Linear Map of Sequence:

EcoRI \ gaattctttctttcacaccttttccatgatttataacatatttattattaactatattta cttaagaaagaaagtgtggaaaaggtactaaatattgtataaataataattgatataaat ^ * ^ * ^ * ^ * ^ * ^ * ttaacagctattaaccttccttatgacttgtcaatagttgttatacacatatttatgtat aattgtcgataattggaaggaatactgaacagttatcaacaatatgtgtataaatacata ^ * ^ * ^ * ^ * ^ * ^ * gaaccactggtttgatatcattgaataaggtaaatattttattaaatatataaaatatgc cttggtgaccaaactatagtaacttattccatttataaaataatttatatattttatacg ^ * ^ * ^ * ^ * ^ * ^ * tttttttgttgttttctttttaagacaggattttctgtgtagccctggctgtcctgaaac aaaaaaacaacaaaagaaaaattctgtcctaaaagacacatcgggaccgacaggactttg ^ * ^ * ^ * ^ * ^ * ^ * tcactctgtagaccaggctggcctcaaacgtagacatccacatcaaaagcatgcgacatc agtgagacatctggtccgaccggagtttgcatctgtaggtgtagttttcgtacgctgtag ^ * ^ * ^ * ^ * ^ * ^ * accacctggctgagagtatgcttttatggtttttcattttaggaaattgtttatcttata tggtggaccgactctcatacgaaaataccaaaaagtaaaatcctttaacaaatagaatat ^ * ^ * ^ * ^ * ^ * ^ * EcoRI \ tatttggaattcttcattttccctgtaagttttaaacccctatgtaacaaatctttcttc ataaaccttaagaagtaaaagggacattcaaaatttggggatacattgtttagaaagaag ^ * ^ * ^ * ^ * ^ * ^ * ccaatgttctttttatttccagacaccgagttttgtcacaaactaagagaaaggcaataa ggttacaagaaaaataaaggtctgtggctcaaaacagtgtttgattctctttccgttatt ^ * ^ * ^ * ^ * ^ * ^ * cttttcaatactcccagcttttctggggaacatttaagtgggtgtgttttgtttgtttgt gaaaagttatgagggtcgaaaagaccccttgtaaattcacccacacaaaacaaacaaaca ^ * ^ * ^ * ^ * ^ * ^ * ttggttggttggtttggttaattttattttgtactagtagcttgttttaatcagcatgga aaccaaccaaccaaaccaattaaaataaaacatgatcatcgaacaaaattagtcgtacct ^ * ^ * ^ * ^ * ^ * ^ * tatgagcaatatttcctggcatagctaatctccctacactttactttcttttctataaaa atactcgttataaaggaccgtatcgattagagggatgtgaaatgaaagaaaagatatttt ^ * ^ * ^ * ^ * ^ * ^ * gaaaacgtactgggtaccttacagggttagttcaagaatgaaatgattagcatatgtaca cttttgcatgacccatggaatgtcccaatcaagttcttactttactaatcgtatacatgt ^ * ^ * ^ * ^ * ^ * ^ * aaggctcagagaatcacccaaaccatagcatgtagaaagatacctgtccactttcttcct ttccgagtctcttagtgggtttggtatcgtacatctttctatggacaggtgaaagaagga ^ * ^ * ^ * ^ * ^ * ^ * ggagaacccacagtatcacggaaggaagccagataggaggaggaggaatctaagtttaaa cctcttgggtgtcatagtgccttccttcggtctatcctcctcctccttagattcaaattt ^ * ^ * ^ * ^ * ^ * ^ * ttcaaagtaatagatggaaaatctaaaatagtatgctaccaccacagagctgaagaatga aagtttcattatctaccttttagattttatcatacgatggtggtgtctcgacttcttact ^ * ^ * ^ * ^ * ^ * ^ * attatttttggcagcactagaccaaagaagtgtgactttcgtgattatttttaaaatttg

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taataaaaaccgtcgtgatctggtttcttcacactgaaagcactaataaaaattttaaac ^ * ^ * ^ * ^ * ^ * ^ * HindIII \ atttggagacaattgcaagcttcgagatatgttgcttagaacaaaagacacagattaaca taaacctctgttaacgttcgaagctctatacaacgaatcttgttttctgtgtctaattgt ^ * ^ * ^ * ^ * ^ * ^ * tctgtgttgctgtctgtcccaccagcttagtgactttctctttgtctattctccctgctg agacacaacgacagacagggtggtcgaatcactgaaagagaaacagataagagggacgac ^ * ^ * ^ * ^ * ^ * ^ * tctttcgcttgtgtttacagacattgacaatcttttctgagctattacaacttgtgcata agaaagcgaacacaaatgtctgtaactgttagaaaagactcgataatgttgaacacgtat ^ * ^ * ^ * ^ * ^ * ^ * ccctatcaacgcaccctgtatattttactgtgtcctcctaagaaaagcaagtcatttcct gggatagttgcgtgggacatataaaatgacacaggaggattcttttcgttcagtaaagga ^ * ^ * ^ * ^ * ^ * ^ * taagtaaccaattattaacttcagaacctaaaacattgctacttttatccaatctatcac attcattggttaataattgaagtcttggattttgtaacgatgaaaataggttagatagtg ^ * ^ * ^ * ^ * ^ * ^ * BamHI \ tcacatagcattttttttccacttgctcagataatttcccctttaaggatccaacatgag agtgtatcgtaaaaaaaaggtgaacgagtctattaaaggggaaattcctaggttgtactc ^ * ^ * ^ * ^ * ^ * ^ * atcacatactgccttcagttgagaaatacaattccttttcagatatttcagaattgttcc tagtgtatgacggaagtcaactctttatgttaaggaaaagtctataaagtcttaacaagg ^ * ^ * ^ * ^ * ^ * ^ * atggaaattcttttacatctccatctatctaacccatctgttggtatctgatagttgacc tacctttaagaaaatgtagaggtagatagattgggtagacaaccatagactatcaactgg ^ * ^ * ^ * ^ * ^ * ^ * ttaactccaatagagagctagtgtgtgtgtgtgtgtctgtgttatacagatgtgcttggt aattgaggttatctctcgatcacacacacacacacagacacaatatgtctacacgaacca ^ * ^ * ^ * ^ * ^ * ^ * accaaaaccatcctgtccttctgcaggtcacttagaaacatggactagcaccatggatgt tggttttggtaggacaggaagacgtccagtgaatctttgtacctgatcgtggtacctaca ^ * ^ * ^ * ^ * ^ * ^ * gtaagagcttctaggagcagccaggatgcaccgccttaaagccacagctgtcaccggcag cattctcgaagatcctcgtcggtcctacgtggcggaatttcggtgtcgacagtggccgtc ^ * ^ * ^ * ^ * ^ * ^ * cacacgctttgtctgcagttagctcttgatgtgacctgcattgactctcaagtttcgcca gtgtgcgaaacagacgtcaatcgagaactacactggacgtaactgagagttcaaagcggt ^ * ^ * ^ * ^ * ^ * ^ * ctgagctgtcttcttttagaagcatatcttccagtttgacaaacggaagaagtgtgtctg gactcgacagaagaaaatcttcgtatagaaggtcaaactgtttgccttcttcacacagac ^ * ^ * ^ * ^ * ^ * ^ * tctatcctatgctatttcattctatgcctggagactgctggagcatccagagggggttca agataggatacgataaagtaagatacggacctctgacgacctcgtaggtctcccccaagt ^ * ^ * ^ * ^ * ^ * ^ * ctatttctaggtgtgaccagacaatctggctttgatacacattttagcaaatgtatatca gataaagatccacactggtctgttagaccgaaactatgtgtaaaatcgtttacatatagt ^ * ^ * ^ * ^ * ^ * ^ * ttaaatattgcatataattctagagaaggaggccgttttccaaagttttaatcccaaatc

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aatttataacgtatattaagatctcttcctccggcaaaaggtttcaaaattagggtttag ^ * ^ * ^ * ^ * ^ * ^ * 1921 aaatcaatgtctcattagcatacttccaaaatagagaaaatgtaaactcattccatttca tttagttacagagtaatcgtatgaaggttttatctcttttacatttgagtaaggtaaagt ^ * ^ * ^ * ^ * ^ * ^ * ataaagtttgaaaagagaaatggatgctggctctctctgggtagaacatgatgaccagta tatttcaaacttttctctttacctacgaccgagagagacccatcttgtactactggtcat ^ * ^ * ^ * ^ * ^ * ^ * gggaaagagaatgggctgctcttttccagtgccaacaaggcacatggcttaaccagtgag ccctttctcttacccgacgagaaaaggtcacggttgttccgtgtaccgaattggtcactc ^ * ^ * ^ * ^ * ^ * ^ * caaaacaacttggtcaggtgaatgtcagaacacatcataccatctccccattcctaaaga gttttgttgaaccagtccacttacagtcttgtgtagtatggtagaggggtaaggatttct ^ * ^ * ^ * ^ * ^ * ^ * ctgggacagccatctccttgcatgagggtcttaagggagtttgttgacctcttttgaaaa gaccctgtcggtagaggaacgtactcccagaattccctcaaacaactggagaaaactttt ^ * ^ * ^ * ^ * ^ * ^ * tagtgaggtactcccatgtggggtcatggctggggaggtcactgtgggcctttccacaag atcactccatgagggtacaccccagtaccgacccctccagtgacacccggaaaggtgttc ^ * ^ * ^ * ^ * ^ * ^ * gggcttaatcacagttgtacttgaagttcaccaggacacttgggaagctaggatagaggc cccgaattagtgtcaacatgaacttcaagtggtcctgtgaacccttcgatcctatctccg ^ * ^ * ^ * ^ * ^ * ^ * 1980

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agaggggaacatctgtggcctgtagccctcaccatgctccagccactgaggactttgccg tctccccttgtagacaccggacatcgggagtggtacgaggtcggtgactcctgaaacggc ^ * ^ * ^ * ^ * ^ * ^ * actctgcttctgtgcagcctcacttcctgctgtctacccttccaccatctgtacatgccc tgagacgaagacacgtcggagtgaaggacgacagatgggaaggtggtagacatgtacggg ^ * ^ * ^ * ^ * ^ * ^ * gggaagggatgaagtgatgcctgaggattttcatgtgcctgcattgctaactctagccgg cccttccctacttcactacggactcctaaaagtacacggacgtaacgattgagatcggcc ^ * ^ * ^ * ^ * ^ * ^ * gtgtcctcatgggcatgactccactacctaaaatatgcacaggatgggatgacagcagat cacaggagtacccgtactgaggtgatggattttatacgtgtcctaccctactgtcgtcta ^ * ^ * ^ * ^ * ^ * ^ * aatccaaggctggaccatcctccatgcctgcaataggcaagcacatggaggaaaacaaag ttaggttccgacctggtaggaggtacggacgttatccgttcgtgtacctccttttgtttc ^ * ^ * ^ * ^ * ^ * ^ * aggaaagttcttatagctgtcaccctggctcagggaaaccaacagtttggtgagggaaaa tcctttcaagaatatcgacagtgggaccgagtccctttggttgtcaaaccactccctttt ^ * ^ * ^ * ^ * ^ * ^ * cacagacaagtctgagcactggttttaagaacaaaaggtaatcctggaagaagagtggta gtgtctgttcagactcgtgaccaaaattcttgttttccattaggaccttcttctcaccat ^ * ^ * ^ * ^ * ^ * ^ * acaggaagaatggctgtcttctcctaaccagtgtgagatctattcattttagaccaagaa tgtccttcttaccgacagaagaggattggtcacactctagataagtaaaatctggttctt ^ * ^ * ^ * ^ * ^ * ^ * gaaatgtttcaccttatcatcatcacatatatatatgcatatcgcattatatattatatg ctttacaaagtggaatagtagtagtgtatatatatacgtatagcgtaatatataatatac ^ * ^ * ^ * ^ * ^ * ^ *

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tatatgctatatagatcatatatacttatatttatatattatagatatatgcttttaacc atatacgatatatctagtatatatgaatataaatatataatatctatatacgaaaattgg ^ * ^ * ^ * ^ * ^ * ^ * EcoRI \ attaacttaaacatcacacatttaaaattcactttactgctttcatctgctgaattcata taattgaatttgtagtgtgtaaattttaagtgaaatgacgaaagtagacgacttaagtat ^ * ^ * ^ * ^ * ^ * ^ * atataaatatatataatagaaaatttaaaaattttaaaatcaaaaggaagaaataaaacg tatatttatatatattatcttttaaatttttaaaattttagttttccttctttattttgc ^ * ^ * ^ * ^ * ^ * ^ * aaggcctctatataaacttacctaccattcactgatgaccagggttgacattttagtcta ttccggagatatatttgaatggatggtaagtgactactggtcccaactgtaaaatcagat ^ * ^ * ^ * ^ * ^ * ^ * tacacaggtctaatctttttatcttaaacatgtgcaagtttcaaaacatcaaacccccat atgtgtccagattagaaaaatagaatttgtacacgttcaaagttttgtagtttgggggta ^ * ^ * ^ * ^ * ^ * ^ * actacaggtaaagacatgcaactgtctttcatttagagaaatttgtttatttttctgctg tgatgtccatttctgtacgttgacagaaagtaaatctctttaaacaaataaaaagacgac ^ * ^ * ^ * ^ * ^ * ^ * ctgcctcttggtgcctgagtgcggctctggaactcgtgtaattctcatgagctcccacaa gacggagaaccacggactcacgccgagaccttgagcacattaagagtactcgagggtgtt ^ * ^ * ^ * ^ * ^ * ^ * acggaggcgccaccctccactcagcagtttctataggcaaacactgcaaaacgctgcgta tgcctccgcggtgggaggtgagtcgtcaaagatatccgtttgtgacgttttgcgacgcat ^ * ^ * ^ * ^ * ^ * ^ * cataatgcatttctagagcgctgcatagggtgagaagcgcgccctttgtctccaaggtca gtattacgtaaagatctcgcgacgtatcccactcttcgcgcgggaaacagaggttccagt ^ * ^ * ^ * ^ * ^ * ^ * EcoRI \ taatggctctgctgacttgaattcctttcactgagctagtaaggacaactcgaaaatgcc attaccgagacgactgaacttaaggaaagtgactcgatcattcctgttgagcttttacgg ^ * ^ * ^ * ^ * ^ * ^ * agagagaatgagagccccctaccccatgatcccaaatgaaaaagcgagagaacacagaaa tctctcttactctcgggggatggggtactagggtttactttttcgctctcttgtgtcttt ^ * ^ * ^ * ^ * ^ * ^ * tccccttacacattaccccccaggccccttttgtgttgttcttgccaacacagcagccat aggggaatgtgtaatggggggtccggggaaaacacaacaagaacggttgtgtcgtcggta ^ * ^ * ^ * ^ * ^ * ^ * cctgctgtatatatatcagctgccactcctgtccccatcacactcaacactgaccatttg ggacgacatatatatagtcgacggtgaggacaggggtagtgtgagttgtgactggtaaac ^ * ^ * ^ * ^ * ^ * ^ * ctgtcaacaacgatgggaaaggtgagccaagggcgaaccctccaggtctgttgagtgccc gacagttgttgctaccctttccactcggttcccgcttgggaggtccagacaactcacggg ^ * ^ * ^ * ^ * ^ * ^ * cctctgtgtgggggatgcggcttccggttaaccatgtgttgttaccccttctcctttaca ggagacacaccccctacgccgaaggccaattggtacacaacaatggggaagaggaaatgt ^ * ^ * ^ * ^ * ^ * ^ * gatcaccttctacgaggaccgaggcttccagggccgctgctatgagtgcagcagcgactg ctagtggaagatgctcctggctccgaaggtcccggcgacgatactcacgtcgtcgctgac

