BI 105Introductory Cell Biology

Spring 2013
Dr. Erin Gerecke
GENER! C"#RSE IN$"R%&I"N
This syllabus serves as a guide for you to refer to throughout the semester. It includes my contact
information, course information and policies, point totals and the grading scale, tips for doing well in the
course, and a lecture and exam schedule. 'le()e keep t*i) docu+ent ,or ,uture re,erence. If you lose
it, you may download another from Moodle (http://moodle.butler.edu.
E-+(il. egerec!e"butler.edu
'*one/0oice+(il. #$%&#$'#
"1ce. (allahue )'#
"1ce *our). *+), T/Th or by appointment many other times during the wee!
Re2uired te3t. Foundations of LifeChemistry, Cells, and Genetics (,nits *, ), and -. /aven, 0ohnson,
Mason, 1osos, 2inger. Mc(raw&3ill. This is an excerpt of the 4rst section of a longer textboo!. the complete
textboo! (Biology, 9th ed., /aven et al. is also acceptable for this course. 5ew and used copies of the
truncated textboo! are available from the 6utler 6oo!store and elsewhere. 7 copy of the complete
textboo! is also on )&hr reserve in the 2cience 1ibrary. 5ew copies purchased from the boo!store include
access to Mc(raw&3ill 8onnect 9lus, an on&line study resource. :ou may purchase access to 8onnect 9lus
separately if you buy a used boo!. 7ccess is not re;uired for the course, but you may 4nd the diagnostic
;ui<<ing application, tutorials, 1earn2mart study modules, etc. to be useful study tools, and I strongly
encourage you to use them. 3owever, again, you don=t have to buy a textboo! with online components.
:ou may be tempted to sell your boo! when you are done with the course, but you should 4nd it a useful
resource for your remaining biology courses at 6utler. 9lan on !eeping it and your course notes for at least
the next few years.
C"#RSE "B4EC&I5ES
This introductory biology course will prepare you for additional coursewor! in the biological sciences that
will be re;uired of you as 8>932 students, most immediately 9rinciples of Immunology (6I -)- and
9rinciples of 9athogenic Microbiology (6I -)'. This course provides a rigorous overview of important
introductory concepts relevant to cell biology, genetics, and related 4elds only and has no laboratory
component. I%'"R&N&. ?or these reasons, this course will not substitute for introductory courses
re;uired of biology ma@ors, or for the 8ore 8urriculum 5atural Aorld re;uirement and may or may not
transfer to other courses of study. It is for 8>932 students only. 9lease see me and/or your advisor if you
have ;uestions about how this course 4ts into your program of study.
Topics to be covered:
B the structure, function, and interrelationships of important cellular molecules
B the structure and function of cellular components
B energy transformations within the cell
B cell communication
B cellular reproduction
B sexual reproduction and early animal development at a cellular level
B the role of genes in determining traits and cellular activities
B various relationships between genes, cellular activities, and human disease
This course also will introduce you to the processes used to generate a body of scienti4c !nowledge. In
other words, what is science and how does it wor!C 0ust !nowing something about the content of biology is
not enough for a science professional, because there is no way to !now everything and because biology is
a dynamic 4eld. 5ew information leads to new theories and the modi4cation or abandonment of old ideas.
It is important for you to understand this process so you can attempt to evaluate new ideas and
information as they come along. Ae will examine:
B the goals and assumptions of science in general and biology in particular and how they have
changed over time
B the basic methodology of biologists and how this scienti4c discipline operates in the DrealE world
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B the limited nature of scienti4c truth, i.e., its inherent uncertainty
This introductory science course will also introduce you to the expectations of college coursewor! in
biology and give you the opportunity to practice the s!ills you will need to be successful, such as study
strategies for learning biology concepts, time management s!ills, etc.
6"7 8"#R GRDE IS DE&ER%INED
E3(+).
