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NORMAL CELL
CELL
CELL FUNCTION
a) INTRACELLULAR
b) EXTRACELLULAR FUNCTIONS
COMPONENTS OF CELL
2. Cytoplasm : All intracellular contents outside the nucleus & include the cystosol
and organelles.
8. Golgi Apparatus : Organelle that process protein for secretion from cell.
11. Centrosomes: Organelle that are responsible for the formation of mitotic spindle
in cell divisions.
Cancer is not a single disease. There are many types of cancers as there are types of tissues in
the body. Cancer develops when cells in a part of the body begin to grow out of control. Normal body
cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells
divide more rapidly until the person becomes an adult. After that, cells in most parts of the body
divide only to replace worn-out or dying cells and to repair injuries.
Cancer cells, however, continue to grow and divide even when there is no need to do so.
Instead of dying, they outlive the normal cells and continue to form new abnormal cells. They
compete with normal cells for the blood supply and nutrients that normal cells need thus causing
weight loss.
Cancer cells often travel to other parts of the body where they begin to grow and replace
normal tissue. This process is called metastasis. It occurs as the cancer cells get into the bloodstream
or lymph vessels of our body.
The immune system seems to play a role in the development and spread of cancer. When the
immune system is intact, isolated cancer cells will usually be detected and removed from the body.
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When the immune system is impaired as in people with immunodeficiency disease, people with organ
transplants who are receiving immunosuppressant drugs, or in AIDS, there is usually an increase in
cancer incidence.
CAUSES OF CANCER
Normal cells transform into cancer cells because of damage to DNA. People can inherit
damaged DNA, which accounts for inherited cancers. Many times though, a person’s DNA becomes
damaged by exposure to something toxic to the environment such as chemicals, radiation or viruses.
Remember though that most cancers have multiple causes and risk factors.
Hereditary/Family History
Certain types of cancers run in the family such as breast cancer.
Carcinogens
A carcinogen is an agent capable of causing cancer. This may be a chemical, an
environment agent, radiation and viruses.
Effects of carcinogenic agents usually depend on the dose or amount of exposure;
the larger the dose or the longer the exposure, the greater the risk of cancer.
Many cancers are associated with lifestyle risk factors such as smoking, dietary
factors and alcohol consumption.
Benzopyrene
Produced when meat and fish are charcoal broiled or smoked (e.g. tinapa
or smoked fish). Avoid eating burned food and eat smoked foods in moderation.
Also produced when food is fried in fat that has been reused repeatedly.
Avoid reusing cooking oil.
Nitrosamines
These are powerful carcinogens used as preservatives in foods like tocino,
longganisa, bacon and hotdog.
Formation of nitrosamines may be inhibited by the presence of
antioxidants such as Vitamin C in the stomach. Limit eating preserved foods and
eat more vegetables and fruits that are rich in dietary fiber.
Radiation
Radiation can also cause cancer including ultraviolet rays from sunlight,
x-rays, radioactive chemicals and other forms of radiation.
Viruses
A virus can enter a host cell and cause cancer. This is found in cervical
cancer (human papilloma virus), liver cancer (hepatitis B virus), certain
leukemias, lymphoma and nasopharyngeal cancer (Epstein-Barr virus).
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• Obesity
• Diet: well-cooked meat
• Occupational exposure: asbestos, organic solvents
• Age: 50-70 years old
Cervical Cancer • Tobacco use (cigarette, cigar, pipe, smokeless
tobacco)
• Human papillomavirus infection
• Chlamydia infection
• Diet: low in fruits and vegetables
• Family history of cervical cancer
Esophageal Cancer • Tobacco use (cigarette, cigar, pipe, smokeless
tobacco)
Among these factors, tobacco use, unhealthy diet and physical inactivity are more likely to
affect personal cancer risk. Smoking alone causes one-third of all cancer deaths. Research also shows
that about one-third of all cancer deaths are related to dietary factors and lack of physical activity in
adulthood.
