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Although UK stands out as the country which carries a greater disease burden related To asthma than any other
country analyzed, prevalence of asthma is estimated to be Increasing in the other major markets, as there is less
difference between pediatric prevalence rates for asthma between the UK & some of the other major markets
 Sales
Generic Name Brands Companies Indications 2006 2007 2008
Fluticasone
Salmetrol Advair GSK Asthma 6.13 7 7.5
Montelukast Singulair Merck Asthma 3.56 4.3 4.3
Boehringer
Tiotropium Spriva Ingelheim, Pfizer COPD 1.74 2.5 1.9
Budesonide +
Formoterol Symbicort AstraZeneca Asthma 1.2 1.5 1.5
Budesonide Pulmicort AstraZeneca Asthma 1.3 1.4 1.2
Schering-Plough
Mometasone Nasonex Sanofi Aventis Allergic rhinitis 0.94 1.1 1.3
Fluticasone Flovent, Flixotide GSK Asthma 1.22 1.25 1.2
Fexofenadine Allegra, Telfas Sanofi-Aventis Allergic rhinitis 0.86 0.99 1.1
Pfizer,UCB, Daiichi
Cetrizine Zyrtec Sankyo Allergic rhinitis 2.4 2.2 1.9
 Molecule Company Indication Phase Revision date

Omalizumab Genentech Allergic asthma Launched (AU, June 2009

BR, CA, EU
unioin, NZ, CH
USA)
Anti-IgE allergy United Biomedical Allergy/ Asthma Preclinical Jan 2007
vaccine (USA)
Anti -C5 Mab therapy Alexion Allergic asthma Preclinical Jan 2007
Pharmaceuticals
(USA)
Ragweed Allergy Vaccine
Pollinex /Quattro (Allergy Allergy Therapeutics Allergic rhinitis Pre-registration Mar 2009
Vaccine) Licensee:
Allerpharma
Ragweed allergy Greer Laboratories Seasonal allergic rhinitis Phase III June 2008
vaccine sublingual (USA)
Ragweed Allergy Circassia (UK) Seasonal Allergic Rhinitis Phase II May 2009
Vaccine
Ragweed allergy ALK-Abello(DK) / Seasonal allergic rhinitis Phase II Nov 2008
vaccine tablet Schering Plough
Microencapsulated Curalogic (DK) Allergy Discontinued III Dec 2007
ragweed pollen
extract
 Molecule Company Indication Phase Revision date

House dust mite allergy vaccine tablet

Oralair Mites (House dust mite Stallergens SA (FR)/ Perennial allergic Phase II April 2009
allergy vaccine tablet ) Paladin Labs; Solvay rhinitis
Pharmaceuticals
ALK Mite tablet ALK-Abello(DK) / Allergic asthma/ Phase II Mar 2008
(House dust mite allergy Schering Plough Allergic rhinitis
vaccine tablet )
House dust mite allergy vaccine Greer Laboratories Allergic rhinitis Phase I Mar 2009

Allergy vaccine subcutaneous Allergy Therapeutics Allergy Preclinical Feb 2007

Anti allergy vaccine tablet ALK-Abello (DK) Allergic Preclinical Jan 2007
asthma/rhinitis
Phylogica (House dust mite Phylogica (AU) Allergy Preclinical Sep 2005
allergy vaccine )
Dust mite allergy vaccine National University of Allergic asthma Preclinical Aug 2004
Singapore
Allergy vaccine University of Edinburgh (UK) Allergy Discontinued Mar 2007
Preclinical
House dust mite allergy vaccine Novozymes Allergy Discontinued Nov 2005
Preclinical
 Molecule Company Indication Phase Revision date

Others
Grazax (Grass pollen ALK-Abello (DK) Seasonal allergic rhinitis Launched Mar 2009
allergy vaccine tablet) (DK, DE, NO, SE,
UK)
Oralgen grasspollen Fornix Biosciences Seasonal allergic rhinitis Pre-registration Jan 2009
(Grass pollen allergy (NL)
vaccine)
Wasp venom allergy Allergopharma (DE) Allergy Phase III April 2009
vaccine
Bee venom allergy Allergopharma (DE) Allergy Phase III Mar 2003
vaccine
MAP3K9 kinase DeCODE genetics Asthma Phase II May 2006
inhibitors (Iceland)
MEM 1414 Memory Allergic asthma Phase II 2009
Pharmaceuticals
Mometasone/ Schering Plough/ Allergic asthma Phase II 2009
formoterol Novartis
Sublingual allergy Allergy Therapeutics Allergy Phase I Feb 2007
vaccine (UK)
Cat allergy vaccine Greer Laboratories Perennial allergic rhinitis Phase I Dec 2005
sublingual (USA)
 Molecule Company Indication Phase Revision date