?our unit exams will be given during the semester on the dates shown on the course schedule. the fourth
unit exam will be part of the nal exam. Tests will consist of multiple&choice ;uestions and other ;uestion
formats, including short essay. Multiple&choice ;uestions will be answered on 2cantron formsFplease bring
a G) pencil on exam days. !uestions often will as" you to go beyond regurgitation of facts and denitions
to tie ideas together or apply what you ha#e learned to no#el situations . $lease prepare for this as you
study. Hach unit exam will be worth '% points, and will cover material spanning several wee!s of study.
Ahile these exams will not be speci4cally designated as cumulative, !eep in mind that this course contains
information that builds on itself. therefore, information from earlier in the semester will continue to be used
throughout the semester, and you will need to remember information for the whole semester to be
successful. To reward you for this eIort, a '%&point cumulative section will constitute the second part of the
4nal exam. 2uccessful mastery of course material throughout the semester will help you earn a good
grade on the 4nal exam, and it will give you the bac!ground you need to be successful in upper&level
biology courses in your 8>932 program.
9ui::e).
Jui<<es will be given throughout the course at the beginning of class on designated days (see schedule.
Jui<<es are designed to help you !eep on trac! with studying the material in a timely manner and will help
you (and me determine your understanding of basic vocabulary and study topics prior to exams. Hach of
the # ;ui<<es will be worth ' points, for a total of $' points. Jui<<es are a reKection of your on&going
comfort level with class material and are typically a good predictor of what your exam grade might be. ?or
example, if you consistently earn $ or ' points out of ' total on your ;ui<<es, it shows that you have solid
initial mastery of course topics. with continued study and reinforcement, you are in good position to earn
an 7 or 6 on the unit exam. 3owever, if you earn only a ) or - out of ', you should use the ;ui< content to
identify gaps in your understanding or test&ta!ing strategies that you can address as you continue
studying and wor! toward better mastery, which should translate to a higher grade on the unit exam. (If
you are earning lower ;ui< grades and ma!e no changes in your preparation, you might expect to earn
only '%L+M%L on the test, which translates to a lower overall course grade.
6o+e;ork.
:our main daily homewor! is to review your lecture notes between classes, use the relevant sections of
your boo! to 4ll in missing details in your notes, organi<e and memori<e vocabulary, learn to use the
vocabulary to describe important concepts, tie related concepts together, and prepare to demonstrate
your understanding on ;ui<<es and exams. I will not give you speci4c assignments from your boo! or from
the 8onnect online software, but be advised that there are practice ;uestions throughout each chapter as
well as at the end that can help you assess your understanding, and the 8onnect software that comes with
the boo! also has tutorials, animations, and 1earn2mart study modules for additional practice. 3owever, to
give you some DbuIerE points toward your grade that do not depend on your performance on a ;ui< or
exam, I will also assign a few speci4c outside assignments on a roughly wee!ly basis that are worth up to
$' points toward your grade. In some cases, you will wor! with a partner to enhance your ability to tal!
through and describe the biological concepts you are studying. These assignments are meant to enrich
and extend your understanding of the various topics we will examine during the semester and in some
cases also explore their Dreal&worldE applications. 2uccessful completion of these assignments will be
helpful toward earning a good grade in the course (and are lower&stress ways to practice concepts and
earn points outside of ;ui<<es and exams.
Su++(ry o, cour)e point).
Three in&class unit exams " '% points each *'% points
?inal exam (half on the last unit material. half cumulative *%% points
Jui<<es (# ;ui<<es " ' pts. each $' points
>ther assignments N% points
2
&"&! '"IN&S. 355 point)
:our 4nal letter grade is based solely on the total number of points at the end of the semester. :ou can
determine your current grade at any time by adding up your points earned and dividing by the total points
possible to date. 9oints will be assigned according to the Oepartment of 6iological 2ciences grading scale.
percentages are rounded up to the nearest whole percent. 7t the end of the semester, I will loo! closely at
each student=s point totals and try to be as fair as possible to each student as well as the entire class in
borderline cases:
7 #)&*%%L 7& #%&#*L 6P QQ&Q#L 6 Q)&QML
6& Q%&Q*L
8P MQ&M#L 8 M)&MML 8& M%&M*L OP NQ&N#L
O N)&NML
O& N%&N*L ? R N%L
C"#RSE '"!ICIES
ttend(nce.
