A 28 y-o man, after a weekend of heavy rum drinking developed

severe abdominal pain and a Cullen (+) sign. At the PE we found

hemorrhagic ascitis. He died. Autopsy feature shown:
-MOST IMPORTANT LAB FEATURES?
-TYPE OF NECROSIS
-MECHANISM
-THE CLEAR YELLOWISH AREAS REPRESENT…
-DIAGNOSIS…
 CELL INJURY &
DEATH: PART II
R. HUGO MARTÍNEZ LOZANO, M.D.

July-21-2009.
 LEARNING OBJECTIVES: K & U
 REVERSIBLE & IRREVERSIBLE
 NECROSIS:

- CAUSES
- MORPHOLOGY
- TYPES
- EXAMPLES
 APOPTOSIS:

- CONCEPT
- MORPHOLOGY
- TYPES
- EXAMPLES
 INTRACEL. ACCUMULATIONS: IDEM.

 MEDICAL SIGNIFICANCE!!!

Ref: pp. 19-32, 34-40 & lecture’s information

 EXAMPLES OF CELL INJURY &
NECROSIS
 ISCHEMIC/HYPOXIC
 ISCHEMIC-REPERFUSION
 CHEMICAL
DIAGNOSIS?
ETIOLOGY?
k for normal cellular shapes and nuclear appearance
mpare with this slide of the patient’s small bowel
ich structures are preserved, which have changed?
REPERFUSION DAMAGE
 TYPES OF NECROSIS
 COAGULATION
 LIQUEFACTION
 GANGRENOUS
 CASEOUS
 FAT (ENZYMATIC)
COAGULATION NECROSIS
IDEM
ABSCESS: TOPOGRAPHY?
LUNG & LYMPH
NODE: TB
APOPTOSIS
2 PATHS:
-EXT. (Death R.)
(TNFR1, FAS)
-INT. (Mitoch.)
(Citochrome C)
ULTRASTRUCTURE:
APOPTOTIC
BODY
TYPES OF ACCUMULATIONS
 LIPIDS
 PROTEINS (HYALINE INCLUDED)
 GLYCOGEN
 PIGMENTS
FATTY LIVER
Kaiser-Fleisher ring
-MOST IMPORTANT LAB FEATURES?
-TYPE OF NECROSIS
-MECHANISM
-THE CLEAR YELLOWISH AREAS REPRESENT…
-DIAGNOSIS…
“Los hombres que no pudieron ser santos, se esforzaron
por ser médicos”.

Albert Camus