DETERMINACIN DE LA SOLUBILIDAD , PEMEABILIDAD Y CLASIFICACIN DE

MEDICAMENTOS
MEDICAMENTO SOLUBILIDAD ML PERMEABILIDAD CLASIFICACIN
Acetysalicylic Acid Vs=500mg/3mg/ml= 1666.6ml Alta
P=I.18<: 1.7165
Baja
GRUPO III
Acyclovir Vs= 800mg/IOmg/ml= 80ml Alta
P=- 1.59< 1.7165
Baja
GRUPO III
Alendronate Sodium Vs= 70mg/33mg/ml= 2.12ml Alta P=-0.17< 1.7165 GRUPO III
Allopurinol Vs= 300mg/0.1 mg/ml= 3000ml Baja
P=0.32<1.7165
Baja
GRUPO IV
Alprazolam Vs= 2mg/0.01mg/ml= 200ml Alta
P=4.23>1.7165
Alta
GRUPO 1

Amitriptyline
Hydrochloride
Vs= 100mg/l00mg/ml= lml Alta
P=4.42> 1.7165
Alta
GRUPOI
Amlodipine Besylate Vs= 10mg/lmg/ml= lOml Alta
P=3.65> 1.7165
Alta
GRUPO 1
Amoxicillin Vs= 875mg/4mg/ml= 218.75ml Alta
P=4.42< 1.7165
Baja
GRUPO III

Amphetamne(mixed
sal ts)
Vs= 30mg/100mg/ml= 0.3ml Alfa
P= 1.394< 1.7165
Baja
GRUPO III
Atenolol Vs= I00mg/26.5mg/ml=3.77ml Alta
P=0.50< 1.7165
Baja
GRUPO III
Atorvastatin Calcium Vs= 80mg/0.1 mg/ml= 8000ml Baja
P=5.05> 1.7165
Alta
GRUPO II

Benazepril
Hydrochloride
Vs= 40mg/33mg/ml= 1.21 mi Alta
P=3.03> 1.7165
Alta
GRUPO 1
Bisoprolol fumarate Vs= 10mg/33mg/ml=0.30ml Alta
P= ],94< 1.7165
Baja
GRUPO III

Bupropion
Hydrochloride
Vs= I00mg/312mg/ml=0.32ml Alta
P=2.7I> 1.7165
Alta
GRUPOI

Buspirone
Hydrochloride
Vs= 30mg/1000mg/ml= 0.03ml Alta
Caplopril Vs= 100mg/l00mg/ml= lml Alta
P=0.24< 1.7165
Baja
GRUPO III
Carbamazepine Vs= 200mg/0.01mg/ml= 2000ml Baja
P=2.93> 1.7165
Alta
GRUPO II
Carbidopa Vs= 25mg/lmg/ml= 25ml Alta
P=0.37< 1.7165
Baja
GRUPO III
Carisoprodol
Vs 350mg/0.48rng/ml= 729. ?ml
Baja
P=-2.89< 1.7165
Baja
GRUPO IV
Carvedilol Vs= 25mg/0.01mg/ml= 2500ml Baja
P=3.12> 1.7165
Alta
GRUPO II
Cephalexin Vs= 500mg/lmg/mN 500ml Baja
P=-0.67< 1.7165
Baja
GRUPO IV

Cetirizine
Hydrochloride
Vs= 10mg/100mg/ml=0.1ml Alta
P=3.11> 1.7165
Alta
GRUPOI
Cimetidine Vs= 800mg/)mg/ml= 800ml Baja
P=0.79< 1.7165
Baja
GRUPO IV

Clprofloxacin
Hydrochloride
Vs= 750mg/10mg/ml= 75ml Alta
P= 1.32< 1.7165
Baja
GRUPO III

Citalopram
Hydrobromide
Vs= 40mg/10mg/ml= 4ml
Al t a
P=3.86> 1.7165
Alta
GRUPO 1
Clarthromycin