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ccccaacctgcagacctacttcagccgctgcaactccatccgcgtggacagtggctgctg ggggttggacgtctggatgaagtcggcgacgttgaggtaggcgcacctgtcaccgacgac ^ * ^ * ^ * ^ * ^ * ^ * gatgctctatgagcgacccaactaccagggctaccagtacttcctgcgacgcggggacta ctacgagatactcgctgggttgatggtcccgatggtcatgaaggacgctgcgcccctgat ^ * ^ * ^ * ^ * ^ * ^ * ccctgactaccagcagtggatgggtttcagcgactccattcgctcctgccgttccattcc gggactgatggtcgtcacctacccaaagtcgctgaggtaagcgaggacggcaaggtaagg ^ * ^ * ^ * ^ * ^ * ^ * ctatgtgagtattgctgcagccgtgctgatgtgagaacactggtcttccttttggccagt gatacactcataacgacgtcggcacgactacactcttgtgaccagaaggaaaaccggtca ^ * ^ * ^ * ^ * ^ * ^ * ttgttcccatttctgttctaatgttctcagcaaagataggaatgcttgacaaatgctcac aacaagggtaaagacaagattacaagagtcgtttctatccttacgaactgtttacgagtg ^ * ^ * ^ * ^ * ^ * ^ * actaaaaccaaggcccgactcttacagctaaatagaacgaacatgtatacacacccgaac tgattttggttccgggctgagaatgtcgatttatcttgcttgtacatatgtgtgggcttg ^ * ^ * ^ * ^ * ^ * ^ * agcagtataagcaatatatagtttcttacttaagggcatgagtgttttgagacataagaa tcgtcatattcgttatatatcaaagaatgaattcccgtactcacaaaactctgtattctt ^ * ^ * ^ * ^ * ^ * ^ * acaacaacaggacctttaaaactaaactcggctgaataagcacatacccttcagccataa tgttgttgtcctggaaattttgatttgagccgacttattcgtgtatgggaagtcggtatt ^ * ^ * ^ * ^ * ^ * ^ * aagaaggaaatcctgtcatttgtggtgacatggatgaacctggaggtcactgtgctaaaa ttcttcctttaggacagtaaacaccactgtacctacttggacctccagtgacacgatttt ^ * ^ * ^ * ^ * ^ * ^ * ggaaggagcaaggtacgtaatgataaaggccacaagttctcgttcgtatgtgggatctac ccttcctcgttccatgcattactatttccggtgttcaagagcaagcatacaccctagatg ^ * ^ * ^ * ^ * ^ * ^ * agcagcaggttcatggaggggtgaagatcgggttggggatttacctcagcggtagtgtgc tcgtcgtccaagtacctccccacttctagcccaacccctaaatggagtcgccatcacacg ^ * ^ * ^ * ^ * ^ * ^ * EcoRI \ ctgtgtagcaagcacgcagccctgaattctgttctgagggtaaaaatgagagagagaggg gacacatcgttcgtgcgtcgggacttaagacaagactcccatttttactctctctctccc ^ * ^ * ^ * ^ * ^ * ^ * gggggggagggagagggagagggagagggagagggagagggagagggagagggagagaga ccccccctccctctccctctccctctccctctccctctccctctccctctccctctctct ^ * ^ * ^ * ^ * ^ * ^ * gagagagagagagagagagagaaagagagagagagagatactagaggctagagtggcaaa ctctctctctctctctctctctttctctctctctctctatgatctccgatctcaccgttt ^ * ^ * ^ * ^ * ^ * ^ * gtcaggaaccagaggtttggaatgacagtcagaaaaagaaaaattacagctagagagaac cagtccttggtctccaaaccttactgtcagtctttttctttttaatgtcgatctctcttg ^ * ^ * ^ * ^ * ^ * ^ * tgtgttctagaaatccgttgtgaagcatggcaatgacagttcatgttatctactagttat acacaagatctttaggcaacacttcgtaccgttactgtcaagtacaatagatgatcaata ^ * ^ * ^ * ^ * ^ * ^ *

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taaaatcatgaaaggtaaggctggaagatggctcagtggttaggagcactggctaccctt attttagtactttccattccgaccttctaccgagtcaccaatcctcgtgaccgatgggaa ^ * ^ * ^ * ^ * ^ * ^ * cttgaggacctgggttcagttccctgcgcccacaagtggctcacaactgaggactccagt gaactcctggacccaagtcaagggacgcgggtgttcaccgagtgttgactcctgaggtca ^ * ^ * ^ * ^ * ^ * ^ * cctaggaaatcccatgaactccaaaagggcaactcatgtagtacacttacaaacacacag ggatcctttagggtacttgaggttttcccgttgagtacatcatgtgaatgtttgtgtgtc ^ * ^ * ^ * ^ * ^ * ^ * gtaaatacttacagacataaaataaaaagaaatacatcttaaacgcacaataaaaaaatg catttatgaatgtctgtattttatttttctttatgtagaatttgcgtgttatttttttac ^ * ^ * ^ * ^ * ^ * ^ * ccgaaagagtggaatctatgtattttcagcacaaaaataatgtgagataagaatatatat ggctttctcaccttagatacataaaagtcgtgtttttattacactctattcttatatata ^ * ^ * ^ * ^ * ^ * ^ * atattgcaaaatcaattaaatttggttagagctagtgtattcagattttattggtgagat tataacgttttagttaatttaaaccaatctcgatcacataagtctaaaataaccactcta ^ * ^ * ^ * ^ * ^ * ^ * ttttttattttactatacactctcacactcacctagagcctagaacaatgtgtgtcaact aaaaaataaaatgatatgtgagagtgtgagtggatctcggatcttgttacacacagttga ^ * ^ * ^ * ^ * ^ * ^ * cgtgtggttttggttttttttaataagtcattactgactagtctgttatgaaacacgtga gcacaccaaaaccaaaaaaaattattcagtaatgactgatcagacaatactttgtgcact ^ * ^ * ^ * ^ * ^ * ^ * ttagaatttcatgagataatgtctacatcacctgtctgaaaggaaggagaaagaaagaaa aatcttaaagtactctattacagatgtagtggacagactttccttcctctttctttcttt ^ * ^ * ^ * ^ * ^ * ^ * gaaagaaagaaagaaagaaaggaagaaagagagaaaggcaaaaagaaaaggaaaagaaaa ctttctttctttctttctttccttctttctctctttccgtttttcttttccttttctttt ^ * ^ * ^ * ^ * ^ * ^ * agaaatttatgtggactcgaagtaaatccgaatcattgcacatcatgcatacaaaaggca tctttaaatacacctgagcttcatttaggcttagtaacgtgtagtacgtatgttttccgt ^ * ^ * ^ * ^ * ^ * ^ * HindIII \ gcttcgaagtaagcttagtaggatttggttccacgggcagtaaatgctttcactccctgc cgaagcttcattcgaatcatcctaaaccaaggtgcccgtcatttacgaaagtgagggacg ^ * ^ * ^ * ^ * ^ * ^ * ctttcggtattcgtttccttcacaagagttcactggtcaggtcagctttatgtgagtgca gaaagccataagcaaaggaagtgttctcaagtgaccagtccagtcgaaatacactcacgt ^ * ^ * ^ * ^ * ^ * ^ * tttcctaatctgttacaacagcagcacaaggagtaggcttaagggagacgcacacttgac aaaggattagacaatgttgtcgtcgtgttcctcatccgaattccctctgcgtgtgaactg ^ * ^ * ^ * ^ * ^ * ^ * agattcgcccgaaagccgtgttttgtgactgtgcacagaggctgtaactctgagtgcata tctaagcgggctttcggcacaaaacactgacacgtgtctccgacattgagactcacgtat ^ * ^ * ^ * ^ * ^ * ^ * catcgctgtttctcctcttctgtcttcctcacaacagaccagctctcacaggataaggct gtagcgacaaagaggagaagacagaaggagtgttgtctggtcgagagtgtcctattccga ^ * ^ * ^ * ^ * ^ * ^ *

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gtacgagagagatgactaccggggccttgtgtctgagctcacggaagactgttcctgcat catgctctctctactgatggccccggaacacagactcgagtgccttctgacaaggacgta ^ * ^ * ^ * ^ * ^ * ^ * ccacgaccgcttccgcctcaacgagatctactccatgcatgtgctagaaggcagctgggt ggtgctggcgaaggcggagttgctctagatgaggtacgtacacgatcttccgtcgaccca ^ * ^ * ^ * ^ * ^ * ^ * cctctatgagatgcccaactaccgaggccgccagtacctgctcaggcctggagactacag ggagatactctacgggttgatggctccggcggtcatggacgagtccggacctctgatgtc ^ * ^ * ^ * ^ * ^ * ^ * gcgctaccacgactggggcgccatggatgccaaagtcggctctctgagacgggtcatgga cgcgatggtgctgaccccgcggtacctacggtttcagccgagagactctgcccagtacct ^ * ^ * ^ * ^ * ^ * ^ * tttgtactaagccccattttgcttgttacaacacacacatgcaataaatatacaacttgt aaacatgattcggggtaaaacgaacaatgttgtgtgtgtacgttatttatatgttgaaca ^ * ^ * ^ * ^ * ^ * ^ * gttcctggcactaagtggctctcgcttatcttcaatatctaaatcctatttagtggtgtc caaggaccgtgattcaccgagagcgaatagaagttatagatttaggataaatcaccacag ^ * ^ * ^ * ^ * ^ * ^ * ctagtaaacttaatgctgaaagaggtttcaaatgtccaccctctgtcctcacatcttcac gatcatttgaattacgactttctccaaagtttacaggtgggagacaggagtgtagaagtg ^ * ^ * ^ * ^ * ^ * ^ * ttgcaaatgttcattgcaatgagtcattgtctggttcatggcctctggcttctgtgacac aacgtttacaagtaacgttactcagtaacagaccaagtaccggagaccgaagacactgtg ^ * ^ * ^ * ^ * ^ * ^ * catcgttatcagatcctcaccagaactcctcctggttatcttgttgttgtcctatgtcat gtagcaatagtctaggagtggtcttgaggaggaccaatagaacaacaacaggatacagta ^ * ^ * ^ * ^ * ^ * ^ * ggagatcctgcagctttggatcagcaggactgtttctttcacacatcccagccatttgca cctctaggacgtcgaaacctagtcgtcctgacaaagaaagtgtgtagggtcggtaaacgt ^ * ^ * ^ * ^ * ^ * ^ * gatgatatacattttggggtgggccaactctgagccctggacctgggcctggtcggcagc ctactatatgtaaaaccccacccggttgagactcgggacctggacccggaccagccgtcg ^ * ^ * ^ * ^ * ^ * ^ * tgagttggtcagcctgccggctttcccttatttgtaccacaggacaggacaagctctcta actcaaccagtcggacggccgaaagggaataaacatggtgtcctgtcctgttcgagagat ^ * ^ * ^ * ^ * ^ * ^ * gcactgcttcggctaggctacccaatcgctgccattggcagaggcaggaacctcctctct cgtgacgaagccgatccgatgggttagcgacggtaaccgtctccgtccttggaggagaga ^ * ^ * ^ * ^ * ^ * ^ * ctgctctcctgctctctcaccctctggactgactcaatcctgcctttgccatcaaggtca gacgagaggacgagagagtgggagacctgactgagttaggacggaaacggtagttccagt ^ * ^ * ^ * ^ * ^ * ^ * gctccactgtgttgcccactcaaggtacatggcccgctctcctgagtgttacagacagtg cgaggtgacacaacgggtgagttccatgtaccgggcgagaggactcacaatgtctgtcac ^ * ^ * ^ * ^ * ^ * ^ * aagggacaaggatagctctcttattctcatgatcccagagccggctctccccattgccac ttccctgttcctatcgagagaataagagtactagggtctcggccgagaggggtaacggtg ^ * ^ * ^ * ^ * ^ * ^ * agatggtgaggggtgaggaggaactggggcatcaccccgcacctatgccacctcttgcac tctaccactccccactcctccttgaccccgtagtggggcgtggatacggtggagaacgtg ^ * ^ * ^ * ^ * ^ * ^ *

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ggccagccctcctgatctcacatcctcagggctggttctacaccccactaccagggtcaa ccggtcgggaggactagagtgtaggagtcccgaccaagatgtggggtgatggtcccagtt ^ * ^ * ^ * ^ * ^ * ^ * cgctgctatgctgtccaggcaaggtacagggctcatttcctgagtgctaaagctggtgag gcgacgatacgacaggtccgttccatgtcccgagtaaaggactcacgatttcgaccactc ^ * ^ * ^ * ^ * ^ * ^ * gggcagcgatagctctcccactcttatgaccccagggccatctcttccagctgccccagg cccgtcgctatcgagagggtgagaatactggggtcccggtagagaaggtcgacggggtcc ^ * ^ * ^ * ^ * ^ * ^ * tggtgggagcatgagagggtaggtgtttttgttttcgattgaggcacggtttctctgtat accaccctcgtactctcccatccacaaaaacaaaagctaactccgtgccaaagagacata ^ * ^ * ^ * ^ * ^ * ^ * agccttggttgtccaggaagtcactatgtagaccaggttaggcctcaaattcagagacgc tcggaaccaacaggtccttcagtgatacatctggtccaatccggagtttaagtctctgcg ^ * ^ * ^ * ^ * ^ * ^ * ctccgcctccgcctccgcctccgcctccgcctccgcctccgcctccgcctccgcctccgc gaggcggaggcggaggcggaggcggaggcggaggcggaggcggaggcggaggcggaggcg ^ * ^ * ^ * ^ * ^ * ^ * ctccgcctccgcctccgcctccgcctccgcctccgcctccgcctccgcctccgcctccgc gaggcggaggcggaggcggaggcggaggcggaggcggaggcggaggcggaggcggaggcg ^ * ^ * ^ * ^ * ^ * ^ * ctctgggtgctgggattaaaggtgtgagccaccaccacctgttgataatattcttaaatt gagacccacgaccctaatttccacactcggtggtggtggacaactattataagaatttaa ^ * ^ * ^ * ^ * ^ * ^ * aaattaacatttaattttaattaaatcccaccaaagagaaaacaaacaaaagtgttggtg tttaattgtaaattaaaattaatttagggtggtttctcttttgtttgttttcacaaccac ^ * ^ * ^ * ^ * ^ * ^ * aggatgtagaaaagttggaacccttttaaattttcgacgggaatgtaaaatgatgctcct tcctacatcttttcaaccttgggaaaatttaaaagctgcccttacattttactacgagga ^ * ^ * ^ * ^ * ^ * ^ * tcgtagaactttgttatccctctaaacagttgccttagggctagcaattccactatgggt agcatcttgaaacaatagggagatttgtcaacggaatcccgatcgttaaggtgataccca ^ * ^ * ^ * ^ * ^ * ^ * gacacaagactgaaaacaagggctcaaatggaaatctatacatgaattgcatagtaatac ctgtgttctgacttttgttcccgagtttacctttagatatgtacttaacgtatcattatg ^ * ^ * ^ * ^ * ^ * ^ * tttcatggcagctaaaaggcggacgcagcccagtgtcctgatgtcgatagagttgccaga aaagtaccgtcgattttccgcctgcgtcgggtcacaggactacagctatctcaacggtct ^ * ^ * ^ * ^ * ^ * ^ * caaacacagtgagaggtgatatctggccatcagaggaatgaggttctgatcacgccatga gtttgtgtcactctccactatagaccggtagtctccttactccaagactagtgcggtact ^ * ^ * ^ * ^ * ^ * ^ * tagtgtacaaagaagactcacacagaccacagacgacacagacgacacagatcacatacg atcacatgtttcttctgagtgtgtctggtgtctgctgtgtctgctgtgtctagtgtatgc ^ * ^ * ^ * ^ * ^ * ^ * agtgcatccagttatatgaagtgcccaaaactagaaagagcattagtggctgcttagggc tcacgtaggtcaatatacttcacgggttttgatctttctcgtaatcaccgacgaatcccg ^ * ^ * ^ * ^ * ^ * ^ * tgaggggatggctaactaaggttgtgatctctggagtacagctttttgttgaggcgataa actcccctaccgattgattccaacactagagacctcatgtcgaaaaacaactccgctatt ^ * ^ * ^ * ^ * ^ * ^ *

