Gliquidone

C27H33N3O6S 527.6 33342-05-1

Action and use

Inhibition of ATP-dependent potassium channels (sulfonylurea); treatment of diabetes
mellitus.
Preparation
Gliquidone Tablets
DEFINITION
Gliquidone is 1-cyclohexyl-3-p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3dioxo2(1H)isoquinolyl)ethyl]phenylsulphonylurea. It contains not less than 98.5% and not more
than
101.5% of C27H33N3O6S, calculated with reference to the dried substance.
CHARACTERISTICS
A white or almost white powder.
Practically insoluble in water; slightly soluble in ethanol (96%) and in methanol ;
soluble in
acetone; freely soluble in dimethylformamide.
IDENTIFICATION
A. Dissolve 30 mg in 10 ml of methanol . Evaporate the methanol using a rotary
evaporator
and dry the residue at a temperature of 50 at a pressure of 2 kPa for 1 hour. The
infrared
absorption spectrum of the dried residue, Appendix II A, is concordant with the
reference
spectrum of gliquidone (RS 170).
B. In the test for Related substances, the principal spot in the chromatogram
obtained with
solution (1) corresponds to that in the chromatogram obtained with solution (2).