Taxon Acaryochloris marina Accumulibacter phosphatis Acetobacter pasteurianus Acholeplasma laidlawii Acidimicrobium ferrooxidans DSM 10331 Acidiphilium cryptum

J !" Acidithiobacillus ferrooxidans A#$$ Acidobacteria bacterium Acidobacterium capsulatum Acidothermus cellulolyticus Acidovorax avenae Acidovorax sp% JS&' Acinetobacter baumannii Acinetobacter sp% AD(1 Actinobacillus pleuropneumoniae Actinobacillus succinogenes Actinosynnema mirum Acyrthosiphon pisum )pea aphid* Aedes aegypti )yellow fever mos,uito* Aeromonas hydrophila Aeromonas salmonicida Aeropyrum pernix Aggregatibacter actinomycetemcomitans Aggregatibacter aphrophilus Agrobacterium radiobacter -.& Agrobacterium tumefaciens $". Agrobacterium vitis S& A++ermansia muciniphila Alcanivorax bor+umensis Alicyclobacillus acidocaldarius Aliivibrio salmonicida / 01'3. Al+alilimnicola ehrlichei Al+aliphilus metalliredigens Al+aliphilus oremlandii Alteromonas macleodii Ammonifex degensii Anabaena sp% ($$11'0 Anabaena variabilis Anaerococcus prevotii Anaeromyxobacter dehalogenans '$(! Anaeromyxobacter sp% w102!" Anaeromyxobacter sp% Anaplasma centrale Anaplasma marginale Anopheles gambiae )mos,uito* Anoxybacillus flavithermus Apis mellifera )honey bee* A,uifex aeolicus

Biotic relationshi Multicellularit Domai p y n symbiotic bacteria free living bacteria symbiotic bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria symbiotic bacteria free living bacteria free living bacteria multicellular eu+arya multicellular eu+arya free living bacteria free living bacteria archaea symbiotic bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria symbiotic bacteria free living bacteria free living bacteria free living bacteria free living bacteria free living bacteria bacteria symbiotic bacteria multicellular eu+arya free living bacteria multicellular eu+arya free living bacteria

Arabidopsis thaliana )thale cress* Archaeoglobus fulgidus Arcobacter but3leri Aromatoleum aromaticum 4b51 Arthrobacter aurescens Arthrobacter chlorophenolicus Arthrobacter sp% 6'& Ashbya gossypii )4remothecium gossypii* Aspergillus fumigatus Aspergillus nidulans Aspergillus niger Aspergillus ory3ae Atopobium parvulum A3oarcus sp% 671' A3orhi3obium caulinodans A3otobacter vinelandii 6abesia bovis 6acillus amyloli,uefaciens 6acillus anthracis 6acillus cereus 6acillus clausii 6acillus cytotoxis 587 321!2. 6acillus halodurans 6acillus licheniformis 6acillus pumilus 6acillus subtilis 6acillus thuringiensis 21!'1 6acillus weihenstephanensis 6acteroides fragilis 6acteroides thetaiotaomicron 6acteroides vulgatus 6artonella bacilliformis 6artonella grahamii 6artonella henselae 6artonella ,uintana 6artonella tribocorum 6aumannia cicadellinicola 6dellovibrio bacteriovorus 6ei9erinc+ia indica 6eutenbergia cavernae 6ifidobacterium adolescentis 6ifidobacterium animalis subsp% lactis 6ifidobacterium longum 6lattabacterium sp% )6lattella germanica* 6ordetella avium 6ordetella bronchiseptica 6ordetella parapertussis 6ordetella pertussis 6ordetella petrii 6orrelia burgdorferi 6orrelia duttonii

multicellular free free free free free living living living living living unicellular unicellular unicellular unicellular unicellular free living free living symbiotic free living unicellular free living free living free living free living free living free living free living free living free living free living free living free living free living free living symbiotic symbiotic

free living free living free living free living free living free living free living symbiotic free living free living free living free living free living free living free living

eu+arya archaea bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya eu+arya eu+arya eu+arya bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria

6orrelia garinii 6orrelia hermsii 6orrelia turicatae 6os taurus )cow* 6rachybacterium faecium 6rachyspira hyodysenteriae 6radyrhi3obium 9aponicum 6radyrhi3obium sp% 6#Ai1 6ranchiostoma floridae ) lorida lancelet* 6revibacillus brevis 6rucella abortus 6rucella canis 6rucella melitensis 6rucella microti 6rucella ovis 6rucella suis 6rugia malayi )filaria* 6uchnera aphidicola 6ur+holderia ambifaria M$&0!: 6ur+holderia cenocepacia 6ur+holderia cepacia 6ur+holderia glumae 6ur+holderia mallei 6ur+holderia multivorans A#$$ 11:1: ) 6ur+holderia phymatum 6ur+holderia phytofirmans 6ur+holderia pseudomallei 6ur+holderia sp% 3.3 6ur+holderia thailandensis 6ur+holderia vietnamiensis 6ur+holderia xenovorans $aenorhabditis briggsae $aenorhabditis elegans )nematode* $aldicellulosiruptor saccharolyticus $aldivirga ma,uilingensis $ampylobacter concisus 13.': $ampylobacter curvus $ampylobacter fetus $ampylobacter hominis A#$$ 6AA!3.1 $ampylobacter 9e9uni $ampylobacter lari $andida albicans $andida glabrata $andidatus Amoebophilus asiaticus $andidatus A3obacteroides pseudotrichonymphae $andidatus 6lochmannia floridanus $andidatus Desulforudis audaxviator $andidatus 7amiltonella defensa $andidatus -orarchaeum cryptofilum $andidatus /iberibacter asiaticus $andidatus Methanoregula boonei

free living free living multicellular free living free living symbiotic symbiotic multicellular free free free free free free free living living living living living living living multicellular symbiotic free living free living free living free living free living free living free living free living free living free living free living free living free living multicellular multicellular free living free free free free free free living living living living living living unicellular unicellular free living free living free living symbiotic

bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya bacteria archaea bacteria bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya bacteria bacteria bacteria bacteria bacteria archaea bacteria archaea

$andidatus Methanosphaerula palustris $andidatus (elagibacter ubi,ue $andidatus (hytoplasma australiense $andidatus (rotochlamydia amoebophila $andidatus ;uthia magnifica $andidatus Sulcia muelleri SMDS4M $andidatus 8esicomyosocius o+utanii $anis familiaris )dog* $apnocytophaga ochracea $arboxydothermus hydrogenoformans $atenulispora acidiphila $aulobacter crescentus 5A1000 $aulobacter sp% -31 $ellvibrio 9aponicus $hitinophaga pinensis $hlamydia muridarum $hlamydia trachomatis $hlamydomonas reinhardtii $hlamydophila caviae $hlamydophila felis $hlamydophila pneumoniae $hlorobaculum parvum 5$06 .3'1 $hlorobaculum tepidum $hlorobium chlorochromatii $hlorobium limicola $hlorobium phaeobacteroides $hlorobium vibrioformis $hloroflexus aggregans $hloroflexus aurantiacus $hloroflexus sp% <!&00!fl $hloroherpeton thalassium $hromobacterium violaceum $hromohalobacter salexigens $iona intestinalis )sea s,uirt* $itrobacter +oseri A#$$ 6AA!.2" $lavibacter michiganensis $lostridium acetobutylicum $lostridium bei9erinc+ii $lostridium botulinum $lostridium cellulolyticum $lostridium difficile $lostridium +luyveri $lostridium novyi $lostridium perfringens $lostridium phytofermentans $lostridium tetani 4.. $lostridium thermocellum $olwellia psychrerythraea $omamonas testosteroni $oprothermobacter proteolyticus $orynebacterium aurimucosum

free living symbiotic symbiotic symbiotic symbiotic multicellular free living free living free living free living free living free living free living symbiotic symbiotic multicellular symbiotic symbiotic symbiotic free living free living free living free living free living free living free living free living free living free living free living free living multicellular free free free free free free free free free free free free free free free free free living living living living living living living living living living living living living living living living living

archaea bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria

$orynebacterium diphtheriae $orynebacterium efficiens $orynebacterium glutamicum $orynebacterium 9ei+eium $orynebacterium urealyticum $oxiella burnetii $ronobacter turicensis $ryptobacterium curtum $ryptococcus neoformans J4$'1 $ryptosporidium hominis $ryptosporidium parvum $upriavidus taiwanensis $yanidioschy3on merolae $yanobacteria <ellowstone $yanothece sp% A#$$ "11&' $yanothece sp% ($$ 1&'& $yanothece sp% ($$ 1&'" $yanothece sp% ($$ ..01 $yanothece sp% ($$ ..0' $ytophaga hutchinsonii Danio rerio )3ebrafish* Debaryomyces hansenii Dechloromonas aromatica Dehalococcoides ethenogenes Dehalococcoides sp% 6A81 Dehalococcoides sp% $6D61 Dehalococcoides sp% 8S Deinococcus deserti Deinococcus geothermalis Deinococcus radiodurans Delftia acidovorans Desulfatibacillum al+enivorans Desulfitobacterium hafniense Desulfobacterium autotrophicum Desulfococcus oleovorans Desulfohalobium retbaense Desulfomicrobium baculatum Desulfotalea psychrophila Desulfotomaculum acetoxidans Desulfotomaculum reducens Desulfovibrio desulfuricans Desulfovibrio magneticus Desulfovibrio salexigens Desulfovibrio vulgaris Desulfurococcus +amchat+ensis Diaphorobacter sp% #(S< Dichelobacter nodosus Dic+eya 3eae Dictyoglomus thermophilum Dictyoglomus turgidum Dictyostelium discoideum )cellular slime mold*

free living free living free living free living free living symbiotic free living unicellular unicellular unicellular symbiotic unicellular free free free free free free free living living living living living living living multicellular unicellular free free free free free free free free free free free free free free free free free free free free free free free free free free free living living living living living living living living living living living living living living living living living living living living living living living living living living living unicellular

bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya eu+arya bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria archaea bacteria bacteria bacteria bacteria bacteria eu+arya