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acatatctgtacacacactaaaaacactgaactatgaacatagaacggtatggccaaagc tgtatagacatgtgtgtgatttttgtgacttgatacttgtatcttgccataccggtttcg ^ * ^ * ^ * ^ * ^ * ^ * HindIII \ tgtctcaaaacactccccatctgattcagaaagcttcttaattgaaggtattctttctga acagagttttgtgaggggtagactaagtctttcgaagaattaacttccataagaaagact ^ * ^ * ^ * ^ * ^ * ^ * ctgaaagaacatgtggggtaaaatgaaattataaagctcaaaacactgggactccaacca gactttcttgtacaccccattttactttaatatttcgagttttgtgaccctgaggttggt ^ * ^ * ^ * ^ * ^ * ^ * gtatcaactatggcagaaaaacctttggcttgctgggagcttggctaattcgctatccca catagttgataccgtctttttggaaaccgaacgaccctcgaaccgattaagcgatagggt ^ * ^ * ^ * ^ * ^ * ^ * cctgttagtgactaatgacttacagctggtgcattcgaatttcctttttaacaaaaaaag ggacaatcactgattactgaatgtcgaccacgtaagcttaaaggaaaaattgtttttttc ^ * ^ * ^ * ^ * ^ * ^ * gtaaaggcctgggtcaggtctcatggaaaacatctgtgctaacttgaaatctcatctcct catttccggacccagtccagagtaccttttgtagacacgattgaactttagagtagagga ^ * ^ * ^ * ^ * ^ * ^ * tttagtctagaagaactgaacagtacagaaaactccttttcagttcataaggcttaatgc aaatcagatcttcttgacttgtcatgtcttttgaggaaaagtcaagtattccgaattacg ^ * ^ * ^ * ^ * ^ * ^ * attccctgttttcattttccaaaataagggtgtggagaaggttcgcgtccttcaagcgca taagggacaaaagtaaaaggttttattcccacacctcttccaagcgcaggaagttcgcgt ^ * ^ * ^ * ^ * ^ * ^ * gacgtgataaggccctgtaggtttctaggtgagatgcatctgtggttcagtgcctcggtc ctgcactattccgggacatccaaagatccactctacgtagacaccaagtcacggagccag ^ * ^ * ^ * ^ * ^ * ^ * BamHI \ tggatcccataaacttggtttcggactgtccaccttgtggctgtgtgagcttgagcgagg acctagggtatttgaaccaaagcctgacaggtggaacaccgacacactcgaactcgctcc ^ * ^ * ^ * ^ * ^ * ^ * tctgtgttctccctagtttcgattctgcactttcatgctctcaggaagattaaatggcac agacacaagagggatcaaagctaagacgtgaaagtacgagagtccttctaatttaccgtg ^ * ^ * ^ * ^ * ^ * ^ * tccgcctgtccacgccagcagatcgtagaggctcaatagataagcaccctcacgcctttg aggcggacaggtgcggtcgtctagcatctccgagttatctattcgtgggagtgcggaaac ^ * ^ * ^ * ^ * ^ * ^ * gtttgcccccattacactcagaccttatggtcatgtgtgcgctgtctccagggaagtcac caaacgggggtaatgtgagtctggaataccagtacacacgcgacagaggtcccttcagtg ^ * ^ * ^ * ^ * ^ * ^ * gggagaacaggagcagagggatgagctatttcccagagagtttctctaagtcaagtgaat ccctcttgtcctcgtctccctactcgataaagggtctctcaaagagattcagttcactta ^ * ^ * ^ * ^ * ^ * ^ * gtgaatagtctattttattttgccacttcgcctcaaaaaccacaatcttcctgcctcagc cacttatcagataaaataaaacggtgaagcggagtttttggtgttagaaggacggagtcg ^ * ^ * ^ * ^ * ^ * ^ * EcoRI

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\ ttctcaggtagctggaattctgggcatgtcctaccttacctacagtgctctgctgttgag aagagtccatcgaccttaagacccgtacaggatggaatggatgtcacgagacgacaactc ^ * ^ * ^ * ^ * ^ * ^ * cttcacctcttactgctgtatcacatgtctgtacccaaactaatgaaccacccttctggt gaagtggagaatgacgacatagtgtacagacatgggtttgattacttggtgggaagacca ^ * ^ * ^ * ^ * ^ * ^ * tggtcttattaccaaacaagacgatatcaattggtctgatgccgtctgaacacactagca accagaataatggtttgttctgctatagttaaccagactacggcagacttgtgtgatcgt ^ * ^ * ^ * ^ * ^ * ^ * ctccagttatggccaaagcacaccaaggctggcagagctgagtagactatgtgggtgata gaggtcaataccggtttcgtgtggttccgaccgtctcgactcatctgatacacccactat ^ * ^ * ^ * ^ * ^ * ^ * gggcttgtagattcatttctgaagaagagatctgcactcctgagaagatgacatctaaag cccgaacatctaagtaaagacttcttctctagacgtgaggactcttctactgtagatttc ^ * ^ * ^ * ^ * ^ * ^ * aggacaagccactagcatgtggaaaggccattagttttaaagcattaagtcttggggcaa tcctgttcggtgatcgtacacctttccggtaatcaaaatttcgtaattcagaaccccgtt ^ * ^ * ^ * ^ * ^ * ^ * atagatgagtttaatctccattttctctcttcactacagtgcatgcctctctataacgta tatctactcaaattagaggtaaaagagagaagtgatgtcacgtacggagagatattgcat ^ * ^ * ^ * ^ * ^ * ^ * agcaaacatggagagactgtgatgccctaacctcgaattatactatcagttgacatatca tcgtttgtacctctctgacactacgggattggagcttaatatgatagtcaactgtatagt ^ * ^ * ^ * ^ * ^ * ^ * aagatgttaatggatattacctctgacaagtatcaaaatgttggcagactgtccctctga ttctacaattacctataatggagactgttcatagttttacaaccgtctgacagggagact ^ * ^ * ^ * ^ * ^ * ^ * tcaaaacttgagctgggtaattctggttgctcagcttggctctgaccttggacttccctc agttttgaactcgacccattaagaccaacgagtcgaaccgagactggaacctgaagggag ^ * ^ * ^ * ^ * ^ * ^ * tatgctggtgcacagtgagattgagccacaaacctgctctctcagttactgactcccttc atacgaccacgtgtcactctaactcggtgtttggacgagagagtcaatgactgagggaag ^ * ^ * ^ * ^ * ^ * ^ * cagccgtgaccaccctggcccgcattcctcatttatcttgctaatcagtttagctggagc gtcggcactggtgggaccgggcgtaaggagtaaatagaacgattagtcaaatcgacctcg ^ * ^ * ^ * ^ * ^ * ^ * ctccttatccttgccgtttcctcttagtaattctctgtccagtgtcctgcttattgacca gaggaataggaacggcaaaggagaatcattaagagacaggtcacaggacgaataactggt ^ * ^ * ^ * ^ * ^ * ^ * ccaacctacttgtacatttgtatggagtcagctaatacctgctcattacaaaacccacac ggttggatgaacatgtaaacatacctcagtcgattatggacgagtaatgttttgggtgtg ^ * ^ * ^ * ^ * ^ * ^ * acatagttattcctcttacccgcttttctatacctcttgctaaatagtcttgccaccatt tgtatcaataaggagaatgggcgaaaagatatggagaacgatttatcagaacggtggtaa ^ * ^ * ^ * ^ * ^ * ^ * agcagctagtagactaatttttcttccataatgaattgtttgctgttaactgatatagtt tcgtcgatcatctgattaaaaagaaggtattacttaacaaacgacaattgactatatcaa ^ * ^ * ^ * ^ * ^ * ^ * cttttccactcctgattgcttttggctgtactttaaaactcattatgttctttgattttc gaaaaggtgaggactaacgaaaaccgacatgaaattttgagtaatacaagaaactaaaag ^ * ^ * ^ * ^ * ^ * ^ *

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ataaattactcttaccttataaatgaggaaactgaggattgagaggttaaatgagtctcc tatttaatgagaatggaatatttactcctttgactcctaactctccaatttactcagagg ^ * ^ * ^ * ^ * ^ * ^ * agggattaaagaagcattaccaaaaattgctaaatatgtgtggatgtatgtatgcatggt tccctaatttcttcgtaatggtttttaacgatttatacacacctacatacatacgtacca ^ * ^ * ^ * ^ * ^ * ^ * tcccctacacatattctccatgaattgtgactattcagaagttcctctgtgttaaaaaac aggggatgtgtataagaggtacttaacactgataagtcttcaaggagacacaattttttg ^ * ^ * ^ * ^ * ^ * ^ * aaagttttaaaggaagcaatgtgaaaataaagaattacacaggaggaaagtcattccaca tttcaaaatttccttcgttacacttttatttcttaatgtgtcctcctttcagtaaggtgt ^ * ^ * ^ * ^ * ^ * ^ * gtgttgtttgcaaacactggatcttctaagtcagtggtcatcaagccctgagagcatcat cacaacaaacgtttgtgacctagaagattcagtcaccagtagttcgggactctcgtagta ^ * ^ * ^ * ^ * ^ * ^ * ttgtgcccaggtctctgatgctcccagtttagaaattgtgagcagaagccactgattaca aacacgggtccagagactacgagggtcaaatctttaacactcgtcttcggtgactaatgt ^ * ^ * ^ * ^ * ^ * ^ * ggcccagacattgtcataattcttcacttatctgaagaggctaactctcaccactgaatc ccgggtctgtaacagtattaagaagtgaatagacttctccgattgagagtggtgacttag ^ * ^ * ^ * ^ * ^ * ^ * agcattttatttctaggtatcttatttaatcgtcaacatgtcataatacatttttgcttc tcgtaaaataaagatccatagaataaattagcagttgtacagtattatgtaaaaacgaag ^ * ^ * ^ * ^ * ^ * ^ * atgaatgctttgggactgccatttttggtcaagatgttggagcaaattctacagcatcac tacttacgaaaccctgacggtaaaaaccagttctacaacctcgtttaagatgtcgtagtg ^ * ^ * ^ * ^ * ^ * ^ * atggtgcaagctaaggagtaggcaggatgcacaaatataactacctcgatactttttcat taccacgttcgattcctcatccgtcctacgtgtttatattgatggagctatgaaaaagta ^ * ^ * ^ * ^ * ^ * ^ * ctgtaacaaactacctgatagaaatacctcagggaagcaaagattcatttggctcacaat gacattgtttgatggactatctttatggagtcccttcgtttctaagtaaaccgagtgtta ^ * ^ * ^ * ^ * ^ * ^ * ttcggaggattatcacctgacatggtgaggaaggataatggccggagagagcaagccatg aagcctcctaatagtggactgtaccactccttcctattaccggcctctctcgttcggtac ^ * ^ * ^ * ^ * ^ * ^ * gctgccgattgcatatggtagcccaccgggagacagaaaaattgggctggaaagagaaga cgacggctaacgtataccatcgggtggccctctgtctttttaacccgacctttctcttct ^ * ^ * ^ * ^ * ^ * ^ * gataatacaacacatgcccctctgactgacgtatttttttttaattaggtcccatttgct ctattatgttgtgtacggggagactgactgcataaaaaaaaattaatccagggtaaacga ^ * ^ * ^ * ^ * ^ * ^ * aaaggttccacagcctgatatacaaaacaccatatgaggacaaagtcctcaaaacatggg tttccaaggtgtcggactatatgttttgtggtatactcctgtttcaggagttttgtaccc ^ * ^ * ^ * ^ * ^ * ^ * gctgtggagaatataacacaatcaatatgtccatgaccccacaaagagtgataacaagac cgacacctcttatattgtgttagttatacaggtactggggtgtttctcactattgttctg ^ * ^ * ^ * ^ * ^ * ^ * caggatataaactcttgcttattaagatctactatcaccacccctttttattagggtggc gtcctatatttgagaacgaataattctagatgatagtggtggggaaaaataatcccaccg ^ * ^ * ^ * ^ * ^ * ^ *

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ataggttaccacgaaagctggttggaccaagaatgctaactgtgacaggggttatctcga tatccaatggtgctttcgaccaacctggttcttacgattgacactgtccccaatagagct ^ * ^ * ^ * ^ * ^ * ^ * gacactctgtcccctgggcactttggagctgcctgaatccttcatgcccacaggatatta ctgtgagacaggggacccgtgaaacctcgacggacttaggaagtacgggtgtcctataat ^ * ^ * ^ * ^ * ^ * ^ * gattcccttgctcctgccaggaaaataaacctttgatcacatgtgaaatggagagccaac ctaagggaacgaggacggtccttttatttggaaactagtgtacactttacctctcggttg ^ * ^ * ^ * ^ * ^ * ^ * agccacttcttagagatcatggttaccacaggaaatcctttcattataacgggcatccat tcggtgaagaatctctagtaccaatggtgtcctttaggaaagtaatattgcccgtaggta ^ * ^ * ^ * ^ * ^ * ^ * gtggctattacaagatggactctttgatttgtgtgctctaagcaccaaacagactgtaag caccgataatgttctacctgagaaactaaacacacgagattcgtggtttgtctgacattc ^ * ^ * ^ * ^ * ^ * ^ * agatcctctaatgccacagaaacggaaccgagggagcatgctgctctcttccccttctaa tctaggagattacggtgtctttgccttggctccctcgtacgacgagagaaggggaagatt ^ * ^ * ^ * ^ * ^ * ^ * tcttcatcacagctggacagctccagtggacgaaactgtactgtctaacttcatccactt agaagtagtgtcgacctgtcgaggtcacctgctttgacatgacagattgaagtaggtgaa ^ * ^ * ^ * ^ * ^ * ^ * BamHI \ tggagctccctgaagactgcttcttcattcaggatcctgtcctctcagggcactgtcttc acctcgagggacttctgacgaagaagtaagtcctaggacaggagagtcccgtgacagaag ^ * ^ * ^ * ^ * ^ * ^ * ctcccccagaccacagaagccctggacctgctctgagatgcccttctgcaaaggagagag gagggggtctggtgtcttcgggacctggacgagactctacgggaagacgtttcctctctc ^ * ^ * ^ * ^ * ^ * ^ * catatcctcgtagctctaaaggaaacaagcatccattattgaagaggggaaacggcaaat gtataggagcatcgagatttcctttgttcgtaggtaataacttctcccctttgccgttta ^ * ^ * ^ * ^ * ^ * ^ * ccacaaggagttacagctgacactgagacatgtgcaaggctcgggtcctattggacctgg ggtgttcctcaatgtcgactgtgactctgtacacgttccgagcccaggataacctggacc ^ * ^ * ^ * ^ * ^ * ^ * tccctttctaaactcctgttcctttgtcttgatttatttttctttttggaatttcatacc agggaaagatttgaggacaaggaaacagaactaaataaaaagaaaaaccttaaagtatgg ^ * ^ * ^ * ^ * ^ * ^ * acatttactcattatttctgtgtaagcatttatactcatgggtaggtcagagaagaactt tgtaaatgagtaataaagacacattcgtaaatatgagtacccatccagtctcttcttgaa ^ * ^ * ^ * ^ * ^ * ^ * tagggaattagtcctctcctcccaccacatgggacccaggaatctatcagattttcaggc atcccttaatcaggagaggagggtggtgtaccctgggtccttagatagtctaaaagtccg ^ * ^ * ^ * ^ * ^ * ^ * tggataacaagaagagccttgcccactgatctgtcttgctgagccctgatttattgttct acctattgttcttctcggaacgggtgactagacagaacgactcgggactaaataacaaga ^ * ^ * ^ * ^ * ^ * ^ * ctcctaagatcattgacctctctgtgcatcagaaccagatcactttgtcaggcatggtga gaggattctagtaactggagagacacgtagtcttggtctagtgaaacagtccgtaccact ^ * ^ * ^ * ^ * ^ * ^ * HindIII

