dextrose Monohydrate Lycasin - Maltitol Solution Polysorb - Aqueous Solution of D-Sorbitol & Sorbitan Hi-Sweet - High Fructose Corn Syrup (HFCS) Starlac - Directly compressible Starch & Lactose compound Starch - Maize (Corn) / Potato / Wheat Nutriose - Soluble Fibre Roferose - Dextrose Monohydrate Tackidex - Dextrin Solulys AST - Corn-steep powder Pharmacoat - HPMC, Low viscosity Metolose SH - HPMC, High viscosity Metolose SM - Methyl Cellulose L-HPC - Low Substituted Hydroxy Propyl Cellulose HPMCP - HPMC Phthalate Aqoat - HPMC Acetate Succinate Ethyl Cellulose Pharm Klucel - Hydroxy Propyl Cellulose Natrosol - Hydroxy Ethyl Cellulose Blanose Sodium Carboxymethylcellulose (Na CMC) Kollidon - Povidone (PVPK 12PF, 17PF, 25, 30, 90F) Kollidon SR - Matrix Sustained Release Excipient Kollidon VA 64 - Copolyvidone (Vinyl Acetate Copolymer) Kollidon CL - Crosspovidone (Crosslinked PVP) Kollicoat - Aqueous Coating Systems for modified release Cremophor - Non-ionic surfactants Lutrol - PEG (Macrogol) / Poloxamer Solutol HS 15 - Macrogol-15-Hydroxystearate Ludipress - Advanced Excipient for direct compression Sicovit - Iron Oxide Soluphor P - 2-Pyrrolidone PVP Iodine - Povidone Iodine

Page
9

Novamatrix

15

Roquette Freres

17

Shin-Etsu Chemical Co.

25

Aqualon (A division of Hercules, Inc.)

29

BASF Aktiengesellschaft

33

Company Asahi Kasei Chemicals Corporation

Products
Celphere - Microcrystalline Cellulose Spheres Ceolus KG - Highly Compactible MCC PCS PC 10 - Partly Pregelatinised Starch Trehalose - Non-reducing Di-Saccharide Di-Tab - Dicalcium Phosphate Dihydrate, Granular A-Tab - Dicalcium Phosphate Anhydrous, Granular Tri-Tab - Tricalcium Phosphate Anhydrous, Granular Calipharm - Calcium Phosphate, Powder Lactochem - Lactose Monohydrate Lactopress - DC Lactose Xantural - Xanthan Gum Talc Luzenac Pharma

Page
39

Innophos

41

Domo CP Kelco Rio Tinto Minerals (Luzenac) Ferro Industrias Quimicas Kronos International Health & Beauty Solutions (Amcol) Specialty Minerals Tereos Hanns G. Werner Dead Sea Periclase

43 45 47

Synpro Stearates - Magnesium Stearate / Calcium Stearate / Zinc Stearate 49 Kronos 1171 Titanium Dioxide - Anatase & Superwhite Grade Magnabrite - Magnesium Aluminium Silicate Sturcal L - Heavy, Precipitated Calcium Carbonate Calopake - Extra Light, Precipitated Calcium Carbonate Compressuc - DC Sucrose Icing Sugar - Milled Sucrose Pharm-a-spheres - Sugar Spheres (Non-Pareil Seeds) Magnesium Oxide Magnesium Carbonate Magnesium Hydroxide Scoralite - Calcium Carbonate Magnesium Carbonate Magnesium Oxide Docusate Sodium (DSS) Stepanol - Sodium Lauryl Sulfate Medicated Chewing Gum Base / DC Chewing Gum Base DUB DUB DUB DUB DUB DUB DUB Microlub - Stearic Acid SE - Sucrose Esters MCT - Medium Chain Triglycerides GMS - Glyceryl Stearate DBS - Dibutyl Sebacate DBHG - Glyceryl Dibehenate PP - Hemi-synthetic Glycerides

51 53 55 57 61 63

Scora

65

Cytec Industries Stepan Co. GumBase Co. Stearinerie Dubois

67 69 71 73

Lonza Musashino Chemical Laboratory

D-L Malic Acid D-L Lactic Acid

77 79

Application Guide
Category Fillers and General Binders
Alveosucre A-Tab Avicel PH Calipharm Calopake Caster Sugar / Crystal Sugar Ceolus KG Compressuc Dextrose GC Di-Tab Glucidex Icing Sugar Lactochem Lactopress Ludipress Lycatab Magnesium Salts Maltisorb Neosorb PCS PC-10 Pearlitol Roferose Scoralite Starch Starlac Sturcal L Tackidex Trehalose Tri-tab Xylisorb Agglomerated Sucrose Dicalcium Phosphate Anhydrous, Granular Microcrystalline Cellulose (MCC) Calcium Phosphate Powder Extra Light, Precipitated Calcium Carbonate Screened Sucrose Highly Compactible MCC Directly Compressible Sucrose Directly Compressible Glucose Monohydrate Dicalcium Phosphate Dihydrate, Granular Maltodextrin Milled Sucrose Lactose Monohydrate DC Lactose Advanced Excipient for direct compression Modified Starch Magnesium Oxide / Magnesium Carbonate / Magnesium Hydroxide Maltitol Sorbitol Partly Pregelatinised Starch Mannitol Dextrose Monohydrate Calcium Carbonate of high purity Maize (Corn) / Potato / Wheat based Directly compressible Starch & Lactose compound Heavy, Precipitated Calcium Carbonate Dextrin Non-reducing Di-Saccharide Tricalcium Phosphate Anhydrous, Granular Xylitol 59 42 10 42 56 60 40 58 23 42 24 58 44 44 37 21 64 20 19 40 18 23 66 21 22 56 24 40 42 20

Product

Page

Granulating Binders
Klucel Kollidon Kollidon VA 64 Lycatab Lycatab DSH Metolose SH Metolose SM Pharmacoat Starch Hydroxy Propyl Cellulose Povidone (PVPK 25, 30, 90F) Copolyvidone (Vinyl Acetate Copolymer) Modified Starch Partially Hydrolyzed Maize Starch Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) Methyl Cellulose Hydroxypropyl Methyl Cellulose (HPMC - Low viscosity) Maize (Corn) / Potato / Wheat based 31 34 34 21 21 27 27 26 21

Binders cum Disintegrating agents

L-HPC Lycatab C PCS PC-10 Low Substituted Hydroxypropyl Cellulose Partially Pregelatinised Maize Starch Partly Pregelatinised Starch 28 21 40

Glidants
Talc Luzenac Pharma Talc 48

Application Guide
Category Disintegrants
Ac-Di-Sol Glycolys Kollidon CL L-HPC Protacid Croscarmellose Sodium Sodium Starch Glycolate Crosspovidone (Crosslinked PVP) Low Substituted Hydroxypropyl Cellulose Alginic Acid 11 22 35 28 13

Product

Page

Coating agents (Functional & Non - Functional)

Aqoat Aquacoat CPD 30 Aquacoat ECD 30 Ethyl Cellulose HPMC P Klucel Kollicoat IR Kollicoat MAE Kollicoat SR 30D Kollidon SR LustreClear LC 103 Lycoat Maltisorb Metolose SH Metolose SR Natrosol 250 Pharm Pharmacoat Protanal Protanal Ester ReadiLYCOAT Xylisorb Hydroxy Propyl Methyl Cellulose Acetate Succinate (HPMCAS) Aqueous dispersion of Cellulose Acetate Phthalate Aqueous dispersion of Ethyl Cellulose Ethyl Cellulose Pharm Hydroxy Propyl Methyl Cellulose Phthalate Hydroxypropyl Cellulose Polyvinyl Alcohol-PEG Graft Copolymer Methacrylic Acid Copolymer Aqueous Dispersion of PVA and PVP Matrix Sustained Release Excipient MCC & Carrageenan based Aqueous Film Coating System Peas Starch Based Aqueous Film Coating System Maltitol Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) Hydroxypropyl Methyl Cellulose (HPMC - Sustained Release grade) Hydroxy Ethyl Cellulose (HEC) Hydroxypropyl Methyl Cellulose (HPMC - Low viscosity) Alginate Propylene Glycol Alginate Ready-to-use, Aqueous film coating system Xylitol 28 12 12 30 26 31 35 36 36 35 12 20 20 27 27 30 26 13 13 20 20

Colourants
Kronos 1171 Titanium Dioxide Sicovit Anatase & Superwhite Grade Iron Oxide 52 38

Chewable and Orodispersible aids

Avicel CE15 Ceolus KG D-L Malic Acid Kollidon CL Ludipress Lycatab Mineral CC Lycoat Maltisorb Neosorb Pearlitol Starlac Xylisorb Microcrystalline Cellulose and Guar Gum Highly Compactible MCC Malic Acid Crosspovidone (Crosslinked PVP) Lactose Monohydrate and povidone (PVPK) compound Compound of Calcium Carbonate & Maize Starch Peas Starch Based Aqueous Film Coating System Maltitol Sorbitol Mannitol Directly compressible Starch & Lactose compound Xylitol 11 40 78 35 37 21 20 20 19 18 22 20

Fermentation aids
Solulys AST Soluten 50 Corn-steep powder Cellulose free, high vegetable protein 19 19

Application Guide
Category Lubricating agents
DUB DBHG DUB MCT DUB Microlub DUB SE Stepanol Synpro Stearates Talc Luzenac Pharma Glyceryl Dibehenate Medium Chain Triglycerides Stearic Acid Sucrose Esters Sodium Lauryl Sulfate Magnesium Stearate / Calcium Stearate / Zinc Stearate Talc 75 75 74 74 70 50 48

Product

Page

Chewing gum base

MedGumBase / CPG Medicated Chewing Gum Base / DC Chewing Gum Base 72

Dental Impression Materials

Protanal Potassium Alginate / Triethanolamine Alginate 13

Mineral supplements
A-Tab Calipharm Calopake Di-Tab Lycatab Mineral CC Magnesium Salts Scoralite Sturcal L Tri-tab Dicalcium Phospate Anhydrous, Granular Calcium Phospate Powder Extra Light, Precipitated Calcium Carbonate Dicalcium Phospate Dihydrate, Granular Compound of Calcium Carbonate & Maize Starch Magnesium Oxide / Magnesium Carbonate / Magnesium Hydroxide Calcium Carbonate Heavy, Precipitated Calcium Carbonate Tricalcium Phospate Anhydrous, Granular 42 42 56 42 21 64 66 56 42

Nutritional supplements
Nutriose DUB MCT Soluble Fibre Medium Chain Triglycerides 22 75

Parenteral & Opthalmic aids

Cremophor ELP Crysmeb Dextrose Anhydrous PF D-L Lactic Acid DUB MCT Kleptose HPB Kollidon Lutrol E Lutrol F Lycadex PF Metolose SH Natrosol 250 Pharm Neosorb PF Pearlitol PF Soluphor P Solutol HS-15 Xylisorb PF Polyoxyl - 35 - Castor Oil (Extra pure grade) Low MS Methyl Betacyclodextrin Injectable Glucose Anhydrous Synthetic Grade Lactic Acid Medium Chain Triglycerides Hydroxypropyl Betacyclodextrin Polyvinyl Pyrrolidone (PVPK - 12PF, 17PF) Polyethylene Glycol (PEG) / Macrogol Poloxamer Injectable Dextrose Monohydrate Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) Hydroxy Ethyl Cellulose Sorbitol Pyrogen Free Grade Mannitol Pyrogen Free Grade 2 - Pyrrolidone Macrogol - 15 - Hydroxystearate Xylitol Pyrogen Free Grade 38 23 23 80 75 23 34 37 37 23 27 30 19 18 36 38 20

Application Guide
Category Encapsulating agents
Aquacoat ECD 30 Crysmeb Ethyl Cellulose Kleptose Kleptose HPB Protanal Aqueous dispersion of Ethyl Cellulose Low MS Methyl Betacyclodextrin Ethyl Cellulose Pharm Betacyclodextrin Hydroxy Propyl Betacyclodextrin Alginate 12 23 30 23 23 13

Product

Page

Plasticizing agents
Cremophor DUB DBS DUB MCT Lutrol E Polysorb 85/70/00 Protanal Ester Hydrogenated Castor Oil Dibutyl Sebacate Medium Chain Triglycerides Polyethylene Glycol (PEG) / Macrogol Aqueous Solution of D-Sorbitol & Sorbitan Propylene Glycol Alginate 38 75 75 37 19 13

