Lujan Soto Eduardo

Farmacologa I

TAREA FARMACOLOGA. DOSIS EXTRAVASCULAR

T(h)

Cp (mcg/mL)

LnCp

ABC

0.25

1.91

0.647103242

0.61125

2.98
3.54
3.8
3.84
3.62
3.04
2.49
2.04
1.67
1.37

1.091923301
1.264126727
1.335001067
1.345472367
1.286474026
1.111857515
0.91228271
0.712949808
0.512823626
0.31481074

0.815
0.9175
1.91
1.865
3.33
2.765
2.265
1.855
1.52
17.85375

Extrapolacin
5.15994025
4.913320568
4.67848809
4.454879445
4.039213521

Cp^-Cp
3.24994025
1.933320568
1.13848809
0.654879445
0.199213521

Ln(Cp^-Cp)
1.178636612
0.659239026
0.129701145

Absorcin

0.5
0.75
1
1.5
2
3
4
5
6
7

Mxima

Eliminacin

T (h)

Cp (mcg/mL)

0.25
0.5
0.75
1
1.5

1.91
2.98
3.54
3.8
3.84

-0.423304113

-1.61337806

PARMETROS FARMACOCINETICOS
K (h-1)

Ka (min-1)

T 1/2 (h)

Cp mx
(mcg/mL)

Tmx (h)

Cp (mcg/mL)

Cl (mL/h)

Vd (mL)

ABC (slo
trapecios)
(mcgh/mL)

ABC (Cp
utlimo)
(mcgh/mL)

0.1959

2.2341

3.538270447

3.84

1.5

5.418938784

17.85375

24.84711396

1.5

y = -0.1959x + 1.6899
R = 0.9996

1
y = -2.2341x + 1.7735
R = 0.9989

Ln Cp

0.5
0
0

-0.5
-1
-1.5
-2

Tiempo (H)