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Another type of giant cell with multiple nuclei is the Touton giant cell, which is seen in lipid-laden lesions
like fat necrosis. Touton giant cells also consist of fused epithelioid macrophages. However, in Touton
giant cells, the nuclei form a ring and are surrounded by foamy cytoplasm.
Youll undoubtedly see a few foreign body giant cells as you go through your pathology course. These
occur when the body is exposed to you guessed it a foreign substance (like talc or sutures). Foreign
body giant cells are formed by the same process (a bunch of epithelioid macrophages fuse together).
However, the nuclei are arranged centrally and in an overlapping fashion (check out the image below).