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\ tgcagatctgtagtcccagtaccaggaggctgaagcttgagaaacacaaacaatttgagg acgtctagacatcagggtcatggtcctccgacttcgaactctttgtgtttgttaaactcc ^ * ^ * ^ * ^ * ^ * ^ * ccagccttggttacatagtaagtcctgtctcaaagtgtgtgaggtgtgtatgggagaaca ggtcggaaccaatgtatcattcaggacagagtttcacacactccacacataccctcttgt ^ * ^ * ^ * ^ * ^ * ^ * cagaggttrggtgaggcttaataaaaaacaaaggtttataaaaaatatacagaaacctac gtctccaayccactccgaattattttttgtttccaaatattttttatatgtctttggatg ^ * ^ * ^ * ^ * ^ * ^ * tgctttataaactaactttaaaaaacaattttaaagatgttttattttaattatatgggg acgaaatatttgattgaaattttttgttaaaatttctacaaaataaaattaatatacccc ^ * ^ * ^ * ^ * ^ * ^ * ggagtgtggcatgcgtaagagtcagaggagggtataggacccctcaaagctggcgccaac cctcacaccgtacgcattctcagtctcctcccatatcctggggagtttcgaccgcggttg ^ * ^ * ^ * ^ * ^ * ^ * agtagctgaaagctctggacacagacactgggtcttctataagaacagtatgtgctttta tcatcgactttcgagacctgtgtctgtgacccagaagatattcttgtcatacacgaaaat ^ * ^ * ^ * ^ * ^ * ^ * attaccaagccatttctccaatccccctgccccccgcccaatataaaggagagctctaag taatggttcggtaaagaggttagggggacggggggcgggttatatttcctctcgagattc ^ * ^ * ^ * ^ * ^ * ^ * tggctgaataatgctcctcccagaagcattaggttttaaatgaaaatcccggtgctggat accgacttattacgaggagggtcttcgtaatccaaaatttacttttagggccacgaccta ^ * ^ * ^ * ^ * ^ * ^ * gtgggatactttcctatgagcattaccagggagatccaaaatgttagagactcttcccac caccctatgaaaggatactcgtaatggtccctctaggttttacaatctctgagaagggtg ^ * ^ * ^ * ^ * ^ * ^ * tgcttttggtcgtctgccaaaactagatgatgaaacttcattgctgcagacactaaacac acgaaaaccagcagacggttttgatctactactttgaagtaacgacgtctgtgatttgtg ^ * ^ * ^ * ^ * ^ * ^ * tttggacacaggacctagagaaaccaagttggaactaagctagaggccttttctctgcta aaacctgtgtcctggatctctttggttcaaccttgattcgatctccggaaaagagacgat ^ * ^ * ^ * ^ * ^ * ^ * gctagtgttcagtgtgtcaaaggttatgcaggggaaaagttatcaatgttcttttccagc cgatcacaagtcacacagtttccaatacgtccccttttcaatagttacaagaaaaggtcg ^ * ^ * ^ * ^ * ^ * ^ * cacgggctctgaatgctacaataccaatatgccagacaagatatggctactgtgggcata gtgcccgagacttacgatgttatggttatacggtctgttctataccgatgacacccgtat ^ * ^ * ^ * ^ * ^ * ^ * cccaactgcttcctggttgtatttcaaaccatcttcatgggaggaaatatatattcttgc gggttgacgaaggaccaacataaagtttggtagaagtaccctcctttatatataagaacg ^ * ^ * ^ * ^ * ^ * ^ * tattttaactctggccaaaagtctatggctggagacgtcgtcacaggccctggtggggaa ataaaattgagaccggttttcagataccgacctctgcagcagtgtccgggaccacccctt ^ * ^ * ^ * ^ * ^ * ^ * agtagtactactgttgttttattaaacggatgtgtagtcaaactgccttctaaatgttta tcatcatgatgacaacaaaataatttgcctacacatcagtttgacggaagatttacaaat ^ * ^ * ^ * ^ * ^ * ^ * tgattctagccatacgttagtgtggctttcaggtgcggttagagaatctctctctctctc actaagatcggtatgcaatcacaccgaaagtccacgccaatctcttagagagagagagag

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tctctctctctctctctctctctctctctctctctccaaagagggtgatggttaatacag agagagagagagagagagagagagagagagagagaggtttctcccactaccaattatgtc ^ * ^ * ^ * ^ * ^ * ^ * agactaattactggtgagagaattgaaaataaatgaatattaaaatactctgccttaagt tctgattaatgaccactctcttaacttttatttacttataattttatgagacggaattca ^ * ^ * ^ * ^ * ^ * ^ * gggacattggtaatattccctgcaaaaccttgcataagaagaggtagaaagattgcaatg ccctgtaaccattataagggacgttttggaacgtattcttctccatctttctaacgttac ^ * ^ * ^ * ^ * ^ * ^ * tttaagatctgagaggagtgctatgcaatgctgttttctgtatttggcatagccattgga aaattctagactctcctcacgatacgttacgacaaaagacataaaccgtatcggtaacct ^ * ^ * ^ * ^ * ^ * ^ * atcatgggcacatagctaccttcacaagaagcatacacctgtacataacacacacacaca tagtacccgtgtatcgatggaagtgttcttcgtatgtggacatgtattgtgtgtgtgtgt ^ * ^ * ^ * ^ * ^ * ^ * cacacacacacacacacacacacgcacgcacgcacgcacgcacgcatgcatgcacacaca gtgtgtgtgtgtgtgtgtgtgtgcgtgcgtgcgtgcgtgcgtgcgtacgtacgtgtgtgt ^ * ^ * ^ * ^ * ^ * ^ * cacaaatcctgaatgtaggagggggacccggcttggaagaaaggagtcagcaggatctta gtgtttaggacttacatcctccccctgggccgaaccttctttcctcagtcgtcctagaat ^ * ^ * ^ * ^ * ^ * ^ * aattgtcgtatatggaatataaaatgttctccctttctccagcctcatgaattgaatctt ttaacagcatataccttatattttacaagagggaaagaggtcggagtacttaacttagaa ^ * ^ * ^ * ^ * ^ * ^ * ggccctcagctgatggccctgcttgaagagggattggaaaccatgagagataaagtctag ccgggagtcgactaccgggacgaacttctccctaacctttggtactctctatttcagatc ^ * ^ * ^ * ^ * ^ * ^ * actgggggtcgggggaggagaggggtcaagtcagggagttaggagtgtctttgaaggtta tgacccccagccccctcctctccccagttcagtccctcaatcctcacagaaacttccaat ^ * ^ * ^ * ^ * ^ * ^ * tgcttggcttgacccctttctcctgcttcctgtctgccctgatgtgaagacctcctcctc acgaaccgaactggggaaagaggacgaaggacagacgggactacacttctggaggaggag ^ * ^ * ^ * ^ * ^ * ^ * tccacacacccacggatgttccgacttaccacaggccaaaaacaatagagccagggctgt aggtgtgtgggtgcctacaaggctgaatggtgtccggtttttgttatctcggtcccgaca ^ * ^ * ^ * ^ * ^ * ^ * ggaatcccaaaaccaaggactgaaaatgagtctttctcccctcctttgtgtcacattgtt ccttagggttttggttcctgacttttactcagaaagaggggaggaaacacagtgtaacaa ^ * ^ * ^ * ^ * ^ * ^ * gtggtacagtacaccgcctgactagtatatgcttcacttaaacatcagactgtcaacgaa caccatgtcatgtggcggactgatcatatacgaagtgaatttgtagtctgacagttgctt ^ * ^ * ^ * ^ * ^ * ^ * aacaggggtgatttaagtcacattaatgctcactcactgaggtttcgttcccatcctaca ttgtccccactaaattcagtgtaattacgagtgagtgactccaaagcaagggtaggatgt ^ * ^ * ^ * ^ * ^ * ^ * ccgagtgacattgaatatattgagttatatataaaataaagttgtggggcctggagagac ggctcactgtaacttatataactcaatatatattttatttcaacaccccggacctctctg ^ * ^ * ^ * ^ * ^ * ^ * gactcagcagttgagaacacttcctgaggtgctcaattcccagcaaccacatggtggctc ctgagtcgtcaactcttgtgaaggactccacgagttaagggtcgttggtgtaccaccgag

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acaaccatctgtaatgggatctgatgcccccttctggtgtgtctgaaaacagtgacatgt tgttggtagacattaccctagactacgggggaagaccacacagacttttgtcactgtaca ^ * ^ * ^ * ^ * ^ * ^ * actcacatacattaaaaaataataaataaatattaaaataaaataaagttgtgactttcc tgagtgtatgtaattttttattatttatttataattttattttatttcaacactgaaagg ^ * ^ * ^ * ^ * ^ * ^ * tcctttcaagggttagaaatcttagcacataaaaatgacagtgtttttcagtgagtcctg aggaaagttcccaatctttagaatcgtgtatttttactgtcacaaaaagtcactcaggac ^ * ^ * ^ * ^ * ^ * ^ * HindIII \ ccgggtgaacttgagtactggagaagcttaatcaagatattggtcctgccaaggttggag ggcccacttgaactcatgacctcttcgaattagttctataaccaggacggttccaacctc ^ * ^ * ^ * ^ * ^ * ^ * cccccagtgtaagggaatgtgggggagagggggtggatggggaggggaacagccttatgg gggggtcacattcccttacaccccctctcccccacctacccctccccttgtcggaatacc ^ * ^ * ^ * ^ * ^ * ^ * aaggggagggggatgggatagggggtttatgtccaggaaactcggaaagggaataacatt ttcccctccccctaccctatcccccaaatacaggtcctttgagcctttcccttattgtaa ^ * ^ * ^ * ^ * ^ * ^ * tgaaatgaaatttaaaaaagaatccaataaaaataaaaagatatggttaagagtccggct actttactttaaattttttcttaggttatttttatttttctataccaattctcaggccga ^ * ^ * ^ * ^ * ^ * ^ * tgatcattactttttctccactgaaatagtaactgtttattaaaaggctaataggatcac actagtaatgaaaaagaggtgactttatcattgacaaataattttccgattatcctagtg ^ * ^ * ^ * ^ * ^ * ^ * cttagctggtgttactgttcactttatttaagagggctcaggatggatggcatgtgtgca gaatcgaccacaatgacaagtgaaataaattctcccgagtcctacctaccgtacacacgt ^ * ^ * ^ * ^ * ^ * ^ * gcacactataacaatagggagtgggctttatatgccttgacgcctggaaaccagatacca cgtgtgatattgttatccctcacccgaaatatacggaactgcggacctttggtctatggt ^ * ^ * ^ * ^ * ^ * ^ * ctgcattaccttagctggtgggatcaggacaagtgcttcttagcgtgagccctgtggtcc gacgtaatggaatcgaccaccctagtcctgttcacgaagaatcgcactcgggacaccagg ^ * ^ * ^ * ^ * ^ * ^ * actgtcacaccatcactcaggaccaaggtgctccgtcccacagacactgacagctcgaaa tgacagtgtggtagtgagtcctggttccacgaggcagggtgtctgtgactgtcgagcttt ^ * ^ * ^ * ^ * ^ * ^ * gtcagtgcaatgagcctccagaacgtccgtcagccaaaggaagctgctgagcgtacctta cagtcacgttactcggaggtcttgcaggcagtcggtttccttcgacgactcgcatggaat ^ * ^ * ^ * ^ * ^ * ^ * tcctacattgtctctctccatggtggcaacctacatcgatttactgagcattaaaggggc aggatgtaacagagagaggtaccaccgttggatgtagctaaatgactcgtaatttccccg ^ * ^ * ^ * ^ * ^ * ^ * acgaagtcccagccccttgttcagtccatgattgctctagattccctgaggaagtcacca tgcttcagggtcggggaacaagtcaggtactaacgagatctaagggactccttcagtggt ^ * ^ * ^ * ^ * ^ * ^ * ccattttattttctcacaattctaatggcatgcaggagaccctgtggaaaagagatggac ggtaaaataaaagagtgttaagattaccgtacgtcctctgggacaccttttctctacctg ^ * ^ * ^ * ^ * ^ * ^ *

