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February 4, 2016
Biol 495-H02: Honors Seminar in Biology
Dr. Stanko & Dr. Fortune
Annotated Bibliography - The Relationship between Traumatic Brain Injuries
(TBIs) and Neurodegenerative Disease
1. Traumatic Brain Injury Football, Warfare, and Long-Term Effects. New
England Journal of Medicine, 363(14), 1293-1296.
doi:10.1056/NEJMp1007051
This paper revolves around TBIs and the information relating to future
affects of a TBI. It touches upon the subject of the development of
neurodegenerative disorders as well as the development of tau tangles in
the brain following repeated mild TBIs. It focuses on comparing mild TBIs,
repeated mild TBIs, and severe TBIs. It goes on to talk about how each of
these types of injuries has their own effects and how they could lead into
more serious problems such as neurodegenerative diseases, but much of
this information is unknown and not backed by a deeper biochemical
understanding.
2. Esopenko, C., & Levine, B. (2015). Aging, neurodegenerative disease,
and traumatic brain injury: the role of neuroimaging. J Neurotrauma,
32(4), 209-220. doi:10.1089/neu.2014.3506
This review article covers the link between neurodegenerative disorders and
TBIs. It also covers the advances in neuroimaging technologies that can help
uncover much of the information that is still unknown about both TBIs and
neurodegenerative disorders as well as the links between them. Lastly the
article also overviews how these technologies have shown some evidience of
the changes that the brain goes through following a TBI.
**Need access to full article**
3. Gardner, R. C., & Yaffe, K. (2015). Epidemiology of mild traumatic brain
injury and neurodegenerative disease. Mol Cell Neurosci, 66(Pt B), 7580. doi:10.1016/j.mcn.2015.03.001
This article reviews how many epidemiological studies have shown that
mTBIs are a risk factor for many neurodegenerative diseases such as
Alzheimers, Parkinsons, ALS, and CTE but at the same time besides this
there is much still unknown regarding the true connection between the
injuries and diseases. It compiles many research studies that go based of
epidemiological research and discusses what needs to be uncovered in order
to get a better understanding of the connection between the two.