Examples:

Javais peur, mais je lai fait quand mme.

I was afraid, but I did it anyway.
in spite of something
Merci quand mme.
Thanks anyway.
I appreciate it all the same.
Cest quand mme difficile.
All the same / Even so / Actually / Still, its hard.
Its really hard.
stressing a point
Quand mme !
Really! Honestly! (disbelief, outrage)
I cant believe it!
Oui, mais quand mme ! Yes, but still!
Stressing a negative or positive aspect of something.
Quel idiot quand mme !
Really, what an idiot!
It makes me furious to see what an idiot he is.
Quelle belle journe quand mme!
Even though something spoiled our plans or expectations, it turned out to be a
nice day.
Quand mme, tu aurais pu me prvenir !
Hey, you could have warned me!
I warn you that you should have told me in advance.
Tu ne vas pas scher les cours quand mme !
Come on, youre not really going to play hooky!
To play hooky? tstsk tsk tsk thats what you shouldnt do!
Il ne veut pas vivre seul quand mme.
He doesnt want to live alone, does he? (rhetorical)
(Also tout de mme) All the still, even though he likes his independance
he doesnt want to live alone.
Tu as nettoy ta chambre quand mme.
You finally cleaned your room.
Youre capable of cleaning your own room. Im surprised at you.

Anne se marie enfin. Rponse: Ah bon?

Et il semble quil a une bonne situation! Rponse: Ah quand mme!
An added expression which hints an approval.
Its hard to translate always exactly the nuance into English,
Often it is used to stress a point.
Each language has its particular way of expression.