Solubilizing aids
Cremophor Crysmeb Docusate Sodium (DSS) DUB Microlub DUB SE Kleptose Kleptose HPB Lutrol F Soluphor P Solutol HS-15 Hydrogenated Castor Oil Low MS Methyl Betacyclodextrin Dioctyl Ester of Sodium Sulfosuccinate Stearic Acid Sucrose Esters Betacyclodextrin Hydroxypropyl Betacyclodextrin Poloxamer 2 - Pyrrolidone Macrogol - 15 - Hydroxystearate 38 23 68 74 74 23 23 37 36 38

Spherical Seed Core

Celphere Pharm-a-spheres Microcrystalline Cellulose Spheres Sugar Spheres (Non-Pareil Seeds) 60 62

Emulsifying agents
Cremophor A Docusate Sodium (DSS) DUB GMS DUB Microlub DUB SE Lutrol F Magnabrite Stepanol Synpro Stearate Macrogol - Cetostaryl Ether Dioctyl Ester of Sodium Sulfosuccinate Glyceryl Stearate Stearic Acid Sucrose Esters Poloxamer Magnesium Aluminum Silicate Sodium Lauryl Sulfate Sodium Stearate 38 68 75 74 74 37 54 70 50

Suspending agents
Avicel RC/CL Blanose Magnabrite Marine Colloids Metolose SH Metolose SM Natrosol 250 Pharm Protanal Xantural Microcrystalline Cellulose and Sodium CMC (Hydrocolloid) Sodium Carboxymethylcellulose (Na CMC) Magnesium Aluminum Silicate Carrageenan Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) Methyl Cellulose Hydroxy Ethyl Cellulose (HEC) Alginate Xanthan Gum 11 32 54 14 27 27 30 13 46

Application Guide
Category Stabilizing agents
D-L Malic Acid Protanal Ester Kollidon CL Malic Acid Propylene Glycol Alginate Crosspovidone (Crosslinked PVP) 78 13 35

Product

Page

Sweetening agents
Alveosucre Caster Sugar / Crystal Sugar Compressuc Flolys Hi-Sweet Icing Sugar Lycasin Maltisorb Neosorb Pearlitol Roclys Sucrose Solution Xylisorb Agglomerated Sucrose Screened Sucrose Directly Compressible Sucrose Dextrose syrup with extensive hydrolysis High Fructose Corn Syrup (HFCS) Milled Sucrose Maltitol Syrup Maltitol Sorbitol Mannitol Dextrose Syrup without extensive hydrolysis Liquid sucrose Xylitol 59 60 58 23 21 58 20 20 19 18 23 59 20

Taste Masking agents

Aquacoat ECD 30 Crysmeb Ethyl Cellulose Kleptose Kleptose HPB Kollicoat IR Kollicoat MAE Trehalose Aqueous dispersion of Ethyl Cellulose Low MS Methyl Betacyclodextrin Ethyl Cellulose Pharm Betacyclodextrin Hydroxypropyl Betacyclodextrin Polyvinyl Alcohol-PEG Graft Copolymer Methacrylic Acid Copolymer Non-reducing Di-Saccharide 12 23 30 23 23 35 36 40

Thickening agents
Blanose DUB GMS Klucel Kollidon Lutrol F Magnabrite Marine Colloids Metolose SH Metolose SM Natrosol 250 Pharm Protanal Tackidex Xantural Sodium Carboxymethylcellulose (Na CMC) Glyceryl Stearate Hydroxy Propyl Cellulose Povidone (PVPK 25, 30, 90F) Poloxamer Magnesium Aluminum Silicate Carrageenan Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) Methyl Cellulose Hydroxy Ethyl Cellulose Alginate Dextrin Xanthan Gum 32 75 31 34 37 54 14 27 27 30 13 24 46

Suppository bases
DUB PP Synpro Stearate Hemi-synthetic Glycerides Sodium Stearate 76 50

Disinfectants
PVP Iodine Povidone Iodine 36

FMC BioPolymer
Microcrystalline Cellulose, Alginate, Carrageenan, Cellulose Gel and Coating Systems. For more than half a century, manufacturers around the world have turned to FMC BIOPOLYMER for the uncompromising performance and quality of these distinctive products. The very name FMC BioPolymer reflects the natural and renewable raw materials from which their products are derived and the polymer chains within the products that create strong and stable applications in the pharmaceutical industry. Apart from a very focussed customer service network, FMC BioPolymer offers partnerships to companies in developing new technologies, applications and other technical support. It has ISO certified manufacturing facilities in Europe, North America and Asia. Their commitment to product quality and functionality exists at every level - from raw material sourcing to manufacturing, process control, storage and shipping. It is one global producer that is different from all others.

AVICEL PH Microcrystalline Cellulose USP/NF, EP, JP

Avicel PH is purified, partially depolymerized alpha cellulose derived from purified speciality grades of wood pulp. The unique properties of Avicel PH makes it an indispensable formulation tool. It is the excipient of choice for direct compression formulations, lending superior compactibility, drug carrying capacity and rapid disintegration. These properties also benefit dry granulation processes such as roller compaction or slugging. When used in wet granulation processes, Avicel reduces the risk of overgranulation, avoids screen blockage and promotes uniform, rapid drying. Avicel PH is an excellent extrusion-spheronization binder. The inclusion of Avicel PH in capsule formulations improves flow, facilitates plug formation and aids capsule disintegration. Grade Avicel PH - 101 Avicel PH - 102 Avicel PH - 103 Avicel PH - 105 Avicel PH - 112 Avicel PH - 113 Avicel PH - 200 Description Standard grade with medium particle size Standard grade with large particle size Low moisture content with fine particle size Extra fine particle size Very low moisture content with large particle size Very low moisture content with fine particle size Largest particle size Application For conventional applications, especially in wet granulation and roller compaction For improved flow in direct compression, the dry phase of wet granulation and dry granulation Well suited to moisture-sensitive drugs For use in direct compression of coarse or hard-tocompress materials For increased flow in direct compression with moisture-sensitive ingredients Helps extend shelf life and improve final product stability especially with moisture-sensitive drugs For best flow rate in direct compression and dry granulation maintaining high levels of compressibility and minimizing problems of weight-variation and content uniformity For best flow rate in direct compression with moisture-sensitive ingredients

Avicel PH - 200 LM Avicel PH - 301 Avicel PH - 302

Largest particle size with very low moisture content

High bulk density with fine Reduces powder stratification, helps mixing of fine particle size actives and facilitates making smaller tablets High bulk density with large particle size Avoids powder segregation, achieves good flow rates and can be used for high dose formulations to produce thin tablets

10

AVICEL RC/CL Microcrystalline Cellulose and Carboxymethylcellulose Sodium USP/NF, BP, JPE
Avicel RC/CL are water dispersible, spray-dried blends of microcrystalline cellulose and sodium carboxymethylcellulose used in preparation of pharmaceutical suspensions and emulsions. Usage of these products eliminate lengthy hydration time and provides long shelf-life stability. They act as viscosity regulators and modifiers thus preventing caking or sedimentation in suspensions. Grade Avicel RC-591 Avicel RC-581 Avicel CL-611 Description Spray dried, requiring low shear for dispersion Bulk dried, requiring high shear for dispersion Spray dried, requiring low shear for dispersion Application Provides a structured dispersion vehicle, acts as a protective colloid and facilitates dispersion Conventional suspending agent and dispersion aid Excellent for reconstitutable / dry suspensions

AVICEL CE Microcrystalline Cellulose and Guar Gum

Avicel CE 15 is a speciality proprietary combination product specially engineered to improve the organoleptic properties of chewable tablets. Grade Avicel CE-15 Description Co-processed MCC and Guar Gum Application Improved mouth feel, less grittiness, chalkiness, softer tablets with reduced friability and in general superior sensory characteristics in chewable tablets

AC-DI-SOL Croscarmellose Sodium USP/NF, EP, JP

Ac-Di-Sol is a crosslinked sodium CMC that facilitates rapid disintegration and drug dissolution in tablets, capsules and other solid dosage forms. It performs dual functionality of water wicking and rapid swelling resulting in it's superior disintegration characteristics. Grade Ac-Di-Sol SD-711 Description Application

Cross linked Sodium CMC Highly effective in wet granulation & direct or Modified Cellulose Gum compression products, independent of tablet hardness with low use level and excellent stability. Best known super disintegrant that is effective intra and extra-granularly

11

LUSTRECLEAR Microcrystalline Cellulose and Carrageenan based Coating System

LustreClear LC-103 is a new product line based on proprietary FMC technology - aesthetic coatings with exciting sensory properties that enhance the patients experience and create unique product design opportunities. Grade LustreClear LC-103 Description Application

An aqueous clear film coating All-in-one solvent free, clear conventional coating for tablets and other solid providing formulators with flexibility and resulting dosage forms in elegant, easy to swallow and taste masked finished forms

AQUACOAT ECD Aqueous dispersion of Ethyl Cellulose USP/NF, EP, JP

Aquacoat Ethyl Cellulose is a 30% solid polymer aqueous dispersion of submicron Ethyl Cellulose spheres for pharmaceutical film coating. Grade Aquacoat ECD-30 Description A water based pseudo-latex system allowing solvent free coating. Also allows a wide choice of plasticizer Application Sustained released beads for capsules / tablets, moisture barrier / sealant and taste masking for powders, granules, tablets and capsules

AQUACOAT CPD Aqueous dispersion of Cellulose Acetate Phthalate USP/NF, EP, JP

Aquacoat Cellulose Acetate Phthalate is a 30% solid polymer aqueous dispersion for enteric coated formulations. Grade Aquacoat CPD-30 Description A water based pseudo-latex system allowing solvent free enteric coating Application Enteric coating of tablets and capsules. Provides an elegant appearance for even embossed tablets and facilitates formation of stable films with 6 - 10% coating level by weight. Can also be coated onto beads for hard gelatin capsules

12

PROTANAL & PROTACID Alginates and Alginic acid USP/NF, EP, JP

Alginates are natural hydrocolloids of vegetable origin that occur as a structural component in marine brown algae, where they give strength and flexibility to the plant. FMC Protanal alginates and Protacid alginic acids offer unique gel-forming, film-forming, thickening and stabilizing properties. Grade Protacid F 120 NM Protanal LFR 5/60 Protanal LFMg 5/60 Protanal LF 240 D Protanal LF 120 M Protanal LF 200 M Protanal LF 10/60 D Protanal LF 10/60 LS Protanal LF 10/60 Protanal Ester SD-LB Protanal HF 12 RBS Protanal LF 200 DL Protanal LF 200 M Protanal LF 200 S Protanal KF 200 RBS Protanal KF 200 Protanal KF 200 S Protanal TA 250 Description Acid Na Salt Mg Salt Na Salt Na Salt Na Salt Na Salt Na Salt Na Salt Propylene Glycol Na Salt Na Salt Na Salt Na Salt K Salt K Salt K Salt Triethanolamine Viscosity (mPas) (1%) Application 300 - 700 (10%) 1000 - 1800 (7.5%) 70 - 200 70 - 150 200 - 400 20 - 70 20 - 70 20 - 70 700 - 1800 (2%) 600 - 1000 200 - 400 200 - 400 200 - 400 200 - 400 200 - 400 200 - 400 200 - 400 Stabilizer, Binder, Plasticizer & Emulsifier Dental Impression Materials Wound Healing Sustained Release Anti-Reflux Tablets Anti-Reflux Suspensions

13

MARINE COLLOIDS CARRAGEENAN Carrageenan USP/NF

Marine Colloids Carrageenan is a naturally-occurring family of polysaccharides extracted from red seaweeds. FMC develops blends for specific gelling, thickening and stabilizing properties desired for pharmaceutical applications. Grade Description CGN Type Viscosity Gelcarin GP-379 Iota High Thixotropic Gel Type Elastic, medium strength Brittle, strong Brittle, firm Non-gelling Non-gelling Creams, Suspensions Polyol and Protein reactive Promotes freeze thaw Stronger gels than GP 911 Syneresis higher than GP 911 Encapsulation / Delivery systems Polyol and Protein reactive Creams, Lotions Polyol and Protein reactive Creams, Lotions Polyol and Protein reactive Suspensions / Reconstitutables Topical lotions / creams Application

Gelcarin GP-812 Kappa Gelcarin GP-911 Kappa Viscarin GP-109 Viscarin GP-209 SeaSpen PF Lambda Lambda Iota

Low Low Medium High

Medium Thixotropic Elastic, weak

14

A business unit of FMC BioPolymer NovaMatrix is a newly created business unit of FMC BioPolymer. Their current products are special ultra pure grades of sodium alginates, chitosan salts & bases and sodium hyaluronates that satisfy functional and regulatory specifications. These are well-characterized and documented biopolymers and biomaterials for use in the development of novel drug delivery therapies, in the formation of biostructures for tissue engineering, wound healing, implants and advanced biotechnology applications. They also have proven properties suitable for parenteral administration of challenging drugs and implants.

