0 évaluation0% ont trouvé ce document utile (0 vote)
6 vues11 pages
A man was found having nausea, vomiting and abdominal pain, sweating, confusion and agitation follow. The lab results were positive for FLUOROACETATE TOXIC. Monoacetin (glyceryl monoacetate) 0. Mg / kg should be injected IM every half hour for 12 hours varying the injection sites.
A man was found having nausea, vomiting and abdominal pain, sweating, confusion and agitation follow. The lab results were positive for FLUOROACETATE TOXIC. Monoacetin (glyceryl monoacetate) 0. Mg / kg should be injected IM every half hour for 12 hours varying the injection sites.
A man was found having nausea, vomiting and abdominal pain, sweating, confusion and agitation follow. The lab results were positive for FLUOROACETATE TOXIC. Monoacetin (glyceryl monoacetate) 0. Mg / kg should be injected IM every half hour for 12 hours varying the injection sites.
A man was found having nausea, vomiting and abdominal pain, sweating, confusion and agitation follow. His next of kin told the triage that he accidentally swallow a rodent poison, which he thought it is some kind of candy placed on the kitchen table. The lab results were positive for fluoroacetate toxic. As a pathology researcher, you have to explain the whole situation (biochemically) to a bunch of industrial trainees in your pathology lab.
How the reaction occur ??
Fluoroacetate combines with coenzyme A (CoA-SH) to form fluoroacetyl CoA, which can substitute for acetyl CoA in the tricarboxylic acid cycle Then, reacts with citrate synthase to produce fluorocitrate, (a metabolite of which then binds very tightly to aconitase, thereby halting the cycle). Many of the features of fluoroacetate poisoning are, therefore, largely direct and indirect consequences of impaired oxidative metabolism. Energy production is reduced and intermediates of the tricarboxylic acid cycle subsequent to citrate are depleted
is mainly symptomatic. If ingested, vomiting should be induced immediately followed by gastric lavage with two to four litres of tap water and instillation of 15-30 g of saline cathartic. Monoacetin (glyceryl monoacetate) 0.5 mg/kg should be injected IM every half hour for 12 hours varying the injection sites.
THE EFFECT OF PH ON THE
TOXICITY OF FLUOROACETIC ACID The inhibition of oxygen consumption which is complete at much lower concentrations of HFA likewise dependent upon the amount of undis-sociated HFA in the cells environment. The Inhibition Of Oxygen Consumption Is pH-Labile,Which Indicates Either That The Inhibitory Agent Is Dissociable,Or That The Metabolic Reactions Of The Cell Change With Variation In Environmental pH.
Artificial respiration with the assistance of oxygen
may be required. Calcium gluconate, 2-3 g per day in 10% solution may be given IV. To control convulsions barbiturates (preferably phenobarbitone or pentobarbitone) should be given IM or IV in sufficient dosage