Dinoroseobacter shibae Drosophila ananassae Drosophila erecta Drosophila grimshawi Drosophila melanogaster )fruit fly* Drosophila persimilis Drosophila pseudoobscura pseudoobscura Drosophila ya+uba Dyadobacter fermentans 4dwardsiella ictaluri 4dwardsiella tarda 4ggerthella lenta 4hrlichia canis 4hrlichia chaffeensis 4hrlichia ruminantium 4lusimicrobium minutum 4ncephalito3oon cuniculi 4ntamoeba histolytica 4nterobacter sa+a3a+ii 4nterobacter sp% :3. 4nterococcus faecalis 4,uus caballus )horse* 4rwinia carotovora 4rwinia tasmaniensis 4rythrobacter litoralis 4scherichia coli 4scherichia fergusonii 4ubacterium rectale 4xiguobacterium sibiricum 4xiguobacterium sp% A#1b ervidobacterium nodosum ibrobacter succinogenes inegoldia magna lavobacteriaceae bacterium lavobacterium 9ohnsoniae lavobacterium psychrophilum rancisella novicida =11' rancisella tularensis ran+ia alni ran+ia sp% $c03 ran+ia sp% 4A51pec usarium graminearum usobacterium nucleatum >allus gallus )chic+en* >emmatimonas aurantiaca >eobacillus +austophilus >eobacillus sp% ?$710 >eobacillus sp% <&1'M$10 >eobacillus sp% <&1'M$:1 >eobacillus thermodenitrificans >eobacter bemid9iensis

free living multicellular multicellular multicellular multicellular multicellular multicellular multicellular free living free living free living free living free living symbiotic symbiotic symbiotic unicellular unicellular free living free living free living multicellular free free free free free free free free free free free living living living living living living living living living living living

free living free living free living free living symbiotic symbiotic symbiotic unicellular free living multicellular free free free free free free free living living living living living living living

bacteria eu+arya eu+arya eu+arya eu+arya eu+arya eu+arya eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria

>eobacter lovleyi >eobacter metallireducens >eobacter sp% ;$!3' >eobacter sp% M'1 >eobacter sulfurreducens >eobacter uraniumreducens >iardia lamblia >loeobacter violaceus >luconacetobacter dia3otrophicus (Al " ) >luconobacter oxydans >ordonia bronchialis >ramella forsetii >ranulobacter bethesdensis 7aemophilus ducreyi 7aemophilus influen3ae 7aemophilus parasuis 7aemophilus somnus 7ahella che9uensis 7aliangium ochraceum 7aloarcula marismortui 7alobacterium salinarum ;1 7alobacterium sp% 5;$!1 7alomicrobium mu+ohataei 7alo,uadratum walsbyi 7alorhabdus utahensis 7alorhodospira halophila 7alorubrum lacusprofundi 7alothermothrix orenii 7alothiobacillus neapolitanus 7elicobacter acinonychis 7elicobacter hepaticus 7elicobacter pylori 7eliobacterium modesticaldum 7erminiimonas arsenicoxydans 7erpetosiphon aurantiacus 7irschia baltica 7omo sapiens )human* 7ydrogenobaculum sp% <0&AAS1 7yperthermus butylicus 7yphomonas neptunium 0diomarina loihiensis 0gnicoccus hospitalis Jannaschia sp% $$S1 Jonesia denitrificans -angiella +oreensis -ineococcus radiotolerans -lebsiella pneumoniae -luyveromyces lactis -ocuria rhi3ophila -osmotoga olearia -ytococcus sedentarius

free free free free free free

living living living living living living unicellular

free living symbiotic free living free living free living free living free living free living free living free living free living free living

free living free free free free free free free free free living living living living living living living living living multicellular free living free living free living free free free free free living living living living living unicellular free living free living free living

bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria archaea archaea archaea archaea archaea archaea bacteria archaea bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria archaea bacteria bacteria archaea bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria

/accaria bicolor /achancea thermotolerans /actobacillus acidophilus /actobacillus brevis /actobacillus casei /actobacillus delbruec+ii A#$$ /actobacillus fermentum /actobacillus gasseri /actobacillus helveticus /actobacillus 9ohnsonii /actobacillus plantarum /actobacillus reuteri J$M 111' /actobacillus rhamnosus /actobacillus sa+ei /actobacillus salivarius /actococcus lactis /aribacter hong+ongensis /awsonia intracellularis /egionella pneumophila /eifsonia xyli xyli $#$601 /eishmania infantum /eishmania ma9or /eptospira biflexa serovar (atoc (atoc 1 )Ames* /eptospira borgpetersenii /eptospira interrogans serovar /eptothrix cholodnii /eptotrichia buccalis /euconostoc citreum /isteria innocua /isteria monocytogenes /isteria welshimeri S/$$"33& /ysinibacillus sphaericus Macaca mulatta )rhesus mon+ey* Macrococcus caseolyticus Magnaporthe grisea Magnetococcus sp% M$!1 Malasse3ia globosa Mannheimia succiniciproducens Maricaulis maris Marinobacter a,uaeolei Marinomonas sp% M?</1 Mesorhi3obium loti Mesorhi3obium sp% 65$1 Methanobacterium thermoautotrophicum Methanobrevibacter smithii A#$$ 3"0:1 Methanocaldococcus fervens Methanocaldococcus vulcanius Methanococcus aeolicus Methanococcus 9annaschii Methanococcus maripaludis $ Methanococcus vannielii

unicellular unicellular free free free free free free free free free free free free free free free free free free living living living living living living living living living living living living living living living living living living unicellular unicellular free free free free free free free free free free living living living living living living living living living living multicellular free living unicellular free living unicellular free living free living free living free living symbiotic symbiotic

eu+arya eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria eu+arya bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria archaea archaea archaea archaea archaea archaea archaea archaea

Methanocorpusculum labreanum Methanoculleus marisnigri Methanopyrus +andleri Methanosaeta thermophila Methanosarcina acetivorans Methanosarcina bar+eri Methanosarcina ma3ei Methanosphaera stadtmanae Methanospirillum hungatei Methylacidiphilum infernorum Methylibium petroleiphilum Methylobacillus flagellatus Methylobacterium chloromethanicum Methylobacterium extor,uens Methylobacterium nodulans Methylobacterium populi Methylobacterium radiotolerans Methylobacterium sp% &!&: Methylocella silvestris Methylococcus capsulatus Methylotenera mobilis Methylovorus sp% S0(3!& Micrococcus luteus Microcystis aeruginosa Minibacterium massiliensis Monodelphis domestica )opossum* Monosiga brevicollis Moorella thermoacetica Mus musculus )mouse* Mycobacterium abscessus A#$$ 12211 Mycobacterium avium Mycobacterium bovis Mycobacterium gilvum Mycobacterium leprae Mycobacterium marinum M Mycobacterium smegmatis Mycobacterium sp% J/S Mycobacterium sp% -MS Mycobacterium sp% M$S Mycobacterium tuberculosis Mycobacterium ulcerans Mycobacterium vanbaalenii Mycoplasma agalactiae Mycoplasma capricolum Mycoplasma con9unctivae Mycoplasma gallisepticum Mycoplasma genitalium Mycoplasma hyopneumoniae Mycoplasma penetrans Mycoplasma pneumoniae Mycoplasma pulmonis

free free free free free free free free free free free free free free free free

living living living living living living living living living living living living living living living living multicellular unicellular

free living multicellular free free free free free free free free free free free free free free free free free free free free free free living living living living living living living living living living living living living living living living living living living living living living

archaea archaea archaea archaea archaea archaea archaea archaea archaea bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria

Mycoplasma synoviae Myxococcus xanthus 5anoarchaeum e,uitans 5asonia vitripennis )9ewel wasp* 5atranaerobius thermophilus 5atronomonas pharaonis 5autilia profundicola 5eisseria gonorrhoeae 5eisseria meningitidis 5ematostella vectensis )sea anemone* 5eoric+ettsia risticii 5eurospora crassa 5itratiruptor sp% S61""!' 5itrobacter hamburgensis 5itrobacter winograds+yi 5itrosococcus oceani 5itrosomonas europaea 5itrosomonas eutropha 5itrosopumilus maritimus 5itrosospira multiformis 5ocardia farcinica 5ocardioides sp% JS:1& 5ostoc punctiforme 5ovosphingobium aromaticivorans @ceanobacillus iheyensis @chrobactrum anthropi @enococcus oeni @ligotropha carboxidovorans @pitutus terrae @rientia tsutsugamushi 6oryong @rnithorhynchus anatinus )platypus* @ry3a sativa 9aponica )Japanese rice* @streococcus lucimarinus (aenibacillus sp% JD;!' (an troglodytes )chimpan3ee* (arabacteroides distasonis (aracoccus denitrificans (aramecium tetraurelia (arvibaculum lavamentivorans (asteurella multocida (ectobacterium carotovorum (ectobacterium wasabiae (ediococcus pentosaceus (edobacter heparinus (elobacter carbinolicus (elobacter propionicus (elodictyon luteolum (elodictyon phaeoclathratiforme (elotomaculum thermopropionicum (ersephonella marina (etrotoga mobilis

free living free living multicellular free living free living free living free living multicellular free living multicellular free free free free free free living living living living living living

free living free living free living symbiotic free living free living free living free living free living free living free living multicellular multicellular multicellular free living multicellular free living free living unicellular free living free living free living free living free living free living free living free living free living free living symbiotic free living free living

bacteria bacteria archaea eu+arya bacteria archaea bacteria bacteria bacteria eu+arya bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria archaea bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya eu+arya bacteria eu+arya bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria

(haeodactylum tricornutum (henylobacterium 3ucineum (hotobacterium profundum (hotorhabdus asymbiotica (hotorhabdus luminescens (hyscomitrella patens subsp% patens (hytoplasma A<?6 (ichia pastoris (ichia stipitis (icrophilus torridus (lasmodium falciparum 3D1 (lasmodium +nowlesi (olaromonas naphthalenivorans (olaromonas sp% JS::: (olynucleobacter necessarius (opulus trichocarpa )blac+ cottonwood* (orphyromonas gingivalis (rochlorococcus marinus (ropionibacterium acnes (rosthecochloris aestuarii (roteus mirabilis (seudoalteromonas atlantica (seudoalteromonas haloplan+tis (seudomonas aeruginosa (seudomonas entomophila (seudomonas fluorescens (seudomonas mendocina (seudomonas putida (seudomonas stut3eri (seudomonas syringae (sychrobacter arcticum (sychrobacter cryohalolentis (sychrobacter sp% (;wf!1 (yrobaculum aerophilum (yrobaculum arsenaticum (yrobaculum calidifontis (yrobaculum islandicum (yrococcus abyssi (yrococcus hori+oshii ;alstonia eutropha ;alstonia metallidurans ;alstonia pic+ettii 1' ;alstonia solanacearum ;attus norvegicus )rat* ;enibacterium salmoninarum ;hi3obium etli $ ;hi3obium leguminosarum ;hi3obium sp% 5>;'3& ;hodobacter sphaeroides ;hodococcus erythropolis ;hodococcus opacus

unicellular free living free living symbiotic symbiotic multicellular symbiotic unicellular unicellular unicellular unicellular free living free living free living multicellular free free free free free free free free free free free free free free free free free living living living living living living living living living living living living living living living living living

free free free free

living living living living multicellular

free living symbiotic symbiotic symbiotic free living free living free living

eu+arya bacteria bacteria bacteria bacteria eu+arya bacteria eu+arya eu+arya archaea eu+arya eu+arya bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria archaea archaea archaea archaea archaea archaea bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria

;hodococcus sp% ;7A1 ;hodoferax ferrireducens ;hodopirellula baltica ;hodopseudomonas palustris ;hodospirillum rubrum ;hodothermus marinus ;ic+ettsia africae ;ic+ettsia a+ari ;ic+ettsia bellii ;ic+ettsia canadensis ;ic+ettsia conorii ;ic+ettsia felis ;ic+ettsia peacoc+ii ;ic+ettsia prowa3e+ii ;ic+ettsia ric+ettsii ;ic+ettsia typhi ;obiginitalea biformata ;oseiflexus castenhol3ii DSM132&1 ;oseiflexus sp% ;S!1 ;oseobacter denitrificans ;ubrobacter xylanophilus Saccharomonospora viridis Saccharomyces cerevisiae )budding yeast* Saccharophagus degradans Saccharopolyspora erythraea Salinibacter ruber Salinispora arenicola Salinispora tropica Salmonella enterica Salmonella typhimurium /#' Schistosoma mansoni Schi3osaccharomyces pombe )fission yeast* Sebaldella termitidis Serratia proteamaculans Shewanella ama3onensis Shewanella baltica @S Shewanella denitrificans Shewanella frigidimarina Shewanella halifaxensis Shewanella loihica Shewanella oneidensis Shewanella pealeana Shewanella pie3otolerans ?(3 Shewanella putrefaciens Shewanella sediminis Shewanella sp% A5A!3 Shewanella sp% M;!& Shewanella sp% M;!1 Shewanella sp% ?3!1.!1 Shewanella woodyi A#$$ "120. Shigella boydii

free living free living free living free living free living free living symbiotic symbiotic symbiotic symbiotic symbiotic symbiotic symbiotic symbiotic symbiotic symbiotic free living free living free living free living free living unicellular free free free free free free free living living living living living living living multicellular unicellular free free free free free free free free free free free free free free free free free free free living living living living living living living living living living living living living living living living living living living

bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria

Shigella dysenteriae Shigella flexneri Shigella sonnei Silicibacter pomeroyi Silicibacter sp% #M10&0 Sinorhi3obium medicae Sinorhi3obium meliloti Slac+ia heliotrinireducens Sodalis glossinidius Solibacter usitatus Sorangium cellulosum Sorghum bicolor )sorghum* Sphaerobacter thermophilus Sphingomonas wittichii Sphingopyxis alas+ensis Staphylococcus aureus Staphylococcus carnosus Staphylococcus epidermidis Staphylococcus haemolyticus Staphylococcus saprophyticus Staphylothermus marinus Stenotrophomonas maltophilia Streptobacillus moniliformis Streptococcus agalactiae Streptococcus dysgalactiae Streptococcus e,ui Streptococcus gordonii Streptococcus mutans Streptococcus pneumoniae Streptococcus pyogenes Streptococcus suis Streptococcus thermophilus Streptococcus uberis Streptomyces avermitilis Streptomyces griseus Streptosporangium roseum Sulfolobus acidocaldarius Sulfolobus islandicus Sulfolobus solfataricus Sulfolobus to+odaii Sulfurihydrogenibium a3orense Sulfurihydrogenibium sp% <@3A@(1 Sulfurimonas denitrificans Sulfurospirillum deleyianum Sulfurovum sp% 56$31!1 Symbiobacterium thermophilum Synechococcus elongatus ($$ Synechococcus sp% $$2311 Synechococcus sp% $$2:0" Synechococcus sp% $$220' Synechococcus sp% ($$100'

free living free living free living free living free living symbiotic symbiotic free living symbiotic free living free living multicellular free free free free free free free free free free free free free free free free free free free free free free free living living living living living living living living living living living living living living living living living living living living living living living

free free free free free free free free free free free

living living living living living living living living living living living

bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria archaea bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria archaea archaea archaea archaea bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria

Synechococcus sp% ;$$301 free living Synechococcus sp% ?71.03 free living Synechococcus sp% ?7.10' free living Synechocystis sp% ($$:.03 free living Syntrophobacter fumaroxidans Syntrophomonas wolfei Syntrophus aciditrophicus #eredinibacter turnerae symbiotic #halassiosira pseudonana #hauera sp% MA1# free living #heileria annulata #heileria parva #hermoanaerobacter pseudethanolicus free living #hermoanaerobacter sp% B"1& free living #hermoanaerobacter tengcongensis free living #hermobaculum terrenum free living #hermobifida fusca free living #hermococcus gammatolerans #hermococcus onnurineus #hermococcus sibiricus #hermodesulfovibrio yellowstonii free living #hermofilum pendens #hermomicrobium roseum free living #hermomonospora curvata free living #hermoplasma acidophilum #hermoplasma volcanium #hermoproteus neutrophilus #hermosipho africanus free living #hermosipho melanesiensis free living #hermosynechococcus elongatus free living #hermotoga lettingae free living #hermotoga maritima free living #hermotoga neapolitana free living #hermotoga petrophila free living #hermotoga sp% ;C' free living #hermus thermophilus 76 free living #hioal+alivibrio sp% 7/!4b>;1 free living #hiobacillus denitrificans free living #hiomicrospira crunogena free living #olumonas auensis free living #oxoplasma gondii #reponema denticola free living #reponema pallidum subsp% pallidum SS1& free living #ribolium castaneum )red flour beetle* #richodesmium erythraeum free living #richoplax adhaerens #ropheryma whipplei # free living #rypanosoma brucei #rypanosoma cru3i =ncultured #ermite group 1 bacterium phylotype ;s!D11 symbiotic =ncultured methanogenic archaeon ;$!0

unicellular unicellular unicellular

unicellular

multicellular multicellular unicellular unicellular

bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria eu+arya eu+arya bacteria bacteria bacteria bacteria bacteria archaea archaea archaea bacteria archaea bacteria bacteria archaea archaea archaea bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria eu+arya bacteria eu+arya bacteria eu+arya eu+arya bacteria archaea

=reaplasma parvum serovar 3 A#$$ =reaplasma urealyticum serovar 10 A#$$ 33:22 =stilago maydis 8anderwalto3yma polyspora 8ariovorax paradoxus 8eillonella parvula 8erminephrobacter eiseniae 8ibrio cholerae 8ibrio fischeri 8ibrio harveyi 8ibrio parahaemolyticus 8ibrio sp% 4x'" 8ibrio splendidus 8ibrio vulnificus 8itis vinifera )wine grape* ?igglesworthia glossinidia ?olbachia pipientis ?olinella succinogenes Banthobacter autotrophicus Banthomonas axonopodis Banthomonas campestris Banthomonas ory3ae Bylanimonas cellulosilytica Bylella fastidiosa Bylella fastidiosa #emecula1 <arrowia lipolytica <ersinia enterocolitica <ersinia pestis <ersinia pseudotuberculosis Aea mays )mai3e* Aygosaccharomyces rouxii Aymomonas mobilis

free living free living unicellular unicellular free living free living symbiotic free living symbiotic free living free living free living free living free living multicellular symbiotic symbiotic free living free living free living free living free living free living free living free living unicellular free living free living free living multicellular unicellular free living

bacteria bacteria eu+arya eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria bacteria eu+arya bacteria bacteria bacteria eu+arya eu+arya bacteria

Oxygen requiremen Motility t Salinity aerobe aerobe aerobe nonmotile facultative motile aerobe motile aerobe motile anaerobe nonmotile aerobe nonmotile aerobe aerobe motile aerobe motile aerobe nonmotile aerobe nonmotile aerobe nonmotile facultative facultative nonmotile aerobe