PRONOVA UP Ultra pure Sodium Alginates

Pronova alginate is a linear copolymer with homopolymeric blocks of (1 4)-linked beta-D-Mannuronate (M) and its C-5 epimer alpha-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. Endotoxin (EU/g) is < _ 100. Grade Pronova UP LVM Pronova UP MVM Pronova UP LVG Pronova UP MVG Pronova UP Test Kit Viscosity (mPas) 20 - 200 > 200 20 - 200 > 200 Contains gram quantities of the above four UP products

PRONOVA SL Sterile Sodium Alginates

Sterilizing alginate solutions may often be an obstacle in pharmaceutical and biomedical applications requiring sterility of the applied material. In particular, this relates to problems with polymer degradation during autoclaving or irradiation procedures. To meet customer demands, NovaMatrix offers PRONOVA SL alginate as a sterilized and lyophilized product. Endotoxin (EU/g) is < _ 100. Grade Pronova SLM20 Pronova SLM100 Pronova SLG20 Pronova SLG100 Viscosity (mPas) 20 - 100 > 100 20 - 100 > 100

15

A business unit of FMC BioPolymer

PROTASAN UP Ultra pure Chitosan salts

PROTASAN ultrapure (UP) chitosan salts and bases is a linear polysaccharide composed of beta-(1 4)linked D-glucosamine (D) and 2-acetamido-2-deoxy-D-glucosamine. The products are characterized by specified parameters reflecting the key properties and purity profile of the material. With it's positively charged amino groups, chitosan differs from most polysaccharides that are neutral or negatively charged. Thus, chitosan becomes water soluble in acidic solutions. Grade Protasan UP CL 113 Protasan UP CL 213 Protasan UP G 113 Protasan UP G 213 Protasan UP Test Kit Description Chitosan Chloride Salt Chitosan Chloride Salt Chitosan Glutamate Salt Chitosan Glutamate Salt Contains gram quantities of the above four UP products

SODIUM HYALURONATE Ultra pure Sodium Hyaluronate USP, JP, JCIC

Sodium Hyaluronate Pharma Grade is a highly purified and well-characterized sodium hyaluronate developed for use in biomedical and pharmaceutical applications. It is manufactured at the NovaMatrix / FMC BioPolymer strategic partner Kibuns state-of-the-art production facility in Japan. The fermentation of ultra pure sodium hyaluronate is made from non-animal origin material. Grade Pharma grade 80 Pharma grade 150 Mol. Weight (kDa) 620 - 1150 1400 - 1800

16

Roquette Freres
ROQUETTE was founded in 1933 and ranks amongst the world's leading producers of starch derivatives and polyols for the pharma, food & cosmetic industry. It has a huge range of excipients and very specialized products that act as humectants, molecular encapsulation solutions, injectables, sweeteners, binders, diluents.... etc. Globally it has 13 production facilities manufacturing over 600 products and a sophisticated Research Centre at Lestrem, France where close to 350 scientists work, who are available to provide technical assistance to customers. Committed to strong customer service, Roquette have a world wide network of subsidiaries and agents.

PEARLITOL Mannitol USP/NF, EP, JP

Mannitol is a polyol manufactured by a process based upon starch. It is remarkably stable and also soluble in different solvents. It occurs as a slightly sweet white crystalline powder, that gives a cooling sensation in the mouth. It is non-cariogenic, has low hygroscopicity and thus forms an ideal excipient for dry formulations.

Crystalline Mannitol
Grade Pearlitol PF (Mannitol PFG) Pearlitol 25 C (Mannitol 25) Pearlitol 50 C (Mannitol 35) Pearlitol 160 C (Mannitol 60) Description Pyrogen free Extra fine particle size Medium particle size Coarse particle size Application Diuretic-osmotic for injectable solutions Diluent, excipient for unstable actives & flash release, freeze drying carrier and sweetener with cooling effect

Spray Dried Mannitol

Grade Pearlitol 100 SD Pearlitol 200 SD Description Fine particle size Medium particle size Application Excellent diluent-binders for direct compression applications (fast dissolving, chewable, oral dispersible, effervescent tablets)

Agglomerated Mannitol
Grade Pearlitol 300 DC Pearlitol 400 DC Pearlitol 500 DC Description Fine particle size Medium particle size Coarse particle size Application Excellent diluent-binder for direct compression applications and in addition can be used as neutral carriers onto which active substances are poured or sprayed

18

NEOSORB Sorbitol USP/NF, EP, JP

Grade Neosorb P 100 T Neosorb P 60 W Neosorb P 20/60 Neosorb P 30/60 Neosorb PFG Neosorb 70/70 B Description Extra fine particle size Fine particle size Medium particle size Coarse particle size Pyrogen free Sorbitol solution Non crystallizing Parenteral nutrition; used in combination with amino acids Humectant and bulk sweetener for syrups, suspensions, oral ampoules, pastilles and lozenges Application Excellent excipient for direct compression of suckable and chewable tablets, diluent for sachet & sweetener for pharma chewing gums

POLYSORB Liquid Sorbitol, partially dehydrated EP

Grade Polysorb 85/70/00 (Anidrisorb 85/70) Description Aqueous solution of D-Sorbitol and Sorbitans Application A superior plasticizing agent in the manufacture of soft gelatin capsules

SOLULYS Corn-steep powder

Grade Solulys AST Soluten 50 Description Spray dried corn-steep powder Application For seed culture as well as in main fermentation

Cellulose free, high vegetable For main fermentation media protein

GLUCONO-DELTA-LACTONE USP/NF
Grade G-D-L G G-D-L T Description Crystalline white powder, slightly sweet before developing an acid taste. Mean Diameter (m) G: 790; T: 330 Application pH acidity regulator, source of gluconate ions and increases the efficacy of preservatives

* Also available as Sodium Gluconate Salt

19

MALTISORB & LYCASIN Maltitol USP/NF, EP

Grade Maltisorb P 90 Maltisorb P 200 Maltisorb 75/75 Lycasin 80/55 Lycasin HBC Description Fine particle size Coarse particle size 72% - 76% dry maltitol syrup 50% - 55% dry maltitol syrup Special grade maltitol syrup Application Diluent for tablets and sachets, excipient for coating with high sweetening power & good solubility. Used for chewable, suckable and effervescent tablets Liquid sweetener for syrups, suspensions, lozenges, oral ampoules, pastilles and pharma chewing gums Hard boiled candies

XYLISORB Xylitol USP/NF, EP, JP

Grade Xylisorb 90 Xylisorb 300 Description Fine particle size Medium particle size Application Diluent for sachets, chewable & suckable tablets. Sugar free coating (non-cariogenic) with sweetening power identical to that of Sucrose.

Xylisorb 700 / PFG Pyrogen free, coarse particle size Parenteral nutrition; used in combination with amino acids

LYCOAT Aqueous Film Coating System

Lycoat is Roquette's innovation in conventional film coating. A new alternative for the formulator; it is patent protected and has exciting benefits like reduced coating time, instant dispersion at room temperature with no foam formation etc. Another important application of Lycoat is to manufacture Orodispersible strips. Grade Lycoat RS Description Modified peas starch based aqueous film coating system Ready to use film coating system Application Cold water soluble, easy-to-prepare system ensuring fast coating process giving a smooth, glossy & uniform colour tablet coat Used for aesthetic and functional benefits in tablets with improved organoleptic properties, ease of solubilisation and process efficiency Used in the manufacture of orally disintegrating films (mouth wafers)

ReadiLYCOATTM

Lycoat NG 73

Modified peas starch based aqueous film

20

STARCH GMO Free Starch USP/NF, EP, JP Native Starches

Grade Maize Starch 5 % (Dried) Maize Starch B Extra White Maize Starch Corn Starch 400 L Wheat Starch TB Potato Starch B Description Extracted from maize. Microbiologically compliant Extracted from maize, wheat or potato origin. Microbiologically compliant Application Dried maize starch is a low moisture grade for moisture sensitive drugs Diluent and disintegrant for tablets and capsules

Modified Starches
Grade Lycatab PGS Lycatab C

Description Fully pregelatinised maize starch Partially pregelatinised maize starch

Application Excellent binder for wet granulation Versatile excipient optimised as a filler for hard gelatin capsules. Also used as a binder cum disintegrant for direct compression with self-lubricating property and as a binder for wet granulation Low viscosity, natural binder for wet granulation. Ready to use, easily dispersible, quickly soluble and no maturation time. It can also be directly incorporated in dry blends Direct compression of chewable calcium tablets with improved mouth-feel

Lycatab DSH

Partially hydrolyzed maize starch

Lycatab Mineral CC

Compound of precipitated calcium carbonate granulated with maize starch

HI-SWEET High Fructose Corn Syrup (HFCS)

Grade Hi-Sweet 55 Hi-Sweet 42 Description Contains minimum 55% fructose (DS basis) Contains minimum 42% fructose (DS basis) Application Used as a bulk sweetner and viscosifier in medicated syrups and suspensions. Provides high sweetness and clear mouth feel compared to sucrose and invert sugar

21

GLYCOLYS Sodium Starch Glycolate USP/NF, EP, JP

Grade Glycolys Description Standard grade - Type A Application Conventional disintegrant for solid dosage forms. Used in both WG and DC processes Designed to resist high sheer in WG process Designed to resist acidic pH in formulations

Glycolys LV Glycolys Low pH

Low viscosity grade - Type A Acid stable grade - Type B

STARLACTM Spray-dried compound of Maize Starch & Lactose Monohydrate USP/NF, EP

Grade Starlac Description Designed for direct compression with superior flowability and exceptional disintegration properties with superior storage stability Application Direct compression filler for oro-dispersible tablets, low-dosage formulations, capsule filling and cores for coating

NUTRIOSE Soluble Fibre

Nutriose products are dextrins developed by Roquette's research centre as innovation soluble fibres with valuable technological advantages. Their chemical stability as well as their controlled powder properties make them flexible ingredients for a variety of pharmaceutical and nutraceutical applications. Grade Nutriose FB Nutriose FM Description Wheat fibre Maize fibre Application For enteral nutrition and low calorie formulations. Has properties like high fibre content (85%), well tolerated digestion, low calorific value, non-cariogenic and low glycaemic & insulinaemic index

22

KLEPTOSE Betacyclodextrin USP/NF, EP, JPE & derivatives

Betacyclodextrins and its hydroxy-propyl derivatives (HPBCD) are cyclic oligosaccharides obtained from starch by enzymatic cyclisation using enzymes called cycloglycosyl transferases. Its non-polar cavity allows the formation of complexes with actives in the solvent or dry phase. Used as encapsulating agents and solubility enhancers for tablets, capsules, sachets, syrups, solutions and oral suspensions. Grade Kleptose STD Kleptose DC Kleptose 10 Kleptose 7PC Kleptose HPB Description Standard grade Granular grade Micronised grade Low water content grade Hydroxy Propyl Betacyclodextrin Medium Molar Substitution Methyl Betacyclodextrin Low Molecular Substitution Application Inclusion in solvent phase Direct compression Suitable for aerosols Inclusion in dry phase Increases water solubility of poorly soluble drugs and also suitable for parenteral use Similar to Kleptose HPB. In addition it is intrinsically crystallisable and has low haemolytic power

Crysmeb

GLUCOSE Dextrose USP/NF, EP, JP

Grade Lycadex PF Dextrose Anhydrous PF Dextrose GC Description Pyrogen free dextrose monohydrate Pyrogen free dextrose anhydrous Agglomerated dextrose monohydrate Dextrose Monohydrate Dextrose syrups without extensive hydrolysis Dextrose syrups with more extensive hydrolysis Application Osmotic agent in injectable & dialysis solutions, parenteral nutrition and treatment of hypoglycaemia

Direct compression diluent with excellent compressability & flowability for tablets, sachets and capsule formulation Diluent for tablets, capsules and sachets Inhibiting sucrose crystallization, texturizer and bulk sweetener in syrups, lozenges, pastilles and pharmaceutical chewing gums

Roferose Roclys Flolys

23

GLUCIDEX Maltodextrin and Dried glucose syrup USP/NF, EP

Grade Glucidex 2 D Glucidex 6 D Glucidex 9 D Glucidex 12 D Glucidex 17 D Glucidex 19 D Glucidex 21 D Glucidex 33 D Glucidex 47 D Description Maltodextrin with dextrose maximum 3 Maltodextrin with dextrose equivalent of 5 to 8 Maltodextrin with dextrose equivalent of 8 to 10 Maltodextrin with dextrose equivalent of 11 to 14 Maltodextrin with dextrose equivalent of 15 to 18 Maltodextrin with dextrose equivalent of 18 to 20 Dried glucose syrup with dextrose equivalent of 20 to 23 Dried glucose syrup with dextrose equivalent of 31 to 34 Dried glucose syrup with dextrose equivalent of 45 to 48 Application Soluble in water and offer high standard of organic, mineral and bacteriological purity Used as diluent for tablets, capsules, sachets; spray-drying carrier and carbohydrate source in infant and enteral foods

Note : Also available in IT grades which provides free flowing properties and better solubilization due to its particular physical structure.

