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ANEXOS

Problema #3 inciso a)
Control
Modelo lineal.

Modelo Lineal

Modelo lineal
DOSIS
E
10

25

10

52.63

30

76.92

80
60

%E

100

y = 2.1081x + 17.949
R = 0.8846

40
20
0
0

10

20

30

40

Dosis

Modelo Logartmico.
Modelo Logartmico
LOGD
10
0
25
0.477121255
52.63
1
76.92
1.477121255
E

Modelo logartmico
100
y = 46.144x + 7.0576
R = 0.9892

80
60
40
20
0
0

0.5

Modelo Hiperblico.

0.3

3.22

10

25

10

52.63

30

76.92

100

91.74

1/E
1/Dosis
3.333 0.310559006
1.000
0.1
0.333
0.04
0.100
0.01900057
0.033
0.01300052
0.010 0.010900371

0.4
y = 0.0902x + 0.01
R = 1

0.3

1/E

%E
(Ctrl)

1.5

Modelo Hiperblico

Modelo hiperblico
Dosis
mg/kg

0.2
0.1
0
0.000

1.000

2.000

3.000

4.000

1/D

Modelo de Hill.

Ecuacin de Hill

Ec. Hill
Dosis
mg/kg
0.3

%E
(Ctrl)
3.22

-0.522878745

10

25

0.477121255

0.333333333

-0.477121255

10

52.63

1.111040743

0.045729985

30

76.92

1.477121255

3.332755633

0.522803471

-1

100

91.74

11.10653753

1.045578688

-1.5

log Dosis

1.5

(E/Emax-E)
Log (E/Emax-E)
0.033271337
-1.477929746
0.111111111
-0.954242509

1
0.5
0
-1

-0.5 0

-2

y = 1.0002x - 0.9545
R = 1

Anlogo X
Modelo lineal
Modelo lineal
DOSIS
E
0.3

13.04

33.33

60

10

83.33

Efecto

Modelo lineal
100
80
60
40
20
0

y = 6.3147x + 24.85
R = 0.8314

10

15

Dosis

Modelo Logartmico.

Modelo Logartmico

Modelo Logartmico
LOGD

13.04

-0.522878745
0
0.477121255
1

60
83.33

Efecto

80

E
33.33

100
60

y = 47.027x + 36.206
R = 0.9957

40
20
0

-1

-0.5

0.5

1.5

3.000

4.000

Log D

Modelo Hiperblico.
Modelo hiperblico
%E (Ctrl)

0.3

13.04

33.33

60

10

83.33

30

93.75

100

98.04

1/Dosis
3.333
1.000
0.333
0.100
0.033
0.010

Modelo hiperblico

1/E
0.076687117
0.030003
0.016666667
0.01200048
0.010666667
0.010199918

0.1

1/E

Dosis
mg/kg

0.05
0
0.000

y = 0.02x + 0.01
R = 1

1.000

2.000

1/D

Modelo de Hill.

Ec. de Hill

EC. Hill
%E
(Ctrl)

log Dosis

0.3

13.04

-0.522878745

0.149954002

-0.82404194

33.33

0.499925004

-0.301095141

60

0.477121255

1.5

0.176091259

10

83.33

4.99880024

0.698865782

30

93.75

1.477121255

15

1.176091259

100

98.04

50.02040816

1.699147231

(E/Emax-E)

Log (E/Emax-E)

Log (e/(Emax-E))

Dosis
mg/kg

-1

y = 1.0001x - 0.3011
1.5
R = 1
1
0.5
0
-0.5
-1

Log D

Anlogo Y
Modelo lineal

Modelo Lineal

Modelo lineal
DOSIS
E
13.86

32.33

10

60.62

30

80.83

y = 2.0493x + 24.368
R = 0.8356

80

Efecto

100
60
40
20
0
0

10

20

30

40

Dosis

Modelo Logartmico

Modelo logartmico
100

Efecto

Modelo Logartmico
E
LOGD
13.04
-0.522878745
33.33
0
60
0.477121255
83.33
1

50

y = 47.027x + 36.206
R = 0.9957

0
-1

-0.5

0.5

1.5

3.000

4.000

Log D

Modelo Hiperblico.

Modelo hiperblico

Modelo hiperblico
Dosis
mg/kg

%E (Ctrl)

0.3

4.62

13.86

1.000

0.072150072

32.33

0.333

0.030931024

10

60.62

0.100

0.016496206

30

80.83

0.033

0.012371644

100

91.51

0.010

0.010927767

1/E
1/Dosis
3.333 0.216450216
1/E

0.25

y0.2
= 0.0618x + 0.0103
R = 1
0.15
0.1
0.05
0
0.000

1.000

2.000

1/D

Modelo de Hill

Ec. de Hill
EC. Hill

%E
(Ctrl)

log Dosis

(E/Emax-E)

Log
(E/Emax-E)
1.314815343
0.793441637
0.320790472

0.3

4.62

-0.522878745

0.048437828

13.86

0.160900859

32.33

0.477121255

0.477759716

10

60.62

1.539360081

0.18734022

30

80.83

1.477121255

4.21648409

0.624950466

100

91.51

10.77856302

1.032560865

1.5

Log (E/(Emax-E))

Dosis
mg/kg

-1

1
0.5

y = 0.9391x - 0.7909
R = 0.9982

0
-0.5 0

-1
-1.5

Log D