Terbinafine Hydrochloride:

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TERBINAFINE
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Terbinafine Hydrochloride - Pharmacological action - antifungal, fungicidal. Are affected, yeastlike and mold
fungi. It strikes the cytoplasmic membranes of fungus cells, it specifically inhibits and it disrupts the synthesis
of ergosterol, causing fungicidal effect. It is active with respect to practically all fungi, pathogenic for the man,
but most of all - red (minimum inhibiting concentration it is 0,001-0,06 g/ml) and pathogenic yeast(s) - mold,
also of the mycelial forms of the kind of Candida.
Because of the Terbinafine Hydrochloride's effect “first passage” compose about 40%. Cmax - 1 g/ml, is
reached for 2 h after method at the dose of 250 mH. In the vascular channel practically completely (to 99%) it
is connected with the proteins of plasma. Histohematic barriers are passed and it is distributed along the
cloths; high concentrations are accumulated in the skin (in such cases in the sebaceous glands and hair
follicles) and subcutaneous cellular tissue. It is characterized by expressed by epidermis and By 2-1 days
after method 250 mH the concentration in the horny layer of the skin grows 10, by the 12th day - 70. The
diffusion rate exceeds the rate of growth in the nail. 1/2 of terminal phase is 200-400 h. Before the excretion it
undergoes biotransformation with the formation of inactive metabolites of Terbinafine. About 70% of the dose
accepted are derived with the urine. During the single putting 100 l of cream on the surface of the skin with an
area of 30 sn2 in the urine is revealed with 3,5% of dose.
With onychomycoses of brushes the result of treatment composes 95%, with onychomycoses the stop - more
than 90%. It is effective with the mold micose, the trichophytosis, Trichophyton purpureum infection,
epidermophytosis, with plural onychomycosis. In the form cream use with the intertriginous micose the stop
also of brushes, Trichophyton purpureum infections of smooth skin and many-colored lichen. Remission is
reached in 75-95% of patients with chronic of smooth skin. The treatment of patients with progressive
candidiasis of smooth skin and injury of large and interdigital folds, caused by Candida albicans, resistance to
the therapy by nystatin.