Temperatur e range mesophile mesophile mesophile thermophile mesophile mesophile mesophile mesophile thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

motile motile

facultative facultative

mesophile psychrophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile psychrophile mesophile mesophile mesophile mesophile thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile thermophile

nonmotile facultative nonmotile facultative motile aerobe motile aerobe motile aerobe nonmotile anaerobe nonmotile aerobe aerobe motile facultative anaerobe motile anaerobe motile anaerobe motile aerobe motile anaerobe motile aerobe motile aerobe nonmotile anaerobe motile anaerobe motile anaerobe motile anaerobe aerobe aerobe motile facultative

halophile

halophile

nonmotile facultative

motile motile motile motile motile

aerobe facultative aerobe aerobe aerobe

mesophile mesophile mesophile mesophile mesophile

nonmotile anaerobe motile facultative motile aerobe aerobe motile motile motile motile motile motile motile motile motile facultative facultative facultative facultative aerobe facultative facultative facultative anaerobe anaerobe anaerobe aerobe aerobe aerobe aerobe aerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile psychrophile mesophile mesophile mesophile mesophile mesophile psychrophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

motile motile

motile

motile aerobe nonmotile aerobe nonmotile aerobe nonmotile anaerobe nonmotile anaerobe nonmotile anaerobe nonmotile aerobe motile aerobe motile aerobe motile aerobe motile aerobe nonmotile anaerobe motile aerobe motile aerobe

motile motile motile

aerobe aerobe aerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

nonmotile aerobe motile anaerobe motile aerobe motile aerobe motile aerobe nonmotile nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile facultative nonmotile aerobe

motile facultative motile motile facultative nonmotile aerobe motile aerobe motile facultative motile facultative motile facultative motile aerobe motile facultative motile aerobe motile facultative motile aerobe

anaerobe motile motile motile motile motile motile aerobe aerobe aerobe aerobe aerobe aerobe

thermophile mesophile mesophile mesophile mesophile mesophile mesophile

motile

anaerobe

mesophile mesophile mesophile mesophile mesophile mesophile

aerobe aerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile mesophile mesophile mesophile mesophile thermophile thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile psychrophile mesophile thermophile mesophile

motile

facultative anaerobe nonmotile aerobe motile aerobe motile aerobe motile aerobe motile aerobe nonmotile nonmotile nonmotile nonmotile nonmotile facultative nonmotile anaerobe motile nonmotile anaerobe nonmotile facultative nonmotile facultative motile facultative motile anaerobe motile motile facultative motile facultative motile facultative motile facultative nonmotile aerobe motile anaerobe motile anaerobe motile motile anaerobe motile anaerobe motile anaerobe motile anaerobe motile anaerobe motile anaerobe motile anaerobe motile anaerobe motile facultative motile aerobe nonmotile anaerobe nonmotile anaerobe

halophile

nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative anaerobe motile facultative nonmotile anaerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile

motile

facultative

mesophile thermophile mesophile mesophile mesophile mesophile mesophile mesophile

motile facultative nonmotile facultative nonmotile anaerobe nonmotile anaerobe nonmotile aerobe nonmotile aerobe motile aerobe

motile facultative motile anaerobe motile anaerobe motile anaerobe motile anaerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe aerobe nonmotile anaerobe motile anaerobe motile anaerobe nonmotile anaerobe motile anaerobe motile anaerobe anaerobe motile anaerobe motile anaerobe motile anaerobe motile anaerobe motile anaerobe motile anaerobe motile facultative anaerobe

halophile

mesophile mesophile mesophile mesophile mesophile mesophile thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile psychrophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile thermophile

nonmotile anaerobe anaerobe

motile

aerobe

mesophile

nonmotile aerobe motile facultative motile facultative nonmotile anaerobe

anaerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

motile facultative motile facultative nonmotile facultative motile motile motile motile motile facultative facultative aerobe facultative facultative anaerobe motile facultative facultative motile anaerobe nonmotile anaerobe anaerobe motile aerobe motile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile anaerobe motile aerobe motile aerobe motile facultative motile facultative motile facultative motile facultative nonmotile anaerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile psychrophile thermophile thermophile mesophile mesophile mesophile psychrophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile thermophile mesophile mesophile thermophile mesophile

motile motile motile motile motile motile

anaerobe anaerobe anaerobe anaerobe anaerobe anaerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

nonmotile motile aerobe motile aerobe nonmotile aerobe aerobe nonmotile anaerobe nonmotile facultative nonmotile facultative nonmotile facultative motile aerobe motile aerobe

halophile halophile

motile

anaerobe anaerobe aerobe aerobe aerobe aerobe anaerobe anaerobe aerobe aerobe aerobe aerobe aerobe

halophile halophile

mesophile thermophile mesophile mesophile mesophile mesophile thermophile mesophile mesophile mesophile thermophile mesophile psychrophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

motile motile motile motile motile motile motile motile motile motile

halophile

nonmotile aerobe motile facultative nonmotile facultative motile aerobe nonmotile facultative nonmotile aerobe motile nonmotile aerobe

facultative motile aerobe nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile nonmotile nonmotile facultative nonmotile aerobe nonmotile facultative nonmotile facultative nonmotile facultative motile anaerobe facultative motile aerobe nonmotile aerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

motile aerobe motile aerobe motile aerobe motile aerobe nonmotile anaerobe nonmotile facultative motile facultative motile facultative motile facultative motile aerobe nonmotile facultative motile facultative

mesophile mesophile mesophile mesophile mesophile psychrophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

nonmotile anaerobe motile facultative motile facultative motile aerobe motile aerobe motile aerobe

halophile

motile motile motile motile aerobe motile aerobe motile aerobe motile aerobe nonmotile aerobe aerobe motile aerobe motile aerobe motile aerobe nonmotile aerobe motile

aerobe facultative aerobe aerobe

thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile psychrophile thermophile mesophile mesophile mesophile mesophile

anaerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile facultative nonmotile facultative nonmotile facultative motile facultative motile facultative nonmotile facultative nonmotile facultative motile facultative motile facultative

thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

nonmotile facultative motile aerobe

mesophile mesophile

nonmotile anaerobe motile anaerobe nonmotile aerobe nonmotile aerobe aerobe nonmotile anaerobe motile aerobe motile facultative motile aerobe motile aerobe motile aerobe motile aerobe nonmotile aerobe nonmotile aerobe motile aerobe motile aerobe motile aerobe motile aerobe nonmotile facultative motile motile anaerobe aerobe

halophile

thermophile thermophile mesophile mesophile mesophile thermophile mesophile mesophile mesophile mesophile mesophile

mesophile mesophile mesophile mesophile mesophile halotolerant mesophile mesophile mesophile mesophile mesophile mesophile

aerobe nonmotile anaerobe nonmotile aerobe motile aerobe nonmotile facultative motile facultative motile facultative nonmotile facultative motile aerobe anaerobe nonmotile anaerobe nonmotile anaerobe nonmotile anaerobe anaerobe motile aerobe motile anaerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile thermophile halotolerant thermophile

motile motile motile motile

aerobe facultative facultative facultative aerobe

mesophile psychrophile mesophile mesophile mesophile

nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile anaerobe nonmotile nonmotile anaerobe nonmotile motile facultative motile aerobe motile aerobe motile aerobe motile aerobe motile aerobe motile aerobe motile aerobe motile aerobe motile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile psychrophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile psychrophile halotolerant psychrophile psychrophile

motile motile motile motile

aerobe aerobe aerobe aerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

nonmotile facultative motile aerobe motile aerobe motile aerobe motile facultative nonmotile aerobe nonmotile aerobe

halophile

nonmotile aerobe anaerobe motile aerobe motile facultative motile facultative nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe nonmotile aerobe motile facultative motile facultative motile aerobe nonmotile aerobe nonmotile aerobe motile aerobe nonmotile aerobe motile aerobe motile aerobe nonmotile aerobe motile facultative motile facultative

halophile

mesophile psychrophile mesophile mesophile mesophile thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile thermophile mesophile thermophile thermophile psychrophile mesophile mesophile mesophile mesophile mesophile mesophile

halophile

nonmotile anaerobe motile facultative motile facultative motile facultative motile facultative motile facultative motile facultative motile anaerobe motile facultative motile facultative motile facultative motile anaerobe motile facultative motile anaerobe motile anaerobe motile anaerobe motile facultative motile facultative motile facultative

mesophile mesophile mesophile mesophile mesophile psychrophile psychrophile mesophile psychrophile psychrophile mesophile psychrophile mesophile mesophile mesophile mesophile psychrophile mesophile

motile facultative motile facultative motile facultative motile aerobe motile aerobe motile aerobe motile aerobe nonmotile anaerobe nonmotile aerobe nonmotile aerobe motile aerobe nonmotile aerobe motile aerobe aerobe nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile aerobe aerobe nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile facultative nonmotile aerobe nonmotile aerobe nonmotile aerobe

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

motile facultative motile facultative nonmotile anaerobe motile aerobe nonmotile anaerobe nonmotile anaerobe motile facultative motile motile motile motile facultative

thermophile thermophile mesophile mesophile thermophile thermophile mesophile mesophile mesophile mesophile mesophile

motile facultative motile motile motile facultative nonmotile anaerobe motile anaerobe nonmotile anaerobe motile motile facultative