(ood attendance is critical to your success in this class, because a large number of detailed topics will be
covered very ;uic!ly, and you will li!ely want my help in distilling the !ey points and drawing connections
among them. Thus, your attendance and participation are expected. I do not formally deduct points for
class absencesFbut !eep in mind that missing class will li!ely cause you to under&perform on assignments
and exams. If you miss an occasional class, please do not e&mail me simply to as! me to tell you what you
missed. get the notes from one or more classmates and use 9ower9oint outlines that are posted for each
class period. If you become ill or have some other valid reason for missing class for an extended period of
time and you=re worried about its eIect on your performance, feel free to consult with me after you have
made eIorts on your own to get caught up on notes.
If you !now in advance that you must miss an exam and have a good reason (for example, participation in
an intercollegiate athletic event, you %#S& cont(ct +e in ( timely manner BE$"RE t*e e3(+ (i.e.,
not the day before so that ma!e&up arrangements can be made. 9lease chec! the syllabus for important
class events 6H?>/H ma!ing plans for vacation periods, since personal travel is 5>T a good excuse for
missing an exam, except under extraordinary circumstances. If you wa!e up on the day of an exam and
have an unexpected emergency situation, please call or e&mail me before class if possible so that I !now
what=s going on. Ma!e&up exams, especially without prior notice, will be granted "N!8 for a legitimate
excuse, such as illness, a death in the family, etc., that can be documented and that you initiate (in other
words, I will not see! you out to ma!e up missed materialFyou must contact me in a timely manner to
ma!e up missing wor!. Ma!e&up exams will be somewhat diIerent from those given to the rest of the
class. Ma!e&up ;ui<<es may be given at my discretion for intercollegiate athletic activities, illness, etc.
Ma!e&up ;ui<<es will not be given to students who are simply late for class, have an unexcused absence, or
who abuse the ma!e&up policy.
c(de+ic *one)ty.
9lease do your own wor! in this class. 8heating (such as copying another individual=s test answers, using
outside materials during tests or ;ui<<es, etc. is forbidden, as is plagiarism. $lagiarism is a form of
cheating and is de4ned by the 2tudent 3andboo! as Dthe fraudulent misrepresentation of any part of
another=s wor! as one=s own.E 9lagiarism thus includes but is not limited to copying assignments from past
or present students, or published or Internet resource materials, failing to cite the sources of ideas or
information (especially in written wor!, using direct ;uotes without ;uotation mar!s, or insuScient
paraphrasing of ideas from other sources (changing one or two words is not suScient and should be
accompanied by a citation, as well as copying someone else=s answers on homewor!, ;ui<<es, and exams.
5o form of cheating will be tolerated in this course. the formal procedures outlined in the 2tudent
3andboo! will be instigated if cheating is discovered. This can result in a <ero on the assignment or exam.
however, a failing grade for the course may be warranted, and a letter may be submitted to your academic
4les. If you have ;uestions or concerns about what constitutes plagiarism, especially on written
assignments, please as" me, consult the online 6utler 1ibrary tutorial on plagiarism, or contact the Ariter=s
2tudio. It is your responsibility to understand what constitutes plagiarismFignorance of the rules is not an
acceptable defense. :our integrity as a student and as a future health professional is at sta!e on this issue:
I and the directors of the 8>932 programs ta!e academic honesty very seriously, and so should you. The
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bottom line: Please submit your own individual efort on written assignments, unless explicitly
stated that you should work with a partner, and do not supply another students answers or
use outside resources on quizzes and exams
Re2ue)t) ,or (c(de+ic (cco++od(tion).