Clindamycin
Hydrochloride

Clonazepam Vs= 2mg/0.0 1 mg/ml= 200ml Alta
P=2.18> 1.7165
Alta
GRUPO 1
Clonldine Vs= 0.3mg/80mq/ml= 0.0037ml P=2.78> 1.7165 GRUPO 1


Hydrochloride Alta Alta

(
Clopidogrel Bisulfate
Vs= 75mg/)00mg/ml= 0.75ml Alta P=3.74> 1.7165
Alta
GRUPO 1

Codeine Phosphate
Vs= 60mg/100mg/ml= O.ml Alta P= 1.45< 1.7165
Baja
GRUPO III
Cyclobenzaprine
Hydrochloride
Vs= 10mg/100mg/ml=0.1ml Alta P=4.31> 1.7165
Alta
GRUPO 1

Desloratadine
Vs= 5mg/l mg/ml= 5ml Alta P=3.56> 1.7165
Alta
GRUPO 1

Desogestrel
Vs=0.16mg/0.01mg/ml= 16ml Alta P=4.40> 1.7165
Alta
GRUPO 1

Diazepam
Vs= 10mg/0.01mg/ml= lOOOml Baja P=4.40> 1.7165
Alta
GRUPO II

Digoxin
Vs= 0.25mg/0.01 mg/ml= 25ml Alta
P= 1.25< 1.7165
Baja
GRUPO III
Diltlazem
Hydrochloride
Vs= 120mg/100mg/ml= 1.2ml
Al t a
P=2.64> 1.7165
Alta
GRUPO 1

Doxazocin Mesylate
Vs= 8mg/8mg/ml= 1 mi Alta P=2.27> 1.7165
Alta
GRUPO 1

Doxycline
Vs= 100mg/0.1mg/ml= lOOOml Baja P=-3.66< 1.7165 Baja
GRUPO IV

Enalapril Malate
Vs= 20mg/25mg/ml= 0.8ml Alta P= ].77> 1.7165 Alta
GRUPO 1

Estradiol Vs= 2mg/0.01mg/ml= 200ml
Al ta
P=3.91> 1.7165 Alta
GRUPO 1

Ethinyl Estradiol
Vs= 0.5mg/0.01mg/ml= 50ml Alta P=4> 1.7165
Alta
GRUPO 1

Famotldine
Vs= 40mg/0.1 mg/ml= 400ml Baja
P=-0.03< 1.7165
Baja
GRUPO IV

Fenofibrate
Vs= 200mg/0.0 1 mg/ml= 20000ml Baja P=4.75> 1.7165 Alta
GRUPO II
Fexofenadine
Hydrochloride
Vs= I80mg/lmg/ml= 180ml Alta P=6.03> 1.7165 Alta
GRUPO 1

Fluconazole
Vs= 200mg/lmg/ml= 200m Alta
P=0.99< 1.7165
Baja
GRUPO III
Fluoxetine
Hydrochloride
Vs= 40mg/33mg/ml= 1.21 mi Alta P=4.27> 1.7165
Alta
GRUPO 1

Folie Acid
Vs= lmg/0.1mg/ml= lOml Alta P=-0.52< 1.7165 Baja
GRUPO III

Fosinopril Sodium
Vs= 40mg/100mg/ml= 0.4ml Alta

Furosemide Vs= 80mg/0.01 mg/ml= 8000ml
Baja
P=0.74< 1.7165
Baja
GRUPO IV

Gabapentin
Vs= 800mg/100mg/ml= 8ml Alta P= 1.K 1.7165
Baja
GRUPO III

Gemfibrozil
Vs= 600mg/0.01mg/ml= 6000ml Baja
P=4.41> 1.7165
Alta
GRUPO II

Glimepiride
Vs= 4mg/0.01mg/ml= 400ml Baja P=2.59> 1.7165 Alta
GRUPO II

Gliplzlde
Vs= lOmg/O.OImg/mh lOOOml Baja P= 1.55< 1.7165
Baja
GRUPO IV

Glyburlde Vs= 6mg/0.01mg/ml= 600ml
Baja
P=3.53> 1.7165 Alta
GRUPO II

Hydrochlothlazlde
Vs= 50mg/l mg/ml= 50ml Alta P=-0.15< 1.7165 Baja
GRUPO III

Hydrocodone Bitartrate
Vs= 10mg/33mg/ml=0.30ml Alta P= 1.29< 1.7165
Baja
GRUPO III
Hydroxyzlne
Hydrochloride
Vs= 50mg/l000mg/ml= 0.5ml Alta P=3.33> 1.7165
Alta
GRUPO 1

