Antiproliferative Constituents of the Roots of Conyza canadensis

Author(s): Csupor-Loffler, B (Csupor-Loeffler, Boglarka) ; Hajdu, Z (Hajdu, Zsuzsanna) ; Zupko, I (Zupko, 2 2 1 1 Istvan) ; Molnar, J (Molnar, Judit) ; Forgo, P (Forgo, Peter) ; Vasas, A (Vasas, Andrea) ;Kele, Z (Kele, 3 1 Zoltan) ; Hohmann, J (Hohmann, Judit) Source: PLANTA MEDICA Volume: 77 Issue: 11 Pages: 1183-1188 DOI: 10.1055/s-00301270714 Published: JUL 2011 Times Cited: 3 (from Web of Science) Cited References: 23 [ view related records ] Citation Map
1 1

Abstract: Bioassay-guided fractionation of the n-hexane and CHCl(3) phases of the methanol extract of the roots of Conyza canadensis (L.) Cronquist led to the isolation of two new dihydropyranones named conyzapyranone A (1) and B (2), and the known 4Z, 8Z-matricaria-gamma-lactone (3), 4E,8Z-matricaria-gamma-lactone (4), 9,12,13trihydroxy-10(E)-octadecenoic acid (5), epifriedelanol (6), friedeline (7), taraxerol (8), simiarenol (9), spinasterol (10), stigmasterol, beta-sitosterol, and apigenin. The structures were determined by means of ESIMS and 1D and 2D NMR spectroscopy, including (1)H-(1)H COSY, NOESY, HSQC, and HMBC experiments. The isolated compounds were evaluated for their anti-proliferative activities and were demonstrated to exert considerable cell growth-inhibitory activity against human cervix adenocarcinoma (HeLa), skin carcinoma (A431), and breast adenocarcinoma (MCF-7) cells. Some of the active components, including 2, 4, and 10, proved to be substantially more potent against these cell lines than against noncancerous human foetal fibroblasts (MRC-5) and can therefore be considered selective anti-proliferative natural products. Accession Number: WOS:000293007700013 Document Type: Article Language: English Author Keywords: Conyza canadensis; Asteraceae; conyzapyranone A, B; antiproliferative activity; 2D NMR KeyWords Plus: PHYTOCHEMICAL CONSTITUENTS; ERIGERON-ANNUUS; SPHINGOLIPIDS; DERIVATIVES; FLAVONOIDS Reprint Address: Hohmann, J (reprint author), Univ Szeged, Dept Pharmacognosy, Eotvos U 6, H-6720 Szeged, Hungary. Addresses: 1. Univ Szeged, Dept Pharmacognosy, H-6720 Szeged, Hungary 2. Univ Szeged, Dept Pharmacodynam & Biopharm, H-6720 Szeged, Hungary 3. Univ Szeged, Dept Med Chem, H-6720 Szeged, Hungary E-mail Address: hohmann@pharm.u-szeged.hu