Synaptic Transmission

Christian Kreipke, PhD

ckreipke@med.wayne.edu
Outline
 Overview of Synaptic Transmission
 Signaling at the Nerve-Muscle Synapse
 Synaptic Integration
 Second Messengers
 Transmitter Release
 Neurotransmitters
Overview

Part I
Gap Junction
Synaptic transmission at
chemical synapses
Neurotransmitters
Signaling at the Nerve-
Muscle Synapse

Part II
Neuromuscular Junction
Synaptic potential is highest at the
end plate region
Ach-gated channels
Binding of ACh in a
postsynaptic muscle cell
opens channels permeable
to both NA+ and K+
Synaptic Integration

Part III
The combination of
excitatory and
inhibitory synaptic
connections
mediating the
stretch reflex is
typical of circuits in
the CNS
Common types of synapses
 Example: Glu

Three classes of
Glutamate receptors
Ligand gated channels
Excitatory and Inhibitory currents
Second Messengers

Part IV
Receptor Classification
Typical second-messenger systems
cAMP cycle
Protein Kinases
Phospholipid hydrolysis
Location of second messenger
synapses
Example of integrating
neurotransmitters with ion channels
Terminating protein kinases
The Big Picture
Transmitter Release

Part V
Steps of cycling synaptic vesicles
Examples of Synaptic Vesicle Proteins
Axo-axonic synapses
Neurotransmitters

Part VI
Brain peptides organized by
tissue localization
Families of Neuroactive Peptides