Ibuprofen Vs= 800mg/0.01mg/ml= 80000ml
Baja
P=3.14> 1.7165
Alta
GRUPO III

Irbesartan
Vs= 300mg/0.01mg/ml= 30000ml Baja P=5.03> 1.7165
Alta
GRUPO II
Isosorbide Mononitrate Vs= 20mg/l00mg/ml= 0.2ml Alta P=- 1.67< 1.7165
Baja
GRUPO III
Lansoprazole Vs= 30mg/0.01 mg/ml= 3000ml
Baja
P=2.78> 1.7165
Alta
GRUPO II
Levodopa Vs= 250mg/l mg/ml= 250ml Alta
Levofloxacin Vs= 750mg/50mg/ml= 15ml
Alta
P= 1.35< 1.7165
Baja
GRUPO III
Levonorgestrel Vs= 0.75mg/0.0l mg/ml= 75ml Alta P=3.06> 1.7165
Alta
GRUPO 1
Levothyroxine sodium Vs= 0.3mg/0.15mg/ml= 2ml
Alta
P=7.36> 1.7165
Alta
GRUPO 1
Llsinopril Vs= 40mg/97mg/ml= 0.41 mi
Alta
P=0.91< 1.7165
Baja
GRUPO III
Loratadine Vs= 10mg/0.01mg/ml= lOOOml
Baja
P=4.13> 1.7165
Alta
GRUPO II
Lorazepam Vs= 2mg/0.08mg/ml= 25ml
Alta
P=3.64> 1.7165
Alta
GRUPO 1
Lozartan Potassium Vs= 100mg/100mg/ml= lml Alta
Meclizine
Hydrochloride
Vs= 50mg/0.01 mg/ml= 5000ml
Baja
P=6.22> 1.7165
Alta
GRUPO II
Medroxiprogesterone
Actate
Vs= 10mg/0.01mg/ml= lOOOml
Baja
P=2.69> 1.7165
Alta
GRUPO II
Metaxalone Vs= 800mg/0.1 mg/ml= 8000ml
Baja
P=2.24> 1.7165
Alta
GRUPO II
Metformin
Hydrochloride
Vs= 1000mg/l00mg/ml= lOml Alta P=0.15< 1.7165
Baja
GRUPO III
Methylphenidate
Hydrochloride
Vs= 20mg/100mg/ml= 0.2ml
Alta
P=2.1> 1.7165
Alta
GRUPO 1
Methylprednlsolone Vs= 32mg/1000mg/ml= 0.032ml
Alta
P=0.81< 1.7165
Baja
GRUPO III
Metoclopramide
Hydrochloride
Vs= 10mg/1000mg/ml=0.01ml Alta P= 1.48< 1.7165
Baja
GRUPO III
Metoprolol tartrate Vs= 100mg/1000mg/ml=0.tml Alta P= 1.72> 1.7165
Alta
GRUPO 1
Metronidazole Vs= 500mg/10mg/ml= 50ml
Alta

Minocycllne
Hydrochloride
Vs= 100mg/33mg/ml= 3.03ml
Alta
P=-2.76< 1.7165
Baja
GRUPO III
Mlrtazaplne Vs= 45mg/lmg/ml= 45ml Alta P=3.22> 1.7165
Alta
GRUPO 1
Montelukast sodium Vs= I0mg/100mg/ml=0.0lml Alta P=8.45> 1.7165
Alta
GRUPO 1
Naproxen sodium Vs= 500mg/33mg/ml= 15.l5ml Alta P=2.86> 1.7165
Alta
GRUPO 1
Nitedlpine Vs= 20mg/0.0l mg/ml= 2000ml
Baja
P= 2.31 > 1.7165
Alta
GRUPO II
N'rtroturantoin Vs= 100mg/0.19mg/ml= 526.3ml
Baja

