COMPARISON OF CALSIUM STATE IN END-STAGE RENAL DISEASE

WITH AND WITHOUT CORRECTION FOR ALBUMIN

Nurul Utami Handayani, Purwanto Adipireno
Departement of Clinical Pathology, Faculty of Medicine, Diponegoro University
Dr. Kariadi Hospital, Semarang
ABSTRACT
Background : Determination of calcium state in End-Stage Renal Disease (ESRD) very
important for clinical management because hypercalcemia and hypocalcemia state known as
independent predictor for mortality increases in patient on hemodialysis. 40% calcium in
blood bound to albumin, therefore albumin decreases can be influence measuring for calcium.
Objective : To compare calcium state in ESRD patient between two measuring which are
with and without correction for albumin.
Methods : Cross sectional study. Difference test was performed in each calcium
concentration using paired t-test and calcium state using paired sample wilcoxon test.
Consecutive sample where taken from patient with inclusion criteria (ESRD with albumin <
35 g/L).
Result : There were 36 patient with ESRD. The mean of albumin serum were 25,9 5,3 g/L.
The mean of total calcium concentration with and without correction for albumin,
respectively were 2,4 0,27 mmol/L and 2,1 0,28 mmol/L. calcium state in ESRD patient
with and without correction for albumin, respectively were hipocalcemia 6%, normocalcemia
19%, hipercalcemia 11% dan hipocalcemia 24%, normocalcemia 11%, hipercalcemia 1%. At
statistical analysis, there are significant difference in calcium state between with and without
correction for albumin in ESRD patient (p< 0,05).
Conclusion : There are significant difference in calcium state between with and without
correction for albumin in ESRD patient.
Key word: End-Stage Renal Disease, Calcium state, Albumin