Antidiabetic

Agents
Dwi Indria Anggraini
Dept. of Pharmacology-Medical Faculty UNILA

Diabetes Mellitus

 TYPE

I DM

Defect:
cells - destroyed,
eliminates insulin
prod.

TYPE II DM

Onset:

Defect:
+ Inadequate prod.
+ Insulin resistance

Onset:

Childhood/puberty

0ver 35 year old

Nutritional status at

Nutritional status at

onset:
Undernourished

onset:
Obese

Treatment Type I DM
Good
2Delays
Exogenous
types:
control
long-term
insulin
of Blood
complications
Glucose

Treatment Type II DM

Insulin
Pork, Beef, Human
Parenteral, per oral

yet established
Preparation

is preferable but not

Rapid action: Regular, lispro

Intermediate action: NPH
Prolonged action: Ultralente
Combination: 30R 70N

ADR: Hypoglycemia

Insulin concentration and binding

in normal and overweight subjects

Development of maturityonset diabetes

ORAL HYPOGLYCAEMICS
Thiazolidinediones
AlphaBiguanides
Sulphonylureas

Action of oral antidiabetic

drugs

Oral Hypoglycemic Agents

Sulfonylureas
First Generation :

Adverse reactions:

Biguanides
Metformine

 -Glucosidase Inhibitor
Inhibits
Acarbose
NIDDM
Monotherapy
AR:
flatulence,
the
andabsorption
IDDM
diarrhea,
of abdominal cramping.

Thiazolidinediones

MOA: