Start monthly iteration

Search PubMed for organism Search PubMed for topical

name(s) AND gene synonym(s) terms e.g. “ubiquitination”

Pubmed List

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Read Abstract Examine each

Figure/Table(and text if necessary)

no
Is article relevant to Mark article as “not
selected organism? selected organism”
<<iterative>>
yes

Is article relevant to
no Enter interactor names or identifiers
Mark article as “abstract read”
interaction curation? into IMS with one evidence code

yes
no Interaction retained in
Can Full text/pdf
no Mark article as “unable
Does annotation exist in IMS for IMS as “erroneous”
chosen gene names/identifiers?
be obtained? to obtain full text”
yes

Obtain full text/pdf

Interaction entered into BioGRID

Does article contain

interaction evidence
no
using high throughput
technology?
yes Give suppl.file(s) with HTP
interaction data to database Mark article as “full text accessed”
admin to load into BioGRID