ANTI-HELMINTHICS Pyrantel pamoate: not effective against trichuris trichura, and not to be used with piperazine(opposite effects) Nicolasamide:

not to be used in Taenia Solium can be used in saginata Prazi!uantel causes spastic paralysis:: also cannot be used in early schistosomiasis Prazi!uantel is "#$ for schistosomiasis %chinococcus is resistant to prazi!uantel de&ameth decreases bioavailability of prazi!uantel, hence not so effective in neurocysticercosis Ivermectin: DOC in strongyloidosis, ONCHOCERCIASIS Ivermectin is not active against adult filaraiae...only against microfilaraie DEC is contraindicated in onchocerciasis causes '()#TT* reaction "o&ycycline can be used in filaria (lbendazole is "#$ for %chinococcus Triclabendazole is "#$ for fascioliasis
Prazi!uantel "#$ in clonorchis, opisthrochis, paragnomiasis, hymeolopsis, diphylobothrium (rtimesnin can be a good alternative in Schistosomiasis ECHANIS O! AC"IONS "rugs inhibiting polymerization of beta tubulin: albendazole, mebendazole, tricla bendazole "rugs causing spastic paralysis: pyrantel pamoate, levamisole "rugs causing flaccid paralysis: Piperazine, *vermectin "rugs atering microfilarial membrane and increasing phagocytosis:: "%$ "rugs causing uncoupling of o&idative phosphorlyation: Niclosamide, +ithionolol "rugs causing influ& of calcium: Prazi!uantel Drugs of c#oices (lbendazole in all nematodes e&cept: entrobius(mebend), ,ilaria, "racunculus('etro), #nchocerca and strongyloides(*vermectin) Prazi!uantel in all trematode and cestodes e&cept:: ,asciola(triclabend) and -ydatid(albend)