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

motile anaerobe motile anaerobe motile anaerobe nonmotile aerobe nonmotile aerobe

thermophile thermophile thermophile thermophile thermophile

motile nonmotile aerobe aerobe

thermophile thermophile thermophile

anaerobe anaerobe motile anaerobe motile anaerobe motile anaerobe motile anaerobe motile anaerobe nonmotile aerobe motile facultative motile facultative motile anaerobe nonmotile facultative motile motile motile anaerobe anaerobe aerobe

thermophile thermophile thermophile thermophile thermophile thermophile thermophile thermophile halotolerant thermophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

nonmotile aerobe

mesophile

nonmotile facultative nonmotile facultative

mesophile mesophile

motile aerobe nonmotile anaerobe motile motile motile motile motile motile motile facultative facultative facultative facultative facultative facultative facultative

halophile

mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile mesophile

nonmotile aerobe motile anaerobe motile facultative motile aerobe motile aerobe motile aerobe nonmotile aerobe aerobe aerobe motile motile motile aerobe facultative facultative

motile

facultative

mesophile

KEGG individuals amr )Acaryochloris marina* app )Accumulibacter phosphatis* apt )Acetobacter pasteurianus* acl )Acholeplasma laidlawii* afo )Acidimicrobium ferrooxidans DSM 10331* acr )Acidiphilium cryptum J !"* afe )Acidithiobacillus ferrooxidans A#$$ "3223*D afr )Acidithiobacillus ferrooxidans A#$$ '3'10* aba )Acidobacteria bacterium* aca )Acidobacterium capsulatum* ace )Acidothermus cellulolyticus* aav )Acidovorax avenae* a9s )Acidovorax sp% JS&'* abb )Acinetobacter baumannii A6301!0'2&*D abc )Acinetobacter baumannii A$0$=*D abm )Acinetobacter bauma aci )Acinetobacter sp% AD(1* apa )Actinobacillus pleuropneumoniae A(1: )serotype 1**D ap9 )Actinobacillus pleuropneumoniae J/03 )serotyp asu )Actinobacillus succinogenes* ami )Actinosynnema mirum* api )Acyrthosiphon pisum )pea aphid** aag )Aedes aegypti )yellow fever mos,uito** aha )Aeromonas hydrophila* asa )Aeromonas salmonicida* ape )Aeropyrum pernix* aat )Aggregatibacter actinomycetemcomitans* aap )Aggregatibacter aphrophilus* ara )Agrobacterium radiobacter -.&* atc )Agrobacterium tumefaciens $". )$ereon**D atu )Agrobacterium tumefaciens $".* avi )Agrobacterium vitis S&* amu )A++ermansia muciniphila* abo )Alcanivorax bor+umensis* aac )Alicyclobacillus acidocaldarius* vsa )Aliivibrio salmonicida / 01'3.* aeh )Al+alilimnicola ehrlichei* amt )Al+aliphilus metalliredigens* aoe )Al+aliphilus oremlandii* amc )Alteromonas macleodii* adg )Ammonifex degensii* ana )Anabaena sp% ($$11'0* ava )Anabaena variabilis* apr )Anaerococcus prevotii* acp )Anaeromyxobacter dehalogenans '$(!1*D ade )Anaeromyxobacter dehalogenans '$(!$* afw )Anaeromyxobacter sp% w102!"* an+ )Anaeromyxobacter sp% -* acn )Anaplasma centrale* ama )Anaplasma marginale St% Maries*D amf )Anaplasma marginale lorida* aga )Anopheles gambiae )mos,uito** afl )Anoxybacillus flavithermus* ame )Apis mellifera )honey bee** aae )A,uifex aeolicus*

ath )Arabidopsis thaliana )thale cress** afu )Archaeoglobus fulgidus* abu )Arcobacter but3leri* eba )Aromatoleum aromaticum 4b51* aau )Arthrobacter aurescens* ach )Arthrobacter chlorophenolicus* art )Arthrobacter sp% 6'&* ago )Ashbya gossypii )4remothecium gossypii** afm )Aspergillus fumigatus* ani )Aspergillus nidulans* ang )Aspergillus niger* aor )Aspergillus ory3ae* apv )Atopobium parvulum* a3o )A3oarcus sp% 671'* a3c )A3orhi3obium caulinodans* avn )A3otobacter vinelandii* bbo )6abesia bovis* bay )6acillus amyloli,uefaciens* bah )6acillus anthracis $D$ :.&*D bai )6acillus anthracis A0'&.*D ban )6acillus anthracis Ames*D bar )6acillus a bca )6acillus cereus A#$$ 102.1*D bcb )6acillus cereus 6&':&*D bce )6acillus cereus A#$$ 1&"12*D bcg )6acillu bcl )6acillus clausii* bcy )6acillus cytotoxis 587 321!2.* bha )6acillus halodurans* bld )6acillus licheniformis DSM13*D bli )6acillus licheniformis A#$$ 1&".0* bpu )6acillus pumilus* bsu )6acillus subtilis* bt+ )6acillus thuringiensis 21!'1* bwe )6acillus weihenstephanensis* bfr )6acteroides fragilis <$7&:*D bfs )6acteroides fragilis 5$#$23&3* bth )6acteroides thetaiotaomicron* bvu )6acteroides vulgatus* bb+ )6artonella bacilliformis* bgr )6artonella grahamii* bhe )6artonella henselae* b,u )6artonella ,uintana* btr )6artonella tribocorum* bci )6aumannia cicadellinicola* bba )6dellovibrio bacteriovorus* bid )6ei9erinc+ia indica* bcv )6eutenbergia cavernae* bad )6ifidobacterium adolescentis* bla )6ifidobacterium animalis subsp% lactis AD011*D blc )6ifidobacterium animalis subsp% lactis 6l!0&*D blt )6ifido bl9 )6ifidobacterium longum DJ@10A*D bln )6ifidobacterium longum subsp% infantis A#$$ 1":21* bbl )6lattabacterium sp% )6lattella germanica** bav )6ordetella avium* bbr )6ordetella bronchiseptica* bpa )6ordetella parapertussis* bpe )6ordetella pertussis* bpt )6ordetella petrii* bbu )6orrelia burgdorferi 631*D bb3 )6orrelia burgdorferi AS1* bdu )6orrelia duttonii*

bga )6orrelia garinii* bhr )6orrelia hermsii* btu )6orrelia turicatae* bta )6os taurus )cow** bfa )6rachybacterium faecium* bhy )6rachyspira hyodysenteriae* b9a )6radyrhi3obium 9aponicum* bbt )6radyrhi3obium sp% 6#Ai1* bfo )6ranchiostoma floridae ) lorida lancelet** bbe )6revibacillus brevis* bmb )6rucella abortus 2!2&1*D bmc )6rucella abortus S12* bcs )6rucella canis* bme )6rucella melitensis 1:M*D bmf )6rucella melitensis biovar Abortus*D bmi )6rucella melitensis A#$$ '3&"1 bmr )6rucella microti* bov )6rucella ovis* bms )6rucella suis 1330*D bmt )6rucella suis A#$$ '3&&"* bmy )6rugia malayi )filaria** bab )6uchnera aphidicola 6p*D bap )6uchnera aphidicola "A*D bas )6uchnera aphidicola Sg*D bau )6uchnera aph bac )6ur+holderia ambifaria M$&0!:* bch )6ur+holderia cenocepacia 70'&'&*D bc9 )6ur+holderia cenocepacia J'31"*D bcm )6ur+holderia cenocepacia bam )6ur+holderia cepacia* bgl )6ur+holderia glumae* bma )6ur+holderia mallei A#$$ '33&&*D bml )6ur+holderia mallei 5$#$ 10''2*D bmn )6ur+holderia mallei 5$# bm9 )6ur+holderia multivorans A#$$ 11:1: )#oho+u**D bmu )6ur+holderia multivorans A#$$ 11:1: )J>0** bph )6ur+holderia phymatum* bpy )6ur+holderia phytofirmans* bpd )6ur+holderia pseudomallei ::.*D bpl )6ur+holderia pseudomallei 110:a*D bpm )6ur+holderia pseudomalle bur )6ur+holderia sp% 3.3* bte )6ur+holderia thailandensis* bvi )6ur+holderia vietnamiensis* bxe )6ur+holderia xenovorans* cbr )$aenorhabditis briggsae* cel )$aenorhabditis elegans )nematode** csc )$aldicellulosiruptor saccharolyticus* cma )$aldivirga ma,uilingensis* cco )$ampylobacter concisus 13.':* ccv )$ampylobacter curvus* cff )$ampylobacter fetus* cha )$ampylobacter hominis A#$$ 6AA!3.1* c9d )$ampylobacter 9e9uni subsp% doylei ':2%21*D c9e )$ampylobacter 9e9uni 5$#$111:.*D c99 )$ampylobacter 9e cla )$ampylobacter lari* cal )$andida albicans* cgr )$andida glabrata* aas )$andidatus Amoebophilus asiaticus* aps )$andidatus A3obacteroides pseudotrichonymphae* bfl )$andidatus 6lochmannia floridanus* dau )$andidatus Desulforudis audaxviator* hde )$andidatus 7amiltonella defensa* +cr )$andidatus -orarchaeum cryptofilum* las )$andidatus /iberibacter asiaticus* mbn )$andidatus Methanoregula boonei*

mpl )$andidatus Methanosphaerula palustris* pub )$andidatus (elagibacter ubi,ue* pal )$andidatus (hytoplasma australiense* pcu )$andidatus (rotochlamydia amoebophila* rma )$andidatus ;uthia magnifica* sms )$andidatus Sulcia muelleri SMDS4M* vo+ )$andidatus 8esicomyosocius o+utanii* cfa )$anis familiaris )dog** coc )$apnocytophaga ochracea* chy )$arboxydothermus hydrogenoformans* cai )$atenulispora acidiphila* ccs )$aulobacter crescentus 5A1000* ca+ )$aulobacter sp% -31* c9a )$ellvibrio 9aponicus* cpi )$hitinophaga pinensis* cmu )$hlamydia muridarum* cta )$hlamydia trachomatis AE7A;!13 )serovar A**D ctb )$hlamydia trachomatis &3&E6u*D ct9 )$hlamydia trach cre )$hlamydomonas reinhardtii* cca )$hlamydophila caviae* cfe )$hlamydophila felis* cpa )$hlamydophila pneumoniae A;32*D cp9 )$hlamydophila pneumoniae J13.*D cpn )$hlamydophila pneumon cpc )$hlorobaculum parvum 5$06 .3'1* cte )$hlorobaculum tepidum* cch )$hlorobium chlorochromatii* cli )$hlorobium limicola* cpb )$hlorobium phaeobacteroides 6S1*D cph )$hlorobium phaeobacteroides DSM '::* pvi )$hlorobium vibrioformis* cag )$hloroflexus aggregans* cau )$hloroflexus aurantiacus* chl )$hloroflexus sp% <!&00!fl* cts )$hloroherpeton thalassium* cvi )$hromobacterium violaceum* csa )$hromohalobacter salexigens* cin )$iona intestinalis )sea s,uirt** c+o )$itrobacter +oseri A#$$ 6AA!.2"* cmi )$lavibacter michiganensis subsp% michiganensis*D cms )$lavibacter michiganensis subsp% sepedonicus* cac )$lostridium acetobutylicum* cbe )$lostridium bei9erinc+ii* cbb )$lostridium botulinum 61 @+ra*D cbf )$lostridium botulinum /angeland*D cbh )$lostridium botulinum A 7 cce )$lostridium cellulolyticum* cdc )$lostridium difficile $D12:*D cdf )$lostridium difficile :30*D cdl )$lostridium difficile ;'0'21* c+l )$lostridium +luyveri DSM """*D c+r )$lostridium +luyveri 56;$ 1'01:* cno )$lostridium novyi* cpe )$lostridium perfringens 13*D cpf )$lostridium perfringens A#$$ 131'&*D cpr )$lostridium perfringens SM10 cpy )$lostridium phytofermentans* ctc )$lostridium tetani 4..* cth )$lostridium thermocellum* cps )$olwellia psychrerythraea* ctt )$omamonas testosteroni* cpo )$oprothermobacter proteolyticus* car )$orynebacterium aurimucosum*

