Aceclofenac

Aceclofenac is a non-steroidal anti-inammatory drug

(NSAID) analog of Diclofenac. It is used for the relief of pain and inammation in rheumatoid arthritis,
osteoarthritis and ankylosing spondylitis. The dose is 100
mg twice daily.
It should not be given to people with porphyria or breastfeeding mothers, and is not recommended for children.
Aceclofenac has higher anti-inammatory action than
conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in
the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in
the body) which cause pain, swelling and inammation.
Aceclofenac is the glycolic acid ester of diclofenac.

Synthesis
O
Cl

Cl

1. NaOH

OBn

OH

NH
O
Cl

2.

Cl

NH
O

OBn

Br

CO2H
O

H2, Pd

NH

Cl

O
Cl

benzylbromoacetate

Aceclofenac synthesis.[1]

References

[1] http://drugsynthesis.blogspot.co.uk/2012/03/
synthesis-of-aceclofenac.html

References
British National Formulary 55, March 2008; ISBN
978-0-85369-776-3 p. 537

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