PATHOPHYSIOLOGY
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When you are healthy, your body has over a trillion cells that divide at standard rate
and pace. When you develop cancer your normal cells turn into cancer cells. Cancer cells
have different DNA than healthy cells. One of the first steps in a healthy cell becoming a
cancer cell is the change of the proto-oncogens to oncogenes. Proto-oncogenes are genes
that are coded to maintain normal cell growth. An oncogene is a gene that has changed to
make the cells grow and divide faster. In cancer cells the cell grows and divides very
quickly. The second step to becoming a cancer cell is the tumor suppressor genes get turned
off. Tumor suppressor genes are a part of a healthy cells DNA that help stop cancer from
forming in healthy cells. Tumor suppressor genes help slow down cell growth, when these
genes are turned off the cell with grow and divide very quickly. The last step to becoming a
Cancer cell is the DNA repair genes gets turned off. DNA repair genes help your healthy
cells know if something is wrong with its DNA and how to fix it. When these genes get
turned off the cell doesn’t know if it is sick, and it can’t fix any problems with its DNA.
STAGES IN CARCINOGENESIS
Carcinogenesis is the process during which normal genes are damaged so that
cells lose normal control mechanisms of growth and proliferate out of control. When the
genes of a single cell are altered by a carcinogenic event, the offspring of the single cell
continue to mutate and divide, producing even more virulent mutant clones.
• Initiation – exposure of normal cells to carcinogens
• Promotion – cigarette smoking, alcohol abuse or dietary components that act on
the transformed cell
• Progression – uncontrollable growth of malignant tumor capable of metastatic
activity
WARNING SIGNS OF CANCER
C – hange in bowel or bladder habits
A – sore that doesn’t heal
U – nusual bleeding/discharge
T – hickening of lump – breast or elsewhere
I – ndigestion/dysphagia
O – bvious change in a wart/mole
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N – agging cough/hoarseness
U – nexplained anemia
S – udden and unexplained weight loss
Persistent headache
CLASSIFICATION
• Grading – defines the origin of the tumor and degree to which tumor cells retain
the functional and histologic characteristics of tissue origin
Grade X: Grade cannot be determined
Grade I: Cells differ slightly from normal cells and are well differentiated
(Mild Dysplasia)
Grade II: Cells are abnormal and are moderately differentiated (Moderate
Dysplasia)
Grade III: Cells are very abnormal and are poorly differentiated (Severe
Dysplasia)
Grade IV: Cells are immature (Anaplasia) and undifferentiated, cell of
origin is difficult to determine.
• Staging – determines the size of the tumor and extent metastasis; determines
extent of the disease
Stage 0 – carcinoma in situ; cancer in place
Stage I – tumor limited to the tissue of origin; localized tumor growth
Stage II – limited local spread
Stage III – extensive local and regional spread
Stage IV- metastasis
DIAGNOSTIC TESTS
• Biopsy – is the definitive means of diagnosing cancer and provides histological
proof of malignancy. It involves the surgical incision of a small piece of tissue of
microscopic examination
Types:
Needle: Aspiration of Cells
Incisional: Removal of a wedge of suspected tissue from a larger
mass
Excisional: Complete removal of the entire lesion
Staging: Multiple needle or incisional biopsies in tissues where
metastasis is suspected or likely.
• Other means of Detection
Mammography
Papanicolaou’s (Pap) test
Stools for occult blood
Sigmoidoscopy
Colonospcopy
Skin Inspection
Cancer cells are abnormal cells and they have characteristics that can be associated with
their ability to grow uncontrollably.Cancer cells are charectarized by undifferentiated and
uncontrolled cell division.Cancer cells are non-specialized, and divide uncontrollably.
Cancer in situ is a tumor located in its place of origin. Malignant tumors establish new
tumor distant from the primary tumors.
Cancer cells characteristics distinguish them from normal cells. They have abnormal
nuclei with many chromosomal irregularities. They form tumors because they do not
exhibit contact inhibition. They induce angiogenesis and cause nearby blood vessels to
form a capillary network that services the tumor.