Norethindrone Vs= lmg/0.01mg/ml= lOOml Alta P=2.64> 1.7165
Alta
GRUPO 1
Norgestimate Vs= 0.25mg/0.0l mg/ml= 25ml Alta P=3.67> 1.7165
Alta
GRUPO 1
Nortrlptiline
Hydrochloride
Vs= 75mg/33mg/ml= 2.27ml
Alta
P=4.25> 1.7165
Alta
GRUPO 1
Nystatin Vs= 100mg/4mg/ml= 25ml
Alta

Olanzapine Vs= 20mg/0.01 mg/ml= 2000ml
Baja

Oxybutynin chloride Vs= 5mg/100mg/ml= 0.05ml
Alta
P=4.12> 1.7165
Alta
GRUPO 1
Oxycodone
Hydrochloride
Vs= 30mg/100mg/ml= 0.3ml
Alta
P=0.36< 1.7165
Baja
GRUPO III
3
Paracetamol Vs= 500mg/0.1 mg/ml= 5000ml
Baja
P=0.89< 1.7165
Baja
GRUPO IV
Paroxetine
Hydrochloride
Vs= 40mg/54mg/ml= 7.41 mi
Alta
P=3.49> 1.7165
Alta
GRUPO 1
Penicillin V Potassium Vs= 500mg/33mg/ml= 15.15ml
Alta
P=0.48< 1.7165
Baja
GRUPO III
Phenytoin (chewable) Vs= 50mg/0.01mg/ml= 5000ml
Baja
P=2.14> 1.7165
Alta
GRUPO II
Phenytoin sodium Vs= 100mg/l00mg/ml= Iml Alta P=2.14> 1.7165
Alta
GRUPO 1
Pioglitazone
Hydrochloride
Vs= 45mg/0.01mg/ml= 4500ml
Baja
P=3.58> 1.7165
Alta
GRUPO II
Pravastatin sodium Vs= 80mg/33mg/ml= 2.42ml
Alta
P= 1.69< 1.7165
Baja
GRUPO III
Prednisolone Vs= 5mg/0.1mg/ml= 50ml
Alta
P=2.51> 1.7165
Al ta
GRUPO 1
Promethazine
Hydrochloride
Vs= 50mg/1000mg/ml= 0.05ml
Alta
P=4.81> 1.7165
Alta
GRUPO 1
Propoxyphene
Hydrochloride
Vs= 65mg/100mg/ml= 0.65ml
Alta
P=4.81> 1.7165
Alta
GRUPO 1
Propanolol
Hydrochloride
Vs= 90mg/33mg/ml= 2.72ml
Alta
P=2.65> 1.7165
Alta
GRUPO 1
Pseudoephedrine
Hydrochloride
Vs= 60mg/2000mg/ml= 0.03ml Alta P= 1.38< 1.7165
Baja
GRUPO III
Quetiapine fumarate Vs= 300mg/10mg/ml= 30ml
Alta
P=3.91> 1.7165
Alta
GRUPO 1
Quinaprll
Hydrochloride
Vs= 40mg/100mg/ml= 0.4ml
Alta
P=3.17> 1.7165
Alta
GRUPO 1
Raloxifene
Hydrochloride
Vs= 60mg/0.1mg/ml= 600ml
Baja
P=5.78> 1.7165
Alta
GRUPO II
Ramipril Vs= 10mg/33mg/ml=0.30ml Alta P=2.48> 1.7165
Alta
GRUPO 1
Ranitidine
Hydrochloride
Vs= 300mg/1000mg/ml= 0.3ml Alta
Risedronate Sodium Vs= 35mg/33mg/ml= 1.06ml
Alta
P=0.83< 1.7165
Baja
GRUPO III
Risperidone Vs= 4mg/0.0lmg/ml= 400ml Baja P=2.10> 1.7165
Alta
