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Based on Panduka sirs lecture.

A little different
with pharmacology lecture
VOMITING CENTER
In medulla oblongata
of brain stem
Chemoreceptor trigger zone
In Floor of 4
th
ventricle in area of
postrema
Stimulated by,
Drugs : Anticancer, opiates,
digoxin, alcohol
Endogenous molecules: uraemia,
radiation, acidosis, hypoxia

Receptors: 5HT3, D2, H1, ACh M1
DRUGS USED IN Mx
1] Serotonin receptor
blockers
2] Dopamine receptor
blockers
3] Antihistamines
4] Anti muscarinic

Vestibular apparatus
In middle year
Vestibular nuclei Cerebellum
Stimulated by,
Motion sickness
Menieres disease
Other vestibular disorders


Receptors : H1, Ach M1
DRUGS USED IN Mx
1] Anti histamines
2] Anti cholinergics
GIT and Vagus nerve
Stimulated by,
Irritation
Overstimulation
Overdistension
Acute MI- vagal stimulation

Receptors : 5HT3
DRUGS USED IN Mx
1] Serotonin receptor blocker
Cortical
input
Stimulated by,
Smells
Tastes
Thoughts
Increased ICP

Receptors :Cannabinoids?????
DRUGS USED IN Mx
1] Anxiolytics