SAMPLE OBJECTIVES: AMAT 180: Introduction to Biomathematics Unit II: Modeling involving Group activity: Mathematical Ordinary Differential

modeling using Simultaneous Equations (Topic: Cellular Decision network and CinquinDifferentiation) Demongeot ODE model At the end of the unit, the student At the end of the activity, the should be able to: student should be able to: 1. translate a basic cellular 1. identify situations where the differentiation process into simultaneous decision mathematical equations; network and the Cinquin2. perform mathematical and Demogeot ODE model can be numerical analysis to used; examine the qualitative 2. explain the meaning of the behavior of the model; and state variables and parameters 3. interpret mathematical results of the ODE model; relevant to the biology of 3. describe the qualitative cellular differentiation behavior of the ODE model process and gene regulatory using established theorems; networks. and 4. examine the limitations of the Cinquin-Demongeot model.

At the end of the course, the student should be able to: 1. classify the types of models that could be used to represent a biological system; 2. discuss the assumptions necessary for a particular mathematical technique to be effective; 3. translate basic biological ideas into mathematical expressions; 4. perform mathematical calculations to analyze the model; and 5. interpret mathematical results relevant to the biological problem.

2. a) how the objectives as written reflect alignment from course to unit to activity, and b) how they represent outcomes of significance for your course/training? a) Everything follows the standard mathematical modeling process. From choosing an appropriate model (including determining the advantages and disadvantages), to formulating models, to solving the model (in this case examining the qualitative behavior), to biological interpretation. b) The activity is very significant because Cinquin-Demongeot model is one of the general models for representing mutually inhibiting biological and social systems (such as gene regulatory networks). 3. how the objectives reflect the uniqueness of the online environment? Mathematical modeling is a complex skill and partnership with other mathematical modelers is essential. By online collaboration (with groupmates), the students will be able to discuss (identify, explain, describe) the Cinquin-Demongeot model.