cdi )$orynebacterium diphtheriae* cef )$orynebacterium efficiens* cgb )$orynebacterium glutamicum A#$$ 1303' )6ielefeld**D cgl )$orynebacterium glutamicum A#$$ 1303' )c9+ )$orynebacterium 9ei+eium* cur )$orynebacterium urealyticum* cbc )$oxiella burnetii $bu-FC1"&*D cbd )$oxiella burnetii Dugway "J10.!111*D cbg )$oxiella burnetii $bu>FC' ctu )$ronobacter turicensis* ccu )$ryptobacterium curtum* cne )$ryptococcus neoformans J4$'1* cho )$ryptosporidium hominis* cpv )$ryptosporidium parvum* cti )$upriavidus taiwanensis* cme )$yanidioschy3on merolae* cya )$yanobacteria <ellowstone A!(rime*D cyb )$yanobacteria <ellowstone 6!(rime* cyt )$yanothece sp% A#$$ "11&'* cyc )$yanothece sp% ($$ 1&'&* cyn )$yanothece sp% ($$ 1&'"* cyp )$yanothece sp% ($$ ..01* cyh )$yanothece sp% ($$ ..0'* chu )$ytophaga hutchinsonii* dre )Danio rerio )3ebrafish** dha )Debaryomyces hansenii* dar )Dechloromonas aromatica* det )Dehalococcoides ethenogenes* deb )Dehalococcoides sp% 6A81* deh )Dehalococcoides sp% $6D61* dev )Dehalococcoides sp% 8S* ddr )Deinococcus deserti* dge )Deinococcus geothermalis* dra )Deinococcus radiodurans* dac )Delftia acidovorans* dal )Desulfatibacillum al+enivorans* dhd )Desulfitobacterium hafniense D$6!'*D dsy )Desulfitobacterium hafniense <"1* dat )Desulfobacterium autotrophicum* dol )Desulfococcus oleovorans* drt )Desulfohalobium retbaense* dba )Desulfomicrobium baculatum* dps )Desulfotalea psychrophila* dae )Desulfotomaculum acetoxidans* drm )Desulfotomaculum reducens* dde )Desulfovibrio desulfuricans >'0*D dds )Desulfovibrio desulfuricans A#$$ '111&* dma )Desulfovibrio magneticus* dsa )Desulfovibrio salexigens* dvl )Desulfovibrio vulgaris D(&*D dvm )Desulfovibrio vulgaris Miya3a+i *D dvu )Desulfovibrio vulgaris 7ildenbor d+a )Desulfurococcus +amchat+ensis* dia )Diaphorobacter sp% #(S<* dno )Dichelobacter nodosus* d3e )Dic+eya 3eae* dth )Dictyoglomus thermophilum* dtu )Dictyoglomus turgidum* ddi )Dictyostelium discoideum )cellular slime mold**

dsh )Dinoroseobacter shibae* dan )Drosophila ananassae* der )Drosophila erecta* dgr )Drosophila grimshawi* dme )Drosophila melanogaster )fruit fly** dpe )Drosophila persimilis* dpo )Drosophila pseudoobscura pseudoobscura* dya )Drosophila ya+uba* dfe )Dyadobacter fermentans* eic )4dwardsiella ictaluri* etr )4dwardsiella tarda* ele )4ggerthella lenta* ecn )4hrlichia canis* ech )4hrlichia chaffeensis* erg )4hrlichia ruminantium >ardel*D eru )4hrlichia ruminantium ?elgevonden )South Africa**D erw )4hrlichia ru emi )4lusimicrobium minutum* ecu )4ncephalito3oon cuniculi* ehi )4ntamoeba histolytica* esa )4nterobacter sa+a3a+ii* ent )4nterobacter sp% :3.* efa )4nterococcus faecalis* ecb )4,uus caballus )horse** eca )4rwinia carotovora* eta )4rwinia tasmaniensis* eli )4rythrobacter litoralis* ebd )4scherichia coli 6/'1)D43**D ebl )4scherichia coli 6/'1*D ebr )4scherichia coli 6 ;4/:0:*D ebw )4scherichia efe )4scherichia fergusonii* ere )4ubacterium rectale* esi )4xiguobacterium sibiricum* eat )4xiguobacterium sp% A#1b* fno ) ervidobacterium nodosum* fsu ) ibrobacter succinogenes* fma ) inegoldia magna* fba ) lavobacteriaceae bacterium* f9o ) lavobacterium 9ohnsoniae* fps ) lavobacterium psychrophilum* ftn ) rancisella novicida =11'* fta ) rancisella tularensis subsp% holarctica #5 00'!00*D ftf ) rancisella tularensis subsp% tularensis S$ 12.*D fal ) ran+ia alni* fra ) ran+ia sp% $c03* fre ) ran+ia sp% 4A51pec* fgr ) usarium graminearum* fnu ) usobacterium nucleatum* gga )>allus gallus )chic+en** gau )>emmatimonas aurantiaca* g+a )>eobacillus +austophilus* gwc )>eobacillus sp% ?$710* gym )>eobacillus sp% <&1'M$10* gyc )>eobacillus sp% <&1'M$:1* gtn )>eobacillus thermodenitrificans* gbm )>eobacter bemid9iensis*

glo )>eobacter lovleyi* gme )>eobacter metallireducens* geo )>eobacter sp% ;$!3'* gem )>eobacter sp% M'1* gsu )>eobacter sulfurreducens* gur )>eobacter uraniumreducens* gla )>iardia lamblia* gvi )>loeobacter violaceus* gdi )>luconacetobacter dia3otrophicus (Al " )6ra3il**D gd9 )>luconacetobacter dia3otrophicus (Al " )J>0** gox )>luconobacter oxydans* gbr )>ordonia bronchialis* gfo )>ramella forsetii* gbe )>ranulobacter bethesdensis* hdu )7aemophilus ducreyi* hin )7aemophilus influen3ae ;d -?'0 )serotype d**D hip )7aemophilus influen3ae (itt44*D hi, )7aemophilus in hap )7aemophilus parasuis* hsm )7aemophilus somnus '33:*D hso )7aemophilus somnus 1'2(#* hch )7ahella che9uensis* hoh )7aliangium ochraceum* hma )7aloarcula marismortui* hsl )7alobacterium salinarum ;1* hal )7alobacterium sp% 5;$!1* hmu )7alomicrobium mu+ohataei* hwa )7alo,uadratum walsbyi* hut )7alorhabdus utahensis* hha )7alorhodospira halophila* hla )7alorubrum lacusprofundi* hor )7alothermothrix orenii* hna )7alothiobacillus neapolitanus* hac )7elicobacter acinonychis* hhe )7elicobacter hepaticus* hpa )7elicobacter pylori 7(A>1*D hpg )7elicobacter pylori >'1*D hp9 )7elicobacter pylori J22*D hpp )7elicobacte hmo )7eliobacterium modesticaldum* har )7erminiimonas arsenicoxydans* hau )7erpetosiphon aurantiacus* hba )7irschia baltica* hsa )7omo sapiens )human** hya )7ydrogenobaculum sp% <0&AAS1* hbu )7yperthermus butylicus* hne )7yphomonas neptunium* ilo )0diomarina loihiensis* iho )0gnicoccus hospitalis* 9an )Jannaschia sp% $$S1* 9de )Jonesia denitrificans* ++o )-angiella +oreensis* +ra )-ineococcus radiotolerans* +pe )-lebsiella pneumoniae 3&'*D +pn )-lebsiella pneumoniae*D +pu )-lebsiella pneumoniae 5#=7!-'0&&* +la )-luyveromyces lactis* +rh )-ocuria rhi3ophila* +ol )-osmotoga olearia* +se )-ytococcus sedentarius*

