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    3 vues11 pages

    Gate

    Transféré par

    Nhr Tronex
    CSIR

    Droits d'auteur :

    © All Rights Reserved
    Téléchargez comme PDF ou lisez en ligne sur Scribd
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    sur 11
    PART-A 1. In a substimtion nucleophilic frst order reaction (Sxl) the stereochemical outcome is (@)Raemsanion (b) Inversion of configuration (©) Reteation of configuration (@) Difficult to predict 2 When isradiated with ultaviolet light Chlorine (Ch) reacts with rewachloroethylene. But under simlar condition whea Oxyzen (0:) is vigerously ‘bubbled through the solution the reaction (a) becomes more stolent (b) doesnot get affected (€)stows down (@) stops 3. Which of the following compounds is optically inacuve? (a) Lactic acid (©)2-Methy! propionte acid (©) Tanarie atid (@Buryne acid 4. Addition of excess bromine Br.) to 1+ pentadine wil yield (a) Only 45 dibromo L-pentene (0) Only 1.2.4.5-tetra bromo pentene (c) Mixture of (a) and (b) (@) There wall be no reaction 5, If you want to synthesize L-Pheny! ethanol from phenyl magnessun: bromide you will have to add (a) Water to (b) Formaldeiyde to it (©) Acetaldehyde to it (@)Acetone 101 6, When you will treat phenol with dilute HNO3 at 20°C. you will get (@) Oniy ortho nitro phenol (b) Only para nitro phenol (©) Mix of ortho and para nitro phenol (4) Onty 2,4 6 trintro phenol 7, Soaps are (@)Esters of fatty acids (©) Metal salts of fatty acids (¢) Giycery! esters of fatty aads (@) Salts of tay acids with organic bases 8, Nanural subber 4s a polymer of (a) Butadiene (b)Tsoprene (©)Chloroprene (@ Nesprene 9. Ethylene whea treated with dilute alkaline KMn0. forms (@) Eth aleobol (b) Ethylene elyco! (c) Acetaldetide (Ethane 10. EDTA is used as, (a) Oxidized agent (b} Reducing agent (©) Chelatng agent (@) Alkylating agent 11. Linkage present in celintose molecules (BA 34) ais 4 (a> (both () and(e) 12, Blocking action of enzyme through blocking its active site is (a) Allosterc inubition (b) Feedback inbibition () Competinive inhibition (@ Non-compettive inhibition 13 Which ose of the following is withour coenzyme activity ? (a) Vitamin E (b) Taiamine (¢) Biotin (@ Riboflain 14, Active transport (a) Releases energy (b) Require energy (6) Produces energy (@) Produces toxic material 15, Correct sequence of stages in cell cycle is (a) G1, §, G2, M (b) Gt, G25, ()M.S.61,G? [) G1. G2,M,5 16. 0.1 Macene acid is mixed with 02 M sodium acetate. Give that pK, of Acetic acid is +76, the pH ofthe mste will be nearly (4s 50 (33 (60 17, The scalar product of tivo vectors (t, 12,133) (a) uP (bo) xd v2 = wo (e)nsvd, + L202 (Quid = nd > wr? 18, The determinant ofa singular matrix (a) isequal 0.0 (b) is greater than O (c) is tess than 0 (d) can be enter greater than, equal to or less than O 19. Ifthe differential equation 1s suff (a) Itshould be solved by Gear’s method, (b) Eaters method (6) 2" order Ruag-Kurta method (@) Cannot be solved 8. Viruses are (@) Cellular organisms (b) Non-celfular organisms (© Unccellalar organisms (@ Cellular without wall 9. Which of the following does not contain both DNA and RNA? (@) Yeast (b) Bacteria (© Mycoplasma (@ Virus 10. Sostiura Dodecyl Sulphate (SDS) is used while separating proteins by polyacrylanide gel clectrophoresis because (@) It helps in solubilization of proteins thereby ‘making it easier to separate (b) It binds to proteins aod confers uniform negative charge density thereby making them move during electrophoresis (©) Decreases the surface tension ofthe buffer used. for electrophoresis (4) Stablizes the proteins 11, Absorption of UV radiation by proteins and nucleic acids és due to transition of Electrons ‘berween the (@) Vibrational energy levels (b) Rotational energy levels Nirleas energy levels (@) Electronic energy levels 12. Which of these statements is true? a. In a pyramid of numbers, the population size ‘ustally gets smaller as the trophic level increases ‘In pyramid of biomass, the weight of a lower ‘trophic level isthe same as the level above it c. In a pyramid of energy. only about 40% of the ‘energy at one jevel 1s available for the next trophic level . The law of conservation which can be applied to the pyramid of energy, means that energy is ‘coastantly created and destroyed. 