Methamphetamine Increases Locomotion and Dopamine Transporter

Activity in Dopamine D5 Receptor-Deficient Mice

Seiji Hayashizaki, Shinobu Hirai, Yumi Ito, Yoshiko Honda, Yosefu Arime Ichiro
Sora,Haruo Okado, Tohru Kodama, Masahiko Takada

Reference:
Hayashizaki, S., Hirai, S., Ito, Y., Honda, Y., Arime, Y., Sora, I., & ... Takada, M.
(2013). Methamphetamine Increases Locomotion and Dopamine Transporter
Activity in Dopamine D5 Receptor-Deficient Mice. Plos ONE, 8(10), 1-8.
doi:10.1371/journal.pone.0075975



Relevance:

The journal showed the importance of dopamine receptors for humans where
they experimented on with mice deficient in these receptors. It is relevant to my
course because first, dopamine a drug naturally produced in our system is
important to maintain a balance in our metabolic and bodily system processes
wherein a deficiency of this drug can cause behavioral and body function
disorder or imbalance thus we must provide a source or alternative drug to
compensate for the deficiency and imbalance in neurotransmitters. Second is the
use of animals in the experiment, which is important to the course for testing
and discovering the effects of different drugs we will produce. Using test subjects
is important for us to see the diverse action of a drug we will produce.