lbc )/accaria bicolor* lth )/achancea thermotolerans* lac )/actobacillus acidophilus* lbr )/actobacillus brevis* lca )/actobacillus casei A#$$ 33&*D lcb )/actobacillus casei 6/'3* lbu )/actobacillus delbruec+ii A#$$ 6AA!3:"*D ldb )/actobacillus delbruec+ii A#$$ 11.&'* lfe )/actobacillus fermentum* lga )/actobacillus gasseri* lhe )/actobacillus helveticus* l9f )/actobacillus 9ohnsonii 021."*D l9o )/actobacillus 9ohnsonii 5$$ "33* lp9 )/actobacillus plantarum JDM1*D lpl )/actobacillus plantarum ?$ S1* lrf )/actobacillus reuteri J$M 111'* lrh )/actobacillus rhamnosus*D lrl )/actobacillus rhamnosus /c 10"* lsa )/actobacillus sa+ei* lsl )/actobacillus salivarius* lla )/actococcus lactis subsp% lactis 0/1&03*D llm )/actococcus lactis subsp% cremoris M>13:3* lh+ )/aribacter hong+ongensis* lip )/awsonia intracellularis* lpc )/egionella pneumophila $orby*D lpf )/egionella pneumophila /ens*D lpn )/egionella pneumophila (hiladelph lxx )/eifsonia xyli xyli $#$601* lif )/eishmania infantum* lma )/eishmania ma9or* lbf )/eptospira biflexa serovar (atoc (atoc 1 )Ames** lb9 )/eptospira borgpetersenii J6121*D lbl )/eptospira borgpetersenii /""0* lic )/eptospira interrogans serovar $openhageni*D lil )/eptospira interrogans serovar lai* lch )/eptothrix cholodnii* lba )/eptotrichia buccalis* lci )/euconostoc citreum* lin )/isteria innocua* lmc )/isteria monocytogenes $lip.1&"2*D lmf )/isteria monocytogenes '3:"*D lmh )/isteria monocytogenes 7$ lwe )/isteria welshimeri S/$$"33&* lsp )/ysinibacillus sphaericus* mcc )Macaca mulatta )rhesus mon+ey** mcl )Macrococcus caseolyticus* mgr )Magnaporthe grisea* mgm )Magnetococcus sp% M$!1* mgl )Malasse3ia globosa* msu )Mannheimia succiniciproducens* mmr )Maricaulis maris* ma, )Marinobacter a,uaeolei* mmw )Marinomonas sp% M?</1* mlo )Mesorhi3obium loti* mes )Mesorhi3obium sp% 65$1* mth )Methanobacterium thermoautotrophicum* msi )Methanobrevibacter smithii A#$$ 3"0:1* mfe )Methanocaldococcus fervens* mvu )Methanocaldococcus vulcanius* mae )Methanococcus aeolicus* m9a )Methanococcus 9annaschii* mm, )Methanococcus maripaludis $"*D mmx )Methanococcus maripaludis $:*D mm3 )Methanococcus maripalud mvn )Methanococcus vannielii*

mla )Methanocorpusculum labreanum* mem )Methanoculleus marisnigri* m+a )Methanopyrus +andleri* mtp )Methanosaeta thermophila* mac )Methanosarcina acetivorans* mba )Methanosarcina bar+eri* mma )Methanosarcina ma3ei* mst )Methanosphaera stadtmanae* mhu )Methanospirillum hungatei* min )Methylacidiphilum infernorum* mpt )Methylibium petroleiphilum* mfa )Methylobacillus flagellatus* mch )Methylobacterium chloromethanicum* mea )Methylobacterium extor,uens AM1*D mex )Methylobacterium extor,uens* mno )Methylobacterium nodulans* mpo )Methylobacterium populi* mrd )Methylobacterium radiotolerans* met )Methylobacterium sp% &!&:* msl )Methylocella silvestris* mca )Methylococcus capsulatus* mmb )Methylotenera mobilis* mei )Methylovorus sp% S0(3!&* mlu )Micrococcus luteus* mar )Microcystis aeruginosa* mms )Minibacterium massiliensis* mdo )Monodelphis domestica )opossum** mbr )Monosiga brevicollis* mta )Moorella thermoacetica* mmu )Mus musculus )mouse** mab )Mycobacterium abscessus A#$$ 12211* mav )Mycobacterium avium 10&*D mpa )Mycobacterium avium paratuberculosis* mbb )Mycobacterium bovis 6$> (asteur 1113('*D mbo )Mycobacterium bovis A '1''E21*D mbt )Mycobacterium mgi )Mycobacterium gilvum* mlb )Mycobacterium leprae 6r&2'3*D mle )Mycobacterium leprae #5* mmi )Mycobacterium marinum M* msm )Mycobacterium smegmatis* m9l )Mycobacterium sp% J/S* m+m )Mycobacterium sp% -MS* mmc )Mycobacterium sp% M$S* mra )Mycobacterium tuberculosis 731;a*D mtb )Mycobacterium tuberculosis -A5 1&3"*D mtc )Mycobacterium t mul )Mycobacterium ulcerans* mva )Mycobacterium vanbaalenii* maa )Mycoplasma agalactiae* mcp )Mycoplasma capricolum* mco )Mycoplasma con9unctivae* mga )Mycoplasma gallisepticum* mge )Mycoplasma genitalium* mh9 )Mycoplasma hyopneumoniae J*D mhp )Mycoplasma hyopneumoniae 1&&.*D mhy )Mycoplasma hyopneumo mpe )Mycoplasma penetrans* mpn )Mycoplasma pneumoniae* mpu )Mycoplasma pulmonis*

msy )Mycoplasma synoviae* mxa )Myxococcus xanthus* ne, )5anoarchaeum e,uitans* nvi )5asonia vitripennis )9ewel wasp** nth )5atranaerobius thermophilus* nph )5atronomonas pharaonis* nam )5autilia profundicola* ng+ )5eisseria gonorrhoeae 5$$(112&"*D ngo )5eisseria gonorrhoeae A 1020* nma )5eisseria meningitidis A'&21 )serogroup A**D nmc )5eisseria meningitidis AM1. )serogroup $**D nme )5 nve )5ematostella vectensis )sea anemone** nri )5eoric+ettsia risticii* ncr )5eurospora crassa* nis )5itratiruptor sp% S61""!'* nha )5itrobacter hamburgensis* nwi )5itrobacter winograds+yi* noc )5itrosococcus oceani* neu )5itrosomonas europaea* net )5itrosomonas eutropha* nmr )5itrosopumilus maritimus* nmu )5itrosospira multiformis* nfa )5ocardia farcinica* nca )5ocardioides sp% JS:1&* npu )5ostoc punctiforme* nar )5ovosphingobium aromaticivorans* oih )@ceanobacillus iheyensis* oan )@chrobactrum anthropi* ooe )@enococcus oeni* oca )@ligotropha carboxidovorans* ote )@pitutus terrae* ots )@rientia tsutsugamushi 6oryong* oaa )@rnithorhynchus anatinus )platypus** osa )@ry3a sativa 9aponica )Japanese rice** olu )@streococcus lucimarinus* p9d )(aenibacillus sp% JD;!'* ptr )(an troglodytes )chimpan3ee** pdi )(arabacteroides distasonis* pde )(aracoccus denitrificans* ptm )(aramecium tetraurelia* pla )(arvibaculum lavamentivorans* pmu )(asteurella multocida* pct )(ectobacterium carotovorum* pwa )(ectobacterium wasabiae* ppe )(ediococcus pentosaceus* phe )(edobacter heparinus* pca )(elobacter carbinolicus* ppd )(elobacter propionicus* plt )(elodictyon luteolum* pph )(elodictyon phaeoclathratiforme* pth )(elotomaculum thermopropionicum* pmx )(ersephonella marina* pmo )(etrotoga mobilis*

pti )(haeodactylum tricornutum* p3u )(henylobacterium 3ucineum* ppr )(hotobacterium profundum* pay )(hotorhabdus asymbiotica* plu )(hotorhabdus luminescens* ppp )(hyscomitrella patens subsp% patens* ayw )(hytoplasma A<?6* ppa )(ichia pastoris* pic )(ichia stipitis* pto )(icrophilus torridus* pfa )(lasmodium falciparum 3D1* p+n )(lasmodium +nowlesi* pna )(olaromonas naphthalenivorans* pol )(olaromonas sp% JS:::* pne )(olynucleobacter necessarius* pop )(opulus trichocarpa )blac+ cottonwood** pgi )(orphyromonas gingivalis ?.3*D pgn )(orphyromonas gingivalis A#$$ 33'11* pma )(rochlorococcus marinus SS1'0*D pmb )(rochlorococcus marinus AS2:01*D pmc )(rochlorococcus marinu pac )(ropionibacterium acnes* paa )(rosthecochloris aestuarii* pmr )(roteus mirabilis* pat )(seudoalteromonas atlantica* pha )(seudoalteromonas haloplan+tis* pae )(seudomonas aeruginosa (A@1*D pag )(seudomonas aeruginosa /4S6".*D pap )(seudomonas aeruginosa pen )(seudomonas entomophila* pfl )(seudomonas fluorescens (f!"*D pfo )(seudomonas fluorescens (f0!1*D pfs )(seudomonas fluorescens S6? pmy )(seudomonas mendocina* ppf )(seudomonas putida 1*D ppg )(seudomonas putida >6!1*D ppu )(seudomonas putida -#'&&0*D ppw )(se psa )(seudomonas stut3eri* psb )(seudomonas syringae pv% syringae 61'.a*D psp )(seudomonas syringae pv% phaseolicola 1&&.A*D pst )(s par )(sychrobacter arcticum* pcr )(sychrobacter cryohalolentis* prw )(sychrobacter sp% (;wf!1* pai )(yrobaculum aerophilum* pas )(yrobaculum arsenaticum* pcl )(yrobaculum calidifontis* pis )(yrobaculum islandicum* pab )(yrococcus abyssi* pho )(yrococcus hori+oshii* reh );alstonia eutropha 71:*D reu );alstonia eutropha JM(13&* rme );alstonia metallidurans* rpf );alstonia pic+ettii 1'D*D rpi );alstonia pic+ettii 1'J* rso );alstonia solanacearum* rno );attus norvegicus )rat** rsa );enibacterium salmoninarum* rec );hi3obium etli $0A# :"'*D ret );hi3obium etli $ 5 &'* rle );hi3obium leguminosarum*D rlg );hi3obium leguminosarum bv% trifolii ?SM13'"*D rlt );hi3obium legumino rhi );hi3obium sp% 5>;'3&* rsh );hodobacter sphaeroides A#$$ 110'2*D rs+ );hodobacter sphaeroides -D131*D rsp );hodobacter sphaero rer );hodococcus erythropolis* rop );hodococcus opacus*