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aagctcagtttactaatgacttggcttgatatatgggttcaagccaaaagcagtgttatt ttcgagtcaaatgattactgaaccgaactatatacccaagttcggttttcgtcacaataa ^ * ^ * ^ * ^ * ^ * ^ * gcatgatgagacctgtggtaggtttgaatatgcttgcccaggagggtgcactattaggag cgtactactctggacaccatccaaacttatacgaacgggtcctcccacgtgataatcctc ^ * ^ * ^ * ^ * ^ * ^ * gtttggccttgttggagtaagtatggccttatgggaggaggtgtgtcactgtcggaggtt caaaccggaacaacctcattcataccggaataccctcctccacacagtgacagcctccaa ^ * ^ * ^ * ^ * ^ * ^ * tgagaccctcctcctggcttacaggttcagaggttcagtccactattatcaaggtggtgt actctgggaggaggaccgaatgtccaagtctccaagtcaggtgataatagttccaccaca ^ * ^ * ^ * ^ * ^ * ^ * atggcagtatccaggcaggcatggtgcaggaggaactgagggttctacattttcatctga taccgtcataggtccgtccgtaccacgtcctccttgactcccaagatgtaaaagtagact ^ * ^ * ^ * ^ * ^ * ^ * agggctaggagaaacctggcttcctcaggcagctaagaggaagctctcaacgcccacact tcccgatcctctttggaccgaaggagtccgtcgattctccttcgagagttgcgggtgtga ^ * ^ * ^ * ^ * ^ * ^ * cacagtgacacacttcctccaataagaccacacttccaaatagtgccatcctgggccaag gtgtcactgtgtgaaggaggttattctggtgtgaaggtttatcacggtaggacccggttc ^ * ^ * ^ * ^ * ^ * ^ * catatttcaaccaccacagccagtcttctcctgtctgcctttggatcaagatataaaact gtataaagttggtggtgtcggtcagaagaggacagacggaaacctagttctatattttga ^ * ^ * ^ * ^ * ^ * ^ * tttgctcctccagccccaggtcttcctggacattgccatcttcctgacatgatgataatg aaacgaggaggtcggggtccagaaggacctgtaacggtagaaggactgtactactattac ^ * ^ * ^ * ^ * ^ * ^ * gactgaacctctgaagctgtaagccagcaccaatcaactgctgtctcttcacagcagtgg ctgacttggagacttcgacattcggtcgtggttagttgacgacagagaagtgtcgtcacc ^ * ^ * ^ * ^ * ^ * ^ * aaaccttaactaagataccacctcactcaggtggcccccaaaactgcagtgaaggtagtc tttggaattgattctatggtggagtgagtccaccgggggttttgacgtcacttccatcag ^ * ^ * ^ * ^ * ^ * ^ * ctcccagggggaaaccttaaagaagtgagtgttgtgctggagagatggctcagtggttag gagggtccccctttggaatttcttcactcacaacacgacctctctaccgagtcaccaatc ^ * ^ * ^ * ^ * ^ * ^ * aagcacttgctgttcttgcagatgacttgggttggattttcggcacccacatggcagctc ttcgtgaacgacaagaacgtctactgaacccaacctaaaagccgtgggtgtaccgtcgag ^ * ^ * ^ * ^ * ^ * ^ * BamHI \ atggccatctgtaactgcagtcccaaaggatccaaagccctcttttgatccctgtaggca taccggtagacattgacgtcagggtttcctaggtttcgggagaaaactagggacatccgt ^ * ^ * ^ * ^ * ^ * ^ * aaaggtatgcatatggtatgcatacgtatctgcaggcaaacactcataaaataataaaat tttccatacgtataccatacgtatgcatagacgtccgtttgtgagtattttattatttta ^ * ^ * ^ * ^ * ^ * ^ * gaacaactatttaaaatacttgtttttttttcttgaaaacaacaaaaaaccctaaaccca cttgttgataaattttatgaacaaaaaaaaagaacttttgttgttttttgggatttgggt ^ * ^ * ^ * ^ * ^ * ^ * aaaactgacaaagtaaataactttaaaatattttatttatttatttttttcttaaaacaa ttttgactgtttcatttattgaaattttataaaataaataaataaaaaaagaattttgtt

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aacaaaacaaagctagctggtcattcacccactttgtgtgtgagcccagggcttaaaagg ttgttttgtttcgatcgaccagtaagtgggtgaaacacacactcgggtcccgaattttcc ^ * ^ * ^ * ^ * ^ * ^ * agtcactgagcgtggtgagtcacttggctagttgattcggggccaagaaagggagagatc tcagtgactcgcaccactcagtgaaccgatcaactaagccccggttctttccctctctag ^ * ^ * ^ * ^ * ^ * ^ * tggagtaagaaggtctggggtagaggtacatgcatggagctacagacatagctacacagt acctcattcttccagaccccatctccatgtacgtacctcgatgtctgtatcgatgtgtca ^ * ^ * ^ * ^ * ^ * ^ * atgaccctgccacacactgctgcctctcacagtgcttccacaacgagaaaatgctaaacc tactgggacggtgtgtgacgacggagagtgtcacgaaggtgttgctcttttacgatttgg ^ * ^ * ^ * ^ * ^ * ^ * acccaagcaagtgacagaactattggaacaaagtactcaaaaatgtcacatccgtggcag tgggttcgttcactgtcttgataaccttgtttcatgagtttttacagtgtaggcaccgtc ^ * ^ * ^ * ^ * ^ * ^ * ctcaggggaaggctgtgctaactgctcccgacaacattaattcagccattaccattatgc gagtccccttccgacacgattgacgagggctgttgtaattaagtcggtaatggtaatacg ^ * ^ * ^ * ^ * ^ * ^ * atcgtcctgtccacctgaaaggcagaagagtcacgcaccttagtgtgctctctgcttttg tagcaggacaggtggactttccgtcttctcagtgcgtggaatcacacgagagacgaaaac ^ * ^ * ^ * ^ * ^ * ^ * aggaagtccaccagcctcttggtggtaacttgactacctaggtcctttccattcaccctt tccttcaggtggtcggagaaccaccattgaactgatggatccaggaaaggtaagtgggaa ^ * ^ * ^ * ^ * ^ * ^ * gctggcatccacatacatctcacaggtatttgttgcctgaagggtagacagtaaacttat cgaccgtaggtgtatgtagagtgtccataaacaacggacttcccatctgtcatttgaata ^ * ^ * ^ * ^ * ^ * ^ * atgctaaataaatagtatatgcttgtgagtaatcaccatatttccccaaagacaacgaaa tacgatttatttatcatatacgaacactcattagtggtataaaggggtttctgttgcttt ^ * ^ * ^ * ^ * ^ * ^ * agatgcattgttttgcacttctgcaaatccttaatttgtgaaaatgtcagtactcatttg tctacgtaacaaaacgtgaagacgtttaggaattaaacacttttacagtcatgagtaaac ^ * ^ * ^ * ^ * ^ * ^ * tgaaagaatcatattttcttaaaatagcaaataaactcagcactgccctgaaaactgtca actttcttagtataaaagaattttatcgtttatttgagtcgtgacgggacttttgacagt ^ * ^ * ^ * ^ * ^ * ^ * ctttacgtcgaccaggggcccccatggttcccacaactacatgtataaggcacactgtca gaaatgcagctggtccccgggggtaccaagggtgttgatgtacatattccgtgtgacagt ^ * ^ * ^ * ^ * ^ * ^ * aggaaccctccacactcctcccaccccccactccacccaccctccacgctccacctccca tccttgggaggtgtgaggagggtggggggtgaggtgggtgggaggtgcgaggtggagggt ^ * ^ * ^ * ^ * ^ * ^ * tgcccaaatcttgccggtatgtacccattatccgaagtctgagaaagttagtggtgggtg acgggtttagaacggccatacatgggtaataggcttcagactctttcaatcaccacccac ^ * ^ * ^ * ^ * ^ * ^ * BamHI \ ctaggaaagtttctgtctggatcctggacaggcatcagcagaagaagatttaaaagtgga gatcctttcaaagacagacctaggacctgtccgtagtcgtcttcttctaaattttcacct ^ * ^ * ^ * ^ * ^ * ^ *

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gaagcataagaatagctgttcttttcccccagtcagggccataacaaggtcttcatgtgc cttcgtattcttatcgacaagaaaagggggtcagtcccggtattgttccagaagtacacg ^ * ^ * ^ * ^ * ^ * ^ * attgaaactctgttctaggtgcaagggtggagaagagacatcacaaactgcagctaacaa taactttgagacaagatccacgttcccacctcttctctgtagtgtttgacgtcgattgtt ^ * ^ * ^ * ^ * ^ * ^ * ttgtttcagaccgtcccccagcaaacattaataatcatagaatcttgaatttgaactaaa aacaaagtctggcagggggtcgtttgtaattattagtatcttagaacttaaacttgattt ^ * ^ * ^ * ^ * ^ * ^ * ctttatgcttttcagaatatttcctcagattaaatctccctgactctctcttactcgaga gaaatacgaaaagtcttataaaggagtctaatttagagggactgagagagaatgagctct ^ * ^ * ^ * ^ * ^ * ^ * ttccttactgtttaagttttcgctttaaaaaaaagtttaaagcatacaaccaaaatccga aaggaatgacaaattcaaaagcgaaattttttttcaaatttcgtatgttggttttaggct ^ * ^ * ^ * ^ * ^ * ^ * agcacgtgcagttgctaaatcagatttgctttgagaagtccgttaagccgagtaagctat tcgtgcacgtcaacgatttagtctaaacgaaactcttcaggcaattcggctcattcgata ^ * ^ * ^ * ^ * ^ * ^ * aaagtaaacgcatagaattagagcttcgcgttcttttgcaaaacaagagcaaagactttt tttcatttgcgtatcttaatctcgaagcgcaagaaaacgttttgttctcgtttctgaaaa ^ * ^ * ^ * ^ * ^ * ^ * ctcattggtagcaacaacacaacagctttagtgaattagagcaacccgaacctaccagaa gagtaaccatcgttgttgtgttgtcgaaatcacttaatctcgttgggcttggatggtctt ^ * ^ * ^ * ^ * ^ * ^ * agaatgagagtaaaccattcagccaactccaatgagcagagggagggagagagctctccg tcttactctcatttggtaagtcggttgaggttactcgtctccctccctctctcgagaggc ^ * ^ * ^ * ^ * ^ * ^ * agcttgcaaatccccttactcactggaatgggcccttttgtgtgatttcctgtggaggca tcgaacgtttaggggaatgagtgaccttacccgggaaaacacactaaaggacacctccgt ^ * ^ * ^ * ^ * ^ * ^ * gcagtcatgacagctatatataccagaggcgctcccctagagcctcacagctcccagggc cgtcagtactgtcgatatatatggtctccgcgaggggatctcggagtgtcgagggtcccg ^ * ^ * ^ * ^ * ^ * ^ * atctcttactatcagcgagatgggaaaggtaagtcccggaaccctgacctttgccctcaa tagagaatgatagtcgctctaccctttccattcagggccttgggactggaaacgggagtt ^ * ^ * ^ * ^ * ^ * ^ * gcagcatccttgctggcagaaatcaattatttgtctggtcccctctgcccttacagatca cgtcgtaggaacgaccgtctttagttaataaacagaccaggggagacgggaatgtctagt ^ * ^ * ^ * ^ * ^ * ^ * ccttcttcgaggaccgaggcttccagggccgctgctatgagtgcagcagcgactgcccca ggaagaagctcctggctccgaaggtcccggcgacgatactcacgtcgtcgctgacggggt ^ * ^ * ^ * ^ * ^ * ^ * acctgcagacctacttcagccgctgcaactccgtccgcgtggacagtggctgctggatgc tggacgtctggatgaagtcggcgacgttgaggcaggcgcacctgtcaccgacgacctacg ^ * ^ * ^ * ^ * ^ * ^ * tctatgagcgacccaactaccagggccaccagtacttcctgcgacgcggggactaccctg agatactcgctgggttgatggtcccggtggtcatgaaggacgctgcgcccctgatgggac ^ * ^ * ^ * ^ * ^ * ^ * actaccagcagtggatgggtttcagcgactccattcgctcctgccgcctcatcccccaag tgatggtcgtcacctacccaaagtcgctgaggtaagcgaggacggcggagtagggggttc ^ * ^ * ^ * ^ * ^ * ^ *

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tgagtttggctctgtcctcattattggtctctggaaacacaaattacctttaaaaaaatc actcaaaccgagacaggagtaataaccagagacctttgtgtttaatggaaatttttttag ^ * ^ * ^ * ^ * ^ * ^ * atcttaaaccaagtcgtttcaattagagcagagagtgggtctgacagtatgtgtgttcag tagaatttggttcagcaaagttaatctcgtctctcacccagactgtcatacacacaagtc ^ * ^ * ^ * ^ * ^ * ^ * tggtatatcatttctcaggaacgtggtgttgagtttcttagaaaactcacatccaccttt accatatagtaaagagtccttgcaccacaactcaaagaatcttttgagtgtaggtggaaa ^ * ^ * ^ * ^ * ^ * ^ *

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EcoRI \ ttatatttataggccatcaagaattcaaacaccagagagtaattttaaaaacaggatatc aatataaatatccggtagttcttaagtttgtggtctctcattaaaatttttgtcctatag ^ * ^ * ^ * ^ * ^ * ^ * gaagacagtgcatttatcatttgcttaacatataaattccctgcatatatatagtcctta cttctgtcacgtaaatagtaaacgaattgtatatttaagggacgtatatatatcaggaat ^ * ^ * ^ * ^ * ^ * ^ * gttcattccaaaccacttctagtcagaaattcaatgtttcttaatctaaaaatataatgt caagtaaggtttggtgaagatcagtctttaagttacaaagaattagatttttatattaca ^ * ^ * ^ * ^ * ^ * ^ * actactatgtcggtgttttaaaatgcgttggttgggtaggatatgctgaagagatagcag tgatgatacagccacaaaattttacgcaaccaacccatcctatacgacttctctatcgtc ^ * ^ * ^ * ^ * ^ * ^ * caagagttcaaggccagcctgagctacccactttgtatagttcagaccaccctgatctca gttctcaagttccggtcggactcgatgggtgaaacatatcaagtctggtgggactagagt ^ * ^ * ^ * ^ * ^ * ^ * tctaaaaacgtgttgccttgcttggccttgcgtttctttctgcttgcttttcccaccttc agatttttgcacaacggaacgaaccggaacgcaaagaaagacgaacgaaaagggtggaag ^ * ^ * ^ * ^ * ^ * ^ * tgcttttcattcatttgtagtggacagtgcccatgggctcgcttggaggaataccccagc acgaaaagtaagtaaacatcacctgtcacgggtacccgagcgaacctccttatggggtcg ^ * ^ * ^ * ^ * ^ * ^ * gcaaaggccagatctaaagctaaagtcccagactcatgctttctggagatggccataggt cgtttccggtctagatttcgatttcagggtctgagtacgaaagacctctaccggtatcca ^ * ^ * ^ * ^ * ^ * ^ * agcatcctaggcaggtagagtgtgggagacatgagacacagtgccacggaaactatagga tcgtaggatccgtccatctcacaccctctgtactctgtgtcacggtgcctttgatatcct ^ * ^ * ^ * ^ * ^ * ^ * atgtaacttcaccatggagagttgcccctgacaggaagggtcagcctacagcgaggaagc tacattgaagtggtacctctcaacggggactgtccttcccagtcggatgtcgctccttcg ^ * ^ * ^ * ^ * ^ * ^ * agggaaaagccgatttgaaccgaaactgaggcttggaaagagaaagaaggaaacacagca tcccttttcggctaaacttggctttgactccgaacctttctctttcttcctttgtgtcgt ^ * ^ * ^ * ^ * ^ * ^ * cctaatttatcacaggggctcagccttctgaattgtagatatgtgaaccaatacacttcg ggattaaatagtgtccccgagtcggaagacttaacatctatacacttggttatgtgaagc ^ * ^ * ^ * ^ * ^ * ^ * tttgcagaaaaaaatcgctgaaggttgataccttgtcaacaagggagataaatcaaaatg aaacgtctttttttagcgacttccaactatggaacagttgttccctctatttagttttac

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^ 18661

* 18720

ctaccttcctggtaacttttagatttcctcccctgcaaagggctgtctcagcactgagat gatggaaggaccattgaaaatctaaaggaggggacgtttcccgacagagtcgtgactcta ^ * ^ * ^ * ^ * ^ * ^ * ggtatgggttttattttttaattatttttagattaagtgtgatgatctttattttaagca ccatacccaaaataaaaaattaataaaaatctaattcacactactagaaataaaattcgt ^ * ^ * ^ * ^ * ^ * ^ * acttttaattgccagggacttatggatgggtaggtaggcatggagagcgctgagggctgt tgaaaattaacggtccctgaatacctacccatccatccgtacctctcgcgactcccgaca ^ * ^ * ^ * ^ * ^ * ^ * HindIII \ ttctcaattggccattgacaccctagagtcttcaagagacaccccaagctttaggaatag aagagttaaccggtaactgtgggatctcagaagttctctgtggggttcgaaatccttatc ^ * ^ * ^ * ^ * ^ * ^ * agacttccgtactctgtaacatgcttgtcctgaacgcaaacttggacttgggattttgag tctgaaggcatgagacattgtacgaacaggacttgcgtttgaacctgaaccctaaaactc ^ * ^ * ^ * ^ * ^ * ^ * gctggaggtgtcgggacaggaaacatctttgtgctcatttgcttttcttcttctgtctgc cgacctccacagccctgtcctttgtagaaacacgagtaaacgaaaagaagaagacagacg ^ * ^ * ^ * ^ * ^ * ^ * ccccaccctcactcccccaccccagcactcgggcacttacagaatgaggatctacgaaag ggggtgggagtgagggggtggggtcgtgagcccgtgaatgtcttactcctagatgctttc ^ * ^ * ^ * ^ * ^ * ^ * agatgacttcagaggacaaatgtcagagatcacagacgactgtctctctcttcaggatcg tctactgaagtctcctgtttacagtctctagtgtctgctgacagagagagaagtcctagc ^ * ^ * ^ * ^ * ^ * ^ * cttccacctcagcgagattcactccctcaatgtaatggagggctgctgggtcctctatga gaaggtggagtcgctctaagtgagggagttacattacctcccgacgacccaggagatact ^ * ^ * ^ * ^ * ^ * ^ * gatgcctagctacagagggcgccagtacctgctgaggccgggagagtacaggagatatct ctacggatcgatgtctcccgcggtcatggacgactccggccctctcatgtcctctataga ^ * ^ * ^ * ^ * ^ * ^ * tgactggggggctgcaaacgccaaagttggctcttttagaagagtcatggatttttactg actgaccccccgacgtttgcggtttcaaccgagaaaatcttctcagtacctaaaaatgac ^ * ^ * ^ * ^ * ^ * ^ * aggcattttgagactctacttttctcctctagaaactaataaaatatgtagcttatgatt tccgtaaaactctgagatgaaaagaggagatctttgattattttatacatcgaatactaa ^ * ^ * ^ * ^ * ^ * ^ * ctggcaccacaagagtcctgcctttcttttaatctcttaagcagagatgggaaggaactt gaccgtggtgttctcaggacggaaagaaaattagagaattcgtctctacccttccttgaa ^ * ^ * ^ * ^ * ^ * ^ * cctatacggggaaatagcattctgggtattctaatgactacatatgtaaggttaaggacc ggatatgcccctttatcgtaagacccataagattactgatgtatacattccaattcctgg ^ * ^ * ^ * ^ * ^ * ^ * ttaagtttaagttatcaagaaaagtcacagctggcctggtgacaggatttagcaggtaaa aattcaaattcaatagttcttttcagtgtcgaccggaccactgtcctaaatcgtccattt ^ * ^ * ^ * ^ * ^ * ^ * gatgcctgtcccaagtctgagtgtcccatgtttgatccccaagaccctcacagaaggaga ctacggacagggttcagactcacagggtacaaactaggggttctgggagtgtcttcctct ^ * ^ * ^ * ^ * ^ * ^ *

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19621

gtgtcaattctcccaagattggttttttgattgaccgcctccccccaaccctcccacaaa cacagttaagagggttctaaccaaaaaactaactggcggaggggggttgggagggtgttt ^ * ^ * ^ * ^ * ^ * ^ * taaataaaaatgcaatggaaaaaaaattaaggataagccaaaccatgaccagtactaaaa atttatttttacgttaccttttttttaattcctattcggtttggtactggtcatgatttt ^ * ^ * ^ * ^ * ^ * ^ * cctggtttttcttacgggtcctagaaaagaggtaactgagtaaaatgtgacaaaaatgac ggaccaaaaagaatgcccaggatcttttctccattgactcattttacactgtttttactg ^ * ^ * ^ * ^ * ^ * ^ * ctgcatttagtaaatgaagttacagggctgtttcttgtaaggctcataaaataagtctga gacgtaaatcatttacttcaatgtcccgacaaagaacattccgagtattttattcagact ^ * ^ * ^ * ^ * ^ * ^ * tgagtttaggtcaaaatgcatcagattgccccatcctttgagaggttaataagttggctc actcaaatccagttttacgtagtctaacggggtaggaaactctccaattattcaaccgag ^ * ^ * ^ * ^ * ^ * ^ * aaatgtcttgcctggagtgggaactttatacaaccaccctttcctacacagacatgaccg tttacagaacggacctcacccttgaaatatgttggtgggaaaggatgtgtctgtactggc ^ * ^ * ^ * ^ * ^ * ^ * ggaaaaggattgtgtggcccatcgtcgccctagcccagagtctcctgcctcaacactgga ccttttcctaacacaccgggtagcagcgggatcgggtctcagaggacggagttgtgacct ^ * ^ * ^ * ^ * ^ * ^ * tgggcgctcacactctcccacgagtgctgattttcccatgggccaccctgacccagatgg acccgcgagtgtgagagggtgctcacgactaaaagggtacccggtgggactgggtctacc ^ * ^ * ^ * ^ * ^ * ^ * agaactcgttctccaatgacccctgacccagctctcacatgtggcttcaatgcacacaac tcttgagcaagaggttactggggactgggtcgagagtgtacaccgaagttacgtgtgttg ^ * ^ * ^ * ^ * ^ * ^ * HindIII \ tgtttttgttatagaggttccggggtatgagtgaagcttataataaagcagggctaatta acaaaaacaatatctccaaggccccatactcacttcgaatattatttcgtcccgattaat ^ * ^ * ^ * ^ * ^ * ^ * tagaaatttaacgctagatgacccctgcttttgagggtgtggctcaacagagagcattta atctttaaattgcgatctactggggacgaaaactcccacaccgagttgtctctcgtaaat ^ * ^ * ^ * ^ * ^ * ^ * tttaacatgagtaaggccataaatgcaaccccgaatattagaaaaagcaaaaagtacttt aaattgtactcattccggtatttacgttggggcttataatctttttcgtttttcatgaaa ^ * ^ * ^ * ^ * ^ * ^ * gttcgatggcctgtggtctgtaggtattagcaggcctgcctcctttccgtccttgttccc caagctaccggacaccagacatccataatcgtccggacggaggaaaggcaggaacaaggg ^ * ^ * ^ * ^ * ^ * ^ * ctcatcgtggtacttatctgtgtacacaggtagctactttcttttgggactcctgtcatt gagtagcaccatgaatagacacatgtgtccatcgatgaaagaaaaccctgaggacagtaa ^ * ^ * ^ * ^ * ^ * ^ * tcatatctttggaaacttcatgttcaatacctaagcactgtatagatacagtaagcatat agtatagaaacctttgaagtacaagttatggattcgtgacatatctatgtcattcgtata ^ * ^ * ^ * ^ * ^ * ^ * aatcggcacataaaatttgtttactttagagagttaaggaccttcctattaataatcttc ttagccgtgtattttaaacaaatgaaatctctcaattcctggaaggataattattagaag ^ * ^ * ^ * ^ * ^ * ^ *

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20581

tataattctggtcaaagaactgttctgagaaaactggggcatacaattataaattttatg atattaagaccagtttcttgacaagactcttttgaccccgtatgttaatatttaaaatac ^ * ^ * ^ * ^ * ^ * ^ * tgaatacatatttagtcagtaaataccttataaaatgttgccatataaatattaacccta acttatgtataaatcagtcatttatggaatattttacaacggtatatttataattgggat ^ * ^ * ^ * ^ * ^ * ^ * gttctttaacctttaactcccaacatcagtttatctgttagaatccactctgggatatat caagaaattggaaattgagggttgtagtcaaatagacaatcttaggtgagaccctatata ^ * ^ * ^ * ^ * ^ * ^ * tcaagtctctgttcaccaccactaacacaccaagcatgagcgaggatggcagaagaggct agttcagagacaagtggtggtgattgtgtggttcgtactcgctcctaccgtcttctccga ^ * ^ * ^ * ^ * ^ * ^ * tgcctgttattttcccactatttgcttgggaggcagaaagattgcacctgagccaacgaa acggacaataaaagggtgataaacgaaccctccgtctttctaacgtggactcggttgctt ^ * ^ * ^ * ^ * ^ * ^ * attattagtaaatacctcgagagatctgcctgcctttgcttccaagtgctggggtcaaag taataatcatttatggagctctctagacggacggaaacgaaggttcacgaccccagtttc ^ * ^ * ^ * ^ * ^ * ^ * gtgtggaccgttatgatcatcatccctgcatctttctcttggagtcattgttcgtgaaaa cacacctggcaatactagtagtagggacgtagaaagagaacctcagtaacaagcactttt ^ * ^ * ^ * ^ * ^ * ^ * ttctctgctctcttctgtggaatacagaaaaagagataggtgttctcacacaacaaaaag aagagacgagagaagacaccttatgtctttttctctatccacaagagtgtgttgtttttc ^ * ^ * ^ * ^ * ^ * ^ * aaaaggtcaccaatggagaatggcttagggaaggactatacccaaactaacaactactac ttttccagtggttacctcttaccgaatcccttcctgatatgggtttgattgttgatgatg ^ * ^ * ^ * ^ * ^ * ^ * tactacttctccacttcctcccgtcctccccctcctcttcctccttctttgatttttttt atgatgaagaggtgaaggagggcaggagggggaggagaaggaggaagaaactaaaaaaaa ^ * ^ * ^ * ^ * ^ * ^ * tttttttttgagatagggtttctctatatagtcttggctgtcccagaactcactctgtag aaaaaaaaactctatcccaaagagatatatcagaaccgacagggtcttgagtgagacatc ^ * ^ * ^ * ^ * ^ * ^ * atcagactggcttgactcataaagtcatgtctatattccagccagagggattaaaggtgt tagtctgaccgaactgagtatttcagtacagatataaggtcggtctccctaatttccaca ^ * ^ * ^ * ^ * ^ * ^ * gtcattccagccagatcacacagacctagaaggctttggacgtgatcccttgccagagca cagtaaggtcggtctagtgtgtctggatcttccgaaacctgcactagggaacggtctcgt ^ * ^ * ^ * ^ * ^ * ^ * gccatgttattggataaattccttgacagtttgtttttttctgcttttcagtaggctgtg cggtacaataacctatttaaggaactgtcaaacaaaaaaagacgaaaagtcatccgacac ^ * ^ * ^ * ^ * ^ * ^ * agtggctgagtcacagtgtggatgtgacagttaatgatagtctaatgtttagccaactga tcaccgactcagtgtcacacctacactgtcaattactatcagattacaaatcggttgact ^ * ^ * ^ * ^ * ^ * ^ * ctgttcacccggctggacagcacgagaggtgggcttttggttcctctggagtactgataa gacaagtgggccgacctgtcgtgctctccacccgaaaaccaaggagacctcatgactatt ^ * ^ * ^ * ^ * ^ * ^ * gtatacatgctcctgcaaacccctacccatgcttctgtaaacacccaaatgcaactcatg catatgtacgaggacgtttggggatgggtacgaagacatttgtgggtttacgttgagtac ^ * ^ * ^ * ^ * ^ * ^ *

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21601

gagtcatagtgaacaacacacacagacagaagaaagcattggtgtcagagttttattgcc ctcagtatcacttgttgtgtgtgtctgtcttctttcgtaaccacagtctcaaaataacgg ^ * ^ * ^ * ^ * ^ * ^ * acaaagaaacattatgaccatggcacctcttataaaggaaaacatttcattggagctggc tgtttctttgtaatactggtaccgtggagaatatttccttttgtaaagtaacctcgaccg ^ * ^ * ^ * ^ * ^ * ^ * ttacactttcagaggttcggtccattattgtcctgatgggaagcatggcagcatgcaggc aatgtgaaagtctccaagccaggtaataacaggactacccttcgtaccgtcgtacgtccg ^ * ^ * ^ * ^ * ^ * ^ * agacacggtgctggagacagagctgagagttctacatcttgatctgaaggcagcagaaag tctgtgccacgacctctgtctcgactctcaagatgtagaactagacttccgtcgtctttc ^ * ^ * ^ * ^ * ^ * ^ * aaactgcgggccacactgggcataacttgagtatataagacctcaaagccccccaacagt tttgacgcccggtgtgacccgtattgaactcatatattctggagtttcggggggttgtca ^ * ^ * ^ * ^ * ^ * ^ * gacacacctccttcaataaggtcatggctcctaatagtgccattccgtatagccacatgc ctgtgtggaggaagttattccagtaccgaggattatcacggtaaggcatatcggtgtacg ^ * ^ * ^ * ^ * ^ * ^ * atctgtgagggttttcctattcaaaccaccacagttggggagactaattaagaaagggag tagacactcccaaaaggataagtttggtggtgtcaacccctctgattaattctttccctc ^ * ^ * ^ * ^ * ^ * ^ * tagtaagagtgtgagggagataagagtgtaaggcggtgagtatgatcaaaatagaatacg atcattctcacactccctctattctcacattccgccactcatactagttttatcttatgc ^ * ^ * ^ * ^ * ^ * ^ * gggctggggatttagctcagtggtagagcgcttacctaggaagcgcaaggccctgggttc cccgacccctaaatcgagtcaccatctcgcgaatggatccttcgcgttccgggacccaag ^ * ^ * ^ * ^ * ^ * ^ * ggtccccagctccaaaaaaaagaaccaaaaaaaaaaaatagaatatgtacacatgtgaaa ccaggggtcgaggttttttttcttggttttttttttttatcttatacatgtgtacacttt ^ * ^ * ^ * ^ * ^ * ^ * gagttatagtgaaatctatctgaaagaattagcaatactagttaaaataataaagagaat ctcaatatcactttagatagactttcttaatcgttatgatcaattttattatttctctta ^ * ^ * ^ * ^ * ^ * ^ * cttttttttttttttggttctttttttcggagctggggaccgagaatcttaataagttgt gaaaaaaaaaaaaaaccaagaaaaaaagcctcgacccctggctcttagaattattcaaca ^ * ^ * ^ * ^ * ^ * ^ * gagcaagaccttatctgtgaagtttttaaagaaaaataaaggaatgggccaggtaagttg ctcgttctggaatagacacttcaaaaatttctttttatttccttacccggtccattcaac ^ * ^ * ^ * ^ * ^ * ^ * gtacagcccataattccagcacttgggaagatgagacaggaagatcacgagttcgaggcc catgtcgggtattaaggtcgtgaacccttctactctgtccttctagtgctcaagctccgg ^ * ^ * ^ * ^ * ^ * ^ *

21660

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22080

22081

22140

22141

22200

22201

22260

22261

22320

22321

22380

22381

22440

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agtccataccacatatcaaatttaaatctgaccttggctatacagaaagactttgcatag tcaggtatggtgtatagtttaaatttagactggaaccgatatgtctttctgaaacgtatc ^ * ^ * ^ * ^ * ^ * ^ * cgtgtcatatacagaggtaaagctagccgcaaaccattaaactgagaatgggaccccatt gcacagtatatgtctccatttcgatcggcgtttggtaatttgactcttaccctggggtaa ^ * ^ * ^ * ^ * ^ * ^ * ggagaagttagagaaaggattgaaggagctggtgcaaccccataagcataacaatgtcaa

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cctcttcaatctctttcctaacttcctcgaccacgttggggtattcgtattgttacagtt ^ * ^ * ^ * ^ * ^ * ^ * 22621 ccaaccagagctccagggactaaaccattatccaaagactatacatggacagacccaggg ggttggtctcgaggtccctgatttggtaataggtttctgatatgtacctgtctgggtccc ^ * ^ * ^ * ^ * ^ * ^ * ctccagctgcatatgtagcagagaatagccttgatgggcaccaatggaagaagttcttgg gaggtcgacgtatacatcgtctcttatcggaactacccgtggttaccttcttcaagaacc ^ * ^ * ^ * ^ * ^ * ^ * tgctatcaaggttggacccccagtgtaggggaatgtcagggggtggggaatagggaggga acgatagttccaacctgggggtcacatccccttacagtcccccaccccttatccctccct ^ * ^ * ^ * ^ * ^ * ^ * gggttggatagggaggggaacacccttatagaagaagggagggatggaataggggtatgt cccaacctatccctccccttgtgggaatatcttcttccctccctaccttatccccataca ^ * ^ * ^ * ^ * ^ * ^ * ccaggaaactgggaaagggaataacatttgaaatgtaaataaagaaataaccaataaaaa ggtcctttgaccctttcccttattgtaaactttacatttatttctttattggttattttt ^ * ^ * ^ * ^ * ^ * ^ * aaagaaagactttgtattaaagcaaattttagaaagttttttttggggggagggggttga tttctttctgaaacataatttcgtttaaaatctttcaaaaaaaacccccctcccccaact ^ * ^ * ^ * ^ * ^ * ^ * gacagggtatctccgtgtatccctagctgtcctggatttcgttctgtagaccaggctagt ctgtcccatagaggcacatagggatcgacaggacctaaagcaagacatctggtccgatca ^ * ^ * ^ * ^ * ^ * ^ * ctcaaactcacagagatttgcctgcctatgcctcccaagtctgggattaaaggtgtgcac gagtttgagtgtctctaaacggacggatacggagggttcagaccctaatttccacacgtg ^ * ^ * ^ * ^ * ^ * ^ * catcactatcttaaaacaatttttaaatcgaaactgaagacttacaagaaactgaaggat gtagtgatagaattttgttaaaaatttagctttgacttctgaatgttctttgacttccta ^ * ^ * ^ * ^ * ^ * ^ * ttatttgttaataattttagttagcatatcacagaatggatttcattgtgacattttcac aataaacaattattaaaatcaatcgtatagtgtcttacctaaagtaacactgtaaaagtg ^ * ^ * ^ * ^ * ^ * ^ * accagtttatcattgcaccattgtacttatatcatatttatccctgactttacctatatc tggtcaaatagtaacgtggtaacatgaatatagtataaatagggactgaaatggatatag ^ * ^ * ^ * ^ * ^ * ^ * tgtcctacccacccctactgatccccttttgttaccacgtcagattattttagaaataaa acaggatgggtggggatgactaggggaaaacaatggtgcagtctaataaaatctttattt ^ * ^ * ^ * ^ * ^ * ^ * gtttccctatacgagagtagtgtatgatatttatctttgtgagtctgtaaattttattta caaagggatatgctctcatcacatactataaatagaaacactcagacatttaaaataaat ^ * ^ * ^ * ^ * ^ * ^ * atacaaagatctctggttccatccatttctttgcaagcaacattcatttcattcttcctt tatgtttctagagaccaaggtaggtaaagaaacgttcgttgtaagtaaagtaagaaggaa ^ * ^ * ^ * ^ * ^ * ^ * ccttaagtaggcattgccacattttcttcattcattcatctcctaaggggtgttcaaact ggaattcatccgtaacggtgtaaaagaagtaagtaagtagaggattccccacaagtttga ^ * ^ * ^ * ^ * ^ * ^ * gcttccactactttggctactgtgaacagtgctgagagacacacaggtgagcaggttgtt cgaaggtgatgaaaccgatgacacttgtcacgactctctgtgtgtccactcgtccaacaa ^ * ^ * ^ * ^ * ^ * ^ * tctcactgacaggatcttcaaagtttagtccaagaattatctagtcctggttaaaacatg 22680

22681

22740

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22800

22801

22860

22861

22920

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23101

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agagtgactgtcctagaagtttcaaatcaggttcttaatagatcaggaccaattttgtac ^ * ^ * ^ * ^ * ^ * ^ * 23641 cagatgctaagattcttgtcttcatttaatgaggtagaatcttcttagggcccagaaata gtctacgattctaagaacagaagtaaattactccatcttagaagaatcccgggtctttat ^ * ^ * ^ * ^ * ^ * ^ * tgtatttttacaagcactgtaattattacacacagtagtttataaactaacaagattatt acataaaaatgttcgtgacattaataatgtgtgtcatcaaatatttgattgttctaataa ^ * ^ * ^ * ^ * ^ * ^ * tcttcttcttcttcttcttcttcttcttcttcttcttcttcttcttcttcttcttcttct agaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaaga ^ * ^ * ^ * ^ * ^ * ^ * ccttctccttctccttctccttctccttctccttctccttctccttctccttctccttct ggaagaggaagaggaagaggaagaggaagaggaagaggaagaggaagaggaagaggaaga ^ * ^ * ^ * ^ * ^ * ^ * cctccttctccttcttcttttcctcctcctccttcttttcttccttctcctcctcctcct ggaggaagaggaagaagaaaaggaggaggaggaagaaaagaaggaagaggaggaggagga ^ * ^ * ^ * ^ * ^ * ^ * ctttctcctttttcttcttctttttgtcttttttttcttctttgagacaggtctctctac gaaagaggaaaaagaagaagaaaaacagaaaaaaaagaagaaactctgtccagagagatg ^ * ^ * ^ * ^ * ^ * ^ * EcoRI \ atagctctggctgcctggaattcaccatgtagtccaagctggcctttaatgcacagagat tatcgagaccgacggaccttaagtggtacatcaggttcgaccggaaattacgtgtctcta ^ * ^ * ^ * ^ * ^ * ^ * ccatcttcctatgccaagttcaggggattaaaggcatgcactgccactcccagcccccct ggtagaaggatacggttcaagtcccctaatttccgtacgtgacggtgagggtcgggggga ^ * ^ * ^ * ^ * ^ * ^ * gacaagattcctaatgtttattctaaatcttatcttttttttttttaaccacaaaatagc ctgttctaaggattacaaataagatttagaatagaaaaaaaaaaaattggtgttttatcg ^ * ^ * ^ * ^ * ^ * ^ * tctatagaagtgaaggtttcaggaaccttttgagaacacttaacctttggtcaggaagca agatatcttcacttccaaagtccttggaaaactcttgtgaattggaaaccagtccttcgt ^ * ^ * ^ * ^ * ^ * ^ * ggctgacatcatccttaataatgtcactctaatgctactgtcaatgtcattaatattacc ccgactgtagtaggaattattacagtgagattacgatgacagttacagtaattataatgg ^ * ^ * ^ * ^ * ^ * ^ * agtgttcatctgcaccaagtagtgtgccaaaaatggtatacatgtagtctggttaaggaa tcacaagtagacgtggttcatcacacggtttttaccatatgtacatcagaccaattcctt ^ * ^ * ^ * ^ * ^ * ^ * cgctaatgtctattagctaaacatctctaggaactgcctacctgtaagcaaattaagttt gcgattacagataatcgatttgtagagatccttgacggatggacattcgtttaattcaaa ^ * ^ * ^ * ^ * ^ * ^ * aagacttgctgcttccagggaaaacacatatcctgaggaaatggggatgttttccaatag ttctgaacgacgaaggtcccttttgtgtataggactcctttacccctacaaaaggttatc ^ * ^ * ^ * ^ * ^ * ^ * ctgactttagaagagctgtgtctcgaatgtataccttgctagtgtggtttgagagaggtc gactgaaatcttctcgacacagagcttacatatggaacgatcacaccaaactctctccag ^ * ^ * ^ * ^ * ^ * ^ * taaaacagtggaggtctgggtggagaagcccatgtatgaataaggtcttgggttcaatcc attttgtcacctccagacccacctcttcgggtacatacttattccagaacccaagttagg ^ * ^ * ^ * ^ * ^ * ^ * 23700

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ctaccactgccatacacaggaagagagagacaggagtagaggtgaaagggagaggaaagg gatggtgacggtatgtgtccttctctctctgtcctcatctccactttccctctcctttcc ^ * ^ * ^ * ^ * ^ * ^ * agggagagagggaagaaagaaaacaagagaaaaaaaaagctcagaaatttgccagagttg tccctctctcccttctttcttttgttctctttttttttcgagtctttaaacggtctcaac ^ * ^ * ^ * ^ * ^ * ^ * gctatgcacacctgtaatcacagaaccgaagtggctgaggcaggaggactgcagtatgtt cgatacgtgtggacattagtgtcttggcttcaccgactccgtcctcctgacgtcatacaa ^ * ^ * ^ * ^ * ^ * ^ * cagggcttgcttaatgagaccctaggggcgggggctgggggtgggggacaaaactgtaaa gtcccgaacgaattactctgggatccccgcccccgacccccaccccctgttttgacattt ^ * ^ * ^ * ^ * ^ * ^ * taaagaagtaacagtgtaacagtttggtgctgggcttggagggtggtgtgatatgtgtgt atttcttcattgtcacattgtcaaaccacgacccgaacctcccaccacactatacacaca ^ * ^ * ^ * ^ * ^ * ^ * gtgtgtgtgtgtgtgtggtgtgtatggatgtgtgtgtgatgtatgtgtgtgcttgtgtgt cacacacacacacacaccacacatacctacacacacactacatacacacacgaacacaca ^ * ^ * ^ * ^ * ^ * ^ * gtgtgtggtgtgtgtatatgtgtgtatgtgtgtgatgtgtatggatgtgtgggtgtgatg cacacaccacacacatatacacacatacacacactacacatacctacacacccacactac ^ * ^ * ^ * ^ * ^ * ^ * tatgtgtgtgtgttgtgtgtatgtgatatgtgtgagtgtgtgtggtgtgtacgtgatgtg atacacacacacaacacacatacactatacacactcacacacaccacacatgcactacac ^ * ^ * ^ * ^ * ^ * ^ * tgtgagtgtgtgtgtgtaagtgtgtgtgtgtgagtgtgtgtgtatgtgtgtttattagca acactcacacacacacattcacacacacacactcacacacacatacacacaaataatcgt ^ * ^ * ^ * ^ * ^ * ^ * aggctctgctggcatctatgagacattgtatttgataaacaaatagctaaaaagtatttt tccgagacgaccgtagatactctgtaacataaactatttgtttatcgatttttcataaaa ^ * ^ * ^ * ^ * ^ * ^ * aaagtgacggttagtcatttgggcccacaaggacagtacagtgctcagcagcctctgggt tttcactgccaatcagtaaacccgggtgttcctgtcatgtcacgagtcgtcggagaccca ^ * ^ * ^ * ^ * ^ * ^ * ggctgtaggtttgtctttgttcaaacaaaatcactttgaataaccttgtctgaggggact ccgacatccaaacagaaacaagtttgttttagtgaaacttattggaacagactcccctga ^ * ^ * ^ * ^ * ^ * ^ * tattaagacatgtttatatctaacagctgaatagcaggtcctaggcagaggcgctggatc ataattctgtacaaatatagattgtcgacttatcgtccaggatccgtctccgcgacctag ^ * ^ * ^ * ^ * ^ * ^ * aggtgactctgacacaggaggtatacgtcttccctggccttggaagcaagtaattctact tccactgagactgtgtcctccatatgcagaagggaccggaaccttcgttcattaagatga ^ * ^ * ^ * ^ * ^ * ^ * ttcgtacatctttgacggtcttgggcctcacaaccatagaaattttttcctttgttctta aagcatgtagaaactgccagaacccggagtgttggtatctttaaaaaaggaaacaagaat ^ * ^ * ^ * ^ * ^ * ^ * actcaagctggttaccagggacggattttgactcacgtactgtgaaaccaccaaggtgga tgagttcgaccaatggtccctgcctaaaactgagtgcatgacactttggtggttccacct ^ * ^ * ^ * ^ * ^ * ^ * agctagcttaggtcctagagtatcagctcaacatagcctggaaaagccaagatccaaatc tcgatcgaatccaggatctcatagtcgagttgtatcggaccttttcggttctaggtttag ^ * ^ * ^ * ^ * ^ * ^ *

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taggtttgtgtcctgtactgaacaagcaaaccctgtaaagaaaagcagggggaagaggaa atccaaacacaggacatgacttgttcgtttgggacatttcttttcgtcccccttctcctt ^ * ^ * ^ * ^ * ^ * ^ * EcoRI \ taagatcgcctggtctctgttgcactagtcgctgcagtattcgaagaattccagcattct attctagcggaccagagacaacgtgatcagcgacgtcataagcttcttaaggtcgtaaga ^ * ^ * ^ * ^ * ^ * ^ * caattctggggatacttctacgaatgcgcagattcctcccagatttaccaagtataatgg gttaagacccctatgaagatgcttacgcgtctaaggagggtctaaatggttcatattacc ^ * ^ * ^ * ^ * ^ * ^ * aatcaaaatgtagggacgtggacttcaggtcaaaagttcaggctgatgtgctgataaatt ttagttttacatccctgcacctgaagtccagttttcaagtccgactacacgactatttaa ^ * ^ * ^ * ^ * ^ * ^ * taaaaaacggtaagaatcggaataaagcaactctgaccagctagctcatccagggcagcg attttttgccattcttagccttatttcgttgagactggtcgatcgagtaggtcccgtcgc ^ * ^ * ^ * ^ * ^ * ^ * ttggaacacactagagaaccaggcgaatctacagtcaccgccactgaatgcagcccgtaa aaccttgtgtgatctcttggtccgcttagatgtcagtggcggtgacttacgtcgggcatt ^ * ^ * ^ * ^ * ^ * ^ * aagccatccatgaaattccctcagcccggagggccccttttgtgcagttccgctaacaca ttcggtaggtactttaagggagtcgggcctcccggggaaaacacgtcaaggcgattgtgt ^ * ^ * ^ * ^ * ^ * ^ * gcaacaaccctcctgctatatagaccggccccgctctgcctggacactgaactcaccacg cgttgttgggaggacgatatatctggccggggcgagacggacctgtgacttgagtggtgc ^ * ^ * ^ * ^ * ^ * ^ * ggtcagccagccatggggaaggtgagcagaacgcaaactaaacgaaaagtcagactgaac ccagtcggtcggtaccccttccactcgtcttgcgtttgatttgcttttcagtctgacttg ^ * ^ * ^ * ^ * ^ * ^ * cgccttgacccaaggagcaaaagatctcattcagaattgctcttcctttacagatcacct gcggaactgggttcctcgttttctagagtaagtcttaacgagaaggaaatgtctagtgga ^ * ^ * ^ * ^ * ^ * ^ * tctacgaggaccgaggcttccagggccgctgctatgagtgcagcagcgactgccccaacc agatgctcctggctccgaaggtcccggcgacgatactcacgtcgtcgctgacggggttgg ^ * ^ * ^ * ^ * ^ * ^ * tgcagacctacttcagccgctgcaactccatccgcgtggacagtggctgctggatgctct acgtctggatgaagtcggcgacgttgaggtaggcgcacctgtcaccgacgacctacgaga ^ * ^ * ^ * ^ * ^ * ^ * atgagcgccccaactaccagggccaccagtacttcctgcgacgcggggactaccctgact tactcgcggggttgatggtcccggtggtcatgaaggacgctgcgcccctgatgggactga ^ * ^ * ^ * ^ * ^ * ^ * accagcagtggatgggtttcagcgactccattcgctcctgccgcctcatcccccatgtga tggtcgtcacctacccaaagtcgctgaggtaagcgaggacggcggagtagggggtacact ^ * ^ * ^ * ^ * ^ * ^ * gtcctgtttgatttcatttcttgctgccgaggggtcctcactgttttactgatccagaga caggacaaactaaagtaaagaacgacggctccccaggagtgacaaaatgactaggtctct ^ * ^ * ^ * ^ * ^ * ^ * atagggtttgtttgtctgtctgtctgtctgtctgtctgtctgtctgtctgtctgtttgtt tatcccaaacaaacagacagacagacagacagacagacagacagacagacagacaaacaa ^ * ^ * ^ * ^ * ^ * ^ * tgtttgttttttctgagtatctaagtgttaagtggtcctcaaatgcctgcctaagtctaa