13. Which of these statements about the amount of food production after 20° Cis tue? s 5 8 Graaf socom temperate) ‘2 Food production stops as temperatures increase ‘beyond 20°C. b. Food profuction continves to increase as ‘temperatures increase beyond 20° C ¢. Food production drops drastically as temperatures increase teyond 20° C 4. Food production remains the same as temperatures increase beyond 20° C. 14, Which of these organisms breaks down and releases nutrients from other dead organisms? a produces b. decomposers ¢ herbivorcs 4. camivores 15. Which of these is NOT an example of a teniestrial ecosystem? a volcano site ‘garden plot € rotting log 4. human skin 16, What is the differeace between muualism and parasitism? a. Mutualism means that one member of a species thrives at tbe expense of the member of the species. Parasitism means that one member of a species thrives at the expense of the member of the species, ‘. Muntatism means that oar member of a species benefits without harming or benefiting the member ‘of another species. Parasitism means that both species’ members benefit from the relationship €. Motualisms mean that both members of a species benefit from living together, Parasiisin means that one member of a species benefits without harming or benefiting the member of ancther species 4, Mivtatism means both members of a species benefit from living together, Parasiism means that ‘one member of a species tinves at the expense of the member ofthe species 17. Based on the data in the graph, witich of the following statement is ve? st u oad 4 There isno food production happens at 10°C 'b. Food production is the smallest at about 20°C . Food production is the greatest at about 30° C 4. Food production at 40° C is about 5 mg of ‘elucose per hour 18, Which of these organisms uses light energy to ‘mamufacture food for itself? a. aheterotroph . an autotroph . acamivore d anommivore 19. Which of the following statements about the biosphere is true? a. Ecologists never study animal in Earth's biosphere 'b. The physical environment of Earth's biosphere 4 the only factor in influencing living things. «. Living things in Earth's biosphere are affected by nonliving things Earth's biosphere includes the portion of Earth ‘within 1 mile of te surface. 20, A relationship among organisms where one species benefits while the other species neither benefits nor is harmed is called 2 mutualism ‘predation € parasitism 4. commensatism 21, ADNA solution of 100M concentration when placed in 2 cavette of path length 1 cm gave an absorbency of 0.66. The extinction coefficient of DNAis- 2. 66x10, 15x10 1.0.66 x 10° 4.00x 10° 22. Trace of a matrix is (@ some of the elements in the main diagonal (D) some of the elements in all the diagonals (©) value of determinant (None of the above 23, Formation of alpha helix in proteins is promoted by (@) Giutanuc acid, arginine and leucine (©) Valine, leucine ann phenylalanine (©) Proline, glycine and aspartic acid (@) Asparagine and serine 24, The mayor Source of stability of the DNA Double helix structure is (2) Hydrogen bonding between bases (©) Screening of phosphate changes by counter ions (©) Stackiag interaction of neighboring basis (@) Solvation of phosphates 25, Urea acts a8 a protein denaturant because it binds 0 the (@) Charged resides of proteins (©) Hydrophobic residues of proteins (©) Peptide groups of proteins (@ CH: group of the protein backbone 26 In Nuclear Magnetic Resonance Spectroscopy the resonance phenomenon i observed after subjecting the nucleus under Question by one of the following electromagnetic radiations, @ Infrared OX (©) Radio frequency @ Microwaves 27, Themoéynamics dictate that entropy, a measure of disorder in a system increase with every spontaneous process. Living system is highly ordered as well as spontaneous. This means that (@ Thermodynamics does not apply to living systems (©) Living systems increase the entropy of the surroundings (© Living systems decrease the entropy of their surroundings (© Living systems are not really ordered systems 28. Highly cooperative binding of a ligand to ‘multiple binding sites on 2 macromolecule 4s best demonstrated by (@) Adair equation (0) Hill Plot (©) Lineweaver Buck Plot @ Arrhenius Plot 29. A hybridoma cell secreting mouse monoclonal antibodies can be generated by (@) fusing spleen cells from immune mice with any cell from that mice (b) culturing B cells im the presence of B cell growth factors (© by transforming splenic B cells from an ‘immune mouse with Epsteim Barr virus (O) by fusing spleen cells from an immune mice ‘with an appropriate plasmacytoma cell line 30. A virus is growing inside a B cell, The Viral antigens (@) cannot be presented to T cells under chat condition (b) wll be presented to T cells n association with MHC-Imolecule (© can be presented t0 T cells in association with both MHC-I and MHC-II molecules (@) the vinis has to use tha B cell before any antigen presentation can take place 31. Super antigens stimulate (@ only T cells by binding to TCA is the absence of antigen presenniag cells (b) canstimulate T, B and any other type of cells (©) only T cells by binding to the VB domain of T cells recepor and the MHC-IE molecule an antigen presenting cells, (@ only T cells by binding to CD: molecules 32. For developing a candidate vaccine for malasia (@) We should identify several T cell and B cell epitopes which can elicit protective response in a large population (b) We should identify oniy few T cell epitopes of the parasite (©) We should identify only few B cell epitopes of the parasite (@ We should identify epitopes which can induce antibody response in the host 33. In a chemical reaction, trensition-state species have free energies {@) lower than either the reactants or the products (b) higher than either the reactants or the product (©) lower than the reactants, but higher than the products (@) higher than the reactants, but lower than the products 34. Mare free energy is released during the citric acid cycle than during glycolysis, but only 1 moie of ATP is produced for each mele of acetyl CoA that enters the cycle. What happens to most of tile remaining free energy that is produced dusillg the citric acid cycle? (2) Itis used to synthesize GTP (@) Itis used to seduce electron carriers © tis lost as heat (@) Itis used to reduce pyruvate 435 The general name for 2a enzyme that transfers ‘phosphite groups fiom ATP to.a Protein is (@) Protein kinase (@) Phosphorylase (© Phosphatase (@ ATPase 36. Hew do the daughter cells at the end of mitosis and cytokinesis compare with their parent cell ‘when itwas in G 1 of the cell cycle? (@) The diughter cells have half the amount of cytoplasm and half the amount of DNA (©) The daughter cells have the same number of chromosomes and the same amount of DNA (©) The daughter cells have the same mmber of chromosomes and half the amcunt af DXA (@ The daughter cells have half the number of ‘chromosomes and half the amount of DNA 37. Which of the following is FALSE in companng prophase I of meiosis and prophase of mitosis (a) Tae nuclear envelope disassembles in both (b) The chromosomes Condense in both (c) Each chromosome has tivo chromatids im both (@) Tetrads form in both 38. Once wanscnbed the eukaryotic primary transcript typically undergoes substantial alteraon that mmcindes, (@) Fusion into circular forms known as plasmids (b) Linkage to histone molecules (©) Union with nbosomes (@) Tetrads form in both 39 All of the following are potemtial control ‘mechanisms for regulation of gene expression in eukaryotic organismus EXCEPT (@) Gene amplification {b) The degradation of mRNA. (©) The lactose operon (@ Transcription 40, It is theoretically possible for a gene from any ‘organism to function in any other organism. Why is this possible? (@) All organisms have similar nuclei (b) All organisms have the same genetic code (©) All organisms are made up of cells (@) All