TACKIDEX Dextrin USP/NF, EP

Grade Tackidex B 147 Description White dextrin from maize starch Application Tablet & capsule filler, binder for tablet granulation, sugar coating ingredient, thickening agent for suspensions

24

Shin-Etsu Chemical Co.

Founded in Japan in 1926, SHIN-ETSU has grown to be a leader in many fields with a major presence in the arena of excipients required by the pharmaceutical industry. It is the world's largest MC & HPMC producer and ranks amongst the top five chemical companies, globally. Their products are pioneering innovations in use since decades with additions constantly being developed and introduced at regular intervals. Specialities include film coating materials, binders, water soluble cellulose ethers and derivatives, sustained release agents, enteric coating materials and several others making them indispensible in the development of new generation formulations.

PHARMACOAT Hydroxypropyl Methylcellulose USP/NF, EP, JP

Pharmacoat is low viscosity Hydroxypropyl Methylcellulose initially developed as an under-coat for sugar coating. It is very versatile, gives an excellent finish and suitable for many applications in the design of film coated tablet formulations. It is also effective as a binder since it does not interact with drugs, has superior stability, non-ionic character and available in various viscosity grades. Grade Description Viscosity (cps) Pharmacoat 603 Pharmacoat 603W Pharmacoat 606 Pharmacoat 606W Pharmacoat 606G Pharmacoat 615 Pharmacoat 645W Pharmacoat 904 3 3 6 6 6 15 4.5 4 USP Substitution Type 2910 2910 2910 2910 2910 2910 2910 2208 Wet granulation binder White grade of 603 Regular film coating White grade of 606 Granular grade of 606 (disperses quickly) Film coating, greater film strength White grade, short processing Sugar coating binder Application

HPMCP Hydroxypropyl Methylcellulose Phthalate USP/NF, EP, JP

HPMCP is a phthalic half ester of HPMC. It is a solvent based enteric coating agent to protect drugs from degradation from gastric acid and to prevent them from causing side effects in the stomach. Grade Description Dissolving pH* HPMCP HP-55 HPMCP HP-55S HPMCP HP-50 > _5.0 > _5.5 Viscosity (cst) 40 170 55 Regular grade Greater film strength Soluble at lower pH Application

* Mcllvaine's buffer (citric acid-Na2HPO4)

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METOLOSE Hydroxypropyl Methylcellulose (HPMC) / Methylcellulose (MC) USP/NF, EP, JP

Metolose is a non-ionic water soluble cellulose ether derived from pulp. It is available in a wide viscosity range from 4 cps to 100000 cps. It provides a variety of functions such as water retention, thickening, protective colloid, surface activity, sustained release etc. Shin-Etsu also manufactures special HPMC grades used as sustained release agents for matrix systems. Grade Description Viscosity (cps) Metolose 60SH-50 Metolose 60SH-4000 Metolose 60SH-10000 Metolose 65SH-50 Metolose 65SH-4000 Metolose 90SH-100 Metolose 90SH-4000 Metolose 90SH-15000 Metolose 90SH-100000 Metolose 90 SH-100SR Metolose 90SH-4000SR Metolose 90SH-100000SR 50 4000 10000 50 4000 100 4000 15000 100000 100 4000 100000 USP Substitution Type 2910 2910 2910 2906 2906 2208 2208 2208 2208 2208 2208 2208 Special HPMC grades used as hydrophilic matrix agents allowing more controllable and reproducible drug release, thus providing consistency in the final product MC polymer used for granule coating MC polymer used as granulating agent, emulsifying agent, thickener, bulk laxative, etc. HPMC polymer used for sustained release, thickener, suspending agent and binder for tablets and granules. Also used for opthalmics Application

Metolose SM-4 Metolose SM-15 Metolose SM-400 Metolose SM-4000

4 15 400 4000

27

L-HPC Low substituted Hydroxypropyl Cellulose USP/NF, EP, JP

L-HPC is a low substituted Hydroxypropyl ether of cellulose. It is insoluble in water and solvents but swells in water. It causes changes in the binding and disintegrating characteristics as a result of subtle changes in physical properties. Thus, it is widely used as dual-functional excipient (disintegrant/binder) for tablets, granules or other pharmaceutical solid dosage forms. Grade Description Mean particle size * (m) Particle type L-HPC LH-11 L-HPC LH-21 L-HPC LH-22 L-HPC LH-31 L-HPC LH-32 L-HPC LH-B1 50 40 40 20 20 50 Non fibrous Highly fibrous Moderately fibrous Moderately fibrous Micronized Direct Compression (anticapping) Regular grade (dry mixing, wet granulation) Lower hydroxypropoxy content (sometimes better disintegration) Micronized grade (pellet extrusion, layering) Lower hydroxypropoxy content High bulk density grade used in direct compression or fluid bed granulation process especially for high load formulations Application

* Laser diffraction method

SHIN-ETSU AQOAT (HPMCAS) Hydroxypropyl Methylcellulose Acetate Succinate USP/NF, JP

Aqoat is a new enteric coating material for application in aqueous, solvent and dry coating system. Can also be used in the design of sustained release dosage form in combination with gastric soluble preparation. Grade Description Dissolving pH* Aqoat AS-LF Aqoat AS-MF Aqoat AS-HF Aqoat AS-LG Aqoat AS-MG Aqoat AS-HG 5.5 6.0 6.5 5.5 6.0 6.5 Acetyl(%) / Succinoyl(%) 8 / 15 9 / 11 12 / 6 8 / 15 9 / 11 12 / 6 Granular grades for solventbased coating Micronized grades for aqueous and dry coating Application

* Mcllvaine's buffer (citric acid-Na2HPO4 )

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Aqualon

(A division of Hercules, Inc.)

AQUALON has been delivering pharmaceutical performance since the 1950s, through the legacy of Hercules Inc. and Henkel GmbH. Aqualon was originally founded in 1987 as a joint venture between the water -soluble polymer groups of these two companies. Aqualon has it's headquarters, corporate research centre and pharmaceutical laboratory in Wilmington, Delaware, USA and production facilities in France, Netherlands and USA. Currently, their product mix includes a series of cellulose ethers that meet requirements for use as excipients in pharmaceutical formulations. All products comply with pharmacopoeial standards laid down by individual regulatory bodies. Aqualon products are well known for their exceptional and consistent quality.

AQUALON ETHYL CELLULOSE PHARM Ethyl Cellulose USP/NF, EP, JP

Ethyl cellulose is a non-ionic ethyl ether of cellulose containing not less than 44% and not more than 51% of ethoxy groups, calculated on dried basis. They are soluble in a wide range of organic solvents. When water-soluble binders cannot be used, ethyl cellulose is often the polymer of choice. They are classified into a range of polymer viscosities for different applications. Grade EC N 7 Pharm EC N 10 Pharm EC N 14 Pharm EC N 22 Pharm EC N 50 Pharm EC N 100 Pharm EC T 10 Pharm Viscosity range (cps)* Application 5.6 to 8 8 to 11 12 to 16 18 to 24 40 to 52 80 to 105 8 to 11 Directly compressible, micronized grade with high ethoxyl content and low viscosity for optimized compactibility and good powder flow Micro encapsulation - Stabilize against active interactions, hydrolysis and oxidation Tablet coating - Impart sustained release to film coatings Tablet binder - Plastic flow, suitable for direct compression, injection molding and melt extrusion Flavor masking - Improved taste through suppression of strong flavors

* Determined using 5% ethyl cellulose in 80 parts toulene, 20 parts ethanol by weight.

NATROSOL 250 PHARM Hydroxy Ethyl Cellulose USP/NF, EP

Natrosol HEC is a non-ionic water-soluble cellulose ether, formed by reaction of cellulose with ethylene oxide. It is used as a modified release tablet matrix, a film former and a thickener, stabilizer & suspending agent for oral and topical applications when a non-ionic material is desired. Natrosol is easily dispersed in cold or hot water to give solutions of varying viscosities and desired properties, yet it is insoluble in organic solvents. Grade Natrosol HHX Pharm Natrosol HX Pharm Natrosol M Pharm Natrosol G Pharm Natrosol L Pharm Viscosity range (cps)* Application 3500 - 5500 (at 1%) 1500 - 2500 (at 1%) 4500 - 6500 (at 2%) 250 - 400 (at 2%) 75 - 150 (at 5%) Modified release - provides effective diffusion limiting matrix systems Tablet coating - Imparts flexibility to films while providing a good barrier to water and oxygen transmission Solution thickening, stabilizing and suspending agent Controls rheology and provides pseudoplasticity

* Concentration in water, weight %. Viscosities determined at 25 0 C, using a Brookfield LVF viscometer.

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KLUCEL Hydroxy Propyl Cellulose USP/NF, EP, JP

Klucel is a non-ionic cellulose ether with a versatile combination of properties. It is soluble in many polar organic solvents and in water below 380 C, but is insoluble in water above 450 C. It's solutions are highly surface-active, with low surface and interfacial tensions. In films and coatings, Klucel is heat-sealable and it is extremely flexible without plasticizers. Grade Klucel EF Pharm Klucel EXF Pharm (extra fine) Klucel LF Pharm Klucel JF Pharm Klucel JXF Pharm (extra fine) Klucel GF Pharm Klucel GXF Pharm (extra fine) Klucel MF Pharm Viscosity range(cps)* Application 300 - 600 (10%) 300 - 600 (10%) 75 - 150 (5%) 150 - 400 (5%) 150 - 400 (5%) 150 - 400 (2%) 150 - 400 (2%) 4000 - 6500 (2%) Tablet binding for immediate release - Yields unmatched tablet hardness and friability in wet granulation and direct compression or dry granulation Modified release - Provides effective diffusion limiting matrix systems Tablet coating - Imparts good flexibility and adhesion to films while providing a good barrier to water and oxygen transmission

Klucel MXF Pharm (extra fine) 4000 - 6500 (2%) Klucel HF Pharm 1500 - 3000 (1%)

Klucel HXF Pharm (extra Fine) 1500 - 3000 (1%)

* Concentration in water, weight %. Viscosities determined at 25 0 C, using a Brookfield LVF viscometer.

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BLANOSE CELLULOSE GUM Sodium Carboxymethylcellulose USP/NF, EP, JP

Blanose cellulose gum is the sodium salt of carboxymethylcellulose (CMC), purified to meet pharmaceutical standards. They are soluble in water but insoluble in organic solvents. Generally are used as thickeners, binders, stabilizers, suspending agents and rheology modifiers. Lower substitution types provide thixotropy and higher substitution types are used where smooth solutions are required. Grade Blanose 7H4F-PH Blanose 7HOF-PH Blanose 7H3SF-PH Blanose 7HF-PH Blanose 7M31F-PH Blanose 7M8SF-PH Blanose 7MF-PH Blanose 7M1F-PH Blanose 7LF-PH Blanose 9H4F-PH Blanose 9M31F-PH Blanose 9M8F-PH Blanose 12M8P Blanose 12M31P Viscosity range (cps)* 2500 - 4500 (1%) 1000 - 2800 (1%) 1000 - 2800 (1%) 1500 - 2500 (1%) 1500 - 3100 (2%) 200 - 800 (2%) 400 - 600 (2%) 50 - 100 (2%) 25 - 50 (2%) 2500 - 4500 (1%) 1500 - 3100 (2%) 400 - 800 (2%) 200 - 800 (2%) 1500 - 3100 (2%) Application Tablet coatings - Film former Mucoadhesives - Absorbency Syrups & suspensions - Thickener, suspending agent Sustained release - Thickener, diffusion barrier Bulk laxatives - Physiologically inert, high water binding capacity Ointments, creams and lotions - Stabilizer, thickener, film-former

* Concentration in water, weight %. Viscosities determined at 25 0 C, using a Brookfield LVF viscometer.

DS-Type 7 9 12 (for USP grades) 12 (for EP grades)

Substitution range 0,65 to 0,90 ** 0,80 to 0,95 1,15 to 1,45 1,12 to 1,21

Sodium content, % 7,0 - 8,9 9,2 - 9,3 10,4 - 12,0 10,2 - 10,8

** in 7S and 7O types, the upper limit of substitution is 0,95.

32

BASF Aktiengesellschaft
BASF is the world's leading chemical company. As a transnational company, it maintains business relationships with customers in more than 170 countries and operates production facilities in 39 countries. BASF's association in India started way back in 1943. It's pharmaceutical involvement includes dozens of actives, excipients and vitamins. Excipients viz. Kollidon, Lutrol, Cremophor etc are familiar names even to students of pharmaceutical sciences. Over the years, several speciality products have been developed and today offer versatile choices to the modern day formulator. They maintain a close partnership with the industry.

KOLLIDON Polyvinylpyrrolidone (PVPK) USP/NF, EF, JP

The soluble grades of Kollidon are obtained by free-radical polymerization of vinylpyrrolidone in water or isopropanol according to the cGMP regulations, yielding the chain structure of polyvinylpyrrolidone [1,141]. Because of its solubility in water and many organic solvents, it's high binding power and ability to form complexes, soluble PVP occupies a special position among the synthetic colloids. Kollidon is available in a wide range depending on their K-value and molecular weight. Grade K-value Kollidon 12 PF Kollidon 17 PF Kollidon 25 Kollidon 30 Kollidon 90 F 10.2 - 13.8 15.3 - 18.0 22.5 - 26.7 27.0 - 32.1 81.0 - 96.3 Description Molecular weight Low Low Medium Medium High Pyrogen free grades for use as solubilzer, crystallization inhibitor, suspension stabilizer and lyophilization agent in injections and ophthalmic preparations Versatile and widely used as binders in tablets, capsules & granules, stabilizers in oral suspensions, film formers, dispersants for pigments, thickeners and bioavailability improvers A highly effective binder, stabilizer for oral and topical suspensions, thickener, hydrophilizer and pore former in medical devices Application

KOLLIDON VA 64 Copolyvidone USP/NF, EP, JPE

Grade K-value Kollidon VA 64 Kollidon VA 64 Fine 25.2 - 30.8 Description Characteristics Copolymer of VinylpyrrolidoneVinylacetate in ratio of 6 : 4 by mass Dry binder, Wet Binder, Film forming agent in coatings and topical sprays Fine particle size grade for increased tablet hardness resulting in less friability and better mechanical stability Application

34

KOLLIDON SR Polyvinyl Acetate and Povidone based excipient

Grade K-value Kollidon SR 60.0 - 65.0 Description Characteristics Mixture of 80% Polyvinyl acetate and 20% Povidone K 30 pH independent matrix former for direct compression of sustained release tablets, pellets and granules Application

KOLLIDON CL Crosslinked Polyvinylpyrrolidone (Crosspovidone) USP/NF, EP, JPE

Grade Kollidon CL Kollidon CL-F Kollidon CL-SF Kollidon CL-M Description Standard grade Fine particle size grade Superfine particle size grade Micronized grade Application Used as a super disintegrant in tablets for improving release of active substances. Fine grade is ideal for small tablets (less content uniformity problems). Superfine grade is for fast dispersible tablets (with superior mouth feel). Micronized grade is used as a stabilizer for suspensions

KOLLICOAT IR Graft copolymers

Grade Kollicoat IR Description Polyvinyl alcohol polyethylene glycol graft copolymer, very soluble in water Application Instant release coatings and quick dissolving formulations. Also used as a pore former in sustained release formulations and as a binder. It has enormous flexibility, low viscosity and rapid rate of dissolution besides not having to use a plasticizer

Kollicoat IR White

Graft copolymer of To produce white tablets or with a colour premix for coloured 75% polyvinyl tablets. Used also for taste masking, appearance enhancing alcohol units and and protection of light sensitive actives 25% polyethylene glycol units with other additions form an instant release white coating system Coprocessed Provides excellent moisture protection and taste masking in product of Kollicoat addition to advantages of Kollicoat IR IR and PVA to form a homogenous powder

Kollicoat IR Protect

35

KOLLICOAT Methacrylic acid / Ethyl acrylate copolymers USP/NF, EP, JPE

Kollicoat grades are state of the art aqueous coating agents characterized by excellent film forming properties, a reliable adjustment of release rates, easy and cost saving coating processes. Grade Kollicoat MAE 30DP Description Aqueous, milky white, low viscosity, fast to use dispersion with solid content of 30% White, redispersible powder preferred when subject to extreme climatic conditions in transport or storage Aqueous dispersion of a copolymer derived from ethyl acrylate / methyl methacrylate with solid content of 30% Application For white, coloured, & colourless enteric film coatings of pellets, crystals, soft gelatin capsules and other solid dosage forms. Also used as a moisture barrier, taste odour masking and a barrier between incompatible actives

Kollicoat MAE 100P

Kollicoat EMM 30D

Sustained release, pH independent membrane coatings and matrix. Forms very flexible films without plasticizer and allows stable and reproducible drug release profiles. Also used for taste masking and moisture barrier applications pH-independent sustained release formulations (coating or matrix), taste masking and protective coatings

Kollicoat SR 30D

Aqueous dispersion of 27% polyvinyl acetate, 2.5% povidone & 0.3% sodium lauryl sulfate with solid content of 30%

POVIDONE-IODINE PVP-Iodine USP/NF, EP, JP

Grade PVP-Iodine 30/06 Description Standard grade Application Used as a disinfectant in topical formulations such as ointments, solutions, creams, ovula and others. It is applied in gargle solutions, surgical scrubs and soaps

PVP-Iodine 30/06 M10 Micronised grade

SOLUPHOR P 2-Pyrrolidone, Distilled

Grade Soluphor P Description Allows more rapid absorption of active substances on topical application of drugs Application Solvent for veterinary injections. Also described for transdermal systems and for transmucosal application

36

LUTROL Plasticizers & Solubilizers Polyethylene Glycol / Macrogol USP/NF, EP

Grade Lutrol E 300 Lutrol E 400 Description Molecular weight : 285 - 315 Viscosity : 5.4 - 6.4 cps Molecular weight : 380 - 420 Viscosity : 6.8 - 8.0 cps Application Solvents for parenteral, topical, ophthalmic, oral, and rectal preparations. Widely used as an ointment base

Poloxamer USP/NF, EP
Grade Lutrol F 68 Lutrol M 68 Lutrol F 127 Lutrol M 127 Description Poloxamer 188 (Block polymer of 81% PEG and 19% PPG) New, micronized grade of F 68 with mean particle size of 50 m Poloxamer 407 (Block polymer of 73% PEG and 27% PPG) New, micronized grade of F 127 with mean particle size of 50 m Application Used as emulsifier, solubilizer, suspension stabilizer, thickener in liquids, orals, topicals, parenterals and for enhancing bioavailability in solid preparations Micronized grades avoids segregation of powder blends, gives a homogenous mixture of actives and excipients, which results in content uniformity concerns with tablets

LUDIPRESS Advanced excipient for direct compression

Grade Ludipress Description Granules of Lactose Monohydrate, Povidone 30 and Crosspovidone Compound of Lactose Monohydrate and Povidone 30 Application For production of fast disintegrating tablets by direct compression process Direct compression of lozenges, sublingual, chewable and effervescent tablets. Also suitable for controlled release formulations

Ludipress LCE

37

CREMOPHOR Non-ionic surfactants USP/NF, EP

Grade Cremophor RH 40 Cremophor EL Cremophor ELP Cremophor A 6 Cremophor A 25 Description Polyoxyl-40 Hydrogenated Castor Oil Polyoxyl-35 Castor Oil (Standard Grade) Polyoxyl-35 Castor Oil (Extra Pure Grade) Macrogol-6 cetostearyl ether Macrogol-25 cetostearyl ether Application To solubilize vitamins, water-insoluble active substances and other hydrophobic substances in oral and topical liquid & semiliquid dosage forms Used as a solubilizer in parenteral dosage form especially for sensitive drugs Non-ionic emulsifiers for production of ointments and creams based on oil-in-water emulsions / water-in-oil emulsions

SOLUTOL HS 15 Macrogol-15-Hydroxystearate EP
Grade Solutol HS 15 Description Application

Well-tolerated, efficient solubilizer For manufacturing aqueous parenteral in aqueous systems for preparations with vitamins and other lipophilic injectables active pharmaceutical ingredients

SICOVIT Iron Oxide USP/NF, EP

Grade Sicovit Red 30 E 172 Description Red colour pigment Application Stable colouring pigments approved for use in the pharma industry

Sicovit Yellow10 E 172 Yellow colour pigment Sicovit Black E 172 Sicovit Brown E 172 Black colour pigment Brown colour pigment

38

Asahi Kasei Chemicals Corporation

ASAHI KASEI CHEMICALS CORPORATION, a member company of Asahi Kasei Group, was founded in 1931 and employs 4500 people. By year 2000, it had four production facilities in Japan and a consolidated net sales turnover of approx. 10 billion US Dollars. Their product line includes some very specialized excipients viz. Celphere (MCC Spheres), starch derivatives amongst others.

CELPHERE Microcrystalline Cellulose Spheres USP/NF, EP, JPE

Grade Celphere SCP-100 Celphere CP-102 Celphere CP-203 Celphere CP-305 Celphere CP-507 Celphere CP 708 Particle size range (m) Description 75 - 212 106 - 212 150 - 300 300 - 500 500 - 710 710 - 850 High mechanical strength, low reactivity, high sphericity, fine & uniform particle size and optimum water absorption Application Used as spherical seed core for drug layering & film coating and in the manufacture of granules with sustained-release, taste-masked and other special properties

CEOLUS KG Microcrystalline Cellulose USP/NF, EP, JP

Grade Ceolus KG-802 Particle size (m) 50 Description Dry binder with a distinctive rod-form particle configuration that provides incomparable compactibility Application Particularly effective in tableting large dose drugs, low compressible drugs, pressure sensitive drugs, coated granules and oral dispersible tablets

Ceolus KG-1000

50

PCS PC-10 Partly Pregelatinized Starch USP/NF, EP, JP

Grade PCS PC-10 Particle size (m) 70 Description It is inert, pHindependent and has good flowability. It achieves disintegrating properties by swelling due to absorption of water Application A stabilizer for moisturesensitive drugs, dissolution enhancer, carrier for hygroscopic ingredients and a granulation aid

TREHALOSE Non-reducing Di-Saccharide

Grade Trehalose P Trehalose G Form Powder Granular Description Low reactive, non-hygroscopic, heat & pH stable, with taste & smell masking effect Application A compactible sugar-type filler & a taste masking agent for solid & liquid dosages

40

Innophos
INNOPHOS is the worlds leading manufacturer of highquality calcium phosphates for the pharmaceutical and food industry. Since 1930 they have been manufacturing calcium phosphates in their Chicago Heights, USA plant which operates to the highest standards, most with ISO 9002 and GMP accreditation. Their client base includes some of the world's leading pharmaceutical companies and is testament to the value of it's consistent ability to supply the highest quality products. Innophos subscribes to the principles of sustainable development. To establish their position as the market leaders in calcium phosphates; they continue to add to their product line and have made repeated improvements in their products and their plant's manufacturing capability.

CALCIUM PHOSPHATE
Calcium Phosphates find wide applications in direct compression and wet granulation tableting. It has many positive characteristics as an excipient, including good compressibility, wide compatibility, stability and white colour. They are used as compressible filler, flow agents and as a source of calcium and phosphorous.

Granular grades USP/NF, EP, JP

Grade Di-Tab Description Di-calcium phosphate dihydrate Application Direct compression granulation, ordered mixing, flow agent, blend densifier, tablet punch polishing agent, time release agent and carrier of actives. Low lead filler and source of calcium & phosphorous Same as Di-Tab with added benefit in stability due to no water of hydration. Higher calcium & phosphorous content

A-Tab

Di-calcium phosphate anhydrous

Tri-Tab

Tri-calcium phosphate anhydrous Direct compression granulation, glidant due to high surface area and carrier of actives. High calcium content nutritional products Tri-calcium phosphate anhydrous For wet granulation, higher density with similar benefits as Tri-Tab Tri-calcium phosphate Excellent for direct compression

Tri-Tab WG TCP DCTM

Powder grades USP/NF, EP, JP

Grade Calipharm D Calipharm A Calipharm T Description Di-calcium phosphate dihydrate Di-calcium phosphate anhydrous Application Filler in wet granulation, vitamin premixes and nutritional drinks Filler in wet granulation, chewable multivitamins and nutritional drinks

Tri-calcium phosphate anhydrous In antacid and other formulations for neutralizing properties. Nutritional drinks and calcium / phosphorous fortifications

42

Domo
DOMO, a subsidiary of The Royal Friesland Foods, Holland is a leading global manufacturer of high quality pharmaceutical lactose. With 30 years experience and a commitment to supply the highest quality products; DOMO offers a broad range of conventinal as well as directly compressible lactose for a variety of pharmaceutical applications. DOMO's distinctive product range of anhydrous, spraydried and monohydrate lactose are manufactured in their FDA inspected state-of-the-art facilities in The Netherlands which meet the standards set by ISO 9001 and HACCP. Their excipients are tailored to meet strict requirements for applications such as tablets, capsules and sachets.

LACTOCHEM Lactose Monohydrate USP/NF, EP, JP

Lactochem is a white, crystalline, alpha monohydrate lactose powder. The water of crystallization is tightly bound and shows no chemical activity while bound. Mositure absorption is extremely low, even at high relative humidity. Lactochem is available in milled and sieved forms. Grade Lactochem Powder Lactochem Coarse Powder Lactochem Regular Powder Lactochem Fine Powder Lactochem Extra Fine Powder Lactochem Super Fine Powder Lactochem Microfine Lactochem Crystals Lactochem Coarse Crystals Lactochem Fine Crystals Lactochem Extra Fine Crystals Sieved lactose Prevents segregation in capsule based formulations, DC formulations and sachets Description Milled Lactose Application Widely used as fillers in wet granulation processes. Also used for capsule filling and powder mixtures

LACTOPRESS Directly Compressible Lactose USP/NF, EP, JP

Lactopress is a white free-flowing DC lactose powder and is available in two forms; spray-dried and anhydrous lactose. Both forms have good flowability and excellent compactibility characteristics making these products ideal for direct compression tabletting. Grade Lactopress Spray Dried 250 Lactopress Spray Dried Lactopress Anhydrous 250 Lactopress Anhydrous Fine Powder Lactopress Anhydrous Description Application

Spray Dried, DC Lactose Ideal for DC tabletting with excellent flow, high compressibility and enables good content uniformity Anhydrous, DC Lactose Improves stability of moisture-sensitive actives as well as their dissolution due to it's high intrinsic solubility

44

CP Kelco
More than 30 years ago, CP KELCO pioneered the commercialization of xanthan gum and developed KELZAN xanthan gum. Today, CP Kelco is the world leader in xanthan and other biopolymers produced by leading-edge fermentation technology. Their products, combined with an unsurpassed depth of technical expertise, bring unique functionality to a broad range of products and applications. With manufacturing facilities located in two continents, extensive processing technology, and research and development resources, CP Kelco have the ability to find the right solution for your specific product or processing needs.

XANTURAL Xanthan Gum USP/NF, EP, JP

Xanthan Gum is an exocellular heteropolysaccharide produced by fermentation. It has a unique polymeric structure where chains tends to associate forming a complex network gel-like structure. When shear is applied, these hydrogen bonds are disrupted and a flowable liquid is produced. The process reverses when shear is removed. Hence, Xanthan Gum solutions exhibit extremely high viscosity at rest and very low viscosity when force is applied. Xantural grades give a clear, transparent gel. Grade Xantural 180 Xantural 75 Xantural 11K Description Standard grade Fine particle size grade Agglomerated grade Application Normal grade for suspensions Used for dry mix powder suspensions, hydrophilic / controlled release tablets Used when good physical dispersion methods are not available and agitation is minimal

46

Rio Tinto Minerals

RIO TINTO MINERALS (LUZENAC) Group is a market focused Talc producer. As world leaders in this field, they are committed to setting the standards for the talc industry in areas such as innovation, technical assistance, product quality, health safety and the environment. Every year, Rio Tinto Minerals (Luzenac) Group produces and sells in excess of 1.4 million tonnes of talc from over 30 mines and processing plants in Europe, North and Central America and Asia Pacific. With the widest talc product range and unsurpassed applications expertise, they are the only talc producer that can meet all end-use requirements worldwide.

TALC LUZENAC PHARMA Talc USP/NF, EP, JP

Talc is a purified and hydrated magnesium silicate. It is a natural material of mineral origin and sterilized for use in the pharmaceutical industry as a lubricant and diluent in solid dosage forms, dusting powder in topical preparations and also used to clarify liquids. The speciality of Luzenac talc is its fine particle size, extra white colour, grittiness free and it is also bacteria controlled. Grade Talc Luzenac Pharma Description Standard grade Application Flow regulator (glidant), reduces fluctuations in tablet weight, enhances tablet homogeneity & quality and increases productivity Anti-tack agent for tablet coating, eliminates stickiness during drying, prevents agglomerations in the coater, reduces coating time and produces flawless coated products Lubricant for easier tablet pressing, reduces friction, prevents binding during compression & ejection and guarantees smooth, crack-free results

Talc Luzenac Pharma M

Micronised grade

Tal Luzenac Pharma UM Ultramicronised grade

48

Ferro Industrias Quimicas

FERRO - INDUSTRIAS QUIMICAS is a leading producer of performance materials sold to a broad range of applications. Ferro materials enhance the performance of products in a variety of end markets, including consumer electronics, telecommunications, pharmaceuticals, building and renovation, appliances, transportation, household furnishings, and industrial products. Ferro pharmaceutical and cosmetic products include Synpro Stearates used in a variety of applications.

SYNPRO STEARATES Stearates USP/NF, EP

Synpro Stearates are special grade vegetable origin stearates. They are made from the salt obtained from a vegetable fatty acid conforming to USP/NF, EP and BP standards with Kosher certification. Widely used as lubricants and mold release agents; they are available in a very fine particle size white powder form which ensures consistent performance. Additionally, they are free from TSE/BSE, GMO, OVI, Gluten, Radiation, Additives and Glycol Ethers. Grade Synpro Magnesium Stearate VG Synpro Zinc Stearate VG Synpro Calcium Stearate VG Synpro Sodium Stearate VG Application Added as a lubricant to granules in tablet-making Lubricant in tablet-making and protective application in the treatment of skin inflammation Added as a lubricant to granules in tablets and capsules Emulsifying and stiffening agent in topicals. An ingredient of Glycerin Suppositories

50

Kronos International
The KRONOS Group is one of the leading manufacturers of Titanium Dioxide with production facilities located in various European countries, Canada and the USA. All Kronos plants use modern, environment-friendly processes. Kronos have more than 80 years of experience in this industry. Besides being a world renowned supplier of Titanium Dioxide pigments for industrial applications, Kronos also produce a high purity grade for pharmaceuticals, cosmetics and foodstuffs having USP, BP and EU approval certification.

KRONOS 1171 Titanium Dioxide USP/NF, EP, JP

Titanium Dioxide has a very high refractive index and consequently unique light scattering properties which are exploited in it's use as a white pigment and opacifier. Grade Description Application Used as a white pigment and opacifier in film-coating mixes for tablets, gelatin capsules and dermatological preparations

Kronos 1171 TiO2 E 171 Anatase grade, super white, fine particle size and bacteria controlled

52

Health & Beauty Solutions

HEALTH AND BEAUTY SOLUTIONS (AMCOL) is a manufacturer of speciality minerals, providing products and technologies for a wide range of pharmaceutical, industrial and consumerrelated markets worldwide. Established in 1927, it operates in more than 12 countries with over 1,200 employees. Health & Beauty Solutions smectite clays comply with the three United States Pharmacopeias-National Formulary (USP/NF) categories viz., Bentonite, Purified Bentonite and Magnesium Aluminium Silicate.

MAGNABRITE Magnesium Aluminium Silicate USP/NF, BP

Magnabrite product line is a blend of highly refined, naturally occurring, complex colloidal white smectite clays. They are unique thixotropic additives for emulsion stabilizing, suspending, binding, gelling, bodying and disintegrating. Grade Magnabrite HV Description High viscosity grade Application Exhibits excellent emulsification and thickening abilities in suspensions. Delivers high viscosity at low solids Used to reduce thickening and flocculation in acidic pH levels of pharmaceutical acid suspensions Used when medium viscosity, high brightness and ease of dispersion in pharmaceutical suspensions are desired

Magnabrite K

Acid stable grade

Magnabrite S

Standard grade

Magnabrite F

Micro fine particle size grade Used as an inert low-bulk disintegrant, excellent for large tablets where the actives are the major weight and bulk of the tablet High stability grade Hydrates readily in warm or cold water producing high electrolyte stability

Magnabrite HS

54

Specialty Minerals
Minerals Technologies produce mineral-based and synthetic mineral products for healthcare and other industries. They have two subsidiaries - SPECIALTY MINERALS INC. and MINTEQ INTERNATIONAL. Specialty Minerals are the world's largest producer of Calcium Carbonate.

STURCAL & CALOPAKE Precipitated Calcium Carbonate USP/NF, EP, JP

Precipitated Calcium Carbonate is manufactured via a series of controlled chemical reactions. Generally, quicklime (CaO) is mixed with water to form a slurry and carbon dioxide is added. This produces a very fine precipitated CaCo3 which is then dried and packaged. Different grades are available depending on particle size, shape, distribution, colour and purity. Grade Sturcal L Description Heavy grade Application Used mainly in antacid tablets and dentifrice because of it's specific flow and polishing properties. Therapeutically used as a calcium supplement Purified with ultra low lead used for food fortification, calcium supplements and other pharmaceutical and nutraceutical applications

Calopake

Extra light grade

56

Tereos
TEREOS, a part of the BeghinSay group was created in 2003 when two French market leaders got together. Tereos is today the world's second largest producer of sugar with plants in Europe, Africa and America. With 9000 employees and 26 plants; Tereos processes 10 million tons of beet and 10 million tons of sugar cane annually. For the pharmaceutical industry, Tereos offers a wide range of dry crystal sugars, liquid sugars and sugar specialities. Consistently pursuing its efforts to bring the best quality; Tereos has developed a perfect control over production and marketing of sucrose-based excipients.

SUCROSE Sugar USP/NF, EP, JP

Sucrose is an essential excipient for pharmaceutical products and a good way to give them a sweet taste. It is the reference sweetening flavour and also facilitates oral ingestion. Tereos produces a wide range of products in different forms and different particle sizes that enables many pharmaceutical uses for dry or liquid galenics.

Spray Dried Sucrose USP/NF, EP, JP

Grade Compressuc MS Description Directly compressible sucrose with maltodextrins / inverted sugar Directly compressible pure sucrose Application A new generation of anhydrous DC Sucrose; it has remarkable free flowing, mixing and compressive properties thus making it an efficient excipient for chewables, efferrvescent and orodispersible tablets

Compressuc PS

Milled Sucrose USP/NF, EP, JP

Grade Icing Sugar Description Milled Sucrose (100% pure) Application Very fine powder and easily compressible; it dissolves quickly in water than regular sugar. Used for granulation, coating and in sachets

Icing Sugar with Starch Milled Sucrose with corn starch added as anti-caking agent Icing Sugar with Silica Milled sucrose with colloidal silica added as fluidizing agent

58

Agglomerated Sucrose USP/NF, EP, JP

Grade Alveosucre Description Obtained by wet granulation of pure icing sugar followed by subsequent drying Application Used for sachets and dry syrups. Highly absorbent, allows for structured mixtures with homogenetic distribution of actives while avoiding separation of ingredients. Instant cold dissolution For DC applications, allows very high densities. Instant cold dissolution

Alveosucre with Dextrine Obtained by wet granulation of pure icing sugar with dehydrated glucose syrup additives Pearl Sugar 30 Obtained by successive screenings of sugar agglomerates

For applications requiring a dry excipient as a fixing medium. The irregular surface of the agglomerates and it's narrow particle size distribution allows highly homogenous and structured mixes

Liquid Sucrose
Grade Sucrose Solution Description Limpid, clear, viscous sugar syrup Application For syrups and coatings

59

Screened Sucrose USP/NF, EP, JP

Grade Caster Sugar 250 Particle size 200 300 m / 70 50 mesh Application Extremely pure crystalline powder with fine, low coefficient particle size facilitating dissolution and ensuring a homogenous mixture. Used for granulation, dry syrup and coating A highly pure fine-grain crystalline powder. Facilitates preparation of syrups due to higher dissolution rate than crystal sugar. Used for granulation, dry syrup and coating A highly pure crystalline powder recommended for applications requiring high quality clear solutions or coatings. Used for syrups, dry syrups and coating Coarse grain and very high level of purity of this crystalline powder makes it easy to pour, transfer and stock in bulk. Used for syrups, dry syrups and coating

Caster Sugar N1 400

300 500 m / 50 35 mesh

Crystal Sugar N1 600 Crystal Sugar N1 700 Crystal Sugar N1 800

500 700 m / 32 25 mesh 500 800 m / 35 22 mesh 700 1000 m / 25 18 mesh

Crystal Sugar N1 1350 1100 1600 m / 17 12 mesh Large sized without fine particles prevents agglomeration. Appreciated for its technical qualitites, especially for slow melting Crystal Sugar N1 2000 1750 2250 m / 11 9 mesh operations. Used for syrups, dry syrups and coating

60

Hanns G. Werner
The HANNS G. WERNER GMBH + Co. KG founded in 1952 and located in Germany is a manufacturer of exceptionally high quality neutral pellets (sugar spheres) and globuli sacchari (sugar globules). Their brand PHARM-A-SPHERES is known globally for superior quality sugar spheres confirming to USP/NF & EP monograph. Werners special manufacturing process enables ideal spherical shape, smooth-nonporous-solvent resistant surface and high mechanical stability to their sugar spheres.

