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The robustness and shortcomings of the system of radiation protection are discussed.
Pediatric exposures to ionizing radiation are identied as a major cause of concern.
Routine sub-mSv (below 1 mSv) CT exams are at reach during this decade.
Signicant progress in the justication of medical exams is mandatory.
The future relies on computational dosimetry, using MC simulations and voxel phantoms.
art ic l e i nf o
a b s t r a c t
Article history:
Received 11 July 2013
Accepted 3 February 2014
Available online 15 February 2014
The technological advances that occurred during the last few decades paved the way to the dissemination of CT-based procedures in radiology, to an increasing number of procedures in interventional
radiology and cardiology as well as to new techniques and hybrid modalities in nuclear medicine and in
radiotherapy. These technological advances encompass the exposure of patients and medical staff to
unprecedentedly high dose values that are a cause for concern due to the potential detrimental effects of
ionizing radiation to the human health. As a consequence, new issues and challenges in radiological
protection and dosimetry in the medical applications of ionizing radiation have emerged.
The scientic knowledge of the radiosensitivity of individuals as a function of age, gender and other
factors has also contributed to raising the awareness of scientists, medical staff, regulators, decision
makers and other stakeholders (including the patients and the public) for the need to correctly and
accurately assess the radiation induced long-term health effects after medical exposure. Pediatric
exposures and their late effects became a cause of great concern.
The scientic communities of experts involved in the study of the biological effects of ionizing
radiation have made a strong case about the need to undertake low dose radiation research and the
International System of Radiological Protection is being challenged to address and incorporate issues
such as the individual sensitivities, the shape of doseresponse relationship and tissue sensitivity for
cancer and non-cancer effects.
Some of the answers to the radiation protection and dosimetry issues and challenges in the medical
applications of ionizing radiation lie in computational studies using Monte Carlo or hybrid methods to
model and simulate particle transport in the organs and tissues of the human body. The development of
sophisticated Monte Carlo computer programs and voxel phantoms paves the way to an accurate
dosimetric assessment of the medical applications of ionizing radiation.
In this paper, the aforementioned topics will be reviewed. The current status and the future trends in
the implementation of the justication and optimization principles, pillars of the International System of
Radiological Protection, in the medical applications of ionizing radiation will be discussed. Prospective
views will be provided on the future of the system of radiological protection and on dosimetry issues in
the medical applications of ionizing radiation.
& 2014 Elsevier Ltd. All rights reserved.
Keywords:
Radiation protection
Dosimetry
Medical exposures
Computer tomography
Justication
Optimization
http://dx.doi.org/10.1016/j.radphyschem.2014.02.007
0969-806X & 2014 Elsevier Ltd. All rights reserved.
24
1. Introduction
During the last 15 years, the radiological protection of the
patient emerged as of paramount importance in view of the
dissemination of the use of computer tomography (CT) in practically all medical specialities and of the increasing utilization of
interventional procedures. Of particular relevance are the pediatric
exposures resulting from the growing prescription of CT procedures to newborns, children and adolescents and the awareness
that such younger individuals feature a much higher radiosensitivity than those of adults and have their life spans over several
decades after exposure, enough time to allow late manifestation of
cancer effects.
General consensus exists about the outstanding progress that
has been achieved during the last decade, on the implementation
of the principle of optimization of protection, one of the three
pillars of the International System of Radiological Protection. The
IAEA International Action Plan (IAEA, 2002) approved shortly after
the Malaga Conference (IAEA, 2001) has been instrumental in
promoting the radiological protection of the patient and the need
for dose reduction in the medical exposures to ionizing radiation.
Such dose reduction has been achieved with the active involvement of several stakeholders, including the equipment manufacturers, namely the CT manufacturers who have developed
sophisticated systems such as Tube Current Modulation and
Automatic Exposure Control and incorporated them into the
equipment for routine clinical use. Signicant progress and technological advancements at the level of the detectors, electronics
and software were also implemented.
In recent years, an awareness emerged about the risks associated to the exposure of medical staff and their critical organs
such as the lens of the eye, the thyroid and the extremities, in
interventional procedures (radiology, cardiology, orthopedy, gastroenterology, urology, coronary angiography, etc.). This awareness
and the epidemiological evidence, during the last few years, about
the late manifestation of non-cancer effects associated to the
protracted or chronic exposures to ionizing radiation, led the ICRP
to review the dose limits to the lens of the eye in 2011 (ICRP
statement, 2011) and to draw the attention of the radiological
protection community to, amongst others, the cerebrovascular
effects associated to absorbed dose values signicantly smaller
than traditionally assumed.
The radiation safety of patients in radiotherapy treatments was
another topic that gained additional importance in view of the
incidents and accidents that occurred in several countries.
Last but not the least, the need to gain further scientic insight
into the risk versus dose relationship for low dose radiation
exposures and to better understand the risks associated to
protracted exposures, exploring novel approaches in radiobiology
and molecular biology and involving communities of experts such
as toxicologists, epidemiologists, geneticians, etc., in addition to
the communities of experts already involved was emphasized by
means of international collaborative efforts (MELODI, 2013) and
scientic projects.
Despite the aforementioned advances in the promotion and
implementation of the optimization principle, it is felt that major
efforts have to be devoted to the implementation of the principle
of justication, another pillar of the International System of
Radiological Protection. Discussion of this issue will be provided
in a later section, after a short description of the International
System of Radiological Protection in the next section, a review of
the medical exposures' dosimetric data and trends and of radiological protection and safety issues associated to CT and interventional procedures.
Last but not the least, a succinct discussion of the computational
dose assessment in the medical examinations and procedures in
25
Fig. 1. The diagrammatic representation of the International System of Radiological Protection: the four upper boxes list the topics addressed by the current system and the
two lower part boxes (marked with interrogation marks) the issues that must be addressed by a future system.
et al., 2012; Mathews et al., 2013) claim that evidence was found
for a signicantly higher cancer risk and incidence in individuals
who had undergone medical CT examinations in childhood and
adolescence.
4.1. Education and training
26
Fig. 3. Time variation, between 1992 and 2001 of the number of coronary angiography (left), PTCA (center) and coronary stenting (right) procedures in Europe.
27
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8. Computational dosimetry
The advent of powerful processors and computing architectures and the development of sophisticated Monte Carlo computer
programs has rendered possible the evolution from the MIRD
phantoms in the late 1960s (Fisher and Snyder, 1967) and since the
late 1990s and beginning of the century to the implementation
and utilization of sophisticated voxel phantoms in radiation
dosimetry. Computational dosimetry became an emerging and
unavoidable discipline in the radiological protection and safety
studies in the framework of the medical applications of ionizing
radiation.
Acknowledgments
The author wishes to thank the outstanding work of an endless
number of experts who have provided through published reports,
journal articles, books and other types of publications, web sites,
etc., signicant contributions in the topics addressed in this paper
and that could not be cited for obvious reasons.
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