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IMMUNITY II:
AUTOIMMUNE DISEASES
R. HUGO MARTÍNEZ LOZANO, M.D.
Aug-12-2009.
LEARNING OBJECTIVES
K & U:
- GENERAL FEATURES
- IMMUNOLOGIC TOLERANCE
- MECHANISMS OF AUTOIMMUNITY
- THE MOST IMPORTANT CHARCT. OF:
- LES
- RA
- SS
- SYSTEMIC SCLEROSIS
Ref: 223-239 & lecture’s information
GENERAL FEATURES
FRECUENCY:
DISEASE VS NORMALITY
o
f
S
y
s
t
e
m
i
LES:
c
ULTRASTRUC-
TURE.
L
u
p
u
s
E
r
Anterior uveitis
LIBMAN-SACHS
ENDOCARDITIS
SLE: DIAGNOSIS
THE 11 CRITERIA CLASS… (P. 228)
ANTI DOUBLE-STRANDED DNA Abs.
SUBCUTANEOUS LE
DR3
SS-A
DRUG-INDUCED LE
HYDRALAZINE
PROCAINAMIDE
ISONIAZID
CLINDAMYCIN
OTHER
… ANTI-HISTONES Abs.
R.A.
Pannus
SEVERE
INTESTINAL
VASCULITIS
SJÖGREN
SYNDROME
(SS)
S.S.
DEFINITION: XEROSTOMIA
K-C SICCA
S.S.
FORMS: PRIMARY (SICCA SYNDROME)
SECONDARY
RISK FACTORS:
HLA: B8, DR3, DRW52, ETC.
EBV, HCV, HTLV-1
MORPHOLOGY…
- LIMITED SD
- CREST SYNDROME
DX: - DNA TOPOISOMERASE-I (ANTI-SCL 70)
(Diffuse)
- ANTICENTROMERE (90%)
(Crest)
SD: MORPHOLOGY
CREST SX:…REYNAUD’S PHENOMENON
SEVERE REYNAUD + NECROSIS
LESIONS?
CALCINOSIS
SUBCUTANEOUS
CALCINOSIS
ESOPHAGEAL
INVOLVEMENT
DX?
QUESTIONS?