Drug Data Classification Mechanism of Action Indication Contraindications Adverse Reaction Nursing Responsibilities

Generic Name Pharmacologic Interferes with bacterial cell wall General Indications Concentrations CNS: Lethargy, hallucinations, Before
Penicillin G Classification synthesis during active - Severe infections - Allergies to penicillins, seizures - Observe 15 rights of drug
Benzathine Penicillin multiplication, causing cell wall caused by sensitive cephalosporins, or administration.
death and resultant bactericidal organisms (streptococci) other allergens GI: Glossitis, stomatitis, gastritis, - Reduce dosage with hepatic or
Trade Name Therapeutic Class activity against susceptible - URTI caused by sore mouth, furry tongue, black renal failure.
Precaution
Penadur Anti-infective, bacteria. sensitive streptococci “hairy” tongue, nausea, vomiting, - Assess for hypersensitivity to drug.
- Renal disorders
Antibiotic - Treatment of syphilis, diarrhea, abdominal pain, bloody - Assess for any contraindications to
Pharmacokinetics - Pregnancy
Minimum Dose bejel, congenital syphilis, diarrhea, enterocolitis, the drug.
- Lactation
300,000 units IM Pregnancy Risk pinta, yaws pseudomembranous colitis, - Educate about side effects of
Factor D: Crosses placenta; enters breast - Prophylaxis of nonspecific hepatitis drug.
milk Drug interaction
Maximum Dose B rheumatic fever and
M: Hepatic Drug to drug
2.4 million units IM chorea GU: Nephritis During
E: Urine - Decreased
weekly for 3 weeks - Drug is not for IV use. Do not
effectiveness with
inject or mix with other IV solutions.
Drug Half Life tetracyclines Hematologic: Anemia,
Contents - Give IM injection in upper outer
30-60 min - Inactivation of thrombocytopenia, leukopenia,
Benzathine quadrant of the buttock.
parenteral neutropenia, prolonged bleeding
benzylpenicillin - Avoid contact with the needle.
aminoglycosides itme - Withdraw needle as quickly as
(amikacin, gentamicin,
Availability and possible to avoid discomfort.
kanamycin, neomycin, Hypersensitivity: Rash, fever,
color - Stay with patient throughout whole
tobramycin) wheezing, anaphylaxis
- Injection: duration of administration.
600,000, 1.2 Drug to food Local: Pain, phlebitis, thrombosis
million, 2.4 million After
- none reported at injection site, Jarisch-Herxheimer
units/dose - Monitor client for at least 30
reaction when used to treat syphilis minutes.
Routes of - Arrange for regular follow-up,
Other: Superinfections, sodium including blood tests, to evaluate
administration
overload leading to heart failure effects.
Intramuscular
- Instruct to report difficulty
breathing, rashes, severe pain at
injection site, mouth sores, unusual
bleeding or bruising.
- Instruct to take medication as
directed for the full course of
therapy, even if feeling better.
- Do proper documentation.

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Karch, Amy: 2009 Karch, Amy: 2009 Karch, Amy: 2009 Lippincott’s Nursing Drug Karch, Amy: 2009 Lippincott’s Karch, Amy: 2009 Lippincott’s Karch, Amy: 2009 Lippincott’s Nursing Drug Karch, Amy: 2009 Lippincott’s Nursing Drug
Lippincott’s Nursing Drug Lippincott’s Nursing Drug Guide, pp. 929, Nursing Drug Guide, pp. 929 Nursing Drug Guide, pp. 929 Guide, pp. 930 Guide, pp. 930
Guide, pp. 929 Guide, pp. 929 http://www.merck.com/mmpe/print/lexicomp/
penicillin%20g%20benzathine.html