Receiving the Signal: G-protein Coupled Receptors (GPCRs)

GPCRs are an important and ubiquitous class of eukaryotic receptors (>700 in humans) The extracellular domain connects to the intracellular domain through 7 transmembrane spans

The intracellular domain is coupled to a heterotrimeric Gprotein

The heterotrimeric g-protein is composed of 3 subunits: G, G, and G When the G subunit is bound to GDP it is OFF; when it is bound to GTP it is ON When the extracellular domain binds to the signal molecule, it causes a conformational change relayed through the transmembrane spans to the intracellular domain The conformational change relayed to the intracellular domain causes the G subunit to release GDP and bind to GTP thereby activating both the G and G/G subunits

Figure 15-30 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-31 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-32 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-33 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-34 Molecular Biology of the Cell ( Garland Science 2008)

Table 15-1 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-35 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-36 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-36 (part 1 of 2) Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-36 (part 2 of 2) Molecular Biology of the Cell ( Garland Science 2008)

Table 15-2 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-37 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-38 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-39 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-40 Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-41a Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-41b Molecular Biology of the Cell ( Garland Science 2008)

Figure 15-43 Molecular Biology of the Cell ( Garland Science 2008)

Table 15-3 Molecular Biology of the Cell ( Garland Science 2008)