organisms have transfer RNA 41, DNA fragments fiom a gel are transferred to a ‘membrane via @ procedure called Souther blotting. ‘The purpose of Southem blottiag is to (a) Analyze the RELPs in the DNA {(b) Separate out the PCRS! (© Pemmaneatly attach the DNA fragments to a substrate @ Separate the two complementary DNA strands 42. Influenza viruses require the presence of the cleus in their host cells because (@) They use reverse transcriptase to make a cDNA ‘which is integrated into the host genome (®) They scavenge capped fragments from host gaRNA in the aucleus to use as primers for viral mRNA (© They we the host RNA polymerse I to transcribe viral mRNAs @ They scavenge poly [A] tails from host miRNAs inthe mcleus 43, HIV is the causative agent of AIDS and is a member of the Lentivirus genus of the family Retroviridae Which of the following features of HIV makes it different fiom other members of this family? (2) HIV uses reverse transcriptase to convert its RNA genome into CDNA (©) HIV infects hnuman cells that are CD4— (Q HIVisenveloped (@ The genonuc RNA of HIV is $’ capped and 3 polyadenylated 44, Which of the following vectors can camry the longest piece of foreign DNA? (@) Plasmids (W) Bacteriophage (© Cosmids (G) Yeast amficial chromosomes (YACs) 45, DNA and RNA synthesis polymerization [of deoxymicleotides] which takes place (@)Ina3't0 5’ drection (b) Ina 5't0 3' direction (c) nether (or both) direcnons (@ DNA m5 to 3’and RNA in 3't0 5! 46. TATA boxes and Pritnow boxes are ‘components of Promo! Sie iam 47. The RNA in the cell with the greatest sequence divesity is (@)MeseagerRNA (>) Ribosomal RNA (© Transfer RNA @(a)and@) 48. During the overall process of protein synthesis, ‘amino acids become covalently attached to aMessengerRNA ——_b. Ribosomal RNA Transfer RNA ‘4. More than one of the above 49, Proteins whose binding to DNA acts to prevent ‘transcription are known 25 (0) Operators @ Activators (0 Repressors (@) Transcription factors 50. Which of the following genes is not common to allretroviruses? (@) pal b)ew (sre @egog 51. The preseuce of an extra chromosome in a ‘eukaryotic cell is most likely due to (@) linkage () fertilization (©) transposition (Noa disjunciton 52. In fruits, the autosomal gene R causes red es and an alternative allele rcauses white eves. A testeross is done witha fly that is Rr. What percent cof the offopring can be expected to have white ees’ @) 0% (0) 25% 50% (@ 15% 53. Which of the followings a function ofa singal peptide? {(@)to direct DNA polymerase to 4 site on DNA () to direct RNA polymerase to 2 site on DNA (©) To direct a ribosome to insert a growing portein info the ER (@) to terminate translation on an mRNA 54, Which of the followings meorporated in the ‘model of logistic population growth but NOT in tae ‘exponential population growth model? (@) change in population size over ime (©) maximum suvainable population size (©) Population birth rate (@ population death rate 55, Which ofthe followings the best example of competinive extusion? (@) tro fish species cannot ive in the same habitat (b) an mtroduced plant species will exchide 2 Samular native species (©) two parasite species caumot occupy the same host (@ Two bied species in the same forest canaot use the same set of rerorces 56. Addition of detergents containing phosphates can disturb aquatic ecosystems because the {@) kill bacteria () poison fish (©) Stunmiate algae growth () ferulize crop plants 57. A genetic defect preveats guard cells fom ‘losing stomata in the leaves ofa plant. This plant will most likely have excessive (@)CO2inits leaves (0) ODimits leaves (© nitrogen fixation _(d) Loss of water 58 A hollow ball of cells best describes a (@) Blastula (b) morula (© gastrala (gamete 59. Ina nephron of the human kidney, ureacan normally leave the aud enter the 5 (G) collecting duct / descending loop of Henle (b) Collecting duct / ascending loop of Henle () ascending loop of Henle’ descending loop of Henle (@ ascending loop of Henle / collecting duct 60, In one complete turn of the Krets cycle, what is the maximam number of ATP molecules that can ‘be produced inthe Krete cycle vel? @o wt ©@2 @3 61. Which of the following do chloroplasts and ‘mitochonckia NOT have in common? (@) ATP synthase () electons transport chain arr (NADH (62. Microfilaments are pan of the stuccure of G@)cilia (b) autotic spindles (© cell cleavage furrows (4) flagella 6. ThepH{ of human blood is stghtty basic. Which ofthe following is most likely tobe the pH of ‘naman blood? @ 106 @ 74 © 70 @ 64 64, Euchromatin contains G) single-copy genectically-active DNA (®) Repetitive and genencally inactive sequences (©) single-copy, genetically-snactve DNA (4) repettive and genetically active sequences 65. Centromeres are directly involved i (2) DNA replication (b) transcription (DNA repait (6) chromosome segregation 66, Telomere repeat sequences contain DT /ARG @)(A Ds cy OGIO; @G'OwT (67. The transcriptional instation site usually starts @AG (0) GC (AT AC 68. A stretch of double-standed DNA contains 1000 base pairs, and its base composition 1s 71% G + C. How many thymine residues are in this region of DNA? @)270 (@) 280 ©B0 300 © __A S-month-old male presents with seizures and, delayed development. Upon newbom screen he ‘was detected to have hyper phenyl alaninemia and is on a phenylalanine-restnicted, synthetic diet. The ‘most likely cause for his curent symptoms is a (G) defect in tetrabydrofolzte reductase (0) defect in dinycropteridine reductase (©) tyrosine deficiency @ tryptophan deficency 70. Coding regions of eukaryotic gene that encode polypeptides are called ‘@) bnRNAS (@) Exons (© Enhancers, (@)Leader peptide PART-A Qt. An eve defect which ususlly results from an. unequal curvature of the comea 35 (a) nearsightedness (b) astigmatisan (©)colour blindness (d) night blindaess Q 2. The velocity of sound in air under normal conditions 1s (@)30msec (332 msec (b) 20 msec (6) 3.320msec Q.3.A photo-electrc cell converts (@) sound energy into electrical energy () light energy into electrical ener {©)an elecincal signal into sound waves (electrical energy into ight energy Q. + Which of the following sounds cannot be heuco by uaa eas? (2) 300 vibrations see (b) 1.000 ribratoas see {¢) 10.000 sabrations sec {4} 30.000 vibrations sec Q. 5 If force is expressed in aenton and the distance ia mee, thea the work done 15 expressed. (ayfoule ©) ) Kgwt wim (@) Watt Q. 6 The Law of Natural Selection is associated. with (2) Dattoa (c) Kepler () Darwin, (6) Mendel Q. 7. When cream is separated flom matic (a) the density of malic nereases () the density of milk decreases (c) the density of milk remains uchanged (4) it becomes more viscous Q. 8. The element of an electric stove ismade of eopper—— (b) iavar (e)mmgaalium (6) mierome Q 9 Which of the following i based om the precesSof fston” (a) Atom bomb _(b) Hy¢rogen bomb (©) Ordinary bomb @Napaim tomb Q.10. Hybridisation is {@) downward movement of water through seal (0)2 process of tilling the land (¢) decayed vegetable matter (d) cross feriiation berveen no vanienes Q. 11. Of the following foods, which one is the best source of protein ? (a) Batter (b) Fish (@) Lettuce (@) Milk Q.12. The red blood ceils are formed m the (@) heart (liver © fympa nodes (@) macrow of bones 13. A.werbulb and a dey-bulb thermometer are hed to determine (2) the minimum temperanure ata place in any 24- hhpur periog (0) relative umudiry (©) urpressure (@) the maxsmum temperarure ata place in any hhour period Q. 14. One of the isotopes of iodine fas a “half Iife" of 25 minutes. This unformation ells us that sf 18e stan with a given quantity of the isoropes, 50 ‘manites later there wll feman (6) one-fourth ofthe ongiaal mouse @) none (@) one-alf ofthe original ameust (@) approximately te same amount Q. 15 Small amount of iodine are necessary in our dietito @) preven peisgra (b) compensate for underactvity of the thyroid (© stimulate cloning of btood (@) sumulate pirutary gland Q_ 16. On sudden cardiac arrest, which of the following % advised as a first step to revive the ‘Ametioning of hun beast ? (2) Mouth to mouth resuscitation (b) Giving external eardiae massage (6) Speinkling water om the fice (@) Giving cool water to dank Q.17.A triode differs fom diode in the way that (G)st can ampu a signal (8) thas vacuum inside (C)athnsa heated eatiode (@) 3s current is caused by the phote electric effect (1S lthe angles of a triangle are in the satio 5: 4 3. how maay degrees ace there in the largest angle (1) 750. (2) 900° (3)400 (4) 450 Q.19. Twonnumbers are in the ratio 5 4, and there sdtterence 110. Wists the Larger muraber” 30 HO ©5060 Q 20. The satio of tae prices of two houses A and B was 45 last year. This yeu. the price of A is sncreased by 25% and that of B by Ks, 50,000. If hei prices are a0w in the satio 9 10, te puice of Alast year was (G) Rs. 360,000 (2) Rs. 4,50,000 @)Rs 4801000 4) Rs. 5.00,000 Q 21, Three-fourths of 68 is less than two thirds of Tid by (12 @25 G35 48 (22. Two cards are drawn together from a pack of 51 cards (a set of traditional playing cards), at random. The probability that one is a spade and ‘other is a heart is, (@ 13/102"@)3/20 (©) 47/100(29/34 Q 23. A bag has 4 red and 5 black balls. A second ‘bag has 3 red and 7 black balls. One ball is drawa from the first bag and two from the second. The ‘probability, that there are two blacks balls and ared ball is (a) 14745 (b) 1145 (9) TIS oss Q 24. The transverse, longitudinal and surface ‘waves in an earthquake originate from (@) the epicentre within the body ofthe earth (©) the focus on the surface ofthe earth () the foens within the body ofthe earth (6 the epicentre on the surface of the earth Q 25, Seasonal contiasts are maximum in (@) Mid tonmites (b) Low lattudes (©) High latirudes (4) Subtropics Q 26, Although aly the southern. part of India lies in the topical region. but the whole of India has tropical climate. This is because (A) Iedia comes under the influence of monsoons. (©) Nontbem part of India ins large tracts of plain region (© Tropic of Cancer passes through the middle of the country (D) High Himalayan mountain ranges separate it from the rest of Asia Q. 27. What is the mam cause of movement in the car's atmosphere? (A) Difference in air pressure (B) Solar energy: (© Difference m temperature ©) Wind Q 28 Among the following which is a general purpose programming language- ac v. COBOL, PASCAL 4 FORTRAN Q 29. Consider the following program: ‘The output of the programme will be 20 5.16 od aly Q 30 Among the following which is not an input device: a Mouse . Scanner . OMR, 4 Plotter PART-B 1. One of the parents ofa cross has a mutation in its mitochondria. In that cross, that parent is taken a a male During segregation of F2 progenies that ‘mutation is found in (1) one-third ofthe progenies (2)None of the progenies G)all the progenies (4) fifly percent of the progenies 2. When a fieshewater protozoan possessing a contractile vacuole. placed in 2 glass convaining marine water, the vacuole will (U)Increase inmumber 2) disappear Gylnceae msize 4) Decreasean size 3. One of the following 1s a very unique feature of the mammalian body: (1) Homeothemy(2) Presence of Diaphragm (3) Four chambered heart (4) Rib cage 4. Chemically hormones are (1) Biogenic amines only (Q} Proteins, steroids and biogenic amines G) Proteins onty (B) Steroids only 5. Which one of the following pairs is act correctly matched? () Vitamin Bi? ~ Pemicious anaemia (2) Vitamm B6 — Loss of appente (G) Vitamin Bl — Beri-beri @) Vitamin B? ~ Pellagra 6. Untcotelism is found in (1) Mammals and birds (Q) Fishes and fresh-water protozoans (3) Bitds, reptiles and insects (G) Frogs and roads 7. Duodeoum has characteristic Brunner’s plands ‘hich secrete wo hormones called (1) Kinase, estrogen @2) secretin, cholecystokanin G) Prolactin, parathormone (4) Estradiol, progesterone '8. Mast cells of connective tissue contain (2) Vasopressin and relaxin (2) heparin and histamine @) Heparin and calcitonin (4) Serotonin and melanin 9. Cancer cells are more easily damaged by ‘adiatin than normal cells because they are () lack of matatioa 2) undergoing rapid division ©) differcat in structure (4) non-

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