Hydrogel-Based Tissue Adhesive to Replace Sutures

Lindsey Sanders (lindses@clemson.edu) Jiro Nagatomi, PhD (jnagato@clemson.edu)

Department of Bioengineering Clemson University

o Increase of laparoscopic and robotic surgeries (e.g.

partial removal of kidney)

o Suturing of bleeding organ in tight space within a small

window of time poses a major challenge

Injectable Surgical Adhesive

Need & Enabling Prevents excess bleeding Improve Clinical Outcome Avoids suturing complications

Cost Effective & Time Saving Reduction in surgery time

Benefits Ease of application to site

Adhesive/ Sealant Biologically Derived

Examples Tisseel - Baxter BioGlue - CryoLife DermabondTM - Ethicon

Limitations Limited mechanical strength Possible hypersensitivity and calcification Limited compliance Toxic for internal use Mechanical weakness Swelling

Cyanoacrylate Coseal - Baxter

Synthetic Polymer

DurasealTM - Confluent Surgical

Spotnitz et al., Transfusion (2008).

Modified Tetronic (multi-functional 4-arm polymer)

+
Crosslinker

Strong bond to tissue High compliance Low cytotoxicity Rapid curing without UV light Negligible swelling High durability

80 Bond Strength (kPa) 70 60 50 40 30 20

10
0

MedMarket Diligence Report #S190.

Surgeons can reduce / eliminate complications in over 143 million procedures each year

MedMarket Diligence Report #S190.

Accomplishments to date
2010 - NIH grant awarded 2013 - Provisional patent filed Ex vivo study data to 2014 be submitted for publications

Funding needed for

Animal studies (2014 - 6) Production scale-up (2014 5) Additional functionalization (hemostasis, 2014) (scar-inhibition, 2015) Design of application device and packaging (2015-6)