Others
HAE 1 Genentech Allergic asthma Phase I 2009
QAX 935 Idera Pharmaceuticals Allergic asthma Phase I 2009
R 343 Rigel Pharmaceuticals Allergic asthma Phase I 2009
Allergy vaccine VLP Biotech (USA) Allergy Preclinical Dec 2004
(E)-2-(3-(3-(3- Actelion Pharmaceuticals Allergy Preclinical Sep 2008
Bromophenylamino)- (CH)
2-cyano-3-oxoprop-1-
enyl)-1H-indol-1-
yl)acetic acid
AFM 19 Affirmed Therapeutics Allergy/ Asthma Preclinical July 2005
(DE)
Asthma therapy Schering Plough ; Oscient Asthma Preclinical Oct 2007
Pharmaceuticals
NX 401 Novavax (USA) Allergy Preclinical July 2005
Allergy/Asthma Rigshospitalet; Santaris Allery /Asthma Preclinical July 2003
therapy (DK)
 Molecule Company Indication Phase Revision date

Others
1217B Medigreen Biotechnology Asthma Preclinical Aug 2007
Corp(CN)

PYM 60001 Phytopharm (England) Asthma Preclinical July 2007

PRS 060 Pieris (DE) Asthma Preclinical July 2007

SRP312 SR Pharma (England) Asthma Preclinical May 2007

Tryptase inhibitirs Selecore (DE) Asthma Preclinical Sep 2005

TARG-ALLERG 1- Targepeutics Allergic asthma Preclinical Sep 2005
200
Asthma therapy Celestar Lexico Sciences Asthma Preclinical May 2005
(JP)
ME-108 Pharmexa (DK) Allergy Discontinued Mar 2007
Preclinical
Food Allergy DNA Unknown Food allergy No development Apr 2002
Vaccine reported

Allergy vaccine University of Brimingham Food allergy Discontinued II July 1999

/ GSK Acambis

Asthma/Allergy therapy Boehringer Ingelheim; Allergy Discontinued Mar 2008

J&J Preclinical
 Molecule Company Indication Phase Revision
date
Other
Allergy therapy Kyorin Pharmaceuticals Allergy Discontinued Preclinical Dec 2007
(JP); Infinity
Pharmaceuticals (USA)
Allergy therapy Katolinska Institute (SE) Allergy Discontinued Preclinical Aug 2007
; Maxygen (USA)
Maxy 320 Maxygen /ALK-Abello Allergic asthma Discontinued Preclinical Jan 2007

Allergy therapy & Diagnostics ImmavaRx (USA) Allergy No development reported Feb 2006

Asthma/Allergy therapy Amgen Allergy/asthma No development reported Aug 2001

E-CpG ODN CJ Corporation (SK) Allergic asthma Discontinued Preclinical Aug 2007

Asthma therapy Sirna Therapeutics Asthma Discontinued Preclinical Dec 2006

(USA)
Asthma therapy OSI Pharmaceuticals Asthma No development reported June 2006

PLIVA ; PLR 8 PLIVA (Croatia) Asthma Discontinued Preclinical May 2006

Stress Protein allergy therapy Nventa Allergy/Asthma Discontinued Preclinical Oct 2002
Biopharmaceuticals
(USA)
VMR 001 Vernalis Group (UK) Asthma Discontinued Preclinical May 2001
 Molecule Company Indication Phase Revision date

Allergic Rhinitis
Allergy Vaccine Allergy Therapeutics Allergic rhinitis Phase III 2009
CP 118 Collegium Pharmaceuticals Allergic rhinitis Phase II 2009

Microencapsulated cat Curalogic Allergy Phase II 2009

hair extract
Z-207 Zeria Allergic rhinitis Phase I Aug 2008
AVP 13358 Avanair Pharmaceuticals Allergic rhinitis / Phase I 2009
asthma
GSK 1004723 Boehringer Ingelheim Allergic rhinitis Phase I 2009
Sodium cromoglicate Emisphere Allergy Phase I 2009
oral
ALR 8 Topigen Pharmaceuticals Allergic rhinitis Preclinical Dec 2005

Allergic conjunctivitis
Alcaftadine Vistakon Pharmaceuticals Allergic conjunctivitis Phase III 2009

Betotastine Ube Industries Allergic conjunctivitis Pre-registration 2009

K 123 Kowa Allergic conjunctivitis Phase II 2009

Prednisolone/ Fovea Pharmaceuticals Allergic conjunctivitis Phase II 2009

ciclosporin