PHARM-A-SPHERES Sugar Spheres (Non-pareil seeds) USP/NF, EP

Pharm-a-spheres are inert / neutral pellets composed of sucrose and maize starch. They offer an excellent quality, a narrow particle size range, high sphericity allowing a precise calculation of drug quantity to be sprayed, perfect flow characteristics and high mechanical stability thus ensuring very low friability. Pharma-spheres are a modern drug excipient with multiple applications and are well-suited for solving problems like insufficient flow characteristics, interaction of ingredients and retardation of drug action. Werners range of pharm-a-spheres covers the whole spectrum of diameters from 100 m to 2000 m. Mesh Size (ASTM) 120 140 100 120 80 100 70 80 60 70 50 60 45 50 45 60 40 60 40 50 40 45 35 55 35 50 35 45 35 40 30 35 25 30 20 25 18 20 16 20 16 18 14 16 12 16 12 14 10 12 Diameter in mm (m) 0,106 0,125 0,125 0,150 0,150 0,180 0,180 0,212 0,212 0,250 0,250 0,300 0,300 0,355 0,250 0,355 0,250 0,425 0,300 0,425 0,355 0,425 0,355 0,500 0,300 0,500 0,400 0,450 0,425 0,500 0,500 0,600 0,600 0,710 0,710 0,850 0,850 1,000 0,850 1,180 1,000 1,180 1,180 1,400 1,400 1,700 1,400 1,700 1,700 2,000 Application Used as drug-free cores for controlled or sustained release technologies

* Special sizes and mixtures are also possible.

62

Dead Sea Periclase

DEAD SEA PERICLASE, a division of ICL Industrial Products is the worlds leading producer of Magnesia products of exceptionally high purity. They operate from two plants (Israel & France) using different processes, both engineered to produce the highest quality and complimentary range of Magnesia products. The waters of the Dead Sea are the most concentrated naturally occuring solutions of dissolved salts in the world. These are the brines which serve as raw material for DSPs plant. DSP's Magnesium Oxide, Magnesium Carbonate and Magnesium Hydroxide are characterised by extremely low levels of all metals; specifically low levels of lead. They are available in a wide range of pharmaceutical grades to be used in antacid preparations, mineral supplements and for a variety of other applications.

MAGNESIUM OXIDE USP/NF, EP, BP

Grade Magnesium Oxide HA Magnesium Oxide HA4 Magnesium Oxide HA5 Magnesium Oxide DC PHRA 50 Description Heavy grade - Sieved Heavy grade - Micronised Heavy grade - Micronised Granular; Directly compressible grade Active pharmaceutical ingredient Application For use in the manufacture of antacid preparations, mineral supplements, as a food additive for colour retention, pH modifier and in the production of pharmaceutical grade magnesium derivatives

MAGNESIUM CARBONATE USP/NF, EP, BP

Grade Description Application For use in the manufacture of antacid preparations and mineral supplements. In food, used as an anti-caking, free flowing agent, colour retainer, dessicant or pH modifier

Magnesium Carbonate BMC Light grade Magnesium Carbonate Heavy Heavy grade

MAGNESIUM HYDROXIDE USP/NF, EP, BP

Grade Magnesium Hydroxide HD5 Magnesium Hydroxide HD7 Magnesium Hydroxide HD9 Description Lowest bulk density grade Low bulk density grade Medium bulk density grade Application Spray dried, directly compressible powders for use in the manufacture of antacid preparations and mineral supplements. Different bulk densities offer a choice of compounding possibilities for tablet and powder dosage system

Magnesium Hydroxide HD12 High bulk density grade

64

Scora
Established in 1931, SCORA located in Caffiers, France is a specialist in calcium and magnesium derivatives. Their deep insight in the chemistry of calcium and magnesium, specialised dedicated equipments and unique production process enables Scora manufacture speciality products of the highest purity with exceptional properties particularly valued in the pharmaceutical and nutraceutical industry. Scoras products comply to USP/NF, EP, JP and are produced according to GMP rules.

SCORALITE Calcium Carbonate USP/NF, EP, JP, BP

Scoralite is a very pure, highly free flowing synthetic calcium carbonate manufactured by using a unique synthesis process. Production of Scralite is carried out according to GMP rules and is supplied under a C-O-S from the European pharmacopeia. Grade Scoralite Description Heavy grade Application Used in the manufacture of antacid preparations, osteoporosis treatment, tablets and production of pharmaceutical calcium derivatives. Also used for mineral supplements, food additives and production of high purity compounds

Scoralite LL

Heavy grade with Low Lead

MAGNESIUM OXIDE USP/NF, EP, BP

Grade Light Magnesium Oxide Description Application

Light grade, free flowing powder Used as a pH modifier, viscosity regulator and as a mineral supplement. Also used in the manufacture of antacids

* Scora can also provide tailor-made grades of Magnesium Oxide

MAGNESIUM CARBONATE USP/NF, EP, BP

Grade Description Application Used in the manufacture of antacid preparations & tablets and the production of magnesium derivatives. Also used as an anti-caking & free flowing agent and as a mineral supplement

Magnesium Carbonate BMC Basic Magnesium Carbonate

66

Cytec Industries
CYTEC is the worlds leading supplier of Docusate Sodium (Dioctyl Ester of Sodium Sulfosuccinate - DSS), a versatile and highly effective anionic surfactant. Cytec manufactures pharmaceutical grade DSS products to the highest quality standards under cGMP, ensuring exceptional quality and performance for use as either active ingredients or excipients / formulating aids. They comply with USP & EP and are compatible with a broad range of active drugs. They meet worldwide recognised standards of quality, strength, purity and potency.

DOCUSATE SODIUM USP, EP Dioctyl Ester of Sodium Sulfosuccinate

Docusate Sodium (DSS) is one of the most versatile and effective anionic surfactants (surface active agents). It is an excellent solubilizing, wetting, dispersing, and emulsifying agent beneficial for use in oral dosage forms. Grade DSS 100 % Appearance Rolls of waxlike plastic sheets Application Aids the granulation process, improves tablet disintegration and dissolution, facilitates tablet coating, emulsifies gels & liquid suspensions. Also used as an active ingredient for laxatives and stool softeners, prenatal and geriatric vitamin preparations and ear wax removal compounds.

DSS Granular 85 % White crystalline with Sodium Benzoate powder DSS 50 % in Polyethylene glycol White to yellow, clear viscous liquid

68

Stepan Co.
STEPAN founded in 1932 is a global manufacturer of anionic surfactants, germicidal quaternary compounds and other speciality products that include flavours, emulsifiers and solubilizers. With headquaters in Illinois, USA it has twelve manufacturing locations worldwide and over 1500 employees. Stepans SLS (Sodium Lauryl Sulfate) is very popular in the pharmaceutical industry, is compliant with most pharmacopeias and has all regulatory approvals.

STEPANOL Sodium Lauryl Sulfate USP/NF, EP, JP, BP

Stepanol WA-100 is sodium lauryl sulfate produced from the sulfation of fatty alcohol via Stepan's SO3 process. The product of this process is then spray dried to produce a high active powder of exceptional quality. Grade Stepanol WA-100 Description Sodium Lauryl Sulfate Application Tablet and capsule lubricant, wetting agent, anionic surfactant, emulsifying agent, skin penetrant and skin cleanser in topical applications

70

GumBase Co.
GUMBASE CO. founded in 1967 is a world leader in the manufacture of compressed powder gum base, chewing gum base and bubble gum base for the pharmaceutical, nutraceutical and confectionary industry. With headquarters in Italy it has sales in over 130 countries and delivers a range of more than 200 different gum base formulations supplied in five different shapes according to customer's requests on product pecularities. At GumBase Co. quality is a matter of constant dedication and improvements. It has achieved BRC (British Retail Consortium) certification which is a global standard that goes beyond other quality standards like HACCP and ISO

GUM BASE Non-nutritive masticatory substance

The chewing gum base is an inert, insoluble preparation designed to deliver flavours, minerals, vitamins, sweetners, functional and pharmaceutical active principles. It is not designed or intended to be swallowed but is removed and disposed adequately after consumption. In the pharma industry, it is now considered as a new, alternative drug delivery system. Unique formulations have been designed with gum base for smoking reduction, weight management, heart-burn relief, dry mouth relief, stress reduction, memory & concentration improvement, pain relief, breath freshening, dental health, etc. Grade MedGumBase Description Advantages

CPG

Specific gum base Absorption through oral mucosa, good distribution of developed for medicated active principles, easy & pleasant administration, chewing gums consumer controlled dosage and kinetics controlled active principle release. Directly compressible Product can be taken anywhere at any time as it does not chewing gum base require liquids for swallowing and is ready-for-use in powder enabling a cold emergencies. and dry process which protects delicate functional ingredients / actives.

* Available in flavours as well as without flavours. Conventional chewing gum base and Bubble gum base can also be provided.

72

Stearinerie Dubois
Founded in 1820 in France, STEARINERIE DUBOIS develops, manufactures and sells a wide range of fatty acid esters specialities for the pharmaceutical, food and cosmetic industry. Their products coming from oleochemistry have outstanding properties and are used as lubricants, solubilizers, compressing agents, suppositories bases etc. With its plant located in Scoury, France; Stearinerie Dubois is committed to producing high quality products and has obtained the international ISO 9001 : 2000 certification. Their specialities comply to global pharmacopeias viz. USP/NF & EP, are exclusively of vegetable and/or synthetic origin and are widely used for tablets and granules, hard and soft capsules, solutions, creams and lotions, coating, suppositories etc.

DUB MICROLUBTM Stearic Acid USP/NF, EP

Stearic acid is a mixture of stearic acid (C18H36O2) and palmitic acid (C16H32O2). The content of stearic acid is not less than 40%. The content of palmitic acid is not less than 40% and the sum of the two is not less than 90%. Hard, white or faintly yellowish, somewhat glossy and crystalline solid or white / yellowish white powder; its odor and taste are slight, suggesting tallow. Grade DUB Microlub 70 DUB Microlub 50 DUB PO 70 DUB PO 50 DUB 70 P DUB 50 P Description Stearic Acid 70% - Micronised powder Stearic Acid 50% - Micronised powder Stearic Acid 70% - Fine powder Stearic Acid 50% - Fine powder Stearic Acid 70% - Pellets Stearic Acid 50% - Pellets Application Used as tablet lubricant. Micronised grades imparts a smooth surface to the film coated tablets. Also used as emulsifying and solubilizing agent in topical formulations.

* Also available is Stearic Acid 95% in flakes form

DUB SETM Sucrose Esters USP/NF, EP

Sucrose esters are natural surfactant materials obtained by the esterification of one or more of the hydroxyl groups of the sucrose molecule with vegetable fatty acids. These compounds are non-ionic and have excellent emulsifying, wetting and dispersing properties. By modifying the esterfication degree of the sucrose, it is possible to obtain a range of different emulsifiers with HLB from 3 to 16. Sucrose esters are tasteless, odorless and non-toxic additives. They are non-irritative and mild to the skin. Grade DUB SE 3S DUB SE 5S DUB SE 11S DUB SE 15P DUB SE 16P Description Sucrose tristearate Sucrose distearate Sucrose stearate Sucrose palmitate Sucrose palmitate Application Used as tablet and / or capsule lubricant, solubilizing agent, foaming enhancer and as an emulsifier to stabilise oil-into water emulsions

74

DUB MCTTM Medium Chain Triglycerides USP/NF, EP

Medium chain triglycerides are a class of fatty acids. Their chemical composition is of a shorter length than the long-chain fatty acids present in most other fats and oils, which accounts for their name. They are also different from other fats in that they have a slightly lower calorie content and they are more rapidly absorbed and burned as energy, resembling carbohydrate more than fat. The unique metabolic and functional properties of MCT, a consequence of their chemical structure make them versatile ingredients in numerous pharmaceutical applications. Grade DUB MCT 5545 DUB MCT 7030 DUB MCT 6535 Appearance Oily liquid Application Used as plasticizer, tablet lubricant and as solutions & suspension base for parenterals. Also used for dietetic preparations (energy with low calorie)

DUB GMS Glyceryl Stearate EP

Grade DUB GMS DUB GMS SE Appearance Liquid Pellets Application Mild emulsifier, used as a co-emulsifier. Also used as a thickener for hard and soft capsules

DUB DBS Dibutyl Sebacate

Grade DUB DBS Appearance Fatty liquid Application Used as plasticizer for tablets and granules

DUB DBHG Glyceryl Dibehenate EP

Grade DUB DBHG Appearance Fine, micronised powder Application Used as lubricant for tablets. Also can be used as lipidic matrix for sustained release

75

DUB PP Hemi-synthetic Glycerides USP/NF, EP

DUB PP are hard fat suppository bases and are a mixture of triglycerides, diglycerides and monodiglycerides which may be obtained either by esterification of natural fatty acids with glycerol or by interesterification of natural fats. Each type of hard fat is characterised by it's melting point, its saponification value and its hydroxyl value. These suppository bases, DUB PP are made from vegetable fatty acids. They are presented in pellets form allowing an easier use and are non-toxic & neutral in active principles. Moreover, they do not contain any oxidizing nor stabilizing agent. Grade DUB PP C 3 DUB PP CDL 1 DUB PP D 1 DUB PP E 1 DUB PP E 3 DUB PP F 1 DUB PP H 1 DUB PP M 1 DUB PP KC 3 DUB PP KCD 1 DUB PP KD 3 DUB PP KE 3 DUB PP KF 1 Saponification Value Melting Point (C) 230 - 240 225 - 245 234 - 247 235 - 245 235 - 245 235 - 245 230 - 240 223 - 233 225 - 240 235 - 245 225 - 240 215 - 236 235 - 250 33 - 35 33,5 - 35,5 34 - 36 35 - 36,5 35 - 36,5 36 - 37,5 38 - 40 42 - 44 33,5 - 35,5 33,5 - 35,5 34 - 36 35,5 - 37,5 36 - 38 Hydroxyl Value 20 - 30 15 10 10 20 - 30 10 10 10 20 - 30 15 20 - 30 20 - 30 15 Specific Suppository Bases Application Multipurpose Suppository Bases

76

Lonza
Lonza SpA ( Polynt SpA), a division of the Swiss-based Alusuisse-Lonza group manufactures a broad range of additives, polymers and speciality chemicals for the pharmaceutical and food industry. With over 5300 employees and sales worth CHF 1.7 billion; it has several plants in Europe, UK and USA. Lonza manufactures Malic Acid by hydration of Maleic Anhydride at high temperature and pressure in their very modern plant in Bargamo, Italy with world class accredition.

MALIC ACID D-L Malic Acid USP/NF, EP

Malic Acid is widely found in nature and is the predominant organic acid in many fruits and berries. It plays an essential role in carbohydrate metabolism and therefore used in the production of basic energy for cellular processes. In the pharmaceutical industy, malic acid is used by blending it with essences and flavours. It's acid taste builds up slowly at the begining but persists for a very long period. The final effect is to give an enhanced sensation of a stronger taste. Grade Malic acid granular Malic acid fine granular Malic acid special fine granular Malic acid powder Description Application

Has the ability to enhance the Used in throat lozenges, cough syrups, effect of the aromas used to effervescent powders and tablets mask the undesirable tastes and smells of medicinals

78

Musashino Chemical Laboratory

MUSASHINO CHEMICAL LABORATORY LTD., are leading manufacturers of Lactic Acid, D-L-alanine and Pyruvic Acid. Established in 1949, they have fulfilled their mission with over a half century of accumulated research, development and production technology, using environmentally friendly facilities to produce highquality products that seek fine balance between the needs of the human race and the environment. Musashino's products are of excellent quality and are used for manufacturing pharmaceuticals, foods & brewing, cosmetics and other industrial products. Their products are used in a variety of applications all over the world.

LACTIC ACID USP/NF, EP, JP

Lactic acid is prepared synthetically by reaction between acetaldehyde and carbon monoxide at high temperature and pressure or by the hydrolysis of hexoses with sodium hydroxide. Grade D-L Lactic Acid Description Synthetic grade Purity 88.0% - 92.0% Application In injections in the form of lactates, as an acidifying agent / acidulant and in topical formulations as a softener

80

Glossary
Brand
Ac-Di-Sol Alveosucre Aqoat Aquacoat A-Tab Avicel CE Avicel PH Avicel RC/CL Blanose Calipharm Calopake Caster Sugar / Crystal Sugar Celphere Ceolus KG Compressuc Cremophor Crysmeb Dextrose Anhydrous PF Dextrose GC Di-Tab Docusate Sodium (DSS) DUB DBHG DUB DBS DUB GMS DUB MCT DUB Microlub DUB PP DUB SE Ethyl Cellulose Flolys G-D-L Glucidex Glycolys Hi-Sweet HPMCP Icing Sugar Kleptose Kleptose HPB Klucel Kollicoat IR Kollicoat MAE / EMM Kollicoat SR 30 D Kollidon Kollidon CL Kollidon SR Kollidon VA 64 Kronos 1171 Titanium Dioxide Lactic Acid Lactochem Lactopress Anhydrous 250 Lactopress Spray Dried 250 L-HPC Ludipress LustreClear LC 103

Product
Croscarmellose Sodium (Crosslinked Sodium CMC) Agglomerated Sucrose Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS) Aqueous Dispersion for modified release Dicalcium Phosphate Anhydrous, Granular (DCPDA) Microcrystalline Cellulose and Guar Gum Microcrystalline Cellulose (MCC) Microcrystalline Cellulose and Sodium CMC (Hydrocolloid) Sodium Carboxymethylcellulose (Na CMC) Calcium Phosphate Precipitated Calcium Carbonate (Extra Light) Screened Sucrose Microcrystalline Cellulose Spheres Microcrystalline Cellulose (Ultracompactible) Directly Compressible Sucrose Non-ionic surfactant Low MS Methyl Betacyclodextrin Injectable Glucose Anhydrous Directly Compressible Glucose Monohydrate Dicalcium Phosphate Dihydrate, Granular (DCPD) Dioctyl Ester of Sodium Sulfosuccinate Glyceryl Dibehenate Dibutyl Sebacate Glyceryl Stearate Medium Chain Triglycerides Stearic Acid Hemi-synthetic Glycerides Sucrose Esters Ethyl Cellulose Dextrose Syrup Glucono Delta Lactone Maltodextrin Sodium Starch Glycolate High Fructose Corn Syrup (HFCS) Hydroxypropylmethylcellulose Phthalate Milled Sucrose Betacyclodextrin Hydroxy Propyl Betacyclodextrin Hydroxy Propyl Cellulose PVA and PEG graft co-polymer for instant release Methacrylic Acid Copolymer / Ethyl Acrylate Aqueous dispersion of PVA and PVP Povidone (PVPK, 12PF, 17PF, 25, 30, 90F) Crosspovidone (Crosslinked PVP) Matrix Sustained Release Excipient Copolyvidone Vinylacetate Copolymer Anatase & Superwhite Grade D-L Lactic Acid Lactose Monohydrate DC Lactose DC Lactose Low-Substituted Hydroxypropyl Cellulose Advanced Excipient for direct compression MCC & Carrageenan based Aqueous Film Coating System

Company
FMC BIOPOLYMER TEREOS SHIN-ETSU FMC BIOPOLYMER INNOPHOS FMC BIOPOLYMER FMC BIOPOLYMER FMC BIOPOLYMER AQUALON - HERCULES INNOPHOS SPECIALTY MINERALS TEREOS ASAHI-KASEI ASAHI-KASEI TEREOS BASF ROQUETTE ROQUETTE ROQUETTE INNOPHOS CYTEC STEARINERIE DUBOIS STEARINERIE DUBOIS STEARINERIE DUBOIS STEARINERIE DUBOIS STEARINERIE DUBOIS STEARINERIE DUBOIS STEARINERIE DUBOIS AQUALON - HERCULES ROQUETTE ROQUETTE ROQUETTE ROQUETTE ROQUETTE SHIN-ETSU TEREOS ROQUETTE ROQUETTE AQUALON - HERCULES BASF BASF BASF BASF BASF BASF BASF KRONOS MUSASHINO DOMO DOMO DOMO SHIN-ETSU BASF FMC BIOPOLYMER

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Brand
Lutrol E Lutrol F Lycadex PF Lycasin Lycatab Lycatab Mineral CC Lycoat Magnabrite Magnesium Carbonate Magnesium Hydroxide Magnesium Oxide Malic Acid Maltisorb Marine Colloids MedGumBase / CPG Metolose SH Metolose SM Metolose SR Natrosol 250 Pharm Neosorb Nutriose PCS PC-10 Pearl Sugar Pearlitol Pharmacoat Pharm-a-spheres Polysorb 85/70/00 Pronova UP / SL Protacid Protanal Protasan UP PVP Iodine ReadiLYCOAT Roclys Roferose Scoralite Sicovit Sodium Hyaluronate Solulys AST Soluphor Soluten 50 Solutol HS 15 Starch Starlac Stepanol Sturcal L Sucrose Solution Synpro Stearates Tackidex Talc Luzenac Pharma Trehalose Tri-Tab Xantural Xylisorb

Product
Polyethylene Glycol (PEG) / Macrogol Poloxamer Injectable Dextrose Monohydrate Maltitol Solution Modified Starch Compound of Calcium Carbonate and Maize Starch Peas Starch based Aqueous Film Coating System Magnesium Aluminium Silicate High Purity Magnesium Carbonate Spray Dried, DC Magnesium Hydroxide High Purity Magnesium Oxide D-L Malic Acid Maltitol Carrageenan Medicated Chewing Gum Base / DC Chewing Gum Base Hydroxypropyl Methylcellulose (HPMC - High viscosity) Methyl Cellulose (MC) Hydroxypropyl Methylcellulose (HPMC - Sustained Release grades) Hydroxy Ethyl Cellulose Sorbitol Soluble Fibre Partly Pregelatinised Starch Sucrose grains Mannitol / DC Manitol Hydroxypropyl Methylcellulose (HPMC - Low viscosity) Sugar Spheres (Non-Pareil Seeds) Aqueous Solution of D-Sorbitol & Sorbitan Ultrapure / Sterile Sodium Alginate Alginic Acid Alginate Ultrapure Chitosan Salt Povidone-Iodine Ready-to-use, Aqueous film coating system Dextrose Syrup Dextrose Monohydrate Calcium Carbonate of high purity Iron Oxide Pharma Grade Sodium Hyaluronate Corn-Steep powder 2-Pyrrolidone Cellulose free, high vegetable protein Macrogol-15-Hydroxystearate Maize (Corn) / Potato / Wheat Directly compressible Starch & Lactose compound Sodium Lauryl Sulfate Precipitated Calcium Carbonate (Heavy) Liquid Sucrose Synpro Stearates - Mg Stearate / Ca Stearate / Zn Sterate / Na Stearate Dextrin Talc Non-reducing Di-Saccharide Tricalcium Phosphate Anhydrous, Granular (TCP) Xanthan Gum Xylitol

Company
BASF BASF ROQUETTE ROQUETTE ROQUETTE ROQUETTE ROQUETTE HBS (AMCOL) DEAD SEA / SCORA DEAD SEA DEAD SEA / SCORA LONZA ROQUETTE FMC BIOPOLYMER GUMBASE CO. SHIN-ETSU SHIN-ETSU SHIN-ETSU AQUALON - HERCULES ROQUETTE ROQUETTE ASAHI-KASEI TEREOS ROQUETTE SHIN-ETSU WERNER ROQUETTE NOVAMATRIX FMC BIOPOLYMER FMC BIOPOLYMER NOVAMATRIX BASF ROQUETTE ROQUETTE ROQUETTE SCORA BASF NOVAMATRIX ROQUETTE BASF ROQUETTE BASF ROQUETTE ROQUETTE STEPAN SPECIALTY MINERALS TEREOS FERRO ROQUETTE RIO TINTO (LUZENAC) ASAHI-KASEI INNOPHOS CP KELCO ROQUETTE

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