rha );hodococcus sp% ;7A1* rfr );hodoferax ferrireducens* rba );hodopirellula baltica* rpb );hodopseudomonas palustris 7aA'*D rpc );hodopseudomonas palustris 6is61.*D rpd );hodopseudomonas rru );hodospirillum rubrum* rmr );hodothermus marinus* raf );ic+ettsia africae* ra+ );ic+ettsia a+ari* rbe );ic+ettsia bellii ;M/3:2!$*D rbo );ic+ettsia bellii @S= ."!3.2* rcm );ic+ettsia canadensis* rco );ic+ettsia conorii* rfe );ic+ettsia felis* rp+ );ic+ettsia peacoc+ii* rpr );ic+ettsia prowa3e+ii* rri );ic+ettsia ric+ettsii Sheila Smith*D rr9 );ic+ettsia ric+ettsii 0owa* rty );ic+ettsia typhi* rbi );obiginitalea biformata* rca );oseiflexus castenhol3ii DSM132&1* rrs );oseiflexus sp% ;S!1* rde );oseobacter denitrificans* rxy );ubrobacter xylanophilus* svi )Saccharomonospora viridis* sce )Saccharomyces cerevisiae )budding yeast** sde )Saccharophagus degradans* sen )Saccharopolyspora erythraea* sru )Salinibacter ruber* sa, )Salinispora arenicola* stp )Salinispora tropica* sea )Salmonella enterica subsp% enterica serovar Agona*D sec )Salmonella enterica subsp% enterica serovar $ho stm )Salmonella typhimurium /#'* smm )Schistosoma mansoni* spo )Schi3osaccharomyces pombe )fission yeast** str )Sebaldella termitidis* spe )Serratia proteamaculans* sa3 )Shewanella ama3onensis* sbl )Shewanella baltica @S1""*D sbm )Shewanella baltica @S1."*D sbn )Shewanella baltica @S12"*D sbp )Shew sdn )Shewanella denitrificans* sfr )Shewanella frigidimarina* shl )Shewanella halifaxensis* slo )Shewanella loihica* son )Shewanella oneidensis* spl )Shewanella pealeana* swp )Shewanella pie3otolerans ?(3* spc )Shewanella putrefaciens* sse )Shewanella sediminis* shn )Shewanella sp% A5A!3* she )Shewanella sp% M;!&* shm )Shewanella sp% M;!1* shw )Shewanella sp% ?3!1.!1* swd )Shewanella woodyi A#$$ "120.* sbc )Shigella boydii $D$ 30.3!2&*D sbo )Shigella boydii Sb''1*

sdy )Shigella dysenteriae* sfl )Shigella flexneri 301 )serotype 'a**D sfv )Shigella flexneri .&01 )serotype "b**D sfx )Shigella flexneri '&"1# ssn )Shigella sonnei* sil )Silicibacter pomeroyi* sit )Silicibacter sp% #M10&0* smd )Sinorhi3obium medicae* sme )Sinorhi3obium meliloti* shi )Slac+ia heliotrinireducens* sgl )Sodalis glossinidius* sus )Solibacter usitatus* scl )Sorangium cellulosum* sbi )Sorghum bicolor )sorghum** sti )Sphaerobacter thermophilus* swi )Sphingomonas wittichii* sal )Sphingopyxis alas+ensis* sab )Staphylococcus aureus ; 1''*D sad )Staphylococcus aureus 4D2.*D sae )Staphylococcus aureus 5ewman* sca )Staphylococcus carnosus* sep )Staphylococcus epidermidis A#$$ 1'''.*D ser )Staphylococcus epidermidis ;(:'A* sha )Staphylococcus haemolyticus* ssp )Staphylococcus saprophyticus* smr )Staphylothermus marinus* sml )Stenotrophomonas maltophilia -'12a*D smt )Stenotrophomonas maltophilia ;""1!3* smf )Streptobacillus moniliformis* sag )Streptococcus agalactiae ':03 )serotype 8**D sa+ )Streptococcus agalactiae A202 )serotype 0a**D san )Str sds )Streptococcus dysgalactiae* se, )Streptococcus e,ui subsp% 3ooepidemicus 710*D seu )Streptococcus e,ui subsp% e,ui &0&1*D se3 )Streptoc sgo )Streptococcus gordonii* smu )Streptococcus mutans* s99 )Streptococcus pneumoniae JJA*D sne )Streptococcus pneumoniae A#$$ 100::2 )serotype '3 S#.1 lineage so3 )Streptococcus pyogenes 5A131 )serotype M&2**D spa )Streptococcus pyogenes M>AS1032& )serotype M: ssb )Streptococcus suis 6M&01*D ssi )Streptococcus suis (1E1*D sss )Streptococcus suis S$.&*D ssu )Streptococ stc )Streptococcus thermophilus $5;A10::*D ste )Streptococcus thermophilus /MD!2*D stl )Streptococcus therm sub )Streptococcus uberis* sma )Streptomyces avermitilis* sgr )Streptomyces griseus* sro )Streptosporangium roseum* sai )Sulfolobus acidocaldarius* sia )Sulfolobus islandicus M%1&%'"*D sid )Sulfolobus islandicus M%1:%&*D sim )Sulfolobus islandicus M%1:%'1*D sin sso )Sulfolobus solfataricus* sto )Sulfolobus to+odaii* saf )Sulfurihydrogenibium a3orense* sul )Sulfurihydrogenibium sp% <@3A@(1* tdn )Sulfurimonas denitrificans* sdl )Sulfurospirillum deleyianum* sun )Sulfurovum sp% 56$31!1* sth )Symbiobacterium thermophilum* syc )Synechococcus elongatus ($$:301*D syf )Synechococcus elongatus ($$12&'* syg )Synechococcus sp% $$2311* syd )Synechococcus sp% $$2:0"* sye )Synechococcus sp% $$220'* syp )Synechococcus sp% ($$100'*

syr )Synechococcus sp% ;$$301* syx )Synechococcus sp% ?71.03* syw )Synechococcus sp% ?7.10'* syn )Synechocystis sp% ($$:.03* sfu )Syntrophobacter fumaroxidans* swo )Syntrophomonas wolfei* sat )Syntrophus aciditrophicus* ttu )#eredinibacter turnerae* tps )#halassiosira pseudonana* tm3 )#hauera sp% MA1#* tan )#heileria annulata* tpv )#heileria parva* tpd )#hermoanaerobacter pseudethanolicus* tex )#hermoanaerobacter sp% B"1&* tte )#hermoanaerobacter tengcongensis* ttr )#hermobaculum terrenum* tfu )#hermobifida fusca* tga )#hermococcus gammatolerans* ton )#hermococcus onnurineus* tsi )#hermococcus sibiricus* tye )#hermodesulfovibrio yellowstonii* tpe )#hermofilum pendens* tro )#hermomicrobium roseum* tcu )#hermomonospora curvata* tac )#hermoplasma acidophilum* tvo )#hermoplasma volcanium* tne )#hermoproteus neutrophilus* taf )#hermosipho africanus* tme )#hermosipho melanesiensis* tel )#hermosynechococcus elongatus* tle )#hermotoga lettingae* tma )#hermotoga maritima* tna )#hermotoga neapolitana* tpt )#hermotoga petrophila* tr, )#hermotoga sp% ;C'* tth )#hermus thermophilus 76'1*D tt9 )#hermus thermophilus 76.* tgr )#hioal+alivibrio sp% 7/!4b>;1* tbd )#hiobacillus denitrificans* tcx )#hiomicrospira crunogena* tau )#olumonas auensis* tgo )#oxoplasma gondii* tde )#reponema denticola* tpp )#reponema pallidum subsp% pallidum SS1&* tca )#ribolium castaneum )red flour beetle** ter )#richodesmium erythraeum* tad )#richoplax adhaerens* twh )#ropheryma whipplei #wist*D tws )#ropheryma whipplei #?0.E'1* tbr )#rypanosoma brucei* tcr )#rypanosoma cru3i* rsd )=ncultured #ermite group 1 bacterium phylotype ;s!D11* rci )=ncultured methanogenic archaeon ;$!0*

upa )=reaplasma parvum serovar 3 A#$$ '1.1"*D uur )=reaplasma parvum serovar 3 A#$$ 100210* uue )=reaplasma urealyticum serovar 10 A#$$ 33:22* uma )=stilago maydis* vpo )8anderwalto3yma polyspora* vap )8ariovorax paradoxus* vpr )8eillonella parvula* vei )8erminephrobacter eiseniae* vch )8ibrio cholerae @1*D vc9 )8ibrio cholerae MJ!1'3:*D vcm )8ibrio cholerae M::!'*D vco )8ibrio cholerae @32 vfi )8ibrio fischeri*D vfm )8ibrio fischeri MJ11* vha )8ibrio harveyi* vpa )8ibrio parahaemolyticus* vex )8ibrio sp% 4x'"* vsp )8ibrio splendidus* vvu )8ibrio vulnificus $M$(:*D vvy )8ibrio vulnificus <J01:* vvi )8itis vinifera )wine grape** wbr )?igglesworthia glossinidia* wbm )?olbachia pipientis w6m*D wol )?olbachia pipientis wMel*D wpi )?olbachia pipientis*D wri )?olbachia pip wsu )?olinella succinogenes* xau )Banthobacter autotrophicus* xac )Banthomonas axonopodis* xca )Banthomonas campestris pv% campestris 6100*D xcb )Banthomonas campestris pv% campestris .00&*D xcc xom )Banthomonas ory3ae MA 31101.*D xoo )Banthomonas ory3ae -A$$10331*D xop )Banthomonas ory3ae xce )Bylanimonas cellulosilytica* xfa )Bylella fastidiosa 2a"c*D xfm )Bylella fastidiosa M1'*D xfn )Bylella fastidiosa M'3* xft )Bylella fastidiosa #emecula1* yli )<arrowia lipolytica* yen )<ersinia enterocolitica* ypa )<ersinia pestis Anti,ua )biovar Anti,ua**D ypg )<ersinia pestis Angola )biovar Anti,ua**D yp+ )<ersinia pes ypb )<ersinia pseudotuberculosis (61EG*D ypi )<ersinia pseudotuberculosis 0(311".*D yps )<ersinia pseudotube 3ma )Aea mays )mai3e** 3ro )Aygosaccharomyces rouxii* 3mn )Aymomonas mobilis subsp% mobilis 5$0M6 111:3*D 3mo )Aymomonas mobilis*

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