It is the policy and practice of 6utler ,niversity to ma!e reasonable accommodations for students with
properly documented disabilities. Aritten noti4cation from 2tudent Oisability 2ervices is re;uired. If you
are eligible to receive an accommodation and would li!e to re;uest it for this course, please discuss it with
me and allow one wee! of advance notice. >therwise, it is not guaranteed that the accommodation can be
received on a timely basis. 2tudents who have ;uestions about 2tudent Oisability 2ervices or who have, or
thin! they may have, a disability (psychiatric, attentional, learning, vision, hearing, physical, medical, etc.
are invited to contact 2tudent Oisability 2ervices for a con4dential discussion in 0ordan 3all *-N or by
phone at x#-%Q.
%i)cell(neou).
Co++unic(tion9lease chec! your 6utler e&mail account and Moodle regularly for announcements and
assignments. I have a class listserv that I can use to contact everyone by e&mail, and I can use e&mail to
communicate with you individually. /emember that e&mail is a ;uic! and convenient but professional mode
of communicationFplease do not use DtextingE dialog and spelling when using e&mail. I will try to respond
to you within one business day in most cases.
Buy ( )t(pler7ny document with more than one page that you turn in should be stapled, so the pages
do not get lost. Oog&earing or paper clipping pages simply causes others= wor! to stic! to yours or causes
pages to be lost and is not eIective. I will not carry a stapler around with me, and I expect you to have
your documents stapled to hand in. :ou can buy small staplers for a couple of dollars. Multi&page unstapled
documents will lose *%L of the points for not following through on this re;uest. Than! you for helping me
!eep your important documents organi<ed while they are in my possession.
&I'S $"R S#CCESS IN BI"!"G8 C!SS
!ou must take responsibility "or your own education It ta!es a lot of dedication to do well in a
college biology class, even if you did well in similar courses in high school (and even more if you feel your
high school bac!ground is wea!. It=s a diIerent ballgame. Ae pic! up the pace, rely on you to wor!
independently outside of class, and expect that you will ta!e the initiative to learn the material and answer
;uestions that go beyond simple memori<ation. 2tudying involves learning vocabulary and describing
complex concepts, which is diIerent than studying for chemistry class, for example. It=s a language&
intensive process. I=m here to help as much as I can and to test you on the material, but ultimately it is you
who must put in the time and eIort on your own to learn it. Time management and study s!ills are very
important. If you feel li!e you need help in this area, contact the 1earning /esource 8enter for information
on study s!ills wor!shops and other forms of academic support. I=m happy to recommend personal
strategies, as well.
ttend cl())< eli+in(te di)tr(ction) =cell p*one)< te3ting< $(ce>ook< etc.?< (nd >e re(dy to >e
(n (cti0e p(rticip(nt. The material moves ;uic!ly, and class time is the only time to 4nd out what I=m
stressing from your reading and hear explanations of more diScult material. Missing class also causes you
to miss ;ui<<es and other point&earning opportunities, which can lower your overall grade. Ahen you
attend class, I expect that you are ready to participate. 6e prepared with the e;uipment you need to ta!e
notes (see below, to answer ;uestions based on a brief perusal of the reading (see below, and to as!
;uestions when you are confused. 9lease do not come to class with the sole intention of sleeping, chatting
(in person or electronically, or texting, and do not use our time together to distract yourself, other
students, or me by multitas!ing with electronic devices. ?or example, if you are chec!ing ?aceboo! during
lecture, you=re probably not ta!ing complete notes, and your screen may divert a neighbor=s attention from
the same tas!. Oo not leave and re&enter the room unnecessarilyFta!e care of personal tas!s before or
after class. 8lass time is still an interpersonal experience and one that re;uires focus on the tas! at hand
for '% minutesFplease ta!e advantage of our time together to maximi<e your learning, and be respectful
of my time, your time, and the time of your fellow classmates.
&(ke note) in cl()) (nd ;*en you )tudy. This does not mean you must record verbatim everything I
say or copy every word from every 9ower9oint slide. 9ower9oints will be posted on 6lac!board, so you can
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go bac! and ma!e sure you have complete notes. 2o be sure to listen carefully, and outline separately the
important vocabulary and concepts from what I=ve said or noted in writing. Ahat have I emphasi<edC
1ater, go bac! and review these terms and concepts while reading in the text (you may 4nd you can s!ip
certain sections or examples, if I noted that they are more detailed than what I=ve as!ed you to focus on.
