Benign Prostatic

Hyperplasia

Benign prostatic hyperplasia (BPH) is

an age-related, nonmalignant
enlargement of the prostate gland
It is characterized by the formation of
large, discrete lesions in the
periurethral region of the prostate
the peripheral zones, which
commonly are affected by prostate
cancer

Pathophysiology of BPH
Both androgens (testosterone and
dihydrotestosterone (DTH) and
estrogens appear to contribute to the
development of BPH.
The prostate consists of a network of
glandular elements embedded in
smooth muscle and supporting tissue,
with testosterone being the most
important factor for prostatic growth

Cont
Free plasma testosterone enters
prostatic cells, where at least 90% is
converted into DHT by the action of
5-reductase
BPH is related to prostatic smooth
muscle tone. The 1-adrenergic
receptors are the main receptors for
the smooth muscle component of the
prostate