GRUPO II
Rofecoxib Vs= 50mg/0.01 mg/ml= 5000ml
Baja
P= 1.83> 1.7165
Alta
GRUPO II
Rosiglitazone Malate Vs= 8mg/33mg/ml= 0.24ml
Alta
P=3.21> 1.7165
Alta
GRUPO 1
Sertraline
Hydrochloride
Vs= 100mg/3.8mg/ml=26.32ml
Al ta
P=5.03> 1.7165
Alta
GRUPO 1
Sildenafil Citrate Vs= 100mg/3.5mg/ml=28.57ml Alta P=2.12> 1.7165
Alta
GRUPO 1
Simvastatin Vs= 80mg/0.03mg/ml= 2666.6ml
Baja
P=4.39> 1.7165
Alta
GRUPO II
Sprionolactone Vs= I00mg/0.01mg/ml= lOOOOml
Baja
P=2.90> 1.7165
Alta
GRUPO II
Sulfamethoxazole Vs= 800mg/0.0l mg/ml= 80000ml
Baja
P=0.86< 1.7165
Baja
GRUPO IV
Sumatripan Succinate Vs= 100mg/100mg/ml= lml Alta
Tamoxifen Citrate Vs= 20mg/0.lmg/ml= 200ml Alta P=6.07> 1.7165
Alta
GRUPO 1
Tansulosim
Hydrochloride
Vs= 0.4mg/10mg/ml= 0.04ml Alta P=2.69> 1.7165
Alta
GRUPO 1
Temazepam Vs= 30mg/0.lmg/ml= 300ml
Baj a
P=3.32> 1.7165
Alta
GRUPO II
Terazosin
Hydrochloride
Vs= 10mg/100mg/ml=0.lml
Al ta
P= 1.13< 1.7165
Baja
GRUPO III
Tetracycline Vs= 500mg/33mg/ml= 15.15ml
4
Hydrochloride Alta
Timolol Malate Vs= 20mg/33mg/ml= O.Oml
Al t a
P=2.34> 1.7165
Alta
GRUPO 1
Totterodlne tartrate Vs= 2mg/12mg/ml= 0.16ml
Alta
P=5.0> 1.7165
Alta
GRUPO 1
Tramadol
Hydrochloride
Vs= 50mg/33mg/ml= 1.52ml
Alta
P=2.53> 1.7165
Alta
GRUPO 1
Trazodone
Hydrochloride
Vs= 300mg/10mg/ml= 30ml Alta P=2.94> 1.7165
Alta
GRUPO 1
Triamterene Vs= 100mg/0.01mg/ml= lOOOOml
Baja
P= 2.11> 1.7165
Alta
GRUPO II
Trimethopim Vs= 200mg/0.4mg/ml= 500ml
Baja
P= 1.43< 1.7165
Baja
GRUPO IV
Valaciclovir
Hydrochloride
Vs= 1000mg/174mg/ml= 5.75ml
Alta
P=-1.06< 1.7165
Baja
GRUPO III
Valdecoxib Vs= 20mg/0.01 mg/ml= 2000ml
Baja

Valsaran Vs= 320mg/lmg/ml= 320ml Baja P=4.57> 1.7165
Alta
GRUPO II
Venlafaxine
Hydrochloride
Vs= 100mg/572mg/ml=0.17ml Alta P=2.81> 1.7165
Alta
GRUPO 1
Verapamil
Hydrochloride
Vs= 120mg/83mg/ml= 1.44ml Alta P=5.69> 1.7165
Alta
GRUPO 1
Warfarim sodium Vs= 10mg/l000mg/ml=0.01ml Alta P=2.97> 1.7165
Alta
GRUPO 1
Zolpidem tartrate Vs= 10mg/23mg/ml= 0.43ml
Alta
P=3.35> 1.7165
Alta
GRUPO 1