Most of the diagrams and 4gures I display in class are also in your boo!. :ou will also want to ta!e
additional notes when you study and practice writing out lists of related vocabulary words and describing
important concepts on your own when you read the text. If you only glance at the 4gures or only use a
highlighter, you aren=t really processing the information through the language centers of your brain. :ou
will be better able to recall information and communicate it to me on an exam if you=ve practiced writing
the information yourself. That=s why I want you to ta!e your own notes in class rather than simply glancing
at a 9ower9oint outline that you printed out right before class.
$or+ good )tudy *(>it). ?or example, ma!e sure you actually read the assigned material. %"im the
assigned chapter in the text before coming to class (this should ta!e only a few minutes. This way, you
will have a general idea of what I plan to cover that day and will have a familiarity with the vocabulary,
even if you don=t necessarily understand everything you read the 4rst time through (which is normalT. I do
not want to spend lecture time spoon&feeding you the materialFthat=s boring (and ta!es too long. I=d
rather use the time to organi<e the information, emphasi<e the important points, explain more diScult
concepts, explore ideas in diIerent ways, and answer your ;uestions. 2oon after class, read the material
7(7I5, more thoroughly this time, using your class notes as a guide for 4nding the important 4gures,
vocabulary, and connections between ideas (and to discern what material in your textboo! you can ignore
for the purposes of this class. :ou=ll be surprised how much more ma!es sense this way. 1earning biology
ta!es time, eIort, and repetition for mastery. good rule o, t*u+> ,or (ny college cl()) i) t*(t you
)*ould )pend t;o *our) )tudying out)ide o, cl()) ,or e0ery one *our in cl()). That=s about right
for this one, if you study regularly throughout the wee! between class sessions. >f course, additional study
time will be needed when preparing for ;ui<<es and exams.
Re0ie; ,re2uently (nd in )+(ll c*unk). In other words, !eep up with the pace of the class. &his li"ely
means studying a little e#ery day, in between each class session. If you wait until the last minute and then
try to cram for ;ui<<es or exams, you will not earn the best grade you probably are capable of. 9arcel
information into small units into your head, and you=ll be better oI. This will ensure that you do well on
both ;ui<<es and exams, and you will be able to as! me ;uestions as they arise.
%e+ori:e 0oc(>ul(ry< >ut don@t )top t*ere. I will be testing you not only on your ability to remember
important vocabulary, concepts, processes, etc., but also on your ability to apply what you=ve learned to
new situations or to build connections between concepts (many of which have very similar&sounding
terminology. >nce you feel comfortable with the basic vocabulary, start thin!ing about how to use the
vocabulary to eIectively describe a biological concept or process. Ma!e lists of !ey vocabulary that
describe particular processes that we explore, and ma!e sure you can actually use those vocabulary words
eIectively to describe the process. Try writing out a paragraph that describes something we=ve tal!ed
about in class, using the appropriate terms as you go. (:ou can get feedbac! from classmates, the peer
tutors, or me if desired. This will help you thin! of the broader importance of why a term is important.
7lso, loo! for how various processes interconnect, or how they are similar to or diIerent from other
concepts we=ve studied. I=ll try to emphasi<e these connections in classFbe on the loo!out for them. :ou
must learn all three levelsFvocabulary, concepts/processes, applications/extensionsFto be successful on
exams.
)k 2ue)tion) in cl()). ' can(t tell where you(re confused unless you tell me. If you=re confused, so is
someone else, so don=t be shy about spea!ing up. I will stop fre;uently to entertain ;uestions, and I expect
to hear them. I=m also happy to answer ;uestions one&on&one: +(ke (n (ppoint+ent to )ee +e or
0i)it t*e )tudy t(>le) i, you@re lo)t.
$or+ ( )+(ll )tudy group o, (>out t*ree people. >ne of the best ways to organi<e your descriptions
about a topic you have studied on your own it is to try explaining the material to others. Aor!ing with a
small group occasionally can be a good way to reinforce your understanding, be ;ui<<ed on your
!nowledge, and clear up your misconceptions.
