Space and Memory

A two-way street
Example #2: memory in synapses

Memory-related processes involve

spatial sensory/motor pathways

Example #1 Memory in activity

Example #2 Memory in synapses
Example #3 Parietal cortex
Example #4 Hippocampus

Example #2 Memory in synapses

Information can also be stored via changes in
synaptic efficacy
Often occurs in (spatial) sensory/motor
pathways

Model system: Vestibulo-ocular reflex

Counter-rotation of the eyes when the head turns
Serves to keep visual image stable on retina
Must be calibrated

Head
Eye

No change in retinal image

These turns must be matched!

Head
Eye

No change in retinal image

Gain of VOR
Eye turn
Gain =
Head turn
E.g. desired gain = 1 if:
-- Looking at something far away
(head and eye rotate about different axes)
-- Not wearing glasses!

Glasses change size of visual scene

VOR gain must be adjusted when

you get new glasses
Changes occur within pathway that senses the
head turn and moves the eye
Notably:
Vestibular nuclei
Cerebellum

Cerebellum

Vestibular nuclei
(inside brainstem)

VOR gain must be adjusted when

you get new glasses
Changes occur within pathway that senses the
head turn and moves the eye
Notably:
Vestibular nuclei
Cerebellum

Synapses
Changes in the gain of the VOR are thought to be
accomplished by changes in the strength of synapses

and are implemented in vestibular-oculomotor pathway

Next Up:
A two-way street
Example #3: space and memory in parietal cortex