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Rising cortisol levels, glucose feed back to acton both hypothalamus and anterior pituitary,
preventing CRH release and shutting off ACTH and cortisol secretion
Disease:
Hypersecretion
Chushings disease
o May be caused by ACTH-releasing pituitary tumor
o Persistent elevated blood glucose levels
o Dramatic losses in muscle and bone protein, water and salt retention
o Hypertension and edema