FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX

TABLETS OF METOPROLOL SUCCINATE

Abstract
The present study was done with the aim to develop sustained release matrix tablets of
Metoprolol succinate which is beta 1 selective adrenergic receptor blocking agent used in
the management of hypertension. Sustained release Metoprolol succinate matrix tablets were
formulated (F1-F11) using different polymers like HPMC K15M, HPMC K100M, Sodium
CMC, Ghatti gum with 1:2 and 1:3 ratios by wet granulation method. 0.1 N HCl and 6.8 pH
phosphate buffer are taken as the buffers. Pre compression, post compression parameters and
preformulation studies are done. F11 is taken as the optimized formulation as the drug release
is 99.56% at 12th hour. FTIR thermo grams obtained for the pure drug and drug + different
polymers indicated that there is no interaction for drug and polymers and suggested the good
miscibility of the drug and polymers. In-vitro dissolution studies showed that tablets of
Metoprolol succinate in 1:3 proportion, prepared by wet granulation is the best to increase
sustain effect due to increase in the polymer concentration. It was observed that the release of
drug followed first order release in all the formulations and controlled by diffusion
mechanism, Non Fickian super case II diffusion

Key words: Sustained release, Metoprolol succinate, Matrix tablets, HPMC K15, HPMC K100,
Sodium CMC, Ghatti gum, FTIR, Dissolution studies.

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