5
Get *elp () )oon () you t*ink you need it. If, in spite of good attendance, note&ta!ing, and study
habits you 4nd you are having diSculty with the course material, please feel free to come see me for help.
I try to ma!e myself available to you outside of class during oSce hours or whenever it is mutually
convenient, but you need to ta!e the initiative to see! me out. Individual appointments can be made by
contacting me in person before or after class or by e&mail. this guarantees that I=ll be around when you
want to see me. 9lease also use the free study tables and peer tutoring provided by the ,niversity. 1imited
one&on&one tutoring is also available through the 1earning /esource 8enter.
6
BI 105 &ent(ti0e Cl()) Sc*eduleSpring 2013
D(te %7$ Cl()) )c*edule &e3t>ook
re(ding)
6o+e;ork
4(n.
*$
Introduction 8h. *
*N ?inish intro, start chemistry
review
8h. ).*&).-
*Q ?inish chemistry and water 8h. ).$&).N 8hemistry 3A due (' pts.
)* %!A D(yNo cl())
)- 9ui: 1. 8arbon U polymers 8h. -.*
)' 8arbohydrates 8h. -.)
)Q 5ucleic acids 8h. -.-
-% 9roteins 8h. -.$
$e>. * 9ui: 2B 1ipids 8h. -.' 6iomolecules 3A due ('
pts.
$ ?inish biomolecules. review
N E3(+ 1
Q Membrane structure 8h. '.*&'.-
** Membrane transport 8h. '
*- 8ell structure 8h. $ >smosis 3A due (' pts.
*' 9ui: 3. ?inish cell structure 8h. $
*Q Hnergy 8h. N.*&N.-
)% Hn<ymes 8h. N.$
)) Metabolic pathways 8h. N.', M.* Hn<yme 3A due (*% pts.
)' 9ui: C. 8ellular respiration 8h. M.*&M.)
)M 8ellular respiration 8h. M.-&M.'
%(r. * 8ellular respiration 8h. M.N&M.#
$ 9ui: 5. 9hotosynthesis 8h. Q.*&Q.$ 8ellular respiration 3A due
(*% pts.
N ?inish photosynthesis and
review
Q E3(+ 2
**&*' Spring >re(kNo cl())
*Q 8ell communication 8h. # (highlights
)% 8ell division 8h. *%.*&*%.$
)) 9ui: D. Mitosis 8h. *%.'
)' 8ell cycle regulation and
cancer
8h. *%.N Mitosis 3A due (' pts.
)M 2exual reproduction and
meiosis
8h. **
)# 9ui: EB Meiosis 8h. **
pr. * 5ondis@unction and
fertili<ation
p. )'%. 8h. '$ Meiosis 3A due (' pts.
- Oevelopment and stem cells 8h. *#.*&*#.-, '$
' E3(+ 3
Q (enetics 8h. *).*&*).-
*% Hxtensions to Mendelian
genetics
8h. *).N, *-.*, *-.)
*) #RC. No cl())
*' 9ui: FB (ene mapping and
genomics
8h. *-.$, parts of
8h. *Q
(enetics 3A due (*% pts.
*M O57 replication 8h. *$.$&*$.N
*# O57 replication. course
evaluations
8h. *$.$&*$.N
)) O57 transcription 8h. *'.*&*'.$
)$ 9ui: G. m/57 and translation 8h. *'.'&*'.Q
7
)N Translation and mutations 8h. *'.M&*'.# (ene expression 3A due ('
pts.
)# 3ighlights of gene regulation 8h. *N.*, *N.-&*N.M
Final exam: &*ur)d(y< %(y 2< FH10 (.+. =1.00 )ection?B %ond(y< %(y D< 1H3 p.+. =12.00? )ection
9lease note the 4nal exam time for this course and mar! it on your calendar right awayT This date and
time is set by the ,niversity and cannot be negotiated except under extraordinary circumstances (vacation
travel is 5>T an extraordinary circumstance.
8