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acaaacaaaaaagactcatagattcacaattcaccaggagtttacggacggattcagatt ^ * ^ * ^ * ^ * ^ * ^ * 26641 gagaatacaggcaggaaaacagaattataaggaagaatccactttcagaaggtccagttg ctcttatgtccgtccttttgtcttaatattccttcttaggtgaaagtcttccaggtcaac ^ * ^ * ^ * ^ * ^ * ^ * ttttttgttttgttttttttttaattttctttgctaccattagattaatcaaaagttgtc aaaaaacaaaacaaaaaaaaaattaaaagaaacgatggtaatctaattagttttcaacag ^ * ^ * ^ * ^ * ^ * ^ * ccaacgaatgtaatcttatgcagggatataaaacaaaactagttgggaatgagagggtaa ggttgcttacattagaatacgtccctatattttgttttgatcaacccttactctcccatt ^ * ^ * ^ * ^ * ^ * ^ * ttacactcatcagattgatttttatgtatttaataaagggattcctggtaagggagttaa aatgtgagtagtctaactaaaaatacataaattatttccctaaggaccattccctcaatt ^ * ^ * ^ * ^ * ^ * ^ * ttaaactttattgtggagtagaaaacattgaaaagtacggagatcagaaactgtacgggc aatttgaaataacacctcatcttttgtaacttttcatgcctctagtctttgacatgcccg ^ * ^ * ^ * ^ * ^ * ^ * agaactcaaatgataattttccttagttttgaagatcggctcagttctcattataagcgg tcttgagtttactattaaaaggaatcaaaacttctagccgagtcaagagtaatattcgcc ^ * ^ * ^ * ^ * ^ * ^ * ttatttaaattaactttccacagaagtgtgtgatttttcagaactccactttagccaggc aataaatttaattgaaaggtgtcttcacacactaaaaagtcttgaggtgaaatcggtccg ^ * ^ * ^ * ^ * ^ * ^ * atagtgatagcctggattcctagggtccaggaagctgagacaaaagtattttaagtttga tatcactatcggacctaaggatcccaggtccttcgactctgttttcataaaattcaaact ^ * ^ * ^ * ^ * ^ * ^ * tggtaatctaggttataaaataaacagaatgggacagatggaaatgatatgaaattctca accattagatccaatattttatttgtcttaccctgtctacctttactatactttaagagt ^ * ^ * ^ * ^ * ^ * ^ * aaaaacaaaaatatatataagtaaaaaatcctattttatatataaaaattatatattttt tttttgtttttatatatattcattttttaggataaaatatatatttttaatatataaaaa ^ * ^ * ^ * ^ * ^ * ^ * atgtataaaaatatatataactaaaaaaatactagttaaaatatgtatttgtataccctc tacatatttttatatatattgatttttttatgatcaattttatacataaacatatgggag ^ * ^ * ^ * ^ * ^ * ^ * caacatacagcttagaatgaatataagaaattgtgaattaagatattttaatttttgata gttgtatgtcgaatcttacttatattctttaacacttaattctataaaattaaaaactat ^ * ^ * ^ * ^ * ^ * ^ * tgctcaaattcacttgtaatatcttataagtcccacctcctagatcagtgggttctcaac acgagtttaagtgaacattatagaatattcagggtggaggatctagtcacccaagagttg ^ * ^ * ^ * ^ * ^ * ^ * tctcctaatgccacaaccgtttaaaaaagttccttatgttgtggtgaccccatgccataa agaggattacggtgttggcaaattttttcaaggaatacaacaccactggggtacggtatt ^ * ^ * ^ * ^ * ^ * ^ * aattccttttgttgctacttcctaactgtaattttgctactgtcgcgtatcataatatag ttaaggaaaacaacgatgaaggattgacattaaaacgatgacagcgcatagtattatatc ^ * ^ * ^ * ^ * ^ * ^ * atacccgtgttttccgatggtcttaagccatcactgtaaacaggtcattggacctataga tatgggcacaaaaggctaccagaattcggtagtgacatttgtccagtaacctggatatct ^ * ^ * ^ * ^ * ^ * ^ * ttgagaaccactgttctaaatgaaaagaaacctgggcgtctctaatgcgagcaggagacc 26700

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aactcttggtgacaagatttacttttctttggacccgcagagattacgctcgtcctctgg ^ * ^ * ^ * ^ * ^ * ^ * 27661 catccatgaatagctctccaaaatccgtcaggctcagatcttactccaacagccccctgc gtaggtacttatcgagaggttttaggcagtccgagtctagaatgaggttgtcgggggacg ^ * ^ * ^ * ^ * ^ * ^ * ctcacccgttgtttagcttgggtgagttctggaagagactcaactgctcttttctcatct gagtgggcaacaaatcgaacccactcaagaccttctctgagttgacgagaaaagagtaga ^ * ^ * ^ * ^ * ^ * ^ * ttctttgtgtgacccaagcagacaggttcccacaggatgcgtctgtatgagaaagaagat aagaaacacactgggttcgtctgtccaagggtgtcctacgcagacatactctttcttcta ^ * ^ * ^ * ^ * ^ * ^ * cacaaaggcgtcatgatggagctgagtgaagactgctcctgcatccaggaccgcttccac gtgtttccgcagtactacctcgactcacttctgacgaggacgtaggtcctggcgaaggtg ^ * ^ * ^ * ^ * ^ * ^ * ctcagtgaggtgcgctcgctgcacgtgctagagggctgctgggtcctctatgagatgcct gagtcactccacgcgagcgacgtgcacgatctcccgacgacccaggagatactctacgga ^ * ^ * ^ * ^ * ^ * ^ * aactaccgaggccggcagtatctgctgaggcctcaagagtaccggcgctaccacgactgg ttgatggctccggccgtcatagacgactccggagttctcatggccgcgatggtgctgacc ^ * ^ * ^ * ^ * ^ * ^ * 27720

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ggcgctgtagatgctaaggcaggctctttgcggagggtggtagatttatactaaaatagg ccgcgacatctacgattccgtccgagaaacgcctcccaccatctaaatatgattttatcc ^ * ^ * ^ * ^ * ^ * ^ * tgaacgctaccattttctcattttggaacctaataaagtatttagtctgtattgttggca acttgcgatggtaaaagagtaaaaccttggattatttcataaatcagacataacaaccgt ^ * ^ * ^ * ^ * ^ * ^ * aaccttgacttctgttattctttcattgtgtgcaaatacatccacctgtaaactctccct ttggaactgaagacaataagaaagtaacacacgtttatgtaggtggacatttgagaggga ^ * ^ * ^ * ^ * ^ * ^ * acagaaggtggagctgagaatggagaggttagggtgttcaagaactttttaatggtgtta tgtcttccacctcgactcttacctctccaatcccacaagttcttgaaaaattaccacaat ^ * ^ * ^ * ^ * ^ * ^ * actttgaacaagtcttagatggctggggatctatgtatgtgtctcagtgatagagctttt tgaaacttgttcagaatctaccgacccctagatacatacacagagtcactatctcgaaaa ^ * ^ * ^ * ^ * ^ * ^ * attcagtgtgcacaaggtcctgggctcgatccctaacactaccagaaagaaaagaaaaaa taagtcacacgtgttccaggacccgagctagggattgtgatggtctttcttttctttttt ^ * ^ * ^ * ^ * ^ * ^ * gttcaggtggagggagactgtacctggtgtggtagggagggtacaccacgtgggggaggg caagtccacctccctctgacatggaccacaccatccctcccatgtggtgcaccccctccc ^ * ^ * ^ * ^ * ^ * ^ * tgtactgtgttggggagggtacaccatgtgggggagggtgtaccatgtgggggaggttat acatgacacaacccctcccatgtggtacaccccctcccacatggtacaccccctccaata ^ * ^ * ^ * ^ * ^ * ^ * accatgtgggggagggtacaccatgtgggggagggtatactgtgttggggaaggtatacc tggtacaccccctcccatgtggtacaccccctcccatatgacacaaccccttccatatgg ^ * ^ * ^ * ^ * ^ * ^ * atggtaggagggtatagctgccggacaatgaaaggccaggtcaagctgaagacacggcaa taccatcctcccatatcgacggcctgttactttccggtccagttcgacttctgtgccgtt ^ * ^ * ^ * ^ * ^ * ^ *

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28621

caagacaaactaccagggaggaagtagttatctgacaaccttgaagaacaacacagtcaa gttctgtttgatggtccctccttcatcaatagactgttggaacttcttgttgtgtcagtt ^ * ^ * ^ * ^ * ^ * ^ * agttgtcttctaatcctggaagtgattggagtccaatgttgacaaacagcctatcaagac tcaacagaagattaggaccttcactaacctcaggttacaactgtttgtcggatagttctg ^ * ^ * ^ * ^ * ^ * ^ * tcataagagaactaatttcatttactatagaacacaatatcacctaaacaagactagagg agtattctcttgattaaagtaaatgatatcttgtgttatagtggatttgttctgatctcc ^ * ^ * ^ * ^ * ^ * ^ * tgacaccaacctcacaaagttaaaacccacttccttctgaaaccattcccaatgagaaag actgtggttggagtgtttcaattttgggtgaaggaagactttggtaagggttactctttc ^ * ^ * ^ * ^ * ^ * ^ * agtcttagccatccaatctaaacagtcctccattaagactcttcctgttgggcagtaatg tcagaatcggtaggttagatttgtcaggaggtaattctgagaaggacaacccgtcattac ^ * ^ * ^ * ^ * ^ * ^ * gtacaggcctttaattccagcactcgggaagcagaggcagggggacgtctgagttcgaag catgtccggaaattaaggtcgtgagcccttcgtctccgtccccctgcagactcaagcttc ^ * ^ * ^ * ^ * ^ * ^ * aggccaacctggtctacagagtgagttccaggacagccagagtttgtacagagagaaacc tccggttggaccagatgtctcactcaaggtcctgtcggtctcaaacatgtctctctttgg ^ * ^ * ^ * ^ * ^ * ^ * ctgtttggggggttggggtgggcaggtgggactttctttccaagtcattttgggttgtgt gacaaaccccccaaccccacccgtccaccctgaaagaaaggttcagtaaaacccaacaca ^ * ^ * ^ * ^ * ^ * ^ * caagttgctgattgtattattacatttctatttccattgtcatcaaaaggaacttataaa gttcaacgactaacataataatgtaaagataaaggtaacagtagttttccttgaatattt ^ * ^ * ^ * ^ * ^ * ^ * HindIII \ agaaagcatgtgtttaagcttatagttccagaagggagtccataatggctggggagtcat tctttcgtacacaaattcgaatatcaaggtcttccctcaggtattaccgacccctcagta ^ * ^ * ^ * ^ * ^ * ^ * gacagctaatgcatgcactaggggcaaactggaagtgggcaaaggctgtaagtctcagct ctgtcgattacgtacgtgatccccgtttgaccttcacccgtttccgacattcagagtcga ^ * ^ * ^ * ^ * ^ * ^ *

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HindIII \ cgccccagtgacaaacttccttccctgaggccgtacctcccaaaagaccttctccaagct 29340 gcggggtcactgtttgaaggaagggactccggcatggagggttttctggaagaggttcga ^ * ^ * ^ * ^ * ^ * ^ * tttccacctcctagggaccaagtgttcacatttgtgagactaaggaaacttcttatagaa aaaggtggaggatccctggttcacaagtgtaaacactctgattcctttgaagaatatctt ^ * ^ * ^ * ^ * ^ * ^ * accacaacaattaaggctacccaccacagccattcataaccttaccacttcacaaattct tggtgttgttaattccgatgggtggtgtcggtaagtattggaatggtgaagtgtttaaga ^ * ^ * ^ * ^ * ^ * ^ * atgaatagaaaagtaaaaagtcctcctagtaccagacaatgctcatttatatttggtggg tacttatcttttcatttttcaggaggatcatggtctgttacgagtaaatataaaccaccc ^ * ^ * ^ * ^ * ^ * ^ * cacctcctgggaggcttccctattcacagagctgaaacagaaatacatattaatttgcaa gtggaggaccctccgaagggataagtgtctcgactttgtctttatgtataattaaacgtt ^ * ^ * ^ * ^ * ^ * ^ * 29400

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29580

29581

tgtttgtttgttacaagacaggatctacgctgctcatgccagcttcaatctttctatctt acaaacaaacaatgttctgtcctagatgcgacgagtacggtcgaagttagaaagatagaa ^ * ^ * ^ * ^ * ^ * ^ * agcttcatgagtgatggcattataagtgggtgtcactatgtagggctgtatgctgtgtta tcgaagtactcactaccgtaatattcacccacagtgatacatcccgacatacgacacaat ^ * ^ * ^ * ^ * ^ * ^ * aaaaaatgtaatccatatgaagttatatttaagtcaatgtcttattctggttcacagctt ttttttacattaggtatacttcaatataaattcagttacagaataagaccaagtgtcgaa ^ * ^ * ^ * ^ * ^ * ^ * agtggtgtgcattgttcagaggttccctaaatcaccacatcttttcctcattgtttactg tcaccacacgtaacaagtctccaagggatttagtggtgtagaaaaggagtaacaaatgac ^ * ^ * ^ * ^ * ^ * ^ *

29640

29641

29700

29701

29760

29761

29820

29821

ggctcttagacacaaaggtacaagcaaatcactatacacaggctctctcatgtggacatg ccgagaatctgtgtttccatgttcgtttagtgatatgtgtccgagagagtacacctgtac ^ * ^ * ^ * ^ * ^ * ^ * ccatagtttcaggagagtagagatccagacagaaggctgactgtttatagtgaaagttgt ggtatcaaagtcctctcatctctaggtctgtcttccgactgacaaatatcactttcaaca ^ * ^ * ^ * ^ * ^ * ^ * ttgcttgttggttttttttttttttttccaggagctgaggaccgaacccaggccttgcgc aacgaacaaccaaaaaaaaaaaaaaaaggtcctcgactcctggcttgggtccggaacgcg ^ * ^ * ^ * ^ * ^ * ^ * ttgctaggcaagtgatctaccactgagctaaatccccaacccctgtttacttgtttttaa aacgatccgttcactagatggtgactcgatttaggggttggggacaaatgaacaaaaatt ^ * ^ * ^ * ^ * ^ * ^ * attttatttctatgggttgcccagtggttgactactaagatagagtctttacagtttact taaaataaagatacccaacgggtcaccaactgatgattctatctcagaaatgtcaaatga ^ * ^ * ^ * ^ * ^ * ^ * gagcatctgtcatgggattgctatccttgagtatgaaacagcacccaaaagtctccctac ctcgtagacagtaccctaacgataggaactcatactttgtcgtgggttttcagagggatg ^ * ^ * ^ * ^ * ^ * ^ * taccactgagccgaatctagaaatacagttacataccaactcggggagatc atggtgactcggcttagatctttatgtcaatgtatggttgagcccctctag ^ * ^ * ^ * ^ * ^ *

29880

29881

29940

29941

30000

30001

30060

30061